银纳米粒子诱导肿瘤细胞自噬与凋亡关系的研究进展
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摘要
近年来,银纳米粒子(AgNP)高效抗肿瘤活性研究受到广泛关注。现研究认为,AgNP可通过调节氧化应激水平、细胞凋亡、DNA损伤和自噬过程发挥抗肿瘤活性,而自噬与凋亡过程又存在交互调控机制,可共同来维持细胞稳态,AgNP通过调节多信号分子诱导自噬和凋亡途径影响肿瘤的发展。本文以肿瘤细胞自噬与凋亡过程的相互关系为基础,综述AgNP的作用及机制,以期为今后拓展相关毒性机制研究和新药研发提供借鉴和参考。
In recent years,researches on the high antitumor activity of silver nanoparticles(AgNPs)have attracted much attention. The researches have shown that AgNPs could exert an antitumor activity via regulating the oxidative stress levels,apoptosis,DNA damage,and autophagy. It has been known that there are interactively regulating mechanisms,between autophagy and apoptosis processes,to maintain the cellular homeostasis. AgNPs participate in and regulate tumor development by coordinating intrinsic multisignal pathways to induce autophagy and apoptosis interactions. Based on the relationship between autophagy and apoptosis,this paper reviews the effect and mechanism of AgNPs,so as to provide a reference for the expanded,AgNP toxicity-related mechanism research and new drug development in future.
In recent years,researches on the high antitumor activity of silver nanoparticles(AgNPs)have attracted much attention. The researches have shown that AgNPs could exert an antitumor activity via regulating the oxidative stress levels,apoptosis,DNA damage,and autophagy. It has been known that there are interactively regulating mechanisms,between autophagy and apoptosis processes,to maintain the cellular homeostasis. AgNPs participate in and regulate tumor development by coordinating intrinsic multisignal pathways to induce autophagy and apoptosis interactions. Based on the relationship between autophagy and apoptosis,this paper reviews the effect and mechanism of AgNPs,so as to provide a reference for the expanded,AgNP toxicity-related mechanism research and new drug development in future.
引文
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[18] Guo X,Li Y,Yan J,et al. Size-and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays[J]. Nanotoxicology,2016,10(9):1373-1384.
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[25] Sakitani K,Hirata Y,Hikiba Y,et al. Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress[J]. BMC Cancer,2015,15(1):795-809.
[26]赵林,吴鹏,章平贵,等.雷公藤甲素对人结肠癌HCT116细胞增殖、自噬和凋亡的影响[J].中国药理学通报,2016,32(10):1399-1404.
[27] Yousefi S,Perozzo R,Schmid I,et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis[J]. Nat Cell Biol,2006,8(10):1124-1132.
[28] Furuya D,Tsuji N,Yagihashi A,et al. Beclin 1 augmented cisdiamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity[J]. Exp Cell Res,2005,307(1):26-40.
[29] Luo S,Rubinsztein DC. Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy[J]. Cell Death Differ,2007,14(7):1247-1250.
[30] Ito H,Daido S,Kanzawa T,et al. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells[J]. Int J Oncol,2005,26(5):1401-1410.
[31] Huang SB,Sinicrope F. Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells[J]. Autophagy,2010,6(2):256-269.
[32] Chen S,Zhou L,Zhang Y,et al. Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik[J]. Mol Cell Biol,2014,34(18):3435-3449.
[33] Ma X,Wu Y,Jin S,et al. Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment[J]. ACS Nano,2011,5(11):8629-8639.
[34] Atashi Fatemeh,Modarressi Ali,Pepper Michael S. The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation:a review[J]. Stem Cells Dev,2015,24(10):1150-1163.
[35] Wang G,Zhang T,Sun W,et al. Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma[J].Free Radical Biol Med,2017,106:24-37.
[36] He ZJ,Zhu FY,Li SS,et al. Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma[J]. Food Chem Toxicol,2017,101:55-66.
[37] Lee YH,Cheng FY,Chiu HW,et al. Cytotoxicity,oxidative stress,apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic?broblasts[J]. Biomaterials,2014,35(16):4706-4715.
[38] Wu H,Lin J,Liu P,et al. Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNP[J]. Biomaterials,2016,101:1-9.
[39] Fageria L,Pareek V,Dilip R. V,et al. Biosynthesized proteincapped silver nanoparticles induce ROS-dependent proapoptotic signals and prosurvival autophagy in cancer cells[J]. ACS Omega,2017,2(4):1489-1504.
[40] Farah MA,Ali MA,Chen SM,et al. Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage,apoptosis and autophagy via generation of reactive oxygen species[J]. Colloid Surfaces B,2016,141:158-169.
[41] Zhu L,Guo D,Sun L,et al. Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells[J]. Nanoscale,2017,9(17):5489-5498.
