吴伟教授运用膏方防治心系疾病用药规律的数据挖掘
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摘要
目的探讨广东省名中医吴伟教授运用膏方防治心系疾病的用药规律。方法收集广州中医药大学第一附属医院2017年10月—2018年3月吴伟教授门诊防治心系疾病的膏方处方,应用软件进行数据挖掘,分析吴伟教授运用膏方防治心系疾病的用药规律。结果纳入病例163例,处方163首,药物共计255味。处方中高频心系疾病为胸痹心痛(60);频次最高的前3位药物为丹参(108)、黄芩(100)、川芎(93);相关度为8,惩罚度为3,应用复杂系统熵聚类的层次聚类分析演化出3～6味药核心组合12组,前三位的组合为"赤芍、桃仁、红花""黄酒、山萸肉、知母、地骨皮""熟党参、陈皮、蜂蜜",挖掘了"赤芍、桃仁、红花、毛冬青、川芎、降香"等新处方6首。结论吴伟教授运用膏方防治心系疾病多用清热、活血、滋阴、化痰之品,佐以"和中"之品,体现其临证防治心系疾病"以心为本、五脏相关、活血化瘀为要、佐以清热、滋阴、化痰"的学术思想。
Objective To probe into the rule of Chinese medicine paste prescription for the prevention and treatment of heart disease by famous professor Wu Wei.Methods The prescriptions of Chinese Medicine paste prescription for the prevention and treatment of heart disease by Professor Wu Wei from October 2017 to March 2018 were collected.The data were analyzed by data mining.Results A total of163 cases of 163 prescriptions and 255 drugs were analyzed.The high frequency heart disease in the prescription was chest stuffiness and chest pain(60).The top 3 drugs with the highest intermediate frequency were Salvia miltiorrhiza(108),Scutellaria baicalensis(100),Chuanxiong(93).The correlation was 8 and the penalty was 3.The top three combinations were "red peony,peach kernel,safflower" "yellow wine,cornus,Anemarrhena,cortex lycii radicis" "cooked Codonopsis pilosula,pericarpium citri reticulatae,honey" and " Radix Paeoniae rubra,peach kernel,safflower,hairy holly root,Ligusticum wallichii,lignum acronychiae" and other six new prescriptions were excavated.Conclusion Professor Wu Wei used paste prescription to prevent and cure heart diseases,which mainly were the goods with properties of clearing heat,activating blood,nourishing yin,resolving phlegm,and combining with drugs of " regulating the middle warmer".It embodied its clinical academic thought of preventing and curing heart diseases: "based on the heart,related to the five viscera,promoting blood circulation and removing blood stasis,assisting with clearing away heat and nourishing yin,resolving phlegm".
Objective To probe into the rule of Chinese medicine paste prescription for the prevention and treatment of heart disease by famous professor Wu Wei.Methods The prescriptions of Chinese Medicine paste prescription for the prevention and treatment of heart disease by Professor Wu Wei from October 2017 to March 2018 were collected.The data were analyzed by data mining.Results A total of163 cases of 163 prescriptions and 255 drugs were analyzed.The high frequency heart disease in the prescription was chest stuffiness and chest pain(60).The top 3 drugs with the highest intermediate frequency were Salvia miltiorrhiza(108),Scutellaria baicalensis(100),Chuanxiong(93).The correlation was 8 and the penalty was 3.The top three combinations were "red peony,peach kernel,safflower" "yellow wine,cornus,Anemarrhena,cortex lycii radicis" "cooked Codonopsis pilosula,pericarpium citri reticulatae,honey" and " Radix Paeoniae rubra,peach kernel,safflower,hairy holly root,Ligusticum wallichii,lignum acronychiae" and other six new prescriptions were excavated.Conclusion Professor Wu Wei used paste prescription to prevent and cure heart diseases,which mainly were the goods with properties of clearing heat,activating blood,nourishing yin,resolving phlegm,and combining with drugs of " regulating the middle warmer".It embodied its clinical academic thought of preventing and curing heart diseases: "based on the heart,related to the five viscera,promoting blood circulation and removing blood stasis,assisting with clearing away heat and nourishing yin,resolving phlegm".
