支气管哮喘急性发作合并肺部感染患者IL-32、IgE水平与预后的相关性分析
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摘要
目的探究支气管哮喘急性发作合并肺部感染患者白细胞介素-32(IL-32)、免疫球蛋白E(IgE)水平与预后的相关性。方法选取医院2015年5月-2016年5月收治的80例支气管哮喘患者作为研究对象,采用随机数表法将患者分为两组,其中40例支气管哮喘急性发作期患者为B组,40例支气管哮喘急性发作合并肺部感染患者为C组,并选取同期40名健康体检者作为A组。对B、C两组进行规范化治疗,比较B、C两组治疗效果,检测三组研究对象IL-32、IgE水平;对B、C两组患者随访,观察预后情况;并分析C组患者预后影响因素。结果随访结束时,B组患者缓解24例,有效率60%,C组患者缓解17例,有效率42.50%,B组患者治疗有效率高于C组(χ2=3.621,P=0.015);支气管哮喘患者IL-32、IgE水平高于健康人群(P<0.05);C组患者IL-32、IgE水平高于B组患者(P<0.05);B、C两组患者治疗后IL-32、IgE水平均低于治疗前(P<0.05);C组患者支气管哮喘急性发作次数、平均住院时间、平均住院次数高于B组,PEF值低于B组(P<0.05);Logistic回归分析显示,哮喘家族史、IL-32水平、IgE水平升高为影响支气管哮喘急性发作合并肺部感染预后的独立危险因素(P<0.05)。结论支气管哮喘急性发作合并肺部感染患者IL-32、IgE水平升高,并发现哮喘家族史、IL-32水平、IgE水平升高与支气管哮喘急性发作合并肺部感染预后密切相关。
OBJECTIVE To explore the correlation between the levels of IL-32 and IgE and the prognosis of patients with acute attack of bronchial asthma and pulmonary infection.METHODS 80 cases of bronchial asthma patients admitted in our hospital from May 2015 to May 2016 were enrolled,and randomly divided into two groups.Among them,group B included 40 cases of acute attack of bronchial asthma,group C included 40 patients with acute exacerbation of bronchial asthma complicated with pulmonary infection,and another 40 healthy persons with physical examination in the same period were selected as group A.The two groups of B and C received normalized treatment.The therapeutic effects of groups B and C were compared.The levels of IL-32 and IgE in the three groups were detected.The prognosis of groups B and C was followed up,and the influencing factors for the prognosis of group C were analyzed.RESULTS At the end of follow-up,24 patients were relieved in group B,with an effective rate of 60%,and 17 patients were relieved in group C,with an effective rate of 42.50%.The effective rate of treatment in group B was significantly higher than that in group C(χ2=3.621,P=0.015).The IL-32 and IgE levels in bronchial asthma patients were significantly higher than those of healthy controls(P<0.05).The IL-32 and IgE levels of patients in group C were significantly higher than those of group B(P<0.05).The IL-32 and IgE levels of patients in groups B and C after treatment were significantly lower than those before treatment(P<0.05).In group C,the frequency of acute attack of bronchial asthma,the average time of hospitalization and the average number of hospitalization were higher than those of group B,and the value of PEF was significantly lower than that in group B(P<0.05).Logistic regression analysis showed that family history of asthma,increased IL-32 level and IgE level were independent risk factors for the prognosis of acute attack of bronchial asthma combined with pulmonary infection(P<0.05).CONCLUSIONThe levels of IL-32 and IgE in patients with acute exacerbation of asthma and pulmonary infection increased significantly.It was found that the family history of asthma,increased IL-32 level and IgE level were closely related to the prognosis of patients with acute exacerbation of bronchial asthma combined with pulmonary infection.
