赭曲霉毒素A免疫毒性研究进展
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摘要
赭曲霉毒素A(OTA)是一类免疫抑制类真菌毒素,主要由曲霉属和青霉属等产毒真菌产生。OTA作为食品和饲料原料的一种常见污染物,在各种粮食作物及其副产品中广泛存在,其自身的免疫毒性效应对动物生产和人类健康造成极大的危害,由此引起人们的高度关注。赭曲霉毒素在饲料中广泛存在,饲料中的OTA对动物危害严重,诱发机体产生严重的免疫毒性,但其具体机制目前尚未完全清楚。论文就OTA对动物器官免疫、非特异性免疫、特异性免疫的研究现状进行综述,为深入研究OTA对动物免疫机能的损害机制提供参考依据。
Ochrotoxin A(OTA)is a class of immunosuppressive mycotoxins that are mainly produced by toxigenic fungi such as Aspergillus and Penicillium.As a common pollutant of food and feedstuffs,it is widely found in various food crops and their by-products.Its own immunotoxicity effects cause great harm to animal production and human health,which have caused people's great concern.Ochratoxins are widely found in feeds.OTA in feeds causes serious animal harm and induces severe immunotoxicity in the body.However,the exact mechanism is not yet fully understood.This article briefly reviewed the research status of OTA on animal organ immunity,non-specific immunity,and specific immunity,and provided a reference for in-depth study on the mechanism of OTA damage to animal immune function.
Ochrotoxin A(OTA)is a class of immunosuppressive mycotoxins that are mainly produced by toxigenic fungi such as Aspergillus and Penicillium.As a common pollutant of food and feedstuffs,it is widely found in various food crops and their by-products.Its own immunotoxicity effects cause great harm to animal production and human health,which have caused people's great concern.Ochratoxins are widely found in feeds.OTA in feeds causes serious animal harm and induces severe immunotoxicity in the body.However,the exact mechanism is not yet fully understood.This article briefly reviewed the research status of OTA on animal organ immunity,non-specific immunity,and specific immunity,and provided a reference for in-depth study on the mechanism of OTA damage to animal immune function.
引文
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[13]Zeferino C P,Wells K D,Moura A S A M T,et al.Changes in renal gene expression associated with induced ochratoxicosis in chickens:activation and deactivation of transcripts after varying durations of exposure[J].Poultry Sci,2016,96(6):1855.
[14]Khatoon A,Zargham K M,Khan A,et al.Amelioration of ochratoxin A-induced immunotoxic effects by silymarin and vitamin E in white leghorn cockerels.[J].J Immunotoxicol,2013,10(1):25.
[15]T Kaymak,L Türker,H Tulay,et al.Determination of aflatoxins and ochratoxin A in traditional turkish concentrated fruit juice products by multi-immunoaffinity column cleanup and LC fluorescence detection[J].J Aoac Int,2018,27(8):63-67.
[16]Brennan K M,Oh S Y,Yiannikouris A,et al.Differential gene expression analysis of bovine macrophages after exposure to the penicillium mycotoxins citrinin and/or ochratoxin A.[J].Toxins,2017,9(11):366.
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[18]Lautert C,Ferreiro L,Wolkmer P,et al.Individual in vitro effects of ochratoxin A,deoxynivalenol and zearalenone on oxidative stress and acetylcholinesterase in lymphocytes of broiler chickens[J].Springerplus,2014,3(1):1-7.
[19]Jahreis S,Kuhn S,Madaj A M,et al.Mold metabolites drive rheumatoid arthritis in mice via promotion of IFN-gamma-and IL-17-producing T cells[J].Food Chem Toxicol,2017,109:405-413.
[20]Solcan C,Pavel G,Floristean V C,et al.Effect of ochratoxin Aon the intestinal mucosa and mucosa-associated lymphoid tissues in broiler chickens.[J].Acta Veterinaria Hungarica,2015,63(1):30-48.
[21]Xu H,Hao S,Gan F,et al.In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages:A role for the ROS-relative TLR4/MyD88signaling pathway[J].Chem Biol Interact,2017,272:107.
[22]Loboda A,Stachurska A,Sobczak M,et al.Nrf2deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo[J].Toxicology,2017,389:42-59.
[23]Periasamy R,Kalal I G,Krishnaswamy R,et al.Quercetin protects human peripheral blood mononuclear cells from OTA‐induced oxidative stress,genotoxicity,and inflammation[J].Environ Toxicol,2016,31(7):855-865.
[24]Ruan D,Wang W C,Lin C X.Effects of curcumin on performance,antioxidation,intestinal barrier and function in ducks fed corn contaminated with ochratoxin A[J].Animal,2018:1-11.
[25]Khatoon A,Khan M Z,Abidin Z U,et al.Effects of feeding bentonite clay upon ochratoxin A induced immunosuppression in broiler chicks[J].Food Additives and Contaminants-Part A Chemistry,Analysis,Control,Exposure and Risk Assessment,2018,35(3):538.
[26]Huang S,Zheng N,Fan C,et al.Effects of Aflatoxin B1combined with ochratoxin A and/or zearalenone on metabolism,immune function,and antioxidant status in lactating dairy goats[J].Asian-Austr J Animal Sci,2018,31(4):505-513.
[2]马晓宇,林英庭.饲料中霉菌毒素的检测技术[J].粮食与饲料工业,2018(3):57-61.