[42] Mishra AR,Zheng J,Tang X,et al. Silver nanoparticle-induced autophagic-lysosomal disruption and NLRP3-inflammasome activation in HepG2 cells is size-dependent[J]. Toxi Sci,2016,150(2):473-487.
[43] MaoBH,TsaiJC,ChenCW,et al.Mechanismsofsilvernanoparticle-induced toxicity and important role of autophagy[J]. Nanotoxicology,2016,10(8):1021-1040.
[44] Jeong JK,Gurunathan S,Kang MH,et al. Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells[J]. Sci R,2016,6(1):21688.
[45] Lin J,Huang ZH,Wu H,et al. Inhibition of autophagy enhances the anticancer activity of silver nanoparticles[J]. Autophagy,2014,10(11):2006-2020.
[46] Lin J,Liu YM,Wu H,et al. Key role of TFEB nucleus translocation for silver nanoparticle-induced cytoprotective autophagy[J]. Small,2018,14(13):e1703711.
[47] Lee TY,Liu MS,Huang LJ,et al. Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration[J]. Part Fibre Toxicol,2013,10(1):40.
[48] Rikiishi H. Novel insights into the interplay between apoptosis and autophagy[J]. Int J Cell Biol,2012,2012:317645.
[2] Asharani PV,Hande MP,Valiyaveettil S. Anti-proliferative activity of silver nanoparticles BMC[J]. BMC Cell Biol,2009,10(1):65-79.
[3] Banerjee PP,Bandyopadhyay A,Harsha SN,et al. Mentha arvensis(Linn.)-mediated green silver nanoparticles trigger caspase 9-dependent cell death in MCF7 and MDA-MB-231 cells[J]. BC,2017,9:265-278.
[4] Ma J,Zhao D,Lu H,et al. Apoptosis signal-regulating kinaseⅠ(ASKⅠ)activation is involved in silver nanoparticles induced apoptosis of A549 lung cancer cell line[J]. J Biomed Nanotechnol,2017,13(3):349-354.
[5] Pandurangan M,Enkhtaivan G,Venkitasamy B,et al. Time and concentration-dependent therapeutic potential of silver nanoparticles in cervical carcinoma cells[J]. Biol Trace Elem Res,2016,170(2):309-319.
[6] Han JW,Gurunathan S,Jeong JK,et al. Oxidative stress mediated cytotoxicity of biologically synthesized silver nanoparticles in human lung epithelial adenocarcinoma cell line[J]. Nanoscale Res Lett,2014,9(1):459.
[7] Chen X,Schluesener HJ. Nanosilver:a nanoproduct in medical application[J]. Toxicol Lett,2008,176(1):1-12.
[8] Carbone M,Donia DT,Sabbatella G,et al. Silver nanoparticles in polymeric matrices for fresh food packaging[J]. J King Saud Univ-Sci,2016,28(4):273-279.
[9] Pannerselvam B,Dharmalingam Jothinathan MK,Rajenderan M,et al. An in vitro study on the burn wound healing activity of cotton fabrics incorporated with phytosynthesized silver nanoparticles in male Wistar albino rats[J]. Eur J Pharm Sci,2017,100:187-196.
[10] Prasath P. Is using nanosilver mattresses/pillows safe? A review of potential health implications of silver nanoparticles on human health[J]. Environ Geochem Hlth,2019,40(180):1-19.
[11] Boudreau MD,Imam MS,Paredes AM,et al. Differential effects of silver nanoparticles and silver ions on tissue accumulation,distribution,and toxicity in the Sprague Dawley rat following daily oral gavage administration for 13-weeks[J]. Toxi Sci,2016,150(1):131-160.
[12] Butler KS,Peeler DJ,Casey BJ,et al. Silver nanoparticles:correlating nanoparticle size and cellular uptake with genotoxicity[J]. Mutagenesis,2015,30(4):577-591.
[13] Hsueh YH,Lin KS,Ke WJ,et al. The antimicrobial properties of silver nanoparticles in Bacillus subtilis are mediated by released Ag+ions[J]. PLoS One,2015,10(12):e0144306.
[14] Veronesi G,Deniaud A,Gallon T,et al. Visualization,quantification and coordination of Ag+ions released from silver nanoparticles in hepatocytes[J]. Nanoscale,2016,8(38):1
[15] Park EJ,Yi J,Kim Y,et al. Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism[J]. Toxi Vitro,2010,24(3):872-878.
[16] Ravi S,Jessica S,Jade M,et al. Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells[J]. Int J Nanomed,2015,10:3937-3953.
[17] Lee YH,Fang CY,Chiu HW,et al. Endoplasmic reticulum stress-triggered autophagy and lysosomal dysfunction contribute to the cytotoxicity of amine-modified silver nanoparticles in NIH3T3cells[J].J Biomed Nanotechnol,2017,13(7):778-794.
[18] Guo X,Li Y,Yan J,et al. Size-and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays[J]. Nanotoxicology,2016,10(9):1373-1384.
