甘草抗抑郁研究与应用
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摘要
甘草为常用补益中药,其抗抑郁作用近年受到关注。通过检索近年国内外有关甘草抗抑郁文献,从甘草提取物、活性成分及其复方制剂的抗抑郁研究进行阐述,表明甘草及其活性成分具有明确的抗抑郁作用,其机理涉及抗氧化、抗凋亡损伤,抗单胺氧化酶、调节单胺神经递质等。通过复方配伍,具有健脾宁心、和中柔肝,和药解毒作用,用于抑郁症具有较好疗效。甘草抗抑郁作用的深入研究对揭示抑郁症发病机制、研发抗抑郁新药、提高抑郁症诊治水平均具有参考价值。
Radix Glycyrrhizae is a commonly used tonic Chinese medicine and its antidepressant effects have attracted attention in recent years. Through the retrieval at home and abroad in recent years about the licorice anti- depression literatures,this article makes a study from the perspective of antidepressant licorice extracts,active ingredients and its compound preparation,and shows that licorice and its active components have clear antidepressant effect,and the mechanism relates to antioxidant,anti apoptotic injury,anti monoamine oxidase,regulate the monoamine neurotransmitter etc. Through compound prescription,licorice has the functions such as strengthening the spleen and calming the heart,reconciling the middle burner and softening the liver,coordinating the drug actions of a prescription and detoxification,etc. and has good curative effect on depression. Further studies on antidepressant effect of Radix Glycyrrhizae have reference value for revealing the pathogenesis of depression,the research and development of new antidepressant drug,and improving the level of diagnosis and treatment of depression.
Radix Glycyrrhizae is a commonly used tonic Chinese medicine and its antidepressant effects have attracted attention in recent years. Through the retrieval at home and abroad in recent years about the licorice anti- depression literatures,this article makes a study from the perspective of antidepressant licorice extracts,active ingredients and its compound preparation,and shows that licorice and its active components have clear antidepressant effect,and the mechanism relates to antioxidant,anti apoptotic injury,anti monoamine oxidase,regulate the monoamine neurotransmitter etc. Through compound prescription,licorice has the functions such as strengthening the spleen and calming the heart,reconciling the middle burner and softening the liver,coordinating the drug actions of a prescription and detoxification,etc. and has good curative effect on depression. Further studies on antidepressant effect of Radix Glycyrrhizae have reference value for revealing the pathogenesis of depression,the research and development of new antidepressant drug,and improving the level of diagnosis and treatment of depression.
引文
[1]何媛媛,徐自升,姚仲青,等.抗抑郁方药研究进展[J].南京中医药大学学报,2011,27(5):495-497.
[2]黄世敬,张颖,王彦云.巴戟天抗抑郁研究进展[J].世界中西医结合杂志,2013,8(7):744-746.
[3]施学丽,陈贵海,赵晓芳,等.基于数据挖掘技术的中药专利复方治疗抑郁症用药规律分析[J].时珍国医国药,2013,24(11):2822-2824.
[4]段艳霞,李洁,史美育.中药治疗中风后抑郁症用药规律探讨[J].中华中医药学刊,2011,29(6):1419-1421.
[5]高雪岩,王文全,魏胜利,等.甘草及其活性成分的药理活性研究进展[J].中国中药杂志,2009,34(21):2697-2700.
[6]程瑞凤,景晶,华冰,等.甘草总黄酮提取部位抗小鼠抑郁活性可能与其增强中枢5-羟色胺能神经功能有关[J].中国药理学与毒理学杂志,2014,30(4):484-490.
[7]果嘉,赵伟鸿,樊紫周,等.甘草总黄酮抗抑郁作用研究[J].中药药理与临床,2012,28(6):59-62.
[8]樊紫周,赵伟鸿,果嘉,等.甘草黄酮的抗抑郁作用及对海马脑区神经再生的保护作用[J].药学学报,2012,47(12):1612-1617.
[9]华冰,程瑞凤,景晶,等.甘草总黄酮抗大鼠应激抑郁作用及对突触可塑性关键蛋白SYP/PSD-95的调节作用[J].中国新药杂志,2014,39(10):1180-1187.
[10]程瑞凤,华冰,景晶,等.甘草总黄酮抗大鼠应激抑郁行为作用及对海马脑区神经细胞凋亡调控相关蛋白表达的影响[J].中药药理与临床,2014,30(2):69-72.
