牙周炎和动脉粥样硬化鼠类模型建立的研究进展
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摘要
牙周炎是发生于牙周支持组织的炎症性疾病。动脉粥样硬化是心血管疾病的主要原因,是由脂质代谢紊乱引起的代谢性疾病。流行病学调查显示牙周炎有增加动脉粥样硬化及其相关疾病的风险,但二者之间具体联系尚不明确。因此建立有效的牙周炎和动脉粥样硬化动物模型具有重要意义。本文就牙周炎和动脉粥样硬化鼠类模型建立的进展进行综述。
Periodontitis is a chronic inflammatory disease occurring in periodontal support tissues. Atherosclerosis,a metabolic disease caused by disorders of lipid metabolism,is a major cause of cardiovascular disease. Epidemiological surveys show that periodontal infection increases the risk of atherosclerosis and related diseases. However,the relationship between periodontitis and atherosclerosis has not yet been clarified. Therefore,to explore the relationship and the potential mechanism between these two diseases,it is of vital importance to establish an effective animal model for periodontitis and atherosclerosis. In this article,recent advances in the primary methods for establishing atherosclerosis and periodontitis murine models are summarized.
Periodontitis is a chronic inflammatory disease occurring in periodontal support tissues. Atherosclerosis,a metabolic disease caused by disorders of lipid metabolism,is a major cause of cardiovascular disease. Epidemiological surveys show that periodontal infection increases the risk of atherosclerosis and related diseases. However,the relationship between periodontitis and atherosclerosis has not yet been clarified. Therefore,to explore the relationship and the potential mechanism between these two diseases,it is of vital importance to establish an effective animal model for periodontitis and atherosclerosis. In this article,recent advances in the primary methods for establishing atherosclerosis and periodontitis murine models are summarized.
引文
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[15]PAN S,LIU H,GAO F,et al.Folic acid delays development of atherosclerosis in low-density lipoprotein receptor-deficient mice[J].JCell Mol Med,2018,22(6):3183-3191.DOI:10.1111/jcmm.13599.
[16]THOMAS M,KIM S,GUO W,et al.High levels of avenanthramides in oat-based diet further suppress high fat diet-induced atherosclerosis in LDLr(-/-)mice[J].J Agric Food Chem,2018,66(2):498-504.DOI:10.1021/acs.jafc.7b04860.
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[20]ABE T,HAJISHENGALLIS G.Optimization of the ligature-induced periodontitis model in mice[J].J Immunol Methods,2013,394(1/2):49-54.DOI:10.1016/j.jim.2013.05.002.
[21]BALCI YUCE H,LEKTEMUR ALPAN A,GEVREK F,et al.Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis[J].J Periodontal Res,2018,53(1):131-138.DOI:10.1111/jre.12497.
[22]DUMITRESCU AL,ABD-EL-ALEEM S,MORALES-AZA B,et al.A model of periodontitis in the rat:effect of lipopolysaccharide on bone resorption,osteoclast activity,and local peptidergic innervation[J].J Clin Periodontol,2004,31(8):596-603.DOI:10.1111/j.1600-051X.2004.00528.x.
[23]AGUIRRE JI,AKHTER MP,NEUVILLE KG,et al.Age-related periodontitis and alveolar bone loss in rice rats[J].Arch Oral Biol,2017,73:193-205.DOI:10.1016/j.archoralbio.2016.10.018.
[24]WANG Q,ZHANG P,APRECIO R,et al.Comparison of experimental diabetic periodontitis induced by porphyromonas gingivalis in mice[J].J Diabetes Res,2016,2016:4840203.DOI:10.1155/2016/4840203.
[25]KURAJI R,FUJITA M,ITO H,et al.Effects of experimental periodontitis on the metabolic system in rats with diet-induced obesity(DIO):an analysis of serum biochemical parameters[J].Odontology,2018,106(2):162-170.DOI:10.1007/s10266-017-0322-5.
[26]任秀云,王冲,刘欣,等.口腔干预措施对牙周炎大鼠颈动脉牙龈卟啉单胞菌检出量及C-反应蛋白表达的影响[J].华西口腔医学杂志,2017,35(2):12-15.DOI:10.7518/hxkq.2017.02.016.
