经阴道彩色多普勒超声用于诊断宫颈癌中的价值
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摘要
目的探究经阴道彩色多普勒超声在宫颈癌临床诊断中的应用价值。方法选择保定市第二中心医院2016年9月至2017年9月收治的50例宫颈正常女性作为对照组(n=50),50例宫颈癌患者作为研究组(n=50),50例宫颈上皮内瘤变患者作为CIN组(n=50)。对三组均实施经阴道彩色多普勒超声检查,记录三组宫颈大小检测结果(宫颈前后径、左右径)、超声血流参数(彩色像素密度、收缩期峰值血流速度显、阻力指数)并进行比较。结果对三组的宫颈大小检测结果进行统计比较,可得研究组的宫颈前后径以及左右径均显著大于对照组与CIN组,差异具有统计学意义(P <0. 05)。CIN组的宫颈前后径以及左右径均大于对照组,但差异无统计学意义(P> 0. 05)。对三组经阴道彩色多普勒超声血流参数统计结果进行比较,可得研究组的彩色像素密度以及收缩期峰值血流速度显著大于对照组与CIN组,差异具有统计学意义(P <0. 05); CIN组的彩色像素密度以及收缩期峰值血流速度显著大于对照组,差异具有统计学意义(P <0. 05);三组阻力指数检测结果基本相当,差异无统计学意义(P> 0. 05)。结论经阴道彩色多普勒超声应用于宫颈癌的临床诊断之中可以较为准确的评价患者的宫颈大小以及血流动力学情况,具有一定的临床应用价值。
Objective To explore the clinical value of transvaginal color Doppler ultrasound in the clinical diagnosis of cervical cancer. Methods 50 normal cervical women,50 cervical cancer patients and 50 patients with cervical intraepithelial neoplasia in our hospital from September 2016 to September 2017 were selected as control group,study group and CIN group accordingly. Transvaginal color Doppler ultrasound examination was performed in all the patients and the cervical size detection results( cervical anteroposterior diameter,left-right diameter),ultrasound blood flow parameters( color pixel density,systolic peak blood flow velocity and resistance index)were recorded and compared. Results The cervical anteroposterior diameter and left-right diameter in the study group were significantly larger than those of the other two groups,P < 0. 05. The cervical anteroposterior diameter and left-right diameter of the CIN group were all larger than those of the control group,without statistically significant difference,P > 0. 05. The color pixel density peak systolic velocity in the study group was significantly higher than that of control group and CIN group,P < 0. 05; the color pixel density and peak systolic blood flow velocity if the CIN group was significantly higher than that of the control group,P < 0. 05; the resistance index in the three groups is basically the same,without statistically significant difference,P > 0. 05. Conclusions Transvaginal color Doppler ultrasound if of certain value for the clinical diagnosis of cervical cancer,which can accurately evaluate the cervical size and hemodynamics of patients.
Objective To explore the clinical value of transvaginal color Doppler ultrasound in the clinical diagnosis of cervical cancer. Methods 50 normal cervical women,50 cervical cancer patients and 50 patients with cervical intraepithelial neoplasia in our hospital from September 2016 to September 2017 were selected as control group,study group and CIN group accordingly. Transvaginal color Doppler ultrasound examination was performed in all the patients and the cervical size detection results( cervical anteroposterior diameter,left-right diameter),ultrasound blood flow parameters( color pixel density,systolic peak blood flow velocity and resistance index)were recorded and compared. Results The cervical anteroposterior diameter and left-right diameter in the study group were significantly larger than those of the other two groups,P < 0. 05. The cervical anteroposterior diameter and left-right diameter of the CIN group were all larger than those of the control group,without statistically significant difference,P > 0. 05. The color pixel density peak systolic velocity in the study group was significantly higher than that of control group and CIN group,P < 0. 05; the color pixel density and peak systolic blood flow velocity if the CIN group was significantly higher than that of the control group,P < 0. 05; the resistance index in the three groups is basically the same,without statistically significant difference,P > 0. 05. Conclusions Transvaginal color Doppler ultrasound if of certain value for the clinical diagnosis of cervical cancer,which can accurately evaluate the cervical size and hemodynamics of patients.
引文
[1]高义军,张亚杰,周红萍,等. MRI联合经阴道彩色多普勒超声诊断早期宫颈癌的价值[J].实用放射学杂志,2016,32(8):1242-1245.
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[3]牛亚玲,赵春刚.经阴道彩色多普勒检查病灶内微血管情况与早期宫颈癌预后的关系分析[J].医学影像学杂志,2014(8):1350-1353.
[4]谢丽珍,陈卫华,杨建勇,等.经阴道彩色多普勒超声诊断宫颈癌的临床价值[J].中国计划生育学杂志,2010,18(9):552-553.
[5]季海峰,李建华,殷晓慧,等.彩色多普勒对复发性宫颈癌三维适形放疗中肿瘤PTV观察研究[J].实用临床医药杂志,2011,15(9):55-56,61.
[6]杨虹,刘轩.经阴道彩色多普勒超声诊断宫颈癌及评估病灶内血管情况价值分析[J].中国妇幼保健,2016,31(24):5491-5493.
[7]黎婧.超声造影与彩色多普勒联合评估宫颈癌术前分期的临床应用价值[J].检验医学与临床,2017,14(4):522-523,527.
[8]郑英娟,王义成,刘宏强,等.下肢静脉超声对宫颈癌术后放疗患者血栓前状态的诊断价值[J].徐州医学院学报,2016,36(11):727-729.