[11]张明发,赵迎春,沈雅琴.甘草及其黄酮类化合物的神经保护作用[J].抗感染药学,2013,10(3):170-175.
[12]杨秋霞,范红展.甘麦大枣解郁汤治疗老年抑郁症32例临床观察[J].河南中医,2012,32(6):734-735.
[13]周喜燕,秦秀德,耿丽芳.甘麦大枣汤治疗中风后抑郁症30例临床观察[J].四川中医,2009,27(10):75-76.
[14]潘玉印.解郁丸联合氢溴酸西酞普兰片治疗老年抑郁症的临床疗效及安全性分析[J].时珍国医国药,2013,24(8):1955-1956.
[15]韦韩荣.归脾汤合甘麦大枣汤治疗心脾两虚型抑郁证56例[J].实用中医内科杂志,2013,27(3):50-51.
[16]王宇亮,党中勤,牛学恩,等.加味六君子汤治疗功能性消化不良伴抑郁症40例临床观察[J].中医杂志,2013,54(17):1480-1482.
[17]刘枉涵.柴胡疏肝散联合西药治疗抑郁型冠心病随机平行对照研究[J].实用中医内科杂志,2014,28(3):45-47.
[18]赵洁萍,李莉.解郁汤治疗冠心病伴发抑郁焦虑症状30例[J].中医研究,2013,26(1):23-25.
[19]杨毓强.解郁化瘀汤治疗老年脑梗死后抑郁症随机平行对照研究[J].实用中医内科杂志,2013,27(3):87-88.
[20]王彦华,赵玉伟.针刺联合振瘫解郁汤治疗卒中后抑郁27例[J].中医研究,2013,26(6):53-55.
[21]龚梦鹃,何伟,唐春萍,等.桂枝解郁胶囊抗抑郁作用的药理实验研究[J].中成药,2011,33(7):1121-1125.
[22]高孟翠,李静,亓媛媛.辨证治疗抑郁症276例临床观察[J].实用中医内科杂志,2013,27(4s):80-81.
[23]夏小玉,邵辉,沈红薇,等.逍遥丸的临床应用进展[J].陕西中医,2012,33(10):1436-1437.
[24]武春丽.逍遥散加减配合西药治疗糖尿病抑郁症疗效观察[J].陕西中医,2011,32(12):1625-1626.
[25]杨靖,龚锡平,刘蓉,等.逍遥散及其功效拆方对应激抑郁模型小鼠的影响[J].中药与临床,2013,4(5):26-29.
[26]张瑜,王亚军,田永萍,等.针药结合对慢性应激抑郁模型大鼠海马脑区NGF的影响[J].中医研究,2012,25(6):67-70.
[27]塔光,王健.柴胡加龙骨牡蛎汤治疗中风后抑郁24例[J].吉林中医药,2008,28(3):179-180.
[28]苏明,韩阳.加味黄连温胆汤治疗2型糖尿病合并抑郁32例疗效观察[J].天津中医药,2013,30(8):465-466.
[29]郑宗和.解郁合剂联合氟西汀辨证分型治疗抑郁症随机平行对照研究[J].实用中医内科杂志,2014,28(7):99-101.
[30]高孟英.丹桂逍遥丸联合米氮平片治疗脑卒中后抑郁32例[J].中医研究,2013,26(5):39-41.
[31]乐文,冯芳,王娅.栀子甘草豉汤的LC-PDA-MS/MS分析及抗抑郁作用研究[J].中国药科大学学报,2009,40(4):342-347.
[2]黄世敬,张颖,王彦云.巴戟天抗抑郁研究进展[J].世界中西医结合杂志,2013,8(7):744-746.
[3]施学丽,陈贵海,赵晓芳,等.基于数据挖掘技术的中药专利复方治疗抑郁症用药规律分析[J].时珍国医国药,2013,24(11):2822-2824.
[4]段艳霞,李洁,史美育.中药治疗中风后抑郁症用药规律探讨[J].中华中医药学刊,2011,29(6):1419-1421.
[5]高雪岩,王文全,魏胜利,等.甘草及其活性成分的药理活性研究进展[J].中国中药杂志,2009,34(21):2697-2700.
[6]程瑞凤,景晶,华冰,等.甘草总黄酮提取部位抗小鼠抑郁活性可能与其增强中枢5-羟色胺能神经功能有关[J].中国药理学与毒理学杂志,2014,30(4):484-490.
