中药治疗乳腺癌疾病研究进展
|
摘要
乳腺癌是女性人群中较为多见疾病之一。它是一种具有多种复杂机制的恶性肿瘤,其发病机制尚未研究清楚,物理、化学和手术治疗手段对女性治疗往往带来呕吐、恶心、头晕、头痛等不良表现。与传统治疗相比,中药治疗乳腺癌具有多靶点、毒副作用小、效果好等特点。本文首先统计了能够治疗乳腺癌的中药有85种,其中69种中药材已被2015年版《中国药典》收录,16种中草药未被收录。这些中草药中治疗乳腺癌的主要药用成分为生物碱、苷类、酚类、萜类、糖类、挥发油、香豆素等,并且按照中药对乳腺癌的作用进行了归类。然后,本文结合国内外最近研究,对中药治疗乳腺癌作用效果进行了归纳总结,包括中药对乳腺癌逆转多药耐药作用、抑制乳腺癌转移作用、增殖作用、诱导肿瘤细胞凋亡作用以及阻滞乳腺癌细胞周期作用。文章也从中药干预治疗乳腺癌3个方面途径机制进行了阐述,分别为中药干预肿瘤细胞相关凋亡基因抑制乳腺癌,抑制细胞膜P糖蛋白的表达逆转乳腺癌细胞多药耐药性,调节相关上皮间质转化信号通路阻止乳腺癌细胞的转移和增殖。中药可降低乳腺癌的耐药性和乳腺癌细胞的转移,可阻滞乳腺癌细胞周期作用,也导致凋亡因子的表达从而促使乳腺癌细胞死亡,中药抑制乳腺癌是中药中多种成分共同作用的结果。因此中药治疗乳腺癌具有化学药、手术治疗无可比拟的优势。中药是治疗乳腺癌疾病的重要手段之一。
Breast cancer is one of the common diseases among women. It is a malignant tumor with a variety of complex mechanisms. Its pathogenesis has not been clearly studied. Physical,chemical and surgical treatments often cause vomiting, nausea, dizziness and headache for women. As compared with traditional treatment,Chinese medicine is characterized by multiple targets,small side effect and good effect in treating breast cancer. In this paper,85 kinds of Chinese herbal medicines that can treat breast cancer were included. Among them,69 kinds of Chinese herbal medicines have been included in the 2015 edition of the Chinese Pharmacopoeia,and 16 kinds of Chinese herbal medicines have not been included. The main medicinal ingredients in these Chinese herbal medicines for treatment of breast cancer were alkaloids,glycosides,phenols,terpenes,carbohydrates,volatile oils,coumarins and so on. In addition,these herbal medicines were classified according to their effects in breast cancer. Then,combined with the recent studies at home and abroad,this paper summarized the effect of traditional Chinese medicine( TCM) on breast cancer,including the reversal of multi-drug resistance,the inhibition of metastasis and proliferation,the induction of tumor cell apoptosis,and the arrest of the cell cycle for breast cancer. This paper also explained three pathways for treating breast cancer by TCM,including intervening the tumor cell related apoptosis gene to inhibit breast cancer,inhibiting the expression of P-glycoprotein in the cell membrane to reverse the multi-drug resistance of breast cancer cells, and regulating the related epithelial mesenchymal transition signal pathway to prevent breast cancer cells metastasis and proliferation. In the end,it was concluded that Chinese medicine can reduce the drug resistance and metastasis of breast cancer cells,block the cell cycle of breast cancer cells,and also intervene the expression of apoptotic factors to promote the death of breast cancer cells. The inhibition of breast cancer by Chinese medicine was the result of the common effect of various ingredients. Therefore,Chinese medicine treatment for breast cancer has the unparalleled advantages as compared with chemical and surgical treatment. Chinese medicine is one of our important means to overcome breast cancer.
