摘要
目的探析高压氧治疗急性脑梗死的临床疗效,并分析对患者神经功能及有关细胞因子的影响。方法将84例急性脑梗死患者随机分为高压氧组与对照组,每组42例。对照组患者给予传统常规疗法治疗,高压氧组患者在常规治疗基础上给予高压氧治疗,治疗3周后对2组患者相关指标予以评估,采用美国国立卫生研究院卒中量表(NIHSS)评价2组患者的神经功能。观察比较2组患者的临床疗效,治疗前后患者的神经功能情况,同时比较2组患者的血清氧化修饰低密度脂蛋白(ox-LDL)、血清巨噬细胞集落刺激因子(M-CSF)以及血清可溶性细胞间粘附分子-1(sICAM-1)的水平。结果高压氧组患者与对照组的临床治疗总有效率比较差异有统计学意义(P<0.05);治疗后高压氧组患者的NIHSS评分、血清ox-LDL、M-CSF及sICAM-1水平均明显低于对照组(P<0.05)。结论高压氧治疗急性脑梗死疗效确切,显著改善了患者的神经功能以及相关细胞因子水平,可作为临床首选治疗方案。
Objective To observe the therapeutic effects of hyperbaric oxygen on acute cerebral infarction, and to investigate its effects on neurologic function and related cytokines in patients with acute cerebral infarction.Methods Eighty-four patients with acute cerebral infarction were randomly divided into hyperbaric oxygen group(n=42) and control group(n=42). The patients in control group were treated by conventional therapy,however, the patients in hyperbaric oxygen group were treated by hyperbaric oxygen on the basis of routine therapy. After 3-week treatment the neurologic function was evaluated according to National Institutes of Health Stroke scale(NIHSS),and the clinical efficacy and the neurological function before and after treatment were observed and compared between the two groups. The serum levels of oxidized low density lipoprotein(LDLX), serum macrophage colony stimulating factor(M-CSF) and serum soluble intercellular adhesion molecule-1(sICAM-1) were also observed and compared between the two groups.Results There was significant difference in total effective rate between hyperbaric oxygen group and control group(P<0.05),after treatment, the NIHSS scores, serum levels of ox-LDL M-CSF and sICAM-1 in hyperbaric oxygen group were significantly lower than those in control group(P<0.05).Conclusion Hyperbaric oxygen(HBO) is effective in treating acute cerebral infarction, which can significantly improve the neurological function and cytokine levels of the patients,and it can be used as the first choice in clinical treatment.
引文
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