[3]胡栋,王晓艺,郭子健,等.常见霉菌毒素对免疫系统的毒害作用与防治[J].北方牧业,2017(10):25-26.
[4]刘康,张佩华.奶牛饲料中霉菌毒素的危害及对策[J].湖南饲料,2018(2):27-29.
[5]Bhatti S A,Khan M Z.Protective role of bentonite againtaflatoxin B1-ang ochratoxin A-induced immunotoxicity in broilers[J].J Immuotoxicol,2017,14:66-76.
[6]Pozzo L,Cavallarin L,Antoniazzi S,et al.Feeding a diet contamina-ted with ochratoxin A for broiler chickens at the maximum level re-commended by the EU for poultry feeds(0.1mg/kg).2.Effects on meat quality,oxidative stress,residues and histological traits[J].J Animl Physiol Animal Nutr,2013,97(S1):23-31.
[7]田静.赭曲霉毒素A致鸡肝细胞损伤及四种常用护肝药保护机理研究[D].江苏南京:南京农业大学,2015.
[8]Gan F,Zhou Y,Hou L,et al.Ochratoxin A induces nephrotoxicity and immunotoxicity through different MAPK signaling pathways in PK15cells and porcine primary splenocytes.[J].Chemosphere,2017,182:630.
[9]李春革.赭曲霉毒素A单克隆抗体的制备及其噬菌体模拟表位的筛选[D].河南郑州:郑州大学,2016.
[10]江朝鑫,杨炀,杨锁荣.霉菌毒素对养猪业的危害及其防治措施[J].云南畜牧兽医,2018(1):5-9.
[11]Domijan A M,Gajski G,Jovanovic I N,et al.In vitro,genotoxicity of mycotoxins ochratoxin A and fumonisin B 1,could be prevented by sodium copper chlorophyllin-implication to their genotoxic mechanism[J].Food Chem,2015,170(170C):455-462.
[12]Nedeljkovictrailovic J,Trailovic S,Resanovic R,et al.Comparative investigation of the efficacy of three different adsorbents against OTA-induced toxicity in broiler chickens.[J].Toxins,2015,7(4):1174-1191.
[13]Zeferino C P,Wells K D,Moura A S A M T,et al.Changes in renal gene expression associated with induced ochratoxicosis in chickens:activation and deactivation of transcripts after varying durations of exposure[J].Poultry Sci,2016,96(6):1855.
[14]Khatoon A,Zargham K M,Khan A,et al.Amelioration of ochratoxin A-induced immunotoxic effects by silymarin and vitamin E in white leghorn cockerels.[J].J Immunotoxicol,2013,10(1):25.
[15]T Kaymak,L Türker,H Tulay,et al.Determination of aflatoxins and ochratoxin A in traditional turkish concentrated fruit juice products by multi-immunoaffinity column cleanup and LC fluorescence detection[J].J Aoac Int,2018,27(8):63-67.
[16]Brennan K M,Oh S Y,Yiannikouris A,et al.Differential gene expression analysis of bovine macrophages after exposure to the penicillium mycotoxins citrinin and/or ochratoxin A.[J].Toxins,2017,9(11):366.
[17]Hou L,Fang G,Xuan Z,et al.Immunotoxicity of ochratoxin Aand aflatoxin B1in combination is associated with the nuclear factor kappa B signaling pathway in 3D4/21cells[J].Chemosphere,2018,199:718.
[18]Lautert C,Ferreiro L,Wolkmer P,et al.Individual in vitro effects of ochratoxin A,deoxynivalenol and zearalenone on oxidative stress and acetylcholinesterase in lymphocytes of broiler chickens[J].Springerplus,2014,3(1):1-7.
[19]Jahreis S,Kuhn S,Madaj A M,et al.Mold metabolites drive rheumatoid arthritis in mice via promotion of IFN-gamma-and IL-17-producing T cells[J].Food Chem Toxicol,2017,109:405-413.
[20]Solcan C,Pavel G,Floristean V C,et al.Effect of ochratoxin Aon the intestinal mucosa and mucosa-associated lymphoid tissues in broiler chickens.[J].Acta Veterinaria Hungarica,2015,63(1):30-48.
[21]Xu H,Hao S,Gan F,et al.In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages:A role for the ROS-relative TLR4/MyD88signaling pathway[J].Chem Biol Interact,2017,272:107.
[22]Loboda A,Stachurska A,Sobczak M,et al.Nrf2deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo[J].Toxicology,2017,389:42-59.
[23]Periasamy R,Kalal I G,Krishnaswamy R,et al.Quercetin protects human peripheral blood mononuclear cells from OTA‐induced oxidative stress,genotoxicity,and inflammation[J].Environ Toxicol,2016,31(7):855-865.
[24]Ruan D,Wang W C,Lin C X.Effects of curcumin on performance,antioxidation,intestinal barrier and function in ducks fed corn contaminated with ochratoxin A[J].Animal,2018:1-11.
[25]Khatoon A,Khan M Z,Abidin Z U,et al.Effects of feeding bentonite clay upon ochratoxin A induced immunosuppression in broiler chicks[J].Food Additives and Contaminants-Part A Chemistry,Analysis,Control,Exposure and Risk Assessment,2018,35(3):538.
[26]Huang S,Zheng N,Fan C,et al.Effects of Aflatoxin B1combined with ochratoxin A and/or zearalenone on metabolism,immune function,and antioxidant status in lactating dairy goats[J].Asian-Austr J Animal Sci,2018,31(4):505-513.