Breast cancer is one of the common diseases among women. It is a malignant tumor with a variety of complex mechanisms. Its pathogenesis has not been clearly studied. Physical,chemical and surgical treatments often cause vomiting, nausea, dizziness and headache for women. As compared with traditional treatment,Chinese medicine is characterized by multiple targets,small side effect and good effect in treating breast cancer. In this paper,85 kinds of Chinese herbal medicines that can treat breast cancer were included. Among them,69 kinds of Chinese herbal medicines have been included in the 2015 edition of the Chinese Pharmacopoeia,and 16 kinds of Chinese herbal medicines have not been included. The main medicinal ingredients in these Chinese herbal medicines for treatment of breast cancer were alkaloids,glycosides,phenols,terpenes,carbohydrates,volatile oils,coumarins and so on. In addition,these herbal medicines were classified according to their effects in breast cancer. Then,combined with the recent studies at home and abroad,this paper summarized the effect of traditional Chinese medicine( TCM) on breast cancer,including the reversal of multi-drug resistance,the inhibition of metastasis and proliferation,the induction of tumor cell apoptosis,and the arrest of the cell cycle for breast cancer. This paper also explained three pathways for treating breast cancer by TCM,including intervening the tumor cell related apoptosis gene to inhibit breast cancer,inhibiting the expression of P-glycoprotein in the cell membrane to reverse the multi-drug resistance of breast cancer cells, and regulating the related epithelial mesenchymal transition signal pathway to prevent breast cancer cells metastasis and proliferation. In the end,it was concluded that Chinese medicine can reduce the drug resistance and metastasis of breast cancer cells,block the cell cycle of breast cancer cells,and also intervene the expression of apoptotic factors to promote the death of breast cancer cells. The inhibition of breast cancer by Chinese medicine was the result of the common effect of various ingredients. Therefore,Chinese medicine treatment for breast cancer has the unparalleled advantages as compared with chemical and surgical treatment. Chinese medicine is one of our important means to overcome breast cancer.
引文
[1] Hashim D,Boffetta P,Vecchia C L,et al. The global decrease in cancer mortality:trends and disparities[J].Ann Oncol,2016,27(5):926-933.
[2] Eroles P,Bosch A,Pérezfidalgo J A,et al. Molecular biology in breast cancer:intrinsic subtypes and signaling pathways[J]. Cancer Treat Rev, 2012, 38(6):698-707.
[3]周淑玲,杨文涛.三阴性乳腺癌的临床病理特征及分子研究进展[J].中国癌症杂志,2013,23(8):603-608.
[4] Rebecca D,Maureen T,Kathleen I,et al. Triplenegative breast cancer:clinical features and patterns of recurrence[J]. Clin Cancer Res,2018,13(15):4429-4434.
[5]郭莉,张娴,柴生颋,等.淫羊藿苷对人乳腺癌MCF-7细胞增殖、凋亡作用的实验研究[J].辽宁中医杂志,2015,42(3):643-645.
[6]刘晓雁,韩凌,刘鹏熙,等.仙茅、淫羊藿含药血清对乳腺癌MCF-7细胞增殖及凋亡的影响[J].时珍国医国药,2011,22(7):1663-1665.
[7]蒋时红,李澜,吴耀松,等.桂枝茯苓丸抑制人乳腺癌细胞MCF-7增殖机制[J].中国实验方剂学杂志,2018,24(15):132-136.
[8] WANG X,CHENG K,HAN Y, et al. Effects of psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells[J]. Biol Pharm Bull,2016,39(5):815-822.
[9]钱丽旗,裴晓华,陈荣明,等.利乳康口服液对乳腺增生大鼠血清性激素的影响[J].中国中医药信息杂志,2004,11(8):684-686.
[10]刘琦,程旭锋,张新峰,等.山慈菇-蜂房药对抑制人乳腺癌MDA-MB-231细胞体外侵袭转移的机理研究[J].中药新药与临床药理,2014,25(4):389-392.
