刺五加抗抑郁作用探析
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摘要
刺五加的化学成分和药理作用繁多且复杂,包含多种苷类、黄酮等活性成分以及多种氨基酸和微量元素,具备抗应激刺激、抗疲劳反应、抗氧化反应等多种药理作用,对中枢神经系统、免疫系统以及内分泌系统等多系统具有双向调控作用。刺五加治疗抑郁症疗效确切,其可能途径包括提高单胺类递质含量、调节脑内神经营养因子、修复受损神经元、清除自由基、抗氧化等多个方面。临床配伍应用刺五加治疗抑郁症疗效亦十分显著。目前,刺五加的不良反应报道主要集中在注射液剂型,刺五加注射液的不良反应主要表现为皮疹、瘙痒、发热、寒战、哮喘、过敏性休克、偏头痛等。因此,刺五加作为临床常用抗抑郁药物,在从活性成分、复方配伍增效、剂型研究等方面还有待进一步研究。
Ciwujia( Acanthopanax) contains a variety of glycosides,flavonoids and other active ingredients and a variety of amino acids and trace elements. It can be used in anti-stress anti-fatigue,and anti-oxidation. It plays a two-way regulatory role working on human central nervous system,the immune system,the endocrine system and other systems. Acanthopanax can be used in curative treatment of depression,which may function in improving the content of monoamine neurotransmitters,regulating the brain neurotrophic factor,repairing the damaged neurons,clearing the free radicals,and being anti-oxidation. Clinical application of Acanthopanax compatibility is also effective in treating depression. However,currently,the reported adverse effect of Acanthopanax is mainly in the injection formulations,such as rash,itching,fever,chills,asthma,anaphylactic shock,and migraine. Therefore,as a commonly used anti-depression medicine in clinical,further research in the component,combination and dosage form of Acanthopanax is needed.
Ciwujia( Acanthopanax) contains a variety of glycosides,flavonoids and other active ingredients and a variety of amino acids and trace elements. It can be used in anti-stress anti-fatigue,and anti-oxidation. It plays a two-way regulatory role working on human central nervous system,the immune system,the endocrine system and other systems. Acanthopanax can be used in curative treatment of depression,which may function in improving the content of monoamine neurotransmitters,regulating the brain neurotrophic factor,repairing the damaged neurons,clearing the free radicals,and being anti-oxidation. Clinical application of Acanthopanax compatibility is also effective in treating depression. However,currently,the reported adverse effect of Acanthopanax is mainly in the injection formulations,such as rash,itching,fever,chills,asthma,anaphylactic shock,and migraine. Therefore,as a commonly used anti-depression medicine in clinical,further research in the component,combination and dosage form of Acanthopanax is needed.
引文
[1]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2010:469.
[2]段艳霞,李洁,史美育.中药治疗中风后抑郁症用药规律探讨[J].中华中医药学刊,2011,29(6):1419-1421.
[3]周晋丽.刺五加注射液穴位注射治疗抑郁症96例[J].中医外治杂志,2012,21(4):34.
[4]蓝丽康,钭志萍,何伟娟.刺五加和黛力新治疗轻-中度抑郁症对照研究[J].中国现代应用药学,2007,24(S1):648-650.
[5]谢湘林,邹洪斌,李晔,等.刺五加注射液对血管性痴呆大鼠的治疗作用[J].中国老年学杂志,2010,30(9):1245-1247.
[6]黄文,吕伟华,庞龙,等.刺五加注射液治疗脑梗塞伴抑郁症的疗效观察[J].中国药物滥用防治杂志,2011,17(3):153-155.
[7]刘宏.刺五加注射液治疗脑卒中后抑郁及神经功能缺损的疗效观察[J].海南医学,2008,19(1):53-56.
[8]陈忠新,李强,闫丽莉,等.刺五加浸膏抗抑郁作用的实验研究[J].黑龙江科技信息,2011,21(13):48.
[9]唐晓伟,李伟,林圣斌,等.刺五加对抑郁症大鼠行为学的影响[J].中国应用生理学杂志,2010,26(3):333-335.
