5’-磷酸吡哆醛的合成研究
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摘要
本文对5’-磷酸吡哆醛的合成工艺进行研究,以离子液体为溶剂合成5’-磷酸吡哆醛,确定了最佳生产工艺参数,并对离子液体进行重复利用5次,该工艺具有操作简单、产率高、后处理方便等特点。
This paper mainly introduces the synthesis process of 5'-pyridoxal phosphate. The synthesis of 5'-pyridoxal phosphate was carried out with ionic liquid as solvent. The optimal production process parameters were determined. The ionic liquid was reused 5 times. The process made the operation easier and more efficient and convenient.
This paper mainly introduces the synthesis process of 5'-pyridoxal phosphate. The synthesis of 5'-pyridoxal phosphate was carried out with ionic liquid as solvent. The optimal production process parameters were determined. The ionic liquid was reused 5 times. The process made the operation easier and more efficient and convenient.
引文
[1]林锦明,卞红平,王小燕,等.磷酸吡哆醛的差热分析法鉴定[J].药学实践杂志,2007,25(1):32-35.
[2]Cellini B,Montioli R,Oppici E,et al.The chaperone role of the pyridoxal5′-phosphate and its implications for rare diseases involving B6-dependent enzymes[J].Clinical Biochemistry,2014,47(3):158-165.
[3]肖玉梅,李楠,傅滨.维生素B6--人体“建筑师”[J].大学化学,2010(s1):57-61.
[4]Kim J H,Kim J,Kim H J,et al.Biotransformation of pyridoxal5'-phosphate from pyridoxal by pyridoxal kinase(pdxY)to support cadaverine production in Escherichia coli.[J].Enzyme&Microbial Technology,2017,104:9-15.
[5]G?owacki R,Stachniuk J,Borowczyk K,et al.Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography.[J].Analytical&Bioanalytical Chemistry,2016,408(7):1935-1941.
[6]Phillips RS.Chemistry and diversity of pyridoxal-5'-phosphate dependent enzymes[J].BBA-Proteins and Proteomics,2015,1854(9):1167-1174.
[7]Peterson E A,Sober H A,Meister A.Crystalline pyridoxamine phosphate[J].Journal of the American Chemical Society,1952,74(2):570-571.
[8]方丁,张富荣.5’-磷酸吡哆醛钙盐的合成[J].生物化学与生物物理进展,1980,20(3):74-78
[9]王淑美.合成5’-磷酸吡哆醛的简便方法[J].华东理工大学学报,1983,3:92-95.
[10]卞红平;周后元.一类磷酸吡哆醛中间体及其制备方法和应用,以及由其制备磷酸吡哆醛的方法:中国,CN200810034362.7[P].2012-11-07.
[11]李腾;王凯;何连顺;等.一种磷酸吡哆醛的合成方法:中国,CN201710850639.2[P].2018-02-02.
[12]施泰格瓦尔德制药有限公司.生产吡哆醛-5'-磷酸谷氨酸镁的方法及由此获得的中间产物:中国,CN1199402[P].1998-11-18.
[2]Cellini B,Montioli R,Oppici E,et al.The chaperone role of the pyridoxal5′-phosphate and its implications for rare diseases involving B6-dependent enzymes[J].Clinical Biochemistry,2014,47(3):158-165.
[3]肖玉梅,李楠,傅滨.维生素B6--人体“建筑师”[J].大学化学,2010(s1):57-61.
[4]Kim J H,Kim J,Kim H J,et al.Biotransformation of pyridoxal5'-phosphate from pyridoxal by pyridoxal kinase(pdxY)to support cadaverine production in Escherichia coli.[J].Enzyme&Microbial Technology,2017,104:9-15.
[5]G?owacki R,Stachniuk J,Borowczyk K,et al.Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography.[J].Analytical&Bioanalytical Chemistry,2016,408(7):1935-1941.
[6]Phillips RS.Chemistry and diversity of pyridoxal-5'-phosphate dependent enzymes[J].BBA-Proteins and Proteomics,2015,1854(9):1167-1174.
[7]Peterson E A,Sober H A,Meister A.Crystalline pyridoxamine phosphate[J].Journal of the American Chemical Society,1952,74(2):570-571.
[8]方丁,张富荣.5’-磷酸吡哆醛钙盐的合成[J].生物化学与生物物理进展,1980,20(3):74-78
[9]王淑美.合成5’-磷酸吡哆醛的简便方法[J].华东理工大学学报,1983,3:92-95.
[10]卞红平;周后元.一类磷酸吡哆醛中间体及其制备方法和应用,以及由其制备磷酸吡哆醛的方法:中国,CN200810034362.7[P].2012-11-07.
[11]李腾;王凯;何连顺;等.一种磷酸吡哆醛的合成方法:中国,CN201710850639.2[P].2018-02-02.
[12]施泰格瓦尔德制药有限公司.生产吡哆醛-5'-磷酸谷氨酸镁的方法及由此获得的中间产物:中国,CN1199402[P].1998-11-18.