[11]刘银花,钟世军,曾涛,等.山慈菇提取液对小鼠4T1乳腺癌细胞抑制作用机制的研究[J].湖北农业科学,2016,55(1):134-137.
[12]刁珂,陈旭,王娟,等.莪术醇对乳腺癌细胞MDAMB-231侵袭能力的影响[J].广东医学,2013,34(12):1804-1808.
[13]江薇.茯苓酸通过激活多聚腺苷二磷酸核糖聚合酶诱导人乳腺癌细胞MDA-MB-231凋亡[J].中草药,2016,47(21):3861-3865.
[14]亓子豪,孟娇,王子良,等.树舌灵芝提取物对三阴乳腺癌模型小鼠肿瘤抑制作用及其机理研究[J].中国中西医结合杂志,2016,36(3):366-369.
[15]刘琦,程旭锋,张新峰,等.附子白术汤通过调节OPG/RANKL保护乳腺癌骨转移裸鼠骨损伤的研究[J].中国实验方剂学杂志,2013,19(15):206-210.
[16]朱华宇,司徒红林,吴元胜,等.林毅治疗乳腺癌化疗后骨髓抑制症80例用药规律分析[J].辽宁中医杂志,2013,40(3):403-405.
[17]潘俊,朱静,孙家艳. 1,048张治疗乳腺癌中药处方分析[J].中医药导报,2016,22(18):34-37,41.
[18] LV Z D,LIU X P,ZHAO W J,et al. Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo[J]. Int J Clin Exp Med,2014,7(6):2818-2824.
[19] HUANG K F,ZHANG G D,HUANG Y Q,et al.Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway[J]. Int Immunopharmacol,2011,12(2):334-341.
[20] GONG Y,LI Y,Abdolmaleky H M,et al. Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of aurora a expression and function[J]. PLo S One,2012,7(4):1-11.
[21] WANG S,ZHONG Z,WAN J,et al. Oridonin induces apoptosis,inhibits migration and invasion on highlymetastatic human breast cancer cells[J]. Am J Chinese Med,2013,41(1):177-196.
[22] YU Y,YU J,PEI C G,et al. Xanthatin,a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells[J]. Int J Clin Exp Med,2015,8(9):10355-10364.
[23]莫宗成,王敏,罗先钦,等.白花蛇舌草半枝莲配伍抗肿瘤作用研究[J].天然产物研究与开发,2016,28(2):210-215.
[24]徐坤山,吴建富,白海,等.紫草素诱导乳腺癌细胞凋亡的研究[J].扬州大学学报:农业与生命科学版,2008,29(2):26-29,47.
[25]张新红,朱佳,徐水凌.龙葵碱通过线粒体途径诱导人乳腺癌MCF-7细胞凋亡[J].中国药学杂志,2014,49(16):1404-1409.
[26]季宇彬,刘家源,高世勇.龙葵碱对乳腺癌MCF-7细胞微管系统的影响[J].中草药,2012,43(1):111-114.
[27]杨柳,倪艳,姚静,等.蛇六谷的基原考证、抗肿瘤作用及临床应用研究进展[J].中国药房,2016,27(34):4876-4879.
[28]薛晓红,刘胜,陆德铭.中医药治疗乳腺癌的疗效与思考[J].上海中医药大学学报,2003,17(2):14-16.
[29] Shak S. Overview of the trastuzumab(Herceptin)antiHER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group[J]. Semin Oncol,1999,26(4 Suppl 12):71-77.
[30] Blumenthal G M,Scher N S,Cortazar P,et al. First FDA approval of dual anti-HER2 regimen:pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer[J]. Clin Cancer Res,2013,19(18):4911-4916.
[31] Beeram M,Burris H A,Modi S,et al. A phase I study of trastuzumab-DM1(T-DM1),a first-in-class HER2antibody-drug conjugate(ADC),in patients(pts)with advanced HER2+breast cancer(BC)[J]. J Clin Oncol,2008,26(15):753-754.