[19] Raza M,Zakia K,Anum R,et al. Size-and shape-dependent antibacterial studies of silver nanoparticles synthesized by wet chemical routes[J]. Nanomaterials,2016,6(4):74.
[20] Hong X,Wen J,Xiong X,et al. Shape effect on the antibacterial activity of silver nanoparticles synthesized via a microwave-assisted method[J]. Environ Sci Pollut R,2016,23(5):4489-4497.
[21] Schlinkert P,Casals E,Boyles M,et al. The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types[J]. J Nano,2015,13(1):1-18.
[22] Ciechomska IA. The role of autophagy in cancer-characterization of crosstalk between apoptosis and autophagy;autophagy as a new therapeutic strategy in glioblastoma[J]. Postepy Biochem,2018,64(2):119-128.
[23] Wirawan E,Vande Walle L,Kersse K,et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria[J]. Cell Death Dis,2010,1(1):1-10.
[24] Laha D,Pramanik A,Maity J,et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7[J]. BBA-Gen Subjects,2014,1840(1):1-9.
[25] Sakitani K,Hirata Y,Hikiba Y,et al. Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress[J]. BMC Cancer,2015,15(1):795-809.
[26]赵林,吴鹏,章平贵,等.雷公藤甲素对人结肠癌HCT116细胞增殖、自噬和凋亡的影响[J].中国药理学通报,2016,32(10):1399-1404.
[27] Yousefi S,Perozzo R,Schmid I,et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis[J]. Nat Cell Biol,2006,8(10):1124-1132.
[28] Furuya D,Tsuji N,Yagihashi A,et al. Beclin 1 augmented cisdiamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity[J]. Exp Cell Res,2005,307(1):26-40.
[29] Luo S,Rubinsztein DC. Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy[J]. Cell Death Differ,2007,14(7):1247-1250.
[30] Ito H,Daido S,Kanzawa T,et al. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells[J]. Int J Oncol,2005,26(5):1401-1410.
[31] Huang SB,Sinicrope F. Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells[J]. Autophagy,2010,6(2):256-269.
[32] Chen S,Zhou L,Zhang Y,et al. Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik[J]. Mol Cell Biol,2014,34(18):3435-3449.
[33] Ma X,Wu Y,Jin S,et al. Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment[J]. ACS Nano,2011,5(11):8629-8639.
[34] Atashi Fatemeh,Modarressi Ali,Pepper Michael S. The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation:a review[J]. Stem Cells Dev,2015,24(10):1150-1163.
[35] Wang G,Zhang T,Sun W,et al. Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma[J].Free Radical Biol Med,2017,106:24-37.
[36] He ZJ,Zhu FY,Li SS,et al. Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma[J]. Food Chem Toxicol,2017,101:55-66.
[37] Lee YH,Cheng FY,Chiu HW,et al. Cytotoxicity,oxidative stress,apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic?broblasts[J]. Biomaterials,2014,35(16):4706-4715.
[38] Wu H,Lin J,Liu P,et al. Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNP[J]. Biomaterials,2016,101:1-9.
[39] Fageria L,Pareek V,Dilip R. V,et al. Biosynthesized proteincapped silver nanoparticles induce ROS-dependent proapoptotic signals and prosurvival autophagy in cancer cells[J]. ACS Omega,2017,2(4):1489-1504.
[40] Farah MA,Ali MA,Chen SM,et al. Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage,apoptosis and autophagy via generation of reactive oxygen species[J]. Colloid Surfaces B,2016,141:158-169.
[41] Zhu L,Guo D,Sun L,et al. Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells[J]. Nanoscale,2017,9(17):5489-5498.
[42] Mishra AR,Zheng J,Tang X,et al. Silver nanoparticle-induced autophagic-lysosomal disruption and NLRP3-inflammasome activation in HepG2 cells is size-dependent[J]. Toxi Sci,2016,150(2):473-487.
[43] MaoBH,TsaiJC,ChenCW,et al.Mechanismsofsilvernanoparticle-induced toxicity and important role of autophagy[J]. Nanotoxicology,2016,10(8):1021-1040.
[44] Jeong JK,Gurunathan S,Kang MH,et al. Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells[J]. Sci R,2016,6(1):21688.
[45] Lin J,Huang ZH,Wu H,et al. Inhibition of autophagy enhances the anticancer activity of silver nanoparticles[J]. Autophagy,2014,10(11):2006-2020.
[46] Lin J,Liu YM,Wu H,et al. Key role of TFEB nucleus translocation for silver nanoparticle-induced cytoprotective autophagy[J]. Small,2018,14(13):e1703711.
[47] Lee TY,Liu MS,Huang LJ,et al. Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration[J]. Part Fibre Toxicol,2013,10(1):40.
[48] Rikiishi H. Novel insights into the interplay between apoptosis and autophagy[J]. Int J Cell Biol,2012,2012:317645.