LASS2基因对恶性肿瘤作用机制研究进展
摘要
人源性长寿保障基因Ⅱ型(LASS2)又名肿瘤转移抑制基因-1(TMSG1),是新发现的一种肿瘤转移抑制基因,多项研究表明其在肝癌、肺癌、膀胱癌、乳腺癌、胃癌、前列腺癌、结直肠癌、脑膜瘤、鼻咽癌等多种恶性肿瘤中表达下降,有研究显示LASS2对恶性肿瘤具有促进凋亡及抑制转移等抑癌基因的作用。本文就目前研究LASS2对不同恶性肿瘤的作用及其作用机制的进展作一综述。
引文
[1] FREDDIE B,JACQUES F,ISABELLE S,et al. Global Cancer Statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2018,68(6):394-424.
[2]唐宁. LASS2在肝癌生长和转移中的作用[D].复旦大学,2009.
[3]徐海芹,李时荣,翁立新,等.不同转移潜能人肺癌细胞系中LASS2/TMSG1的表达及其意义[J].山西医科大学学报,2016,47(10):884-889.
[4] CHEN Y J,WANG H F,XIONG T,et al. The role of LASS2in regulating bladder cancer cell tumorigenicity in a nude mouse model[J]. Oncol Lett,2017,14(5):5149-5156.
[5] FAN S,NIU Y,TAN N,et al. LASS2 enhance chemosensitivity of breast cancer by counteracting acidic tumor microenvironment thought inhibiting activity of V-ATPase proton pump[J].Oncogene,2013,32(13):1682-1690.
[6]汪波. TMSG1在胃癌中的表达及其临床意义[J].中国实用医药,2013,8(23):1-2.
[7] MA C,LIU Y,ZHENG J,et al. Identification of tumor metastasis related gene TMSG-1 by mRNA differential display[J].Sci China C Life Sci,2002,45(5):553-560.
[8] PAN H,QIN W X,HUO K K,et al. Cloning,mapping,and characterization of a human homologue of the yeast longevity assurance gene LAG1[J]. Genomics,2001,77(1-2):58-64.
[9] ZOU P C,YANG Y F,XU X Y. Silencing of vacuolar ATPase c subunit ATP6V0C inhibits invasion of prostate cancer cells[J]. Beijing Da Xue Xue Bao Yi Xue Ban,2017,49(6):937-947.
[10]陈玉锦,王海峰,颜汝平,等. LASS2-3′-非翻译区rs8444单核苷酸多态性与膀胱癌易感性的相关性研究[J].中国肿瘤临床,2017,44(3):107-111.
[11] ROFSTAD E K,MATHIESEN B,KINDEM K. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice[J]. Cancer Res,2006,66(13):6699-6707.
[12] COUSSENS L M,FINGLETON B,MATRISIAN L M. Matrix metalloproteinase inhibitors and cancer:Trials and tribulations[J]. Science,2002,295(5564):2387-2392.
[13] XU X,LIU B,ZOU P,et al. Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell[J]. J Cell Biochem,2014,115(4):731-743.
[14] SUN X,YANG L V,TIEQS B C,et al. Deletion of the pH sensor GPR4 decreases renal acid excretion[J]. J Am Soc Nephrol,2010,21(10):1745-1755.
[15] WANG H F,ZUO Y G,DING M X,et al. LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity[J]. Oncology Letters,2017,13(2):661-668.
[16] MULLANY L K,WHITE P,HANSE E A,et al. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo[J]. Cell Cycle,2008,7(14):2215-2224.
[17] MO J,LIN M,HE B,et al. Recombinant human adenovirusp53 improves the outcome of mid-late stage pancreatic cancer via arterial infusion[J]. Oncol Let,2017,14(6):6829-6832.
[18] SMITS V A. EDD induces cell cycle arrest by increasing p53levels[J]. Cell Cycle,2012,11(4):715-720.
[19] KASTAN M B,CANMAN C E,LEONARD C J. P53,cell cycle control and apoptosis:Implications for cancer[J]. Cancer Metastasis Rev,1995,14(1):3-15.
[20] WANG Y,QIU C,LU N,et al. FOXD1 is targeted by miR-30a-5p and miR-200a-5p and suppresses the proliferation of human ovarian carcinoma cells by promoting p21 expression in a p53-independent manner[J]. Int J Oncol,2018,52(6):2130-2142.