[10]黎功炳,雷宁,龙军,等.刺五加胶囊改善抑郁大鼠学习记忆能力及对海马BDNF表达的影响[J].现代生物医学进展,2012,12(6):1078-1080.
[11]Zeman M,Jachymova M,Jirak R,et al.Polymorphisms of genes for brain-derived neurotrophic factor,methylenetetrahydrofolate reductase,tyrosine hydroxylase,and endothelial nitric oxide synthase in depression and metabolic syndrome[J].Folia Biol(Praha),2010,56(1):19-26.
[12]Fu AL,Wu SP,Dong ZH,et al.A novel therapeutic approach to depression via supplement with tyrosine hydroxylase[J].Biochem Biophys Res Commun,2006,351(1):140-145.
[13]Kuteeva E,Wardi T,Lundstrom L,et al.Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level[J].Neuropsy chopharmacology,2008,33(11):2573-2585.
[14]Zhao Y,Ma R,Shen J,et al.A mouse model of depression induced by repeated corticosterone injections[J].Eur J Pharmacol,2008,581(1-2):113-120.
[15]孙薇,吴博,石伟彬,等.刺五加胶囊对抑郁大鼠海马组织TH、TPH表达的影响[J].现代生物医学进展,2011,11(22):4247-4249.
[16]Tohda C,Ichimura M,Bai Y,et al.Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss[J].J Pharmacol Sci,2008,107(3):329-339.
[17]陈剑峰,张烽.刺五加皂苷对体外培养大鼠脊髓运动神经元缺氧损伤的保护作用[J].第二军医大学学报,2006,27(2):173-177.
[18]顾晓苏,顾永健,施建生,等.刺五加皂甙对大鼠海马脑片长时程增强效应的影响[J].江苏医药,2005,31(5):373-374.
[19]睢大员,曲绍春,于小风,等.刺五加叶皂苷对大鼠心肌缺血再灌注损伤的保护作用[J].中国中药杂志,2004,29(1):75-78.
[20]秦晓松.一氧化氮与抑郁症的脑损害[J].国外医学·精神病学分册,2002,29(3):150-152.
[21]Coskun O,Ocakci A,Bayraktaroglu T,et al.Exercise training prevents and protects streptozotocin-induced oxidative stress and betacell damage in rat pancreas[J].Tohoku J Exp Med,2004,203(3):145-154.
[22]张向阳,周东丰,郭华.抑郁症、精神分裂症患者细胞免疫和血超氧化物歧化酶的对照研究[J].中华精神科杂志,2000,3(1):25-27.
[23]乌兰格日乐,白海泉,翁慧.黄酮的抗氧化活性研究进展[J].内蒙古民族大学学报:自然科学版,2008,23(3):277-280.
[24]陈貌连,宋凤瑞,郭明全,等.刺五加叶中黄酮类化合物的分析[J].分析化学,2002,30(6):690-694.
[25]张英华,关雪.刺五加叶中黄酮类提取物的抗氧化性及抑菌作用研究[J].东北农业大学学报,2012,43(3):85-90.
[26]Wang GH,Dong HY,Dong WG,et al.Protective effect of Radix Acanthopanacis Senticosi capsule on colon of rat depression model[J].World J Gastroenterol,2005,11(9):1373-1377.
[27]徐向青.刺五加配伍桅子治疗老年抑郁障碍患者的疗效[J].中国老年学杂志,2012,32(24):5383-5384.
[28]王继伟,任平,徐娜.刺五加配伍栀子治疗老年抑郁障碍的随机双盲对照研究[J].中国医药导报,2013,10(8):11-12.
[29]张妍燕.加味疏肝益肾汤合刺五加注射液治疗妇女更年期抑郁症43例[J].中医药临床杂志,2007,19(3):244-245.
[30]张玉军,齐增平,王玉强,等.银杏叶与刺五加注射液联合治疗脑梗死后抑郁症的临床研究[J].山西医药杂志,2012,41(4):396-397.