[27]张源明,倪佳,徐隽,等.白细胞介素-6在大鼠慢性牙周炎合并动脉粥样硬化模型中的表达[J].中华口腔医学研究杂志,2009,3(3):12-15.
[28]CHUKKAPALLI SS,EASWARAN M,RIVERA-KWEH MF,et al.Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice[J].Pathog Dis,2017,75(1):1-10.DOI:10.1093/femspd/ftx003.
[29]CHUKKAPALLI SS,VELSKO IM,RIVERA-KWEH MF,et al.Polymicrobial oral infection with four periodontal bacteria orchestrates a distinct inflammatory response and atherosclerosis in ApoE null mice[J].PLoS One,2015,10(11):e0143291.DOI:10.1371/journal.pone.0143291.
[2]CHISTIAKOV DA,OREKHOV AN,BOBRYSHEV YV.Links between atherosclerotic and periodontal disease[J].Exp Mol Pathol,2016,100(1):220-235.DOI:10.1016/j.yexmp.2016.01.006.
[3]BARTOVA J,SOMMEROVA P,LYUYA-MI Y,et al.Periodontitis as a risk factor of atherosclerosis[J].J Immunol Res,2014,2014:636893.DOI:10.1155/2014/636893.
[4]LEE YT,LAXTON V,LIN HY,et al.Animal models of atherosclerosis[J].Biomed Rep,2017,6(3):259-266.DOI:10.3892/br.2017.843.
[5]LEE YT,LIN HY,CHAN YW,et al.Mouse models of atherosclerosis:a historical perspective and recent advances[J].Lipids Health Dis,2017,16(1):12.DOI:10.1186/s12944-016-0402-5.
[6]GETZ GS,REARDON CA.Animal models of atherosclerosis[J].Arterioscler Thromb Vasc Biol,2012,32(5):1104-1115.DOI:10.1161/ATVBAHA.111.237693.
[7]AUBIN MC,LAJOIE C,CLEMENT R,et al.Female rats fed a highfat diet were associated with vascular dysfunction and cardiac fibrosis in the absence of overt obesity and hyperlipidemia:therapeutic potential of resveratrol[J].J Pharmacol Exp Ther,2008,325(3):961-968.DOI:10.1124/jpet.107.135061.
[8]LI X,LU Y,SUN Y,et al.Effect of curcumin on permeability of coronary artery and expression of related proteins in rat coronary atherosclerosis heart disease model[J].Int J Clin Exp Pathol,2015,8(6):7247-7253.
[9]杨钦钦,马全鑫,奚晓青,等.球囊损伤联合高脂及维生素D3致大鼠动脉粥样硬化的方法学优化[J].中国比较医学杂志,2015,25(1):35-39.
[10]LEE WR,KIM KH,AN HJ,et al.Effects of chimeric decoy oligodeoxynucleotide in the regulation of transcription factors NF-kappa Band Sp1 in an animal model of atherosclerosis[J].Basic Clin Pharmacol Toxicol,2013,112(4):236-243.DOI:10.1111/bcpt.12029.
[11]STOKA KV,MAEDEKER JA,BENNETT L,et al.Effects of increased arterial stiffness on atherosclerotic plaque amounts[J].JBiomech Eng,2018,140(5).DOI:10.1115/1.4039175.
[12]ZHANG S,ZOU J,LI P,et al.Curcumin protects against atherosclerosis in apolipoprotein E-knockout mice by inhibiting Toll-like receptor 4 expression[J].J Agric Food Chem,2018,66(2):449-456.DOI:10.1021/acs.jafc.7b04260.
[13]PENDSE AA,ARBONES-MAINAR JM,JOHNSON LA,et al.Apolipoprotein E knock-out and knock-in mice:atherosclerosis,metabolic syndrome,and beyond[J].J Lipid Res,2009,50(Suppl):S178-S182.DOI:10.1194/jlr.R800070-JLR200.