[7]果嘉,赵伟鸿,樊紫周,等.甘草总黄酮抗抑郁作用研究[J].中药药理与临床,2012,28(6):59-62.
[8]樊紫周,赵伟鸿,果嘉,等.甘草黄酮的抗抑郁作用及对海马脑区神经再生的保护作用[J].药学学报,2012,47(12):1612-1617.
[9]华冰,程瑞凤,景晶,等.甘草总黄酮抗大鼠应激抑郁作用及对突触可塑性关键蛋白SYP/PSD-95的调节作用[J].中国新药杂志,2014,39(10):1180-1187.
[10]程瑞凤,华冰,景晶,等.甘草总黄酮抗大鼠应激抑郁行为作用及对海马脑区神经细胞凋亡调控相关蛋白表达的影响[J].中药药理与临床,2014,30(2):69-72.
[11]张明发,赵迎春,沈雅琴.甘草及其黄酮类化合物的神经保护作用[J].抗感染药学,2013,10(3):170-175.
[12]杨秋霞,范红展.甘麦大枣解郁汤治疗老年抑郁症32例临床观察[J].河南中医,2012,32(6):734-735.
[13]周喜燕,秦秀德,耿丽芳.甘麦大枣汤治疗中风后抑郁症30例临床观察[J].四川中医,2009,27(10):75-76.
[14]潘玉印.解郁丸联合氢溴酸西酞普兰片治疗老年抑郁症的临床疗效及安全性分析[J].时珍国医国药,2013,24(8):1955-1956.
[15]韦韩荣.归脾汤合甘麦大枣汤治疗心脾两虚型抑郁证56例[J].实用中医内科杂志,2013,27(3):50-51.
[16]王宇亮,党中勤,牛学恩,等.加味六君子汤治疗功能性消化不良伴抑郁症40例临床观察[J].中医杂志,2013,54(17):1480-1482.
[17]刘枉涵.柴胡疏肝散联合西药治疗抑郁型冠心病随机平行对照研究[J].实用中医内科杂志,2014,28(3):45-47.
[18]赵洁萍,李莉.解郁汤治疗冠心病伴发抑郁焦虑症状30例[J].中医研究,2013,26(1):23-25.
[19]杨毓强.解郁化瘀汤治疗老年脑梗死后抑郁症随机平行对照研究[J].实用中医内科杂志,2013,27(3):87-88.
[20]王彦华,赵玉伟.针刺联合振瘫解郁汤治疗卒中后抑郁27例[J].中医研究,2013,26(6):53-55.
[21]龚梦鹃,何伟,唐春萍,等.桂枝解郁胶囊抗抑郁作用的药理实验研究[J].中成药,2011,33(7):1121-1125.
[22]高孟翠,李静,亓媛媛.辨证治疗抑郁症276例临床观察[J].实用中医内科杂志,2013,27(4s):80-81.
[23]夏小玉,邵辉,沈红薇,等.逍遥丸的临床应用进展[J].陕西中医,2012,33(10):1436-1437.
[24]武春丽.逍遥散加减配合西药治疗糖尿病抑郁症疗效观察[J].陕西中医,2011,32(12):1625-1626.
[25]杨靖,龚锡平,刘蓉,等.逍遥散及其功效拆方对应激抑郁模型小鼠的影响[J].中药与临床,2013,4(5):26-29.
[26]张瑜,王亚军,田永萍,等.针药结合对慢性应激抑郁模型大鼠海马脑区NGF的影响[J].中医研究,2012,25(6):67-70.
[27]塔光,王健.柴胡加龙骨牡蛎汤治疗中风后抑郁24例[J].吉林中医药,2008,28(3):179-180.
[28]苏明,韩阳.加味黄连温胆汤治疗2型糖尿病合并抑郁32例疗效观察[J].天津中医药,2013,30(8):465-466.
[29]郑宗和.解郁合剂联合氟西汀辨证分型治疗抑郁症随机平行对照研究[J].实用中医内科杂志,2014,28(7):99-101.
[30]高孟英.丹桂逍遥丸联合米氮平片治疗脑卒中后抑郁32例[J].中医研究,2013,26(5):39-41.
[31]乐文,冯芳,王娅.栀子甘草豉汤的LC-PDA-MS/MS分析及抗抑郁作用研究[J].中国药科大学学报,2009,40(4):342-347.