丹紫康膝冲剂治疗膝骨关节炎肝肾不足证30例临床观察
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摘要
目的观察丹紫康膝冲剂治疗膝骨关节炎(KOA)肝肾不足证的临床疗效。方法将60例KOA肝肾不足证患者按照随机数字表法分为对照组和治疗组,各30例。对照组给予骨康胶囊治疗,治疗组给予丹紫康膝冲剂治疗。4周为1个疗程,1个疗程后比较2组治疗前后的视觉模拟评分法(VAS)评分、临床症状及体征总评分、中医证候总评分、临床疗效及治疗结束1月后的复发率。结果治疗后2组VAS评分、临床症状及体征总评分、中医证候总评分均显著下降,差异有统计学意义(P<0.05或P<0.01),且治疗组的中医证候总评分下降更显著,与对照组比较差异有统计学意义(P<0.05);对照组总有效率为90.00%,治疗组为93.33%,2组比较差异无统计学意义(P>0.05);治疗组复发率为12.50%,对照组为28.57%,2组比较差异无统计学意义(P>0.05)。结论丹紫康膝冲剂治疗KOA肝肾不足证临床疗效显著,可明显改善患者的临床症状,并能有效预防复发,提高患者生活质量,值得临床推广应用。
Objective To observe the efficacy of Danzi Kangxi Granule in treating knee osteoarthritis( KOA).Methods 60 KOA patients with insufficiency of liver and kidney were randomly divided into control group and treatment group,30 cases in each. The control group was given Gukang Capsule,while the treatment group was intervened with Danzi Kangxi Granule. 4 weeks was as one course. After 1 course,VAS score,clinical symptom and sign total score,TCM symptom score,clinical efficacy,after one-month recurrence rate were compared. Results After treatment,all scores of 2 groups decreased obviously,the difference was significant( P<0.05 or P<0.01),while TCM symptom score in treatment group dropped more( P<0.05). The total effective rate of two groups were 90.00%and 93.33% respectively,showing no difference( P > 0.05). The recurrence rate of treatment group was 12. 50%,which of control group was 28.57%,there was no any statistical significance( P>0.05). Conclusion Danzi Kangxi Granule is effective in treating KOA due to insufficiency of liver and kidney with significant improvement of the clinical syndromes and recurrence prevention. It can enhance the patients' life quality and is worth popularizing in clinic.
Objective To observe the efficacy of Danzi Kangxi Granule in treating knee osteoarthritis( KOA).Methods 60 KOA patients with insufficiency of liver and kidney were randomly divided into control group and treatment group,30 cases in each. The control group was given Gukang Capsule,while the treatment group was intervened with Danzi Kangxi Granule. 4 weeks was as one course. After 1 course,VAS score,clinical symptom and sign total score,TCM symptom score,clinical efficacy,after one-month recurrence rate were compared. Results After treatment,all scores of 2 groups decreased obviously,the difference was significant( P<0.05 or P<0.01),while TCM symptom score in treatment group dropped more( P<0.05). The total effective rate of two groups were 90.00%and 93.33% respectively,showing no difference( P > 0.05). The recurrence rate of treatment group was 12. 50%,which of control group was 28.57%,there was no any statistical significance( P>0.05). Conclusion Danzi Kangxi Granule is effective in treating KOA due to insufficiency of liver and kidney with significant improvement of the clinical syndromes and recurrence prevention. It can enhance the patients' life quality and is worth popularizing in clinic.
引文
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[2]张延辉,高春阳,李少华,等.骨性关节炎患者退变软骨及滑膜组织中细胞因子的表达[J].中国组织工程研究,2013,17(37):6671-6675.
[3]中华医学会骨科学分会.骨关节炎诊疗指南(2007年版)[M].中华骨科杂志,2007,27(10):793-796.
[4]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:349-353.
[5]何采辉,梁蔚莉.毫火针配合康复训练对早中期膝骨关节炎患者WOMAC评分及VAS评分的影响[J].中国中医急症,2015,24(12):2228-2230.
[6]杨帅,徐峰,秦丽娜.近5年针灸治疗膝骨关节炎的文献综述[J].世界中西医结合杂志,2016,11(2):278-280,284.
[7]余庆阳,黄巍.膝骨关节炎从痹论治的病因与证候探讨[J].风湿病与关节炎,2015,4(3):40-43.
[8]汤8),叶盛开,嵇辉,等.中医药治疗膝骨关节炎[J].环球中医药,2015,8(增刊2):5-6.