肺鳞癌结肠黏膜转移一例报告和文献复习
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摘要
肺癌患者发生结肠转移非常罕见,患者一般无典型症状,晚期可出现腹痛、消化道出血、梗阻、穿孔等症状,并发症和死亡率较高,短期预后差。本中心报道一位63岁男性患者,以"间断咳嗽和右下腹隐痛"就诊,诊断肺鳞状细胞癌并纵隔淋巴结转移和结肠寡转移,经过PD-1免疫治疗,症状改善明显,目前仍在治疗和随访中。
Colonic metastasis is rare in patients with lung cancer, generally no typical symptoms at first, until the advanced stage, patients may present with symptoms such as abdominal pain, gastrointestinal bleeding, obstruction and perforation, complications associated with high mortality and poor short-term prognosis. Here, we report a 63-year-old male patient with intermittent cough and abdominal dull pain at right lower quadrant, clinic diagnosis is lung squamous cell carcinoma with mediastinal lymph node metastasis and single colonic metastasis, after treatment, the symptoms improved significantly, the patient is still under treatment and follow-up.
Colonic metastasis is rare in patients with lung cancer, generally no typical symptoms at first, until the advanced stage, patients may present with symptoms such as abdominal pain, gastrointestinal bleeding, obstruction and perforation, complications associated with high mortality and poor short-term prognosis. Here, we report a 63-year-old male patient with intermittent cough and abdominal dull pain at right lower quadrant, clinic diagnosis is lung squamous cell carcinoma with mediastinal lymph node metastasis and single colonic metastasis, after treatment, the symptoms improved significantly, the patient is still under treatment and follow-up.
引文
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[24]Kim MS,Kook EH,Ahn SH,et al.Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation[J].J Cancer Res ClinOncol,2009,135(2):297-301.
[25]钱俊,孙文勇,李德川,等.肺癌合并右半结肠转移病例报道1例[J].大肠肛门病外科杂志,2001,7(1):49.
[26]Huang YM,Hsing TY,Chen JR,et al.Gastric and colonic metastases from primary lung adenocarcinoma:A case report and review of the literature[J].Oncol Lett,2012,4(3):517-520.
[27]Ji M,Liu Y,Li Q,et al.PD-1/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR/KRAS mutations[J].Cancer Biol Ther,2016,17(4):407-413.
[2]Lou HZ,Wang CH,Pan HM,et al.Colonic metastasis after resection of primary squamous cell carcinoma of the lung:A case report and literature review[J].World J Gastroenterol,2014,20(19):5930-5934.
[3]Papanikolaou IS,Gkolfakis P,Tziatzios G,et al.An unusual cause of acute lower gastrointestinal bleeding:lung adenocarcinoma metastasis to the descending colon[J].Clin Case Rep,2017,5(8):1411-1413.
[4]吕志栋,赵伟军,刘福囡,等.小细胞肺癌结肠转移并肠穿孔1例报道[J].肿瘤基础与临床,2010,23(5):451.
[5]Habe?o?lu MA,O?uzülgen KI,Oztürk C,et al.A case of bronchogenic carcinoma presenting with acute abdomen[J].Tuberk Toraks,2005,53(3):280-283.
[6]McNeill PM,Wagman LD,Neifeld JP.Small bowel metastases from primary carcinoma of the lung[J].Cancer,1987,59(8):1486-1489.
[7]Sakai H,Egi H,Hinoi T,et al.Primary lung cancer presenting with metastasis to the colon:a case report[J].World J Surg Oncol,2012,10(1):127.
[8]Detterbeck FC,Falen S,Rivera MP,et al.Seeking a home for a PET,part 2:Defining the appropriate place for positron emission tomography imaging in the staging of patients with suspected lung cancer[J].Chest,2004,125(6):2300-2308.
[9]Anagnostopoulos G,Sakorafas GH,Kostopoulos P,et al.Squamous cell carcinoma of the rectum:a case report and review of the literature[J].Eur J Cancer Care(Engl),2005,14(1):70-74.
[10]Williams GT,Blackshaw AJ,Morson BC.Squamous carcinoma of the colorectum and its genesis[J].J Pathol,1979,129(3):139-147.
[11]Rossi G,Marchioni A,Romagnani E,et al.Primary lung cancer presenting with gastrointestinal tract involvement:clinicopathologic and immunohistochemical features in a series of 18 consecutive cases[J].J Thorac Oncol,2007,2(2):115-120.
[12]Pezzuto A,Mariotta S,Fioretti F,et al.Metastasis to the colon from lung cancer presenting with severe hyponatremia and dyspnea in a young male:A case report and review of the literature[J].Oncol Lett,2013,5(5):1477-1480.
[13]Gonzalez-Tallon AI,Vasquez-Guerrero J,Garcia-Mayor MA.Colonic Metastases From Lung Carcinoma:A Case Report and Review of the Literature[J].Gastroenterology Res,2013,6(1):29-33.
[14]Khan AM,Khan S,Dave V,et al.Small cell lung carcinoma presenting as a caecal polyp on surveillance colonoscopy[J].BMJCase Rep,2014,2014(2014).
[15]Iwamuro M,Miyabe Y,Hanae K,et al.Regression of metastatic colon tumour from primary adenocarcinoma of the lung due to fistulisation to the bowel lumen[J].Ecancermedicalscience,2014,8(1):412.
[16]Linsen PV,Linsen VM,Buunk G,et al.Iron deficiency anemia as initial presentation of a non-small cell lung carcinoma:A case report[J].Respir Med Case Rep,2015,16:109-111.
[17]Nunes V,Santiago I,Marinho R,et al.Duodeno-colic fistula as a rare presentation of lung cancer-surgical treatment of a stage IVoligometastatic lung disease[J].Int J Surg Case Rep,2015,13:125-128.
[18]Jevremovic V,Abboud A,Krauss S.Colonic Metastasis with Anemia Leading to a Diagnosis of Primary Lung Adenocarcinoma[J].Case Rep Oncol Med,2016,2016(2):1-4.
[19]Badipatla KR,Yadavalli N,Vakde T,et al.Lung cancer metastasis to the gastrointestinal system:An enigmatic occurrence[J].World J GastrointestOncol,2017,9(3):129-134.
[20]Yamada H,Akahane T,Horiuchi A,et al.A case of lung squamous cell carcinoma with metastases to the duodenum and small intestine[J].Int Surg,2011,96(2):176-181.
[21]马向涛,付静,余力伟,等.肺鳞状细胞癌结肠转移合并副瘤综合征1例[J].肿瘤,2006,26(8):792.
[22]李秋敬,林香春,吴静,等.肺癌结肠转移1例[J].中华消化杂志,2014,34(12):859-860.
[23]王紫云.原发性肺癌横结肠转移一例报道并文献复习[J].世界最新医学信息文摘,2014,14(4):215.
[24]Kim MS,Kook EH,Ahn SH,et al.Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation[J].J Cancer Res ClinOncol,2009,135(2):297-301.
[25]钱俊,孙文勇,李德川,等.肺癌合并右半结肠转移病例报道1例[J].大肠肛门病外科杂志,2001,7(1):49.
[26]Huang YM,Hsing TY,Chen JR,et al.Gastric and colonic metastases from primary lung adenocarcinoma:A case report and review of the literature[J].Oncol Lett,2012,4(3):517-520.
[27]Ji M,Liu Y,Li Q,et al.PD-1/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR/KRAS mutations[J].Cancer Biol Ther,2016,17(4):407-413.