[21] ZENG F,HUANG L,CHENG X,et al. Overexpression of LASS2 inhibits proliferation and cause GO/G1 cell cycle arrest in papillary thyroid cancer[J]. Cancer Cell Int,2018,18:151.
[22] NICOLAE C M,O′CONNOR M J,Constantin D,et al. NF-κB regulates p21 expression and controls DNA damage-induced leukemic differentiation[J]. Oncogene,2018,37(27):3647-3656.
[23] LEDOUX A C,PERKINS N D. NF-κB and the cell cycle[J].Biochem Soc Trans,2014,42(1):76-81.
[24] BARRéB,PERKINS N D. A cell cycle regulatory network controlling NF-kappaB subunit activity and function[J]. EMBO J,2007,26(23):4841-55.
[25] SCHUMM K,ROCHA S,CAAMANO J,et al. Regulation of p53 tumour suppressor target gene expression by the p52 NFkappaB subunit[J]. EMBO J,2006,25(20):4820-4832.
[26] CHAN D C. Mitochondrial fusion and fission in mammals[J].Annu Rev Cell Dev Biol,2006,22:79-99.
[27] HUANG L J,LUANG T,CHEN Y J,et al. LASS2 regulates invasion chemoresistance via ERK/Drp1 modulated mitochondrial dynamics in bladder cancer cell[J]. J Cancer,2018,9(6):1017-1024.
[28] FERREIRA-DA-SILVA A,VALACCA C,RIOS E,et al. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration[J]. PLoS One,2015,10(3):e0122308.
[29] WANG H F,ZHANG W,ZUO Y G,et al. miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer[J]. Tumor Biol,2015,36(12):9631-9640.
[30]陈玉锦,王剑松,颜汝平,等. miRNA-20a在膀胱癌中的表达及其机制研究[J].中国肿瘤临床,2017,44(20):1014-1018.
[31] LUAN T,ZOU R,HUANG L J,et al. Hsa-miR-3658 Promotes Cell Proliferation,Migration and Invasion by Effecting LASS2 in Bladder Cancer[J]. Clin lab,2018,64(4):515-525.
[32]蒋昌毅,柯昌兴,叶枝能,等. MIR-3622a通过LASS2调控对膀胱癌细胞的生物学行为影响[J].现代泌尿外科杂志,2018,23(2):132-137.
[33] LIU J Y,WANG H F,WANG Y,et al. Repression of the miR-93-enhanced sensitivity of bladder carcinoma to chemotherapy involves the regulation of LASS2[J]. OncoTargets and Therapy,2016,9:1813-1822.
[34] FAN S H,WANG Y Y,WU Z Y,et al. AGPAT9 suppresses cell growth,invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer[J]. Oncotarget,2015,6(21):18406-18417.
[35] GU D,JIN H,JIN G,et al. The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity[J]. Cancer Lett,2016,379(1):107-116.
[36] XU X,LIU B,ZOU P,et al. Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell[J]. J Cell Biochem,2014,115(4):731-743.
[37] XU X,YOU J,PEI F. LASS2/TMSG1 gene silencing promotes the invasiveness and metastatic of human prostatic carcinoma cells through increase in vacuolar ATPase activity[J]. Zhonghua Bing Li Xue Za Zhi,2014,43(3):177-183.
[38] YU W,WANG L,WANG Y,et al. A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain[J]. J Cell Biochem,2013,114(3):570-583.
[39]游海燕,金浩,唐宁,等.重组腺病毒载体介导人LASS2基因在肝癌细胞转移中的抑制作用[J].肿瘤,2012,32(4):244-250.
[40] TANG N,JIN J,DENG Y,et al. LASS2 interacts with VATPase and inhibits cell growth of hepatocellular carcinoma[J]. Sheng Li Xue Bao,2010,62(3):196-202.
[41] LU X,CHEN Y,ZENG T,et al. Knockout of the HCC suppressor gene LASS2 downregulates the expression level of miR-694[J]. Oncol Rep,2014,32(6):2696-2702.
[42] RUAN H, WANG T, YANG C, et al. Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma[J]. Sci Rep,2016,6:32421.
[43] WANG H F,WANG J S,ZUO Y G,et al. Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma[J]. Med Oncol,2012,29(3):1921-1927.
[44] MEI F,YOU J,LIU B,et al. LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity[J]. Tumor Biol,2015,36(4):2831-2844.
