血尿酸、低密度脂蛋白与老年女性冠心病患者冠脉狭窄程度的相关性
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摘要
目的探讨血清尿酸、低密度脂蛋白水平与老年女性冠心病患者冠脉狭窄程度的相关性。方法选取60岁及以上拟诊冠心病的女性患者270例,据冠脉造影检查结果分为冠脉病变组及对照组。计算Gensini积分,空腹静脉血检测血清尿酸及低密度脂蛋白水平,比较各组尿酸及低密度脂蛋白水平。结果冠脉病变组血清尿酸及低密度脂蛋白水平明显高于对照组(P<0.05),三支病变组高于单支病变组(P <0.01)。结论老年女性冠心病患者血清尿酸及低密度脂蛋白水平与冠状动脉狭窄程度相关。
Objective To investigate the correlation between serum uric acid and LDL levels and the degree of coronary artery stenosis in elderly women with coronary heart disease.Me thods 270 female patients aged 60 and over who were to be diagnosed with coronary heart disease were selected and divided into the coronary artery disease group and the control group according to the results of coronary angiography. Gensini integral was calculated and fasting venous blood was used to detect serum uric acid and LDL levels. Uric acid and LDL levels in each group were compared. Re s ults The serum uric acid and LDL levels in the coronary artery disease group were significantly higher than those in the control group, and the levels in the three-branch disease group were significantly higher than those in the single-branch disease group(P < 0.05). Conclus ion Serum uric acid and LDL levels in elderly women with coronary heart disease are correlated with the degree of coronary artery stenosis.
Objective To investigate the correlation between serum uric acid and LDL levels and the degree of coronary artery stenosis in elderly women with coronary heart disease.Me thods 270 female patients aged 60 and over who were to be diagnosed with coronary heart disease were selected and divided into the coronary artery disease group and the control group according to the results of coronary angiography. Gensini integral was calculated and fasting venous blood was used to detect serum uric acid and LDL levels. Uric acid and LDL levels in each group were compared. Re s ults The serum uric acid and LDL levels in the coronary artery disease group were significantly higher than those in the control group, and the levels in the three-branch disease group were significantly higher than those in the single-branch disease group(P < 0.05). Conclus ion Serum uric acid and LDL levels in elderly women with coronary heart disease are correlated with the degree of coronary artery stenosis.
引文
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[9]张玫媚,田雅军,罗毅.血清同型半胱氨酸、血尿酸水平与脑卒中的相关性分析[J].齐齐哈尔医学院学报,2018,39(7):751-754.
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[11]钱漪,陈颖,周菁,等.冠心病与颈动脉粥样硬化发生及斑块性质的相关性研究[J].中外医学研究,2017,15(14):31-32.
[12]SUNH,KOIKE T,I CHIKAWA T,et al.Creactive protein in atherosclerotic lesions:its origin anspathophysiological significance[J].Am J pathol,2005,167(4):1139-1148.
[13] LAIX,YANGL,LEGARES,et al.Dose-response relationship between serum uric acid levels and risk of incident coronary heart disease in the Dongfeng-Tongjicohort[J].Int J Cardiol,2016,224(2):299-303.
[14]COLLINS T,CYBULSKY MI.NF-kappa B:pivotal mediator or innocent bystander In atherogenesis[J].J Clin Invest,2001,107(3):255-264.
[2] GENDINI G G.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.
[3] ATP III pannel,ATP III final report,special considersions for different population groups[J].Circulation,2002,106(20):3349-3352.
[4]黄瑄.颈动脉内膜中层厚度与动脉粥样硬化的关系及临床意义[J].华夏医学,2009,18(6):1063-1064.
[5] SHORT R A,JOHNSON R J,TUTTLE K R.Uric acid,microalbum inuria and cardiovascular events in high-risk patients[J].Am J Nephrol,2005,25(1):36-43.
[6]王丹丹,夏勇.尿酸与心血管疾病的关系[J].当代医学,2010,16(27):56-57.
[7]郭海鹏,魏燕.PCI术前口服高剂量阿托伐他汀对STEME病人术后冠状动脉血流和血尿酸、炎症介入质的影响[J].中西医结合心脑血管病杂志,2018,16(7):928-931.
[8]李英博,低密度脂蛋白胆固醇与心血管发病关系的前瞻性研究[J].中西医结合心脑血管病杂志,2018,6(12):180.
[9]张玫媚,田雅军,罗毅.血清同型半胱氨酸、血尿酸水平与脑卒中的相关性分析[J].齐齐哈尔医学院学报,2018,39(7):751-754.
[10] IDILMAN I S,AKATA D,HAZIROLAN T,et al.Nonalcoholic fatty liver disease is associated with significant artery disease in type 2 diabetic patients:a computed tomography angiography study 2[J].Diabetes,2015,7(2):279-86.
[11]钱漪,陈颖,周菁,等.冠心病与颈动脉粥样硬化发生及斑块性质的相关性研究[J].中外医学研究,2017,15(14):31-32.
[12]SUNH,KOIKE T,I CHIKAWA T,et al.Creactive protein in atherosclerotic lesions:its origin anspathophysiological significance[J].Am J pathol,2005,167(4):1139-1148.
[13] LAIX,YANGL,LEGARES,et al.Dose-response relationship between serum uric acid levels and risk of incident coronary heart disease in the Dongfeng-Tongjicohort[J].Int J Cardiol,2016,224(2):299-303.
[14]COLLINS T,CYBULSKY MI.NF-kappa B:pivotal mediator or innocent bystander In atherogenesis[J].J Clin Invest,2001,107(3):255-264.