OBJECTIVE To explore the correlation between the levels of IL-32 and IgE and the prognosis of patients with acute attack of bronchial asthma and pulmonary infection.METHODS 80 cases of bronchial asthma patients admitted in our hospital from May 2015 to May 2016 were enrolled,and randomly divided into two groups.Among them,group B included 40 cases of acute attack of bronchial asthma,group C included 40 patients with acute exacerbation of bronchial asthma complicated with pulmonary infection,and another 40 healthy persons with physical examination in the same period were selected as group A.The two groups of B and C received normalized treatment.The therapeutic effects of groups B and C were compared.The levels of IL-32 and IgE in the three groups were detected.The prognosis of groups B and C was followed up,and the influencing factors for the prognosis of group C were analyzed.RESULTS At the end of follow-up,24 patients were relieved in group B,with an effective rate of 60%,and 17 patients were relieved in group C,with an effective rate of 42.50%.The effective rate of treatment in group B was significantly higher than that in group C(χ2=3.621,P=0.015).The IL-32 and IgE levels in bronchial asthma patients were significantly higher than those of healthy controls(P<0.05).The IL-32 and IgE levels of patients in group C were significantly higher than those of group B(P<0.05).The IL-32 and IgE levels of patients in groups B and C after treatment were significantly lower than those before treatment(P<0.05).In group C,the frequency of acute attack of bronchial asthma,the average time of hospitalization and the average number of hospitalization were higher than those of group B,and the value of PEF was significantly lower than that in group B(P<0.05).Logistic regression analysis showed that family history of asthma,increased IL-32 level and IgE level were independent risk factors for the prognosis of acute attack of bronchial asthma combined with pulmonary infection(P<0.05).CONCLUSIONThe levels of IL-32 and IgE in patients with acute exacerbation of asthma and pulmonary infection increased significantly.It was found that the family history of asthma,increased IL-32 level and IgE level were closely related to the prognosis of patients with acute exacerbation of bronchial asthma combined with pulmonary infection.
引文
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[11]Wang L,Chen Q,Shi C,et al.Changes of serum TNF-α,IL-5and IgE levels in the patients of Mycoplasma pneumonia infection with or without bronchial asthma.[J].Int J Clin Exp Med,2015,8(3):3901-3906.
[12]Rogala B,Bozek A,Gluck J,et al.Prevalence of IgE-mediated allergy and evaluation of Th1/Th2cytokine profiles in patients with severe bronchial asthma[J].Postepy Dermatol Alergol,2015,32(4):274-280.
[2]Kantor DB,Stenquist N,McDonald MC,et al.Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children[J].J Allergy Clin Immunol,2016,138(5):1467-1471.e9.
[3]孙婉璐,陈亚红.2016版全球哮喘防治创议更新简介[J].中国医学前沿杂志:电子版,2016,8(7):33-40.
[4]中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(2016年版)[J].中华结核和呼吸杂志,2016,39(9):675-697.
[5]Rojas-Dotor S,Gonzalez-Hernandez A,Leon-Aguilar FH,et al.Pro and anti-inflammatory cytokine production in CD4+T lymphocytes in children with asthma and allergic rhinitis exposed to the monocyte locomotion inhibitory factor(MLIF)[J].Iran J Allergy Asthma Immunol,2018,17(4):388-392.
[6]Ren YF,Li H,Xing XH,et al.Preliminary study on pathogenesis of bronchial asthma in children.[J].Pediatr Res,2015,77(4):506-510.
[7]Mao W,Cui EH.Distribution of pathogens causing nosocomial infection in patients with bronchial asthma.[J].Genet Mol Ress,2015,14(4):16146-16150.
[8]张巧凤.不同雾化吸入方式治疗支气管哮喘急性发作的临床效果分析[J].转化医学电子杂志,2015,2(11):33-34.
[9]宁正庆.支气管哮喘药物治疗现状及进展研究[J].现代诊断与治疗,2015,26(13):2930-2932.
[10]郭元,王文文,郑常龙,等.支气管哮喘患者外周血中白细胞介素32表达水平及其意义[J].中国卫生检验杂志,2015,25(3):313-314.
[11]Wang L,Chen Q,Shi C,et al.Changes of serum TNF-α,IL-5and IgE levels in the patients of Mycoplasma pneumonia infection with or without bronchial asthma.[J].Int J Clin Exp Med,2015,8(3):3901-3906.
[12]Rogala B,Bozek A,Gluck J,et al.Prevalence of IgE-mediated allergy and evaluation of Th1/Th2cytokine profiles in patients with severe bronchial asthma[J].Postepy Dermatol Alergol,2015,32(4):274-280.