[45]徐晓燕,伊日贵,李秀霞,等. LASS2/TMSG-1基因过表达对人肺癌95D细胞体外侵袭迁移能力的影响及其机制[J].临床与实验病理学杂志,2016,32(8):901-907.
[46]张红梅,周红燕,汪佩,等.甲状腺癌基因检测在甲状腺结节早期诊断中的临床应用[J].实用医学杂志,2018,34(6):970-973.
[2]唐宁. LASS2在肝癌生长和转移中的作用[D].复旦大学,2009.
[3]徐海芹,李时荣,翁立新,等.不同转移潜能人肺癌细胞系中LASS2/TMSG1的表达及其意义[J].山西医科大学学报,2016,47(10):884-889.
[4] CHEN Y J,WANG H F,XIONG T,et al. The role of LASS2in regulating bladder cancer cell tumorigenicity in a nude mouse model[J]. Oncol Lett,2017,14(5):5149-5156.
[5] FAN S,NIU Y,TAN N,et al. LASS2 enhance chemosensitivity of breast cancer by counteracting acidic tumor microenvironment thought inhibiting activity of V-ATPase proton pump[J].Oncogene,2013,32(13):1682-1690.
[6]汪波. TMSG1在胃癌中的表达及其临床意义[J].中国实用医药,2013,8(23):1-2.
[7] MA C,LIU Y,ZHENG J,et al. Identification of tumor metastasis related gene TMSG-1 by mRNA differential display[J].Sci China C Life Sci,2002,45(5):553-560.
[8] PAN H,QIN W X,HUO K K,et al. Cloning,mapping,and characterization of a human homologue of the yeast longevity assurance gene LAG1[J]. Genomics,2001,77(1-2):58-64.
[9] ZOU P C,YANG Y F,XU X Y. Silencing of vacuolar ATPase c subunit ATP6V0C inhibits invasion of prostate cancer cells[J]. Beijing Da Xue Xue Bao Yi Xue Ban,2017,49(6):937-947.
[10]陈玉锦,王海峰,颜汝平,等. LASS2-3′-非翻译区rs8444单核苷酸多态性与膀胱癌易感性的相关性研究[J].中国肿瘤临床,2017,44(3):107-111.
[11] ROFSTAD E K,MATHIESEN B,KINDEM K. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice[J]. Cancer Res,2006,66(13):6699-6707.
[12] COUSSENS L M,FINGLETON B,MATRISIAN L M. Matrix metalloproteinase inhibitors and cancer:Trials and tribulations[J]. Science,2002,295(5564):2387-2392.
[13] XU X,LIU B,ZOU P,et al. Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell[J]. J Cell Biochem,2014,115(4):731-743.
[14] SUN X,YANG L V,TIEQS B C,et al. Deletion of the pH sensor GPR4 decreases renal acid excretion[J]. J Am Soc Nephrol,2010,21(10):1745-1755.
[15] WANG H F,ZUO Y G,DING M X,et al. LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity[J]. Oncology Letters,2017,13(2):661-668.
[16] MULLANY L K,WHITE P,HANSE E A,et al. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo[J]. Cell Cycle,2008,7(14):2215-2224.
[17] MO J,LIN M,HE B,et al. Recombinant human adenovirusp53 improves the outcome of mid-late stage pancreatic cancer via arterial infusion[J]. Oncol Let,2017,14(6):6829-6832.
[18] SMITS V A. EDD induces cell cycle arrest by increasing p53levels[J]. Cell Cycle,2012,11(4):715-720.
[19] KASTAN M B,CANMAN C E,LEONARD C J. P53,cell cycle control and apoptosis:Implications for cancer[J]. Cancer Metastasis Rev,1995,14(1):3-15.
[20] WANG Y,QIU C,LU N,et al. FOXD1 is targeted by miR-30a-5p and miR-200a-5p and suppresses the proliferation of human ovarian carcinoma cells by promoting p21 expression in a p53-independent manner[J]. Int J Oncol,2018,52(6):2130-2142.
[21] ZENG F,HUANG L,CHENG X,et al. Overexpression of LASS2 inhibits proliferation and cause GO/G1 cell cycle arrest in papillary thyroid cancer[J]. Cancer Cell Int,2018,18:151.
[22] NICOLAE C M,O′CONNOR M J,Constantin D,et al. NF-κB regulates p21 expression and controls DNA damage-induced leukemic differentiation[J]. Oncogene,2018,37(27):3647-3656.