[31]苏亚妹,郭艳青.背俞穴透刺配合刺五加注射液治疗抑郁症39例临床观察[J].河南中医,2010,30(6):604-605.
[32]厉秀云,鲍继奎,李振民.活血开窍法联合刺五加注射液治疗脑卒中后抑郁症30例[J].陕西中医,2011,32(2):155-156.
[33]唐记华,王高华,白雪光,等.刺五加合并碳酸锂治疗青少年抑郁障碍随机双盲对照研究[J].中国神经精神疾病杂志,2005,31(3):225-227.
[34]崔隽,黄艳.小剂量舒必利合并刺五加静滴治疗抑郁症61例疗效观察[J].包头医学院学报,2007,23(1):40-41.
[35]崔吉峰,郑运宵,宋贺.刺五加联合黛力新治疗脑卒中后抑郁的前瞻性研究[J].西部医学,2014,26(1):69-71.
[36]沈斌,周月红.127例中药注射剂不良反应分析及原因探讨[J].中华中医药杂志,2015,30(2):428-431.
[37]黄崇刚,莫宗成,吴思澜,等.常用中药注射剂致敏性研究[J].世界科学技术:中医药现代化,2014,16(4):886-889.
[38]冯宇飞,王艳宏,邢希旺,等.刺五加注射液致敏性物质筛选的初步研究[J].中医药信息,2011,28(6):72-75.
[2]段艳霞,李洁,史美育.中药治疗中风后抑郁症用药规律探讨[J].中华中医药学刊,2011,29(6):1419-1421.
[3]周晋丽.刺五加注射液穴位注射治疗抑郁症96例[J].中医外治杂志,2012,21(4):34.
[4]蓝丽康,钭志萍,何伟娟.刺五加和黛力新治疗轻-中度抑郁症对照研究[J].中国现代应用药学,2007,24(S1):648-650.
[5]谢湘林,邹洪斌,李晔,等.刺五加注射液对血管性痴呆大鼠的治疗作用[J].中国老年学杂志,2010,30(9):1245-1247.
[6]黄文,吕伟华,庞龙,等.刺五加注射液治疗脑梗塞伴抑郁症的疗效观察[J].中国药物滥用防治杂志,2011,17(3):153-155.
[7]刘宏.刺五加注射液治疗脑卒中后抑郁及神经功能缺损的疗效观察[J].海南医学,2008,19(1):53-56.
[8]陈忠新,李强,闫丽莉,等.刺五加浸膏抗抑郁作用的实验研究[J].黑龙江科技信息,2011,21(13):48.
[9]唐晓伟,李伟,林圣斌,等.刺五加对抑郁症大鼠行为学的影响[J].中国应用生理学杂志,2010,26(3):333-335.
[10]黎功炳,雷宁,龙军,等.刺五加胶囊改善抑郁大鼠学习记忆能力及对海马BDNF表达的影响[J].现代生物医学进展,2012,12(6):1078-1080.
[11]Zeman M,Jachymova M,Jirak R,et al.Polymorphisms of genes for brain-derived neurotrophic factor,methylenetetrahydrofolate reductase,tyrosine hydroxylase,and endothelial nitric oxide synthase in depression and metabolic syndrome[J].Folia Biol(Praha),2010,56(1):19-26.
[12]Fu AL,Wu SP,Dong ZH,et al.A novel therapeutic approach to depression via supplement with tyrosine hydroxylase[J].Biochem Biophys Res Commun,2006,351(1):140-145.
[13]Kuteeva E,Wardi T,Lundstrom L,et al.Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level[J].Neuropsy chopharmacology,2008,33(11):2573-2585.
[14]Zhao Y,Ma R,Shen J,et al.A mouse model of depression induced by repeated corticosterone injections[J].Eur J Pharmacol,2008,581(1-2):113-120.
[15]孙薇,吴博,石伟彬,等.刺五加胶囊对抑郁大鼠海马组织TH、TPH表达的影响[J].现代生物医学进展,2011,11(22):4247-4249.