引文
[1]高颖,方祝元,吴伟.中医内科学[M].北京:人民卫生出版社,2015:1-5.
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[3]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2010:1-5.
[4]唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):329-331.
[5]孙玉姣,李盼盼,原嘉民,等.国医大师颜德馨含川芎膏方用药规律的数据挖掘[J].时珍国医国药,2015,26(12):3026-3028.
[6]金政,许书嘉,褚庆民,等.吴伟运用清热活血法干预冠状动脉慢性完全闭塞病变支架术后经验[J].广州中医药大学学报,2016,33(6):890-892.
[7]吴伟,彭锐.冠心病热毒病机的探讨[J].新中医,2007,39(6):3-4.
[8]金政,吴伟,邓铁涛.邓铁涛运用“少火生气”理论治疗心血管疾病之经验[J].中医杂志,2018,59(5):374-376.
[9]范竹鸣,王佑华,谢瑞芳,等.降香化学成分和药理作用研究进展[J].时珍国医国药,2016,27(10):2478-2480.
[10]陆小华,马骁,王建,等.赤芍的化学成分和药理作用研究进展[J].中草药,2015,46(4):595-602.
[11]姚艺新,华芳,洪远林,等.川芎药材、饮片及其中成药抗血小板聚集活性的生物检定方法学研究[J].中草药,2017,48(11):2249-2254.
[12]许筱凰,李婷,王一涛,等.桃仁的研究进展[J].中草药,2015,46(17):2649-2655.
[13]曹利华,郑雁,辛卫云,等.毛冬青总黄酮对小鼠血瘀合并脑缺血耐受模型的影响[J].中国中药杂志,2016,41(18):2419-2424.
[14]陈路,李玮玮,刘春慧.药对丹参-红花对脑缺血再灌注损伤大鼠脑保护作用的研究[J].中药药理与临床,2017,33(1):161-166.
[2]国家中医药管理局.中医病症诊断疗效标准[M].北京:中国医药科技出版社,2012:37-38.
[3]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2010:1-5.
[4]唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):329-331.
[5]孙玉姣,李盼盼,原嘉民,等.国医大师颜德馨含川芎膏方用药规律的数据挖掘[J].时珍国医国药,2015,26(12):3026-3028.
[6]金政,许书嘉,褚庆民,等.吴伟运用清热活血法干预冠状动脉慢性完全闭塞病变支架术后经验[J].广州中医药大学学报,2016,33(6):890-892.
[7]吴伟,彭锐.冠心病热毒病机的探讨[J].新中医,2007,39(6):3-4.
[8]金政,吴伟,邓铁涛.邓铁涛运用“少火生气”理论治疗心血管疾病之经验[J].中医杂志,2018,59(5):374-376.
[9]范竹鸣,王佑华,谢瑞芳,等.降香化学成分和药理作用研究进展[J].时珍国医国药,2016,27(10):2478-2480.
[10]陆小华,马骁,王建,等.赤芍的化学成分和药理作用研究进展[J].中草药,2015,46(4):595-602.
[11]姚艺新,华芳,洪远林,等.川芎药材、饮片及其中成药抗血小板聚集活性的生物检定方法学研究[J].中草药,2017,48(11):2249-2254.
[12]许筱凰,李婷,王一涛,等.桃仁的研究进展[J].中草药,2015,46(17):2649-2655.
[13]曹利华,郑雁,辛卫云,等.毛冬青总黄酮对小鼠血瘀合并脑缺血耐受模型的影响[J].中国中药杂志,2016,41(18):2419-2424.
[14]陈路,李玮玮,刘春慧.药对丹参-红花对脑缺血再灌注损伤大鼠脑保护作用的研究[J].中药药理与临床,2017,33(1):161-166.