非瓣膜病性心房纤颤并发急性缺血性脑卒中危险因素调查
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摘要
目的探讨非瓣膜病性心房纤颤并发急性缺血性脑卒中危险因素。方法选择2016年4月～2017年10月本院收治的非瓣膜病性心房纤颤并发急性缺血性脑卒中患者80例,针对入组者性别、年龄、遗传因素、血压水平、甲状腺功能、低密度脂蛋白水平等进行统计,行单因素分析及Logistic多因素回归分析,确定急性缺血性脑卒中发病高危因素。结果甲状腺功能亢进、合并高血压、存在遗传因素、低密度脂蛋白升高为非瓣膜病性心房纤颤并发急性缺血性脑卒中的相关及独立危险因素。结论对于甲状腺功能亢进,低密度脂蛋白升高者,且合并非瓣膜病性心房纤颤,其发生急性缺血性脑卒中的危险性增加。
Objective To discuss risk factors for acute ischemic stroke in patients with non-valvular atrial fibrillation.Methods Eighty cases of patients with non-valvular atrial fibrillation complicated with acute ischemic stroke admitted to our hospital from April 2016 to October 2017 were selected.According to the gender,age,genetic factors,blood pressure level,thyroid function,low density lipoprotein level and other statistical analysis,univariate analysis and Logistic multivariate regression analysis were performed to determine the risk factors of acute ischemic stroke. Results Hyperthyroidism,concomitant hypertension,presence of genetic factors,and elevated LDL were related and independent risk factors for non-valvular atrial fibrillation complicated with acute ischemic stroke. Conclusion The risk of acute ischemic stroke is increased in patients with hyperthyroidism,elevated LDL,and nonvalvular atrial fibrillation.
Objective To discuss risk factors for acute ischemic stroke in patients with non-valvular atrial fibrillation.Methods Eighty cases of patients with non-valvular atrial fibrillation complicated with acute ischemic stroke admitted to our hospital from April 2016 to October 2017 were selected.According to the gender,age,genetic factors,blood pressure level,thyroid function,low density lipoprotein level and other statistical analysis,univariate analysis and Logistic multivariate regression analysis were performed to determine the risk factors of acute ischemic stroke. Results Hyperthyroidism,concomitant hypertension,presence of genetic factors,and elevated LDL were related and independent risk factors for non-valvular atrial fibrillation complicated with acute ischemic stroke. Conclusion The risk of acute ischemic stroke is increased in patients with hyperthyroidism,elevated LDL,and nonvalvular atrial fibrillation.
引文
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[17]潘忙忙,刘晓琰,顾智淳.慢性肾功能不全合并非瓣膜房颤患者抗血栓药物治疗的有效性和安全性概述[J].药物流行病学杂志,2018,27(9):626-630.
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[19]张浩,刘俊,李晓枫,等.非瓣膜病性心房颤动合并心房血栓患者的临床特征及溶栓效果分析[J].中国心脏起搏与心电生理杂志,2018,17(5):1-2.
[2]Casajuana M,Giner-Soriano M,Roso-Llorach A,et al.Annual costs attributed to atrial fibrillation management:cross-sectional study of primary healthcare electronic records[J].The European Journal of Health Economics,2018,19(8):1129-1136.
[3]Fukamachi D,Hirayama A,Miyauchi K,et al.Corrigendum to"Antithrombotic therapy trends in non-valvularatrial fibrillation patients undergoing percutaneous coronary stent implantation:Results from a survey among fellows at the Japanese College of Cardiology"[J].Journal of Cardiology,2018,72(5):444.
[4]赵靖华,姚艳,尚美生.心源性脑卒中诊断及防治的研究进展[J].中华老年心脑血管病杂志,2017,19(1):94-96.
[5]邹建平.双联抗血小板治疗非心源性缺血性脑卒中的有效性及安全性[J].中国实用神经疾病杂志,2015,18(8):11-13.
[6]王伟英,桑文文,焉双梅,等.急性缺血性脑卒中患者1年复发危险因素Cox回归分析[J].中华老年心脑血管病杂志,2016,18(1):46-50.
[7]韩晓霞,左瑞菊,韩婷婷,等.缺血性脑卒中患者LpPLA2水平及意义[J].中国医药导报,2017,14(17):50-53.
[8]冯雪华,王金光,丁健,等.急性缺血性脑卒中患者肺部感染对病情影响的研究[J].中华医院感染学杂志,2015,25(16):3726-3728.
[9]陈芝彪.氯吡格雷/阿司匹林双抗预防非心源性缺血性脑卒中的效果观察[J].中国实用神经疾病杂志,2016,19(19):74-76.
[10]Vedovati MC,Giustozzi M,Verdecchia P,et al.Patients with cancer and atrial fibrillation treated with doacs:A prospective cohort study[J].International Journal of Cardiology,2018,10(9269):152-157.
[11]李晶,石婧,林琴,等.年龄≥80岁高龄非瓣膜病心房颤动患者抗栓治疗与脑卒中的相关性[J].中华高血压杂志,2018,17(8):800.
[12]冯跃明,杨辉.急性缺血性脑卒中患者静脉溶栓后不同部位出血转化的影响因素[J].中国实用神经疾病杂志,2016,19(3):59-61.
[13]吴士青,王伟.上海金山石化地区老年非瓣膜病性心房颤动急性进行性缺血性脑卒中的抗凝研究[J].临床急诊杂志,2016,17(10):801-802.
[14]王航,许晓刚,黄品芳,王长连.不同抗凝强度华法林对非瓣膜病心房颤动疗效和安全性的meta分析[J].第二军医大学学报,2016,37(2):256-261.
[15]颜小均,黄斯倩,姚钦元,等.通心络胶囊治疗非心源性缺血性脑卒中的疗效及减毒作用[J].海峡药学,2016,28(11):164-165.
[16]Inaba O,Yamauchi Y,Sekigawa M,et al.Atrial fibrillationtype matters:greater infarct volume and worse neurological defects seen in acute cardiogenic cerebral embolism due to persistent or permanent rather than paroxysmal atrial fibrillation[J].Europace:European Pacing,Arrhythmias,and Cardiac Electrophysiology:Journal of the Working Groups on Cardiac Pacing,Arrhythmias,and Cardiac Cellular Electrophysiology of the European Society of Cardiology,2018,10(20):1591-1597.
[17]潘忙忙,刘晓琰,顾智淳.慢性肾功能不全合并非瓣膜房颤患者抗血栓药物治疗的有效性和安全性概述[J].药物流行病学杂志,2018,27(9):626-630.
[18]Inoue H,Yamashita T,Akao M,et al.Prospective observational study in elderly patients with nonvalvularatrial fibrillation:Rationale and design of the All Nippon AF In the Elderly(ANAFIE)Registry[J].Journal of Cardiology,2018,72(4):300-306.
[19]张浩,刘俊,李晓枫,等.非瓣膜病性心房颤动合并心房血栓患者的临床特征及溶栓效果分析[J].中国心脏起搏与心电生理杂志,2018,17(5):1-2.