[32] Krop I E,Mita M,Burris H A,et al. A phase I study of weekly dosing of trastuzumab-DM1(T-DM1)in patients with advanced HER2+breast cancer[J]. J Clin Oncol,2009,69(2 Supplement):3136.
[33] XU H B,LI L,FU J,et al. Reversion of multidrug resistance in a chemoresistant human breast cancer cell line byβ-elemene[J]. Pharmacology,2012,89(5/6):303-312.
[34]谭成,俞惠新,林秀峰,等.中药逆转乳腺癌细胞多药耐药性的实验研究[J].中药药理与临床,2005,21(3):32-34.
[35] ZHANG Y,LIU X,ZUO T,et al. Tetramethylpyrazine reverses multidrug resistance in breast cancer cells through regulating the expression and function of P-glycoprotein[J]. Med Oncol, 2012, 29(2):534-538.
[36] WANG H,CHEN X,LI T,et al. Amyrsinol diterpene isolated from a traditional herbal medicine,LANGDU reverses multidrug resistance in breast cancer cells[J].J Ethnopharmacol,2016,194(12):1-5.
[37] Kasaian J,Mosaffa F,Behravan J,et al. Reversal of P-glycoprotein-mediated multidrug resistance in MCF-7/Adr cancer cells by sesquiterpene coumarins[J].Fitoterapia,2015,103(4):149-154.
[38] Sun K L,Park K K,Park J H Y,et al. The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction[J].Phytother Res,2013,27(12):1776-1783.
[39] TU Y,Roberts L,Shetty K,et al. Rhodiola crenulata induces death and inhibits growth of breast cancer cell lines[J]. J Med Food,2008,11(3):413-423.
[40]税晓容,张智,张远起,等.虫草素对乳腺癌细胞增殖的调控作用及其相关机制研究[J].基因组学与应用生物学,2015,34(12):2560-2563.
[41]安宏元,向川南,喻小兰,等.黄芩素和U0126体外抗人乳腺癌的作用及机制研究[J].中国免疫学杂志,2017,33(2):206-211.
[42]王健,陈荣昌,孙桂波,等.红豆杉提取物对乳腺癌T47D细胞生长与凋亡的影响[J].中国实验方剂学杂志,2015,21(15):88-91.
[43] ZHONG Z,CHEN X,TAN W,et al. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis[J].Eur J Pharmacol,2011,667(1/3):50-55.
[44] REN L,LI Z,DAI C,et al. Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines[J]. Mol Med Report,2018,17(3):4376-4382.
[45]徐伟,孙维峰,汪立新.中药抗化疗呕吐作用机制的实验研究进展[J].中国中西医结合消化杂志,2007,15(1):65-67.
[46] CHEN P H,PENG C Y,PAI H C,et al. Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways[J]. J Nutr Biochem,2011,22(8):732-740.
[47] ZHANG Y. Ganoderma lucidum(Reishi)suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/β-catenin signaling[J]. Biochem Biophys Res Commun,2017,488(4):679-684.
[48] LIU X, ZHAO W, WANG W, et al. Puerarin suppresses LPS-induced breast cancer cell migration,invasion and adhesion by blockage NF-κB and Erk pathway[J]. Biomed Pharmacother,2017,92(8):429-436.
[49] JIANG K,LU Q,LI Q,et al. AstragalosideⅣinhibits breast cancer cell invasion by suppressing Vav3mediated Rac1/MAPK signaling[J]. Int Immunopharmacol,2017,42(1):195-202.
[50] WANG S,ZHONG Z,WAN J,et al. Oridonin induces apoptosis,inhibits migration and invasion on highlymetastatic human breast cancer cells[J]. Am J Chinese Med,2013,41(1):177-196.
[51] TAN X L,GUO L,WANG G H. Polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer[J]. Biomed Pharmacother,2016,83(10):526-535.
[52]陈文静,李辉斌,杜瑞,等. PTEN蛋白在乳腺癌中的表达及意义[J].广东医学,2017,38(16):2478-2480.
[53] CHEN X X,Lam K H,CHEN Q X,et al. Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats[J]. Food Chem Toxicol,2017,110(12):49-61.
[54] ZHOU W J,WANG S,HU Z,et al. Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated Caspase-3 activation[J]. Biochem Biophys Res Commun,2015,467(3):562-569.
[55] GAO S,SUN D,WANG G,et al. Growth inhibitory effect of paratocarpin E,a prenylated chalcone isolated from Euphorbia humifusa Wild. by induction of autophagy and apoptosis in human breast cancer cells[J]. Bioorg Chem,2016,69(12):121-128.
[56] WANG L,PENG Y,SHI K,et al. Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis[J]. J Biomed Res,2015,29(2):132-138.
[57] Barzegar E,Fouladdel S,Movahhed T K,et al. Effects of berberine on proliferation,cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines[J]. Iran J Basic Med Sci, 2015, 18(4):334-342.
[58] ZHU X,WANG K,ZHANG K,et al. ZiyuglycosideⅡinhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway[J]. Int J Mol Sci,2013,14(9):18041-18055.
[59] Kim J B,YU J E,Lee K W,et al. The alkaloid berberine inhibits the growth of anoikis-resistant MCF-7and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest[J]. Phytomed, 2010, 17(6):436-440.
[60] WANG L,WU J Z,LU J W,et al. Regulation of the cell cycle and PI3K/Akt/m TOR signaling pathway by tanshinone I in human breast cancer cell lines[J]. Mol Med Report,2015,11(2):931-939.
[61] WU G,QIAN Z,GUO J,et al. Ganoderma lucidum extract induces G1cell cycle arrest,and apoptosis in human breast cancer cells[J]. Am J Chinese Med,2012,40(3):631-642.
[62] Levine B, Sinha S C, Kroemer G. Bcl-2 family members:dual regulators of apoptosis and autophagy[J]. Autophagy,2008,4(5):600-606.
[63] Danial N N. Bcl-2 family proteins:critical checkpoints of apoptotic cell death[J]. Clin Cancer Res,2007,13(24):7254-7263.
[64] JUN S Y, Choi Y H, Shin H M. Siegesbeckia glabrescens induces apoptosis with different pathways in human MCF-7 and MDA-MB-231 breast carcinoma cells[J]. Oncol Rep,2006,15(6):1461-1467.
[65]俞鸣,黄国伟,史玉荣,等.三羟异黄酮诱导人乳腺癌MCF-7细胞凋亡作用机制的研究[J].中国肿瘤临床,2009,36(17):1006-1009.
[66] YUAN Z,JIANG H,ZHU X,et al. Ginsenoside Rg3promotes cytotoxicity of Paclitaxel through inhibiting NF-κB signaling and regulating Bax/Bcl-2 expression on triple-negative breast cancer[J]. Biomed Pharmacother,2017,89(5):227-232.
[67] ZHANG L. Quercetin inhibits human breast cancer cell proliferation and induces,apoptosis via Bcl-2 and Bax regulation[J]. Mol Med Report, 2012, 5(6):1453-1456.
[68] Ambudkar S V, Dey S, Hrycyna C A, et al.Biochemical,cellular,and pharmacological aspects of the multidrug transporter[J]. Annu Rev Pharmacol Toxicol,1999,39(1):361-398.
[69] Bani M,Decio A,Giavazzi R,et al. Contribution of tumor endothelial cells to drug resistance:antiangiogenic tyrosine kinase inhibitors act as Pglycoprotein antagonists[J]. Angiogenesis,2017,20(2):233-241.
[70] YE R P, CHEN Z D. Saikosaponin A, an active glycoside from Radix bupleuri,reverses P-glycoproteinmediated multidrug resistance in MCF-7/ADR cells and Hep G2/ADM cells[J]. Xenobiotica,2017,47(2):176-184.
[71] LI C, GUAN X, XUE H, et al. Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells[J]. Pathol Res Pract,2017,213(7):848-853.
[72] ZHANG P R,ZHANG J H,YU M,et al. Triptolide reverses MCF-7/ADR cell resistance by down-regulating P-glycoprotein expression[J]. Int J Clin Exp Med,2017,10(1):1513-1521.
[73] WANG S,WANG L,CHEN M,et al. Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression[J]. Chem-Biol Interact,2015,235(6):76-84.
[74] Acloque H,Adams M S,Fishwick K,et al. Epithelialmesenchymal transitions:the importance of changing cell state in development and disease[J]. J Clin Invest,2009,119(6):1438-1449.
[75]马一平.异长春花碱抑制人乳腺癌细胞转移侵袭的作用及其机制[J].中草药,2013,44(13):1786-1792.
[76] MA X,YAN W,DAI Z,et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway[J]. Drug Des Devel Ther,2016,10(1):1419-1441.
[2] Eroles P,Bosch A,Pérezfidalgo J A,et al. Molecular biology in breast cancer:intrinsic subtypes and signaling pathways[J]. Cancer Treat Rev, 2012, 38(6):698-707.
[3]周淑玲,杨文涛.三阴性乳腺癌的临床病理特征及分子研究进展[J].中国癌症杂志,2013,23(8):603-608.
[4] Rebecca D,Maureen T,Kathleen I,et al. Triplenegative breast cancer:clinical features and patterns of recurrence[J]. Clin Cancer Res,2018,13(15):4429-4434.
[5]郭莉,张娴,柴生颋,等.淫羊藿苷对人乳腺癌MCF-7细胞增殖、凋亡作用的实验研究[J].辽宁中医杂志,2015,42(3):643-645.
[6]刘晓雁,韩凌,刘鹏熙,等.仙茅、淫羊藿含药血清对乳腺癌MCF-7细胞增殖及凋亡的影响[J].时珍国医国药,2011,22(7):1663-1665.
[7]蒋时红,李澜,吴耀松,等.桂枝茯苓丸抑制人乳腺癌细胞MCF-7增殖机制[J].中国实验方剂学杂志,2018,24(15):132-136.
[8] WANG X,CHENG K,HAN Y, et al. Effects of psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells[J]. Biol Pharm Bull,2016,39(5):815-822.
[9]钱丽旗,裴晓华,陈荣明,等.利乳康口服液对乳腺增生大鼠血清性激素的影响[J].中国中医药信息杂志,2004,11(8):684-686.
[10]刘琦,程旭锋,张新峰,等.山慈菇-蜂房药对抑制人乳腺癌MDA-MB-231细胞体外侵袭转移的机理研究[J].中药新药与临床药理,2014,25(4):389-392.
[11]刘银花,钟世军,曾涛,等.山慈菇提取液对小鼠4T1乳腺癌细胞抑制作用机制的研究[J].湖北农业科学,2016,55(1):134-137.
[12]刁珂,陈旭,王娟,等.莪术醇对乳腺癌细胞MDAMB-231侵袭能力的影响[J].广东医学,2013,34(12):1804-1808.
[13]江薇.茯苓酸通过激活多聚腺苷二磷酸核糖聚合酶诱导人乳腺癌细胞MDA-MB-231凋亡[J].中草药,2016,47(21):3861-3865.
[14]亓子豪,孟娇,王子良,等.树舌灵芝提取物对三阴乳腺癌模型小鼠肿瘤抑制作用及其机理研究[J].中国中西医结合杂志,2016,36(3):366-369.
[15]刘琦,程旭锋,张新峰,等.附子白术汤通过调节OPG/RANKL保护乳腺癌骨转移裸鼠骨损伤的研究[J].中国实验方剂学杂志,2013,19(15):206-210.
[16]朱华宇,司徒红林,吴元胜,等.林毅治疗乳腺癌化疗后骨髓抑制症80例用药规律分析[J].辽宁中医杂志,2013,40(3):403-405.
[17]潘俊,朱静,孙家艳. 1,048张治疗乳腺癌中药处方分析[J].中医药导报,2016,22(18):34-37,41.
[18] LV Z D,LIU X P,ZHAO W J,et al. Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo[J]. Int J Clin Exp Med,2014,7(6):2818-2824.
[19] HUANG K F,ZHANG G D,HUANG Y Q,et al.Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway[J]. Int Immunopharmacol,2011,12(2):334-341.
[20] GONG Y,LI Y,Abdolmaleky H M,et al. Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of aurora a expression and function[J]. PLo S One,2012,7(4):1-11.
[21] WANG S,ZHONG Z,WAN J,et al. Oridonin induces apoptosis,inhibits migration and invasion on highlymetastatic human breast cancer cells[J]. Am J Chinese Med,2013,41(1):177-196.
[22] YU Y,YU J,PEI C G,et al. Xanthatin,a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells[J]. Int J Clin Exp Med,2015,8(9):10355-10364.
[23]莫宗成,王敏,罗先钦,等.白花蛇舌草半枝莲配伍抗肿瘤作用研究[J].天然产物研究与开发,2016,28(2):210-215.
[24]徐坤山,吴建富,白海,等.紫草素诱导乳腺癌细胞凋亡的研究[J].扬州大学学报:农业与生命科学版,2008,29(2):26-29,47.
[25]张新红,朱佳,徐水凌.龙葵碱通过线粒体途径诱导人乳腺癌MCF-7细胞凋亡[J].中国药学杂志,2014,49(16):1404-1409.
[26]季宇彬,刘家源,高世勇.龙葵碱对乳腺癌MCF-7细胞微管系统的影响[J].中草药,2012,43(1):111-114.
[27]杨柳,倪艳,姚静,等.蛇六谷的基原考证、抗肿瘤作用及临床应用研究进展[J].中国药房,2016,27(34):4876-4879.
[28]薛晓红,刘胜,陆德铭.中医药治疗乳腺癌的疗效与思考[J].上海中医药大学学报,2003,17(2):14-16.
[29] Shak S. Overview of the trastuzumab(Herceptin)antiHER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group[J]. Semin Oncol,1999,26(4 Suppl 12):71-77.
[30] Blumenthal G M,Scher N S,Cortazar P,et al. First FDA approval of dual anti-HER2 regimen:pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer[J]. Clin Cancer Res,2013,19(18):4911-4916.
[31] Beeram M,Burris H A,Modi S,et al. A phase I study of trastuzumab-DM1(T-DM1),a first-in-class HER2antibody-drug conjugate(ADC),in patients(pts)with advanced HER2+breast cancer(BC)[J]. J Clin Oncol,2008,26(15):753-754.
[32] Krop I E,Mita M,Burris H A,et al. A phase I study of weekly dosing of trastuzumab-DM1(T-DM1)in patients with advanced HER2+breast cancer[J]. J Clin Oncol,2009,69(2 Supplement):3136.
[33] XU H B,LI L,FU J,et al. Reversion of multidrug resistance in a chemoresistant human breast cancer cell line byβ-elemene[J]. Pharmacology,2012,89(5/6):303-312.
[34]谭成,俞惠新,林秀峰,等.中药逆转乳腺癌细胞多药耐药性的实验研究[J].中药药理与临床,2005,21(3):32-34.
[35] ZHANG Y,LIU X,ZUO T,et al. Tetramethylpyrazine reverses multidrug resistance in breast cancer cells through regulating the expression and function of P-glycoprotein[J]. Med Oncol, 2012, 29(2):534-538.
[36] WANG H,CHEN X,LI T,et al. Amyrsinol diterpene isolated from a traditional herbal medicine,LANGDU reverses multidrug resistance in breast cancer cells[J].J Ethnopharmacol,2016,194(12):1-5.
[37] Kasaian J,Mosaffa F,Behravan J,et al. Reversal of P-glycoprotein-mediated multidrug resistance in MCF-7/Adr cancer cells by sesquiterpene coumarins[J].Fitoterapia,2015,103(4):149-154.
[38] Sun K L,Park K K,Park J H Y,et al. The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction[J].Phytother Res,2013,27(12):1776-1783.
[39] TU Y,Roberts L,Shetty K,et al. Rhodiola crenulata induces death and inhibits growth of breast cancer cell lines[J]. J Med Food,2008,11(3):413-423.
[40]税晓容,张智,张远起,等.虫草素对乳腺癌细胞增殖的调控作用及其相关机制研究[J].基因组学与应用生物学,2015,34(12):2560-2563.
[41]安宏元,向川南,喻小兰,等.黄芩素和U0126体外抗人乳腺癌的作用及机制研究[J].中国免疫学杂志,2017,33(2):206-211.
[42]王健,陈荣昌,孙桂波,等.红豆杉提取物对乳腺癌T47D细胞生长与凋亡的影响[J].中国实验方剂学杂志,2015,21(15):88-91.
[43] ZHONG Z,CHEN X,TAN W,et al. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis[J].Eur J Pharmacol,2011,667(1/3):50-55.
[44] REN L,LI Z,DAI C,et al. Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines[J]. Mol Med Report,2018,17(3):4376-4382.
[45]徐伟,孙维峰,汪立新.中药抗化疗呕吐作用机制的实验研究进展[J].中国中西医结合消化杂志,2007,15(1):65-67.
[46] CHEN P H,PENG C Y,PAI H C,et al. Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways[J]. J Nutr Biochem,2011,22(8):732-740.
[47] ZHANG Y. Ganoderma lucidum(Reishi)suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/β-catenin signaling[J]. Biochem Biophys Res Commun,2017,488(4):679-684.
[48] LIU X, ZHAO W, WANG W, et al. Puerarin suppresses LPS-induced breast cancer cell migration,invasion and adhesion by blockage NF-κB and Erk pathway[J]. Biomed Pharmacother,2017,92(8):429-436.
[49] JIANG K,LU Q,LI Q,et al. AstragalosideⅣinhibits breast cancer cell invasion by suppressing Vav3mediated Rac1/MAPK signaling[J]. Int Immunopharmacol,2017,42(1):195-202.
[50] WANG S,ZHONG Z,WAN J,et al. Oridonin induces apoptosis,inhibits migration and invasion on highlymetastatic human breast cancer cells[J]. Am J Chinese Med,2013,41(1):177-196.
[51] TAN X L,GUO L,WANG G H. Polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer[J]. Biomed Pharmacother,2016,83(10):526-535.
[52]陈文静,李辉斌,杜瑞,等. PTEN蛋白在乳腺癌中的表达及意义[J].广东医学,2017,38(16):2478-2480.
[53] CHEN X X,Lam K H,CHEN Q X,et al. Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats[J]. Food Chem Toxicol,2017,110(12):49-61.
[54] ZHOU W J,WANG S,HU Z,et al. Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated Caspase-3 activation[J]. Biochem Biophys Res Commun,2015,467(3):562-569.
[55] GAO S,SUN D,WANG G,et al. Growth inhibitory effect of paratocarpin E,a prenylated chalcone isolated from Euphorbia humifusa Wild. by induction of autophagy and apoptosis in human breast cancer cells[J]. Bioorg Chem,2016,69(12):121-128.
[56] WANG L,PENG Y,SHI K,et al. Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis[J]. J Biomed Res,2015,29(2):132-138.
[57] Barzegar E,Fouladdel S,Movahhed T K,et al. Effects of berberine on proliferation,cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines[J]. Iran J Basic Med Sci, 2015, 18(4):334-342.
[58] ZHU X,WANG K,