[23] LEDOUX A C,PERKINS N D. NF-κB and the cell cycle[J].Biochem Soc Trans,2014,42(1):76-81.
[24] BARRéB,PERKINS N D. A cell cycle regulatory network controlling NF-kappaB subunit activity and function[J]. EMBO J,2007,26(23):4841-55.
[25] SCHUMM K,ROCHA S,CAAMANO J,et al. Regulation of p53 tumour suppressor target gene expression by the p52 NFkappaB subunit[J]. EMBO J,2006,25(20):4820-4832.
[26] CHAN D C. Mitochondrial fusion and fission in mammals[J].Annu Rev Cell Dev Biol,2006,22:79-99.
[27] HUANG L J,LUANG T,CHEN Y J,et al. LASS2 regulates invasion chemoresistance via ERK/Drp1 modulated mitochondrial dynamics in bladder cancer cell[J]. J Cancer,2018,9(6):1017-1024.
[28] FERREIRA-DA-SILVA A,VALACCA C,RIOS E,et al. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration[J]. PLoS One,2015,10(3):e0122308.
[29] WANG H F,ZHANG W,ZUO Y G,et al. miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer[J]. Tumor Biol,2015,36(12):9631-9640.
[30]陈玉锦,王剑松,颜汝平,等. miRNA-20a在膀胱癌中的表达及其机制研究[J].中国肿瘤临床,2017,44(20):1014-1018.
[31] LUAN T,ZOU R,HUANG L J,et al. Hsa-miR-3658 Promotes Cell Proliferation,Migration and Invasion by Effecting LASS2 in Bladder Cancer[J]. Clin lab,2018,64(4):515-525.
[32]蒋昌毅,柯昌兴,叶枝能,等. MIR-3622a通过LASS2调控对膀胱癌细胞的生物学行为影响[J].现代泌尿外科杂志,2018,23(2):132-137.
[33] LIU J Y,WANG H F,WANG Y,et al. Repression of the miR-93-enhanced sensitivity of bladder carcinoma to chemotherapy involves the regulation of LASS2[J]. OncoTargets and Therapy,2016,9:1813-1822.
[34] FAN S H,WANG Y Y,WU Z Y,et al. AGPAT9 suppresses cell growth,invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer[J]. Oncotarget,2015,6(21):18406-18417.
[35] GU D,JIN H,JIN G,et al. The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity[J]. Cancer Lett,2016,379(1):107-116.
[36] XU X,LIU B,ZOU P,et al. Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell[J]. J Cell Biochem,2014,115(4):731-743.
[37] XU X,YOU J,PEI F. LASS2/TMSG1 gene silencing promotes the invasiveness and metastatic of human prostatic carcinoma cells through increase in vacuolar ATPase activity[J]. Zhonghua Bing Li Xue Za Zhi,2014,43(3):177-183.
[38] YU W,WANG L,WANG Y,et al. A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain[J]. J Cell Biochem,2013,114(3):570-583.
[39]游海燕,金浩,唐宁,等.重组腺病毒载体介导人LASS2基因在肝癌细胞转移中的抑制作用[J].肿瘤,2012,32(4):244-250.
[40] TANG N,JIN J,DENG Y,et al. LASS2 interacts with VATPase and inhibits cell growth of hepatocellular carcinoma[J]. Sheng Li Xue Bao,2010,62(3):196-202.
[41] LU X,CHEN Y,ZENG T,et al. Knockout of the HCC suppressor gene LASS2 downregulates the expression level of miR-694[J]. Oncol Rep,2014,32(6):2696-2702.
[42] RUAN H, WANG T, YANG C, et al. Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma[J]. Sci Rep,2016,6:32421.
[43] WANG H F,WANG J S,ZUO Y G,et al. Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma[J]. Med Oncol,2012,29(3):1921-1927.
[44] MEI F,YOU J,LIU B,et al. LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity[J]. Tumor Biol,2015,36(4):2831-2844.
[45]徐晓燕,伊日贵,李秀霞,等. LASS2/TMSG-1基因过表达对人肺癌95D细胞体外侵袭迁移能力的影响及其机制[J].临床与实验病理学杂志,2016,32(8):901-907.
[46]张红梅,周红燕,汪佩,等.甲状腺癌基因检测在甲状腺结节早期诊断中的临床应用[J].实用医学杂志,2018,34(6):970-973.