加替沙星滴眼液治疗细菌性结膜炎效果观察
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摘要
目的分析加替沙星滴眼液治疗细菌性结膜炎临床疗效与安全性。方法 112例细菌性结膜炎患者按照随机数表法分为对照组和治疗组,每组56例。对照组患者采用左氧氟沙星滴眼液治疗,治疗组患者采用加替沙星滴眼液治疗,比较两组患者治愈时间、临床疗效及不良反应发生情况。结果治疗组患者治疗总有效率为92.86%(52/56),明显高于对照组[83.93%(47/56)],差异具有显著性(P<0.05)。治疗组患者治愈时间为(3.07±1.01)天,明显短于对照组[(6.75±1.17)天],差异具有显著性(t=-18.912,P<0.05)。治疗组患者不良反应发生率为1.79%(1/56),明显低于对照组[8.93%(5/56)],差异具有显著性(P<0.05)。结论加替沙星滴眼液治疗细菌性结膜炎,可提高临床治疗效果,促进患者康复,减轻患者痛苦,不良反应少,值得临床推广应用。
Objective Evaluate and analysis of patients with bacterial conjunctivitis application for effect of clinical curative effect and security. Method 112 patients with bacterial conjunctivitis according to random number table method were divided into control group and treatment group, 56 cases in each group. Control group were treated by levofloxacin eye drops, treatment group were treated by gatifloxacin eye drops. Compared two groups of patients cure time, clinical curative effect and adverse reactions. Result Patients in treatment group total effective rate was 92.86%(52/56), significantly higher than control group [83.93%(47/56)], the difference was significant(P < 0.05). Cured time of treatment group was(3.07±1.01) days, significantly shorter than control group [(6.75±1.17) days], the difference was significant(t =-18.912, P < 0.05). The adverse reaction rate in treatment group was 1.79%(1/56), significantly lower than control group [8.93%(5/56)], the difference was significant(P < 0.05). Conclusion For clinical application and effect of gatifloxacin eye drops in the treatment of bacterial conjunctivitis, it can improve the effect of clinical treatment, accelerate the cure patients and relieve patients' pain, clinical adverse reaction less at the same time, worthy of clinical application.
Objective Evaluate and analysis of patients with bacterial conjunctivitis application for effect of clinical curative effect and security. Method 112 patients with bacterial conjunctivitis according to random number table method were divided into control group and treatment group, 56 cases in each group. Control group were treated by levofloxacin eye drops, treatment group were treated by gatifloxacin eye drops. Compared two groups of patients cure time, clinical curative effect and adverse reactions. Result Patients in treatment group total effective rate was 92.86%(52/56), significantly higher than control group [83.93%(47/56)], the difference was significant(P < 0.05). Cured time of treatment group was(3.07±1.01) days, significantly shorter than control group [(6.75±1.17) days], the difference was significant(t =-18.912, P < 0.05). The adverse reaction rate in treatment group was 1.79%(1/56), significantly lower than control group [8.93%(5/56)], the difference was significant(P < 0.05). Conclusion For clinical application and effect of gatifloxacin eye drops in the treatment of bacterial conjunctivitis, it can improve the effect of clinical treatment, accelerate the cure patients and relieve patients' pain, clinical adverse reaction less at the same time, worthy of clinical application.
引文
[1]姜洋,金玉梅,罗岩,等.我国急性细菌性结膜炎最新病原学分析[J].眼科新进展,2013,33(4):335-337.
[2]葛鹤立.加替沙星滴眼液治疗细菌性结膜炎58例临床观察[J].临床合理用药杂志,2013,6(19):85-86.
[3]黄丽云,李花香,陈慧,等.急性细菌性结膜炎患者的中西医结合治疗及辨证施护[J].齐齐哈尔医学院学报,2013,34(18):2807.
[4]冯连顺,王硕.治疗细菌性结膜炎的新氟喹诺酮类抗菌药贝西沙星[J].国外医药(抗生素分册),2011,32(3):116-123.
[5]张志叶,杨彦彪,张华,等.新氟喹诺酮类抗菌药物贝西沙星在眼科的应用[J].中国药房,2011,22(30):2867-2869.
[6]朱晓谦,刘海凤,宋建.急性细菌性结膜炎治疗前后的眼表改变[J].眼科新进展,2011,31(9):851-853.
[7]张盛建.加替沙星联合阿奇霉素治疗泌尿系统感染的临床研究[J].现代医药卫生,2012,28(5):656-657.
[8]李林.细菌性结膜炎的常用药物治疗方案[J].中国社区医师,2010,12(6):11.
[9]郗砚彬,张宇,杨丽钦,等.治疗结膜炎的新喹诺酮类药物贝西沙星[J].中国新药杂志,2010,19(4):267-269.
[10]叶婉萍,梁震野.氟罗沙星和加替沙星治疗呼吸道细菌性感染的药物经济学评价[J].海峡药学,2010,22(4):170-171,
[11]张海波,王长青,严瑾,等.加替沙星和左旋氧氟沙星治疗细菌性感染文献的药物经济学评价[J].南京医科大学学报(自然科学版),2010,30(9):1271-1274.
[12]吴俊姬.左氧氟沙星滴眼液联合复方血栓通胶囊治疗细菌性结膜炎临床疗效分析[J].亚太传统医药,2013,9(12):169-170.
[2]葛鹤立.加替沙星滴眼液治疗细菌性结膜炎58例临床观察[J].临床合理用药杂志,2013,6(19):85-86.
[3]黄丽云,李花香,陈慧,等.急性细菌性结膜炎患者的中西医结合治疗及辨证施护[J].齐齐哈尔医学院学报,2013,34(18):2807.
[4]冯连顺,王硕.治疗细菌性结膜炎的新氟喹诺酮类抗菌药贝西沙星[J].国外医药(抗生素分册),2011,32(3):116-123.
[5]张志叶,杨彦彪,张华,等.新氟喹诺酮类抗菌药物贝西沙星在眼科的应用[J].中国药房,2011,22(30):2867-2869.
[6]朱晓谦,刘海凤,宋建.急性细菌性结膜炎治疗前后的眼表改变[J].眼科新进展,2011,31(9):851-853.
[7]张盛建.加替沙星联合阿奇霉素治疗泌尿系统感染的临床研究[J].现代医药卫生,2012,28(5):656-657.
[8]李林.细菌性结膜炎的常用药物治疗方案[J].中国社区医师,2010,12(6):11.
[9]郗砚彬,张宇,杨丽钦,等.治疗结膜炎的新喹诺酮类药物贝西沙星[J].中国新药杂志,2010,19(4):267-269.
[10]叶婉萍,梁震野.氟罗沙星和加替沙星治疗呼吸道细菌性感染的药物经济学评价[J].海峡药学,2010,22(4):170-171,
[11]张海波,王长青,严瑾,等.加替沙星和左旋氧氟沙星治疗细菌性感染文献的药物经济学评价[J].南京医科大学学报(自然科学版),2010,30(9):1271-1274.
[12]吴俊姬.左氧氟沙星滴眼液联合复方血栓通胶囊治疗细菌性结膜炎临床疗效分析[J].亚太传统医药,2013,9(12):169-170.