中国人群慢性阻塞肺病相关危险因素的Meta分析
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摘要
目的探讨影响中国人群慢性阻塞肺病相关危险因素的Meta分析。方法收集2000-2015年我国公开发表的关于中国人群慢性阻塞肺病相关危险因素的研究文献资料共14篇。应用Rev Man 5.0软件进行Meta分析。结果吸烟、有被动吸烟史、BMI、职业粉尘或化学品暴露、家族呼吸道疾病史、儿童时期呼吸道疾病史、受教育程度、使用煤及柴草燃料及厨房通风情况与慢性阻塞肺病OR值之间存在关联,且均为危险因素。根据其OR估计值的大小,吸烟3.08(95%CI:2.26,4.21)、使用煤及柴草燃料3.10(95%CI:1.77,3.71)、家族呼吸道疾病史3.42(95%CI:2.76,3.98)与慢性阻塞肺病OR值呈较强的关联强度,被动吸烟1.46(95%CI:1.15,1.98)、职业粉尘或化学品暴露1.57(95%CI:1.17,2.45)、厨房通风情况1.28(95%CI:1.82,2.43)与慢性阻塞肺病OR值呈较弱关联,其他因素均呈中等强度关联。男性、高龄与慢性阻塞肺病OR值无相关。采用固定效应模型和随机效应模型分别计算慢性阻塞肺病发病危险因素的OR合并值及95%CI,结果两种模型分析结果基本相似。结论吸烟、有被动吸烟史、BMI、职业粉尘或化学品暴露、家族呼吸道疾病史、儿童时期呼吸道疾病史、受教育程度、使用煤及柴草燃料及厨房通风情况是影响中国人群慢性阻塞肺病发病的危险因素。
Objective To explore the risk factors associated with chronic obstructive lung disease in Chinese population by Meta analysis. Methods We collected a total of 14 domestic published studies regarding the risk factors related to chronic obstructive lung disease among Chinese population during 2000-2015,and then Meta analysis was performed by using Rev Man 5. 0 software. Results Smoking,passive smoking history,body mass index( BMI),occupational dust or chemical exposure,family history of respiratory disease,childhood respiratory disease history,educational background,use of coal and straw fuel and kitchen ventilation were correlated with the OR value of chronic obstructive pulmonary disease; moreover,they were all risk factors. According to the OR estimated values,smoking( 3.08,95%CI: 2.26-4.21),use of coal and straw fuel( 3.10,95%CI: 1.77-3.71)and family history of respiratory disease( 3.42,95%CI: 2.76-3.98) showed a strong correlation with the OR value of chronic obstructive pulmonary disease( COPD),while passive smoking( 1.46,95%CI: 1.15-1.98),occupational dust or chemical exposure( 1.57,95%CI: 1.17-2.45) and kitchen ventilation( 1.28,95%CI: 1.82-2.43) showed a slight correlation with the OR value of COPD. And other factors displayed a moderate correlation with the OR value. Male and age were not associated with the OR value.The fixed effect model and random effect model were used to respectively calculate the OR combined value and 95%CI of risk factors for COPD and got basically similar results. Conclusions Smoking,passive smoking history,BMI,occupational dust or chemical exposure,family history of respiratory disease and childhood respiratory disease history,educational background,use of coal and straw fuel and kitchen ventilation are the risk factors affecting the occurrence of chronic obstructive pulmonary disease in Chinese population.
Objective To explore the risk factors associated with chronic obstructive lung disease in Chinese population by Meta analysis. Methods We collected a total of 14 domestic published studies regarding the risk factors related to chronic obstructive lung disease among Chinese population during 2000-2015,and then Meta analysis was performed by using Rev Man 5. 0 software. Results Smoking,passive smoking history,body mass index( BMI),occupational dust or chemical exposure,family history of respiratory disease,childhood respiratory disease history,educational background,use of coal and straw fuel and kitchen ventilation were correlated with the OR value of chronic obstructive pulmonary disease; moreover,they were all risk factors. According to the OR estimated values,smoking( 3.08,95%CI: 2.26-4.21),use of coal and straw fuel( 3.10,95%CI: 1.77-3.71)and family history of respiratory disease( 3.42,95%CI: 2.76-3.98) showed a strong correlation with the OR value of chronic obstructive pulmonary disease( COPD),while passive smoking( 1.46,95%CI: 1.15-1.98),occupational dust or chemical exposure( 1.57,95%CI: 1.17-2.45) and kitchen ventilation( 1.28,95%CI: 1.82-2.43) showed a slight correlation with the OR value of COPD. And other factors displayed a moderate correlation with the OR value. Male and age were not associated with the OR value.The fixed effect model and random effect model were used to respectively calculate the OR combined value and 95%CI of risk factors for COPD and got basically similar results. Conclusions Smoking,passive smoking history,BMI,occupational dust or chemical exposure,family history of respiratory disease and childhood respiratory disease history,educational background,use of coal and straw fuel and kitchen ventilation are the risk factors affecting the occurrence of chronic obstructive pulmonary disease in Chinese population.