[9]钟梅,吴建云,欧珏,等.经阴道彩色多普勒与三维能量多普勒超声在早期宫颈癌中的诊断[J].中国医药指南,2014,(31):117-118.
[10] Tanaka K,Umesaki N. Impact of three-dimensional(3D)ultra. sonography and power Doppler angiography in the management of cervical cancer[J]. Eur J Gynaecol Oncol,2010,31:10-17.
[11]古红芳,任群.早期宫颈癌与癌前病变诊断中阴道镜联合经阴道彩色多普勒超声的临床应用价值探讨[C].北京:2015临床急重症经验交流第二次高峰论坛. 2015:1-1.
[12]杨丽玲,陈俊,张翔珍,等.妇科门诊患者对宫颈癌知识的认知程度及其对宫颈癌检出率的影响[J].中国性科学,2016,25(5):26-28.
[13] Hsu KF,Su JM,Huang SC,et al. Three-dimensional power Doppler imaging of early stage cervical cancer[J]. Ultrasound Obstet Gynecol,2004,24:664-671.
[14] Zhang Y,Wang X,Wei S,et al. Transvaginal color Doppler ultrasound in diagsosis and preoperative staging of invasive cervical cancer[J].Chin J Med Imaging Technol,2010,26(7):1318-1320.
[15]彭雪芳.探讨经阴道彩色多普勒超声诊断宫颈癌56例的价值.医学信息,2013,26(5):172-173.
[16] Alc6zar JL,Jurado M,L6pez—Garcia G. Tumor vascularization in cervical cancer by 3-dimensional power Doppler angiography:correlation with tumor characteristics[J]. Int J Gynecol Cancer,2010,20:393-397.
[17]姚有娣,程易凡,王丹凤,等.宫颈液基薄层细胞学检测与人乳头瘤病毒检测对宫颈癌诊断的效用评价[J].中国性科学,2016,25(2):44-47.
[18]胡东昊,王乔新,牛海燕,等.基质细胞衍生因子-1、人绒毛膜促性腺激素β亚基及基质金属蛋白酶2的表达与宫颈癌分期与预后的相关性研究[J].中国性科学,2016,25(2):48-50.
[2]刘长云.阴道镜联合经阴道彩色多普勒超声诊断早期宫颈癌与癌前病变的临床价值[J].中国内镜杂志,2013,19(5):541-544.
[3]牛亚玲,赵春刚.经阴道彩色多普勒检查病灶内微血管情况与早期宫颈癌预后的关系分析[J].医学影像学杂志,2014(8):1350-1353.
[4]谢丽珍,陈卫华,杨建勇,等.经阴道彩色多普勒超声诊断宫颈癌的临床价值[J].中国计划生育学杂志,2010,18(9):552-553.
[5]季海峰,李建华,殷晓慧,等.彩色多普勒对复发性宫颈癌三维适形放疗中肿瘤PTV观察研究[J].实用临床医药杂志,2011,15(9):55-56,61.
[6]杨虹,刘轩.经阴道彩色多普勒超声诊断宫颈癌及评估病灶内血管情况价值分析[J].中国妇幼保健,2016,31(24):5491-5493.
[7]黎婧.超声造影与彩色多普勒联合评估宫颈癌术前分期的临床应用价值[J].检验医学与临床,2017,14(4):522-523,527.
[8]郑英娟,王义成,刘宏强,等.下肢静脉超声对宫颈癌术后放疗患者血栓前状态的诊断价值[J].徐州医学院学报,2016,36(11):727-729.
[9]钟梅,吴建云,欧珏,等.经阴道彩色多普勒与三维能量多普勒超声在早期宫颈癌中的诊断[J].中国医药指南,2014,(31):117-118.
[10] Tanaka K,Umesaki N. Impact of three-dimensional(3D)ultra. sonography and power Doppler angiography in the management of cervical cancer[J]. Eur J Gynaecol Oncol,2010,31:10-17.
[11]古红芳,任群.早期宫颈癌与癌前病变诊断中阴道镜联合经阴道彩色多普勒超声的临床应用价值探讨[C].北京:2015临床急重症经验交流第二次高峰论坛. 2015:1-1.
[12]杨丽玲,陈俊,张翔珍,等.妇科门诊患者对宫颈癌知识的认知程度及其对宫颈癌检出率的影响[J].中国性科学,2016,25(5):26-28.
[13] Hsu KF,Su JM,Huang SC,et al. Three-dimensional power Doppler imaging of early stage cervical cancer[J]. Ultrasound Obstet Gynecol,2004,24:664-671.
[14] Zhang Y,Wang X,Wei S,et al. Transvaginal color Doppler ultrasound in diagsosis and preoperative staging of invasive cervical cancer[J].Chin J Med Imaging Technol,2010,26(7):1318-1320.
[15]彭雪芳.探讨经阴道彩色多普勒超声诊断宫颈癌56例的价值.医学信息,2013,26(5):172-173.
[16] Alc6zar JL,Jurado M,L6pez—Garcia G. Tumor vascularization in cervical cancer by 3-dimensional power Doppler angiography:correlation with tumor characteristics[J]. Int J Gynecol Cancer,2010,20:393-397.
[17]姚有娣,程易凡,王丹凤,等.宫颈液基薄层细胞学检测与人乳头瘤病毒检测对宫颈癌诊断的效用评价[J].中国性科学,2016,25(2):44-47.
[18]胡东昊,王乔新,牛海燕,等.基质细胞衍生因子-1、人绒毛膜促性腺激素β亚基及基质金属蛋白酶2的表达与宫颈癌分期与预后的相关性研究[J].中国性科学,2016,25(2):48-50.