胃癌组织中HMGB1和RAGE蛋白的表达及与临床病理参数的关系
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摘要
目的研究胃癌组织中高迁移率族蛋白B1(HMGB1)和受体晚期糖基化终末产物受体(RAGE)蛋白表达情况及与临床病理参数的关系,为临床诊疗提供依据。方法选取拟行手术治疗的胃癌患者230例,取胃癌组织为研究组,癌旁正常组织为对照组,检测2组HMGB1和RAGE表达情况,观察其与临床病理参数的关系,应用Spearman相关分析法分析HMGB1和RAGE的相关性。结果研究组HMGB1和RAGE阳性表达率分别为43.91%(101/230)和44.78%(103/230),对照组HMGB1和RAGE阳性表达率分别为17.39%(40/230)和19.57%(45/230),2组比较差异具有统计学意义(P均<0.05);HMGB1表达与TNM分期、淋巴结转移有关(P均<0.05),RAGE表达与淋巴结转移有关(P<0.05);Spearman相关分析显示:HMGB1和RAGE表达呈正相关关系(P<0.05)。结论胃癌组织中HMGB1和RAGE会出现高表达,其对胃癌转移和浸润有预测作用,且HMGB1和RAGE存在正相关关系。
引文
[1]李人立,瞿发林,李秋晨,等.HMGB1在胃癌组织及细胞系中表达的研究[J].现代生物医学进展,2015,15(16):3065-3068
[2]张彦秋,王春生,王坤正,等.长期应用糖皮质激素对大鼠骨组织中HMGB1、RAGE、OPG和RANKL表达的影响[J].吉林大学学报:医学版,2015,41(5):907-913;后插2
[3]Nankali M,Karimi J,Goodarzi MT,et al.Increased expression of the receptor for advanced glycation end-products(RAGE)is associated with advanced breast cancer stage[J].Oncol Res Treat,2016,39(10):622-628
[4]郭晓华,吴洁,翁洁,等.高迁移率族蛋白B1对内皮细胞通透性的影响[J].广东医学,2015,36(16):2479-2483
[5]黄斌,孟然,冯斌,等.棕榈酸通过高迁移率族蛋白1诱导人胃腺癌细胞增殖及侵袭相关蛋白表达的研究[J].临床内科杂志,2016,33(4):273-275
[6]Cerwenka A,Kopitz J,Schirmacher P,et al.HMGB1:The metabolic weapon in the arsenal of NK cells[J].Mol Cell Oncol,2016,3(4):e1175538
[7]庄利萍,于璐,杨倩,等.HMGB1 RAGE蛋白在肝癌中的表达及临床意义[J].河北医学,2015,21(3):377-382
[8]Tian Y,Pan D,Chordia MD,et al.The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE[J].Basic Res Cardiol,2016,111(6):62
[9]高文华,付勇,谷翠华,等.EGFR、CEA、P53在胃癌组织中的表达及意义[J].现代肿瘤医学,2015,23(13):1874-1878
[10]Stock AJ,Kasus-Jacobi A,Wren JD,et al.The role of neutrophil proteins on the amyloid beta-RAGE axis[J].PLo S One,2016,11(9):e0163330
[11]王一曌,郭琳,刘乙蒙,等.Rack1与β-catenin在胃癌组织中的表达与临床意义[J].中国生化药物杂志,2016,36(3):30-33
[12]Di Maggio S,Gatti E,Liu J,et al.The mouse-specific splice variant mRAGE_v4 encodes a membrane-bound RAGE that is resistant to shedding and does not contribute to the production of soluble RAGE[J].PLo S One,2016,11(9):e0153832
[13]王成,袁丽萍,殷麟,等.老年胃癌患者胃癌组织中血管内皮生长因子-C、-D、-A、成纤维细胞生长因子-2表达、幽门螺旋菌-L型感染与淋巴结转移的关系[J].中国老年学杂志,2015,35(7):1841-1843
[14]叶石才,孙碧兰,黄昕,等.Eph受体酪氨酸激酶A2和CD133在胃癌组织的表达及其与胃癌发生发展的关系[J].中华实验外科杂志,2015,32(1):165-167
[15]郭云娣,白光辉.胃癌组织HMGB1和RAGE蛋白表达与临床病理因素相关性分析[J].中华肿瘤防治杂志,2014,21(9):684-687;691
[2]张彦秋,王春生,王坤正,等.长期应用糖皮质激素对大鼠骨组织中HMGB1、RAGE、OPG和RANKL表达的影响[J].吉林大学学报:医学版,2015,41(5):907-913;后插2
[3]Nankali M,Karimi J,Goodarzi MT,et al.Increased expression of the receptor for advanced glycation end-products(RAGE)is associated with advanced breast cancer stage[J].Oncol Res Treat,2016,39(10):622-628
[4]郭晓华,吴洁,翁洁,等.高迁移率族蛋白B1对内皮细胞通透性的影响[J].广东医学,2015,36(16):2479-2483
[5]黄斌,孟然,冯斌,等.棕榈酸通过高迁移率族蛋白1诱导人胃腺癌细胞增殖及侵袭相关蛋白表达的研究[J].临床内科杂志,2016,33(4):273-275
[6]Cerwenka A,Kopitz J,Schirmacher P,et al.HMGB1:The metabolic weapon in the arsenal of NK cells[J].Mol Cell Oncol,2016,3(4):e1175538
[7]庄利萍,于璐,杨倩,等.HMGB1 RAGE蛋白在肝癌中的表达及临床意义[J].河北医学,2015,21(3):377-382
[8]Tian Y,Pan D,Chordia MD,et al.The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE[J].Basic Res Cardiol,2016,111(6):62
[9]高文华,付勇,谷翠华,等.EGFR、CEA、P53在胃癌组织中的表达及意义[J].现代肿瘤医学,2015,23(13):1874-1878
[10]Stock AJ,Kasus-Jacobi A,Wren JD,et al.The role of neutrophil proteins on the amyloid beta-RAGE axis[J].PLo S One,2016,11(9):e0163330
[11]王一曌,郭琳,刘乙蒙,等.Rack1与β-catenin在胃癌组织中的表达与临床意义[J].中国生化药物杂志,2016,36(3):30-33
[12]Di Maggio S,Gatti E,Liu J,et al.The mouse-specific splice variant mRAGE_v4 encodes a membrane-bound RAGE that is resistant to shedding and does not contribute to the production of soluble RAGE[J].PLo S One,2016,11(9):e0153832
[13]王成,袁丽萍,殷麟,等.老年胃癌患者胃癌组织中血管内皮生长因子-C、-D、-A、成纤维细胞生长因子-2表达、幽门螺旋菌-L型感染与淋巴结转移的关系[J].中国老年学杂志,2015,35(7):1841-1843
[14]叶石才,孙碧兰,黄昕,等.Eph受体酪氨酸激酶A2和CD133在胃癌组织的表达及其与胃癌发生发展的关系[J].中华实验外科杂志,2015,32(1):165-167
[15]郭云娣,白光辉.胃癌组织HMGB1和RAGE蛋白表达与临床病理因素相关性分析[J].中华肿瘤防治杂志,2014,21(9):684-687;691