[14]THORNGATE FE,RUDEL LL,WALZEM RL,et al.Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice[J].Arterioscler Thromb Vasc Biol,2000,20(8):1939-1945.
[15]PAN S,LIU H,GAO F,et al.Folic acid delays development of atherosclerosis in low-density lipoprotein receptor-deficient mice[J].JCell Mol Med,2018,22(6):3183-3191.DOI:10.1111/jcmm.13599.
[16]THOMAS M,KIM S,GUO W,et al.High levels of avenanthramides in oat-based diet further suppress high fat diet-induced atherosclerosis in LDLr(-/-)mice[J].J Agric Food Chem,2018,66(2):498-504.DOI:10.1021/acs.jafc.7b04860.
[17]STRUILLOU X,BOUTIGNY H,SOUEIDAN A,et al.Experimental animal models in periodontology:a review[J].Open Dent J,2010,29(4):37-47.DOI:10.2174/1874210601004010037.
[18]VARGAS-SANCHEZ PK,MORO MG,SANTOS FD,et al.Agreement,correlation,and kinetics of the alveolar bone-loss measurement methodologies in a ligature-induced periodontitis animal model[J].J Appl Oral Sci,2017,25(5):490-497.DOI:10.1590/1678-7757-2016-0517.
[19]OZ HS,PULEO DA.Animal models for periodontal disease[J].J Biomed Biotechnol,2011,2011:754857.DOI:10.1155/2011/754857.
[20]ABE T,HAJISHENGALLIS G.Optimization of the ligature-induced periodontitis model in mice[J].J Immunol Methods,2013,394(1/2):49-54.DOI:10.1016/j.jim.2013.05.002.
[21]BALCI YUCE H,LEKTEMUR ALPAN A,GEVREK F,et al.Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis[J].J Periodontal Res,2018,53(1):131-138.DOI:10.1111/jre.12497.
[22]DUMITRESCU AL,ABD-EL-ALEEM S,MORALES-AZA B,et al.A model of periodontitis in the rat:effect of lipopolysaccharide on bone resorption,osteoclast activity,and local peptidergic innervation[J].J Clin Periodontol,2004,31(8):596-603.DOI:10.1111/j.1600-051X.2004.00528.x.
[23]AGUIRRE JI,AKHTER MP,NEUVILLE KG,et al.Age-related periodontitis and alveolar bone loss in rice rats[J].Arch Oral Biol,2017,73:193-205.DOI:10.1016/j.archoralbio.2016.10.018.
[24]WANG Q,ZHANG P,APRECIO R,et al.Comparison of experimental diabetic periodontitis induced by porphyromonas gingivalis in mice[J].J Diabetes Res,2016,2016:4840203.DOI:10.1155/2016/4840203.
[25]KURAJI R,FUJITA M,ITO H,et al.Effects of experimental periodontitis on the metabolic system in rats with diet-induced obesity(DIO):an analysis of serum biochemical parameters[J].Odontology,2018,106(2):162-170.DOI:10.1007/s10266-017-0322-5.
[26]任秀云,王冲,刘欣,等.口腔干预措施对牙周炎大鼠颈动脉牙龈卟啉单胞菌检出量及C-反应蛋白表达的影响[J].华西口腔医学杂志,2017,35(2):12-15.DOI:10.7518/hxkq.2017.02.016.
[27]张源明,倪佳,徐隽,等.白细胞介素-6在大鼠慢性牙周炎合并动脉粥样硬化模型中的表达[J].中华口腔医学研究杂志,2009,3(3):12-15.
[28]CHUKKAPALLI SS,EASWARAN M,RIVERA-KWEH MF,et al.Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice[J].Pathog Dis,2017,75(1):1-10.DOI:10.1093/femspd/ftx003.
[29]CHUKKAPALLI SS,VELSKO IM,RIVERA-KWEH MF,et al.Polymicrobial oral infection with four periodontal bacteria orchestrates a distinct inflammatory response and atherosclerosis in ApoE null mice[J].PLoS One,2015,10(11):e0143291.DOI:10.1371/journal.pone.0143291.