[16]Tohda C,Ichimura M,Bai Y,et al.Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss[J].J Pharmacol Sci,2008,107(3):329-339.
[17]陈剑峰,张烽.刺五加皂苷对体外培养大鼠脊髓运动神经元缺氧损伤的保护作用[J].第二军医大学学报,2006,27(2):173-177.
[18]顾晓苏,顾永健,施建生,等.刺五加皂甙对大鼠海马脑片长时程增强效应的影响[J].江苏医药,2005,31(5):373-374.
[19]睢大员,曲绍春,于小风,等.刺五加叶皂苷对大鼠心肌缺血再灌注损伤的保护作用[J].中国中药杂志,2004,29(1):75-78.
[20]秦晓松.一氧化氮与抑郁症的脑损害[J].国外医学·精神病学分册,2002,29(3):150-152.
[21]Coskun O,Ocakci A,Bayraktaroglu T,et al.Exercise training prevents and protects streptozotocin-induced oxidative stress and betacell damage in rat pancreas[J].Tohoku J Exp Med,2004,203(3):145-154.
[22]张向阳,周东丰,郭华.抑郁症、精神分裂症患者细胞免疫和血超氧化物歧化酶的对照研究[J].中华精神科杂志,2000,3(1):25-27.
[23]乌兰格日乐,白海泉,翁慧.黄酮的抗氧化活性研究进展[J].内蒙古民族大学学报:自然科学版,2008,23(3):277-280.
[24]陈貌连,宋凤瑞,郭明全,等.刺五加叶中黄酮类化合物的分析[J].分析化学,2002,30(6):690-694.
[25]张英华,关雪.刺五加叶中黄酮类提取物的抗氧化性及抑菌作用研究[J].东北农业大学学报,2012,43(3):85-90.
[26]Wang GH,Dong HY,Dong WG,et al.Protective effect of Radix Acanthopanacis Senticosi capsule on colon of rat depression model[J].World J Gastroenterol,2005,11(9):1373-1377.
[27]徐向青.刺五加配伍桅子治疗老年抑郁障碍患者的疗效[J].中国老年学杂志,2012,32(24):5383-5384.
[28]王继伟,任平,徐娜.刺五加配伍栀子治疗老年抑郁障碍的随机双盲对照研究[J].中国医药导报,2013,10(8):11-12.
[29]张妍燕.加味疏肝益肾汤合刺五加注射液治疗妇女更年期抑郁症43例[J].中医药临床杂志,2007,19(3):244-245.
[30]张玉军,齐增平,王玉强,等.银杏叶与刺五加注射液联合治疗脑梗死后抑郁症的临床研究[J].山西医药杂志,2012,41(4):396-397.
[31]苏亚妹,郭艳青.背俞穴透刺配合刺五加注射液治疗抑郁症39例临床观察[J].河南中医,2010,30(6):604-605.
[32]厉秀云,鲍继奎,李振民.活血开窍法联合刺五加注射液治疗脑卒中后抑郁症30例[J].陕西中医,2011,32(2):155-156.
[33]唐记华,王高华,白雪光,等.刺五加合并碳酸锂治疗青少年抑郁障碍随机双盲对照研究[J].中国神经精神疾病杂志,2005,31(3):225-227.
[34]崔隽,黄艳.小剂量舒必利合并刺五加静滴治疗抑郁症61例疗效观察[J].包头医学院学报,2007,23(1):40-41.
[35]崔吉峰,郑运宵,宋贺.刺五加联合黛力新治疗脑卒中后抑郁的前瞻性研究[J].西部医学,2014,26(1):69-71.
[36]沈斌,周月红.127例中药注射剂不良反应分析及原因探讨[J].中华中医药杂志,2015,30(2):428-431.
[37]黄崇刚,莫宗成,吴思澜,等.常用中药注射剂致敏性研究[J].世界科学技术:中医药现代化,2014,16(4):886-889.
[38]冯宇飞,王艳宏,邢希旺,等.刺五加注射液致敏性物质筛选的初步研究[J].中医药信息,2011,28(6):72-75.