引文
[1]陈何健,边红燕.稳定期慢性阻塞性肺疾病患者生活质量及其影响因素分析[J].实用预防医学,2015,10(4):470-471.
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[13]张雅囡,邱洁,张锦,等,宁夏慢性阻塞性肺疾病危险因素流行病学调查[J].中国实用内科杂志,2013,33(11):876-880.
[14]洪秀琴,戴爱国,尹培生,等.农村居民慢性阻塞性肺疾病及影响因素分析[J].中国公共卫生,2012,28(4):442-445.
[15]唐刚,张国祥,沈亚红.社区慢性阻塞性肺疾病高危人群的患病状况及危险因素分析[J].安徽医药,2014,18(1):97-100.
[16]荣艳,凌敏,胡翠芬,等.新疆阿克苏农村地区慢性阻塞性肺疾病危险因素分析[J].中国实用内科杂志,2010,30(1):1-3.
[17]石小倩,胡楠,李晓燕,等.2004-2005年中国西部农村地区居民慢性阻塞性肺部疾病的死亡负担[J].中华预防医学杂志,2011,45(1):68-72.
[18]Targowski T,Janda P,Owczarek W,et al.Evaluation of occurrence frequency of circulating p53 protein in serum of patients with chronic obstructive pulmonary diseases and non-small cell lung cancer[J].Pol Merkuriusz Lek,2010,28(166):265-267.
[19]侯刚,尹燕,孙丽丽,等.社区35岁以上人群慢性阻塞性肺疾病流行病学患病率及危险因素研究[J].中国全科医学,2012,15(6):1831-1833.
[20]马真,卓宋明,周路球,等.体质量指数与慢性阻塞性肺疾病的相关性研究[J].现代预防医学,2011,38(12):2417-2418.
[2]杨秀娜,杨梅,刘新会,等.慢性阻塞性肺疾病患者血清IL-13、TGF-α浓度变化及其肺功能相关性研究[J].实用预防医学,2017,24(1):92-94.
[3]运玲,徐应军,喻昌利,等.唐山市农村地区慢性阻塞性肺疾病危险因素病例对照研究[J].中国慢性病预防与控制,2009,17(5):498-500.
[4]史清明,张宜文,倪进发.慢性阻塞性肺病危险因素的病例对照研究[J].安徽预防医学杂志,2002,8(4):209-212.
[5]徐昕,夏书月,刘献萍,等.慢性阻塞性肺疾病危险因素病例对照研究[J].中国慢性病预防与控制,2008,16(5):471-473.
[6]李文峰.慢性阻塞性肺疾病患病危险因素的病例对照研究[J].南方医科大学学报,2010,30(8):2009-2012.
[7]苏晴,葛艳,张勇,等.慢性阻塞性肺疾病危险因素的1:2病例对照[J].中国实用医刊,2011,38(1):76-78.
[8]陈伟国,毛锐.慢性阻塞性肺疾病患病危险因素分析—1:1病例对照研究[J].广东药学院学报,2008,24(2):188-189.
[9]徐斐.慢性阻塞性肺病的流行病学研究[D].南京:南京医科大学,2008.
[10]郭元.广州居民COPD危险因素的病例-对照研究[D].广州:广州医学院,2011.
[11]覃善芳,张庆团,张凯.慢性阻塞性肺疾病发病相关危险因素Logistic回归分析[J].中华全科医学,2013,11(4):597-662.
[12]肖耀来,李合友,林勇,等.慢性阻塞性肺疾病患病危险因素分析[J].中国行为医学科学,2005,14(9):786-787.
[13]张雅囡,邱洁,张锦,等,宁夏慢性阻塞性肺疾病危险因素流行病学调查[J].中国实用内科杂志,2013,33(11):876-880.
[14]洪秀琴,戴爱国,尹培生,等.农村居民慢性阻塞性肺疾病及影响因素分析[J].中国公共卫生,2012,28(4):442-445.
[15]唐刚,张国祥,沈亚红.社区慢性阻塞性肺疾病高危人群的患病状况及危险因素分析[J].安徽医药,2014,18(1):97-100.
[16]荣艳,凌敏,胡翠芬,等.新疆阿克苏农村地区慢性阻塞性肺疾病危险因素分析[J].中国实用内科杂志,2010,30(1):1-3.
[17]石小倩,胡楠,李晓燕,等.2004-2005年中国西部农村地区居民慢性阻塞性肺部疾病的死亡负担[J].中华预防医学杂志,2011,45(1):68-72.
[18]Targowski T,Janda P,Owczarek W,et al.Evaluation of occurrence frequency of circulating p53 protein in serum of patients with chronic obstructive pulmonary diseases and non-small cell lung cancer[J].Pol Merkuriusz Lek,2010,28(166):265-267.
[19]侯刚,尹燕,孙丽丽,等.社区35岁以上人群慢性阻塞性肺疾病流行病学患病率及危险因素研究[J].中国全科医学,2012,15(6):1831-1833.
[20]马真,卓宋明,周路球,等.体质量指数与慢性阻塞性肺疾病的相关性研究[J].现代预防医学,2011,38(12):2417-2418.