防控输血传播梅毒的筛查技术应用进展
摘要
<正>梅毒(Syphilis)作为一种性传播疾病,可经输血传播,临床表现复杂,可累及全身多个器官。据世界卫生组织(WHO)统计,每年约有1 200万梅毒的新增病例,其中发展中国家占90%以上,更为重要的是,近[30年调查研究发现梅毒与HIV感染风险呈正相关1-2]。采供血机构通过对献血者进行筛查、血液
引文
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[15]曾铁兵,刘小军,张跃军,等.梅毒螺旋体Tp0971重组蛋白的表达及其在梅毒血清学诊断中的初步评价[J].中国病原生物学杂志,2010,5(6):411-413.
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[21]徐长根,朱阳泉,李浩,等.胶体金免疫层析法快速筛查献血者梅毒螺旋体抗体[J].临床输血与检验,2009,11(3):234-235.
[22] LeslieD E,AzzatoF,KarapanagiotidisT,etal.Development of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing[J]. J Clin Microbiol,2007,45(1):93-96.
[23]Janier M,Hegyi V,Dupin N,et al. 2014 European guideline on the management of syphilis[J]. Journal of the European Academy of Dermatology&Venereology Jeadv,2014,28(12):1581-1593.
[2]Chen M J,Scheer S,Nguyen T Q,et al. HIV Co-infection among Persons Diagnosed with Sexually Transmitted Diseases,San Francisco,2007-2014[J]. Sexually Transmitted Diseases,2018:1.
[3]Kaur G,Kaur P. Syphilis testing in blood donors:an update[J]. Blood transfusion,2015,13(2):197.
[4]Orton S. Syphilis and blood donors:What we know,what we do not know,and what we need to know[J]. Transfusion Medicine Reviews,2001,15(4):282-292.
[5]Zeltser R,Kurban A K. Syphilis[J]. Clinics in Dermatology,2004,22(6):461-468.
[6]Chambers R W,Foley H T,Schmidt P J. Transmission of Syphilis by Fresh Blood Components[J]. Transfusion,1969,9(1):3.
[7]Tagny C T, Owusu-ofori S, Mbanya D, et al. The blood donor in sub-Saharan Africa:a review[J]. Transfusion Medicine,2010,20(1):1-10.
[8]杨楠,王秀菊,高明. 2010-2014年兰州地区TP抗体阳性献血者特征分析[J].中国艾滋病性病,2016,22(3):210-213.
[9]余桂华,刘琼芬.曲靖市无偿献血者梅毒检测结果分析[J].临床血液学杂志:输血与检验,2013,26(2):267-268.
[10]Singh A E,Romanowski B. Syphilis:Review with Emphasis on Clinical,Epidemiologic,and Some Biologic Features[J]. Clinical Microbiology Reviews,1999,12(2):187-209.
[11]Sommese L,Paolillo R,Sabia C,et al. Syphilis detection:evaluation of serological screening and pilot reverse confirmatory assay algorithm in blood donors[J]. International Journal of Std&Aids,2016,27(8):644-649.
[12]邓美霞,张晓红,赵飞骏.梅毒实验室检测方法的研究进展[J].微生物学免疫学进展,2016,44(1):76-82.
[13]Van Voorhis W C,Barrett L K,Lukehart S A,et al. Serodiagnosis of syphilis:antibodies to recombinant Tp0453,Tp92,and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum[J]. J Clin Microbiol,2003,41(8):3668-3674.
[14]Smith B C,Simpson Y,Morshed M G,et al. New proteins for a new perspective on syphilis diagnosis[J]. J Clin Microbiol,2013,51(1):105-111.
[15]曾铁兵,刘小军,张跃军,等.梅毒螺旋体Tp0971重组蛋白的表达及其在梅毒血清学诊断中的初步评价[J].中国病原生物学杂志,2010,5(6):411-413.
[16]伍宁,肖勇建.梅毒螺旋体Tp0821基因的克隆、表达、纯化及免疫活性研究[J].中华皮肤性病学杂志,2010,43(7):489-492.
[17]Long F Q,Zhang J P,Shang G D,et al. Seroreactivity and immunogenicity of Tp0965,a hypothetical membrane protein of Treponema pallidum[J]. Chin Med J(Eng),2012,125(11):1920-1924.
[18]Wicher K,Horowitz H W,Wicher V. Laboratory methods of diagnosis of syphilis for the beginning of the third millennium[J]. Microbes&Infection,1999,1(12):1035.
[19]国家卫生计生委.国家卫生计生委关于印发血站技术操作规程(2015版)的通知[EB/OL].(2015-12-31)[2016-03-15].http://www.nhfpc.gov.cn/yzygj/s7658/201512/d9c61 cbe48c14b88ab82ebae72036223.shtml.
[20]Tao C,Hao X,Xu W,et al. Evaluation of the Elecsys syphilis immunoassay for routine screening of serum samples in China[J]. Scientific Reports,2017,7(1):1473-1476.
[21]徐长根,朱阳泉,李浩,等.胶体金免疫层析法快速筛查献血者梅毒螺旋体抗体[J].临床输血与检验,2009,11(3):234-235.
[22] LeslieD E,AzzatoF,KarapanagiotidisT,etal.Development of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing[J]. J Clin Microbiol,2007,45(1):93-96.
[23]Janier M,Hegyi V,Dupin N,et al. 2014 European guideline on the management of syphilis[J]. Journal of the European Academy of Dermatology&Venereology Jeadv,2014,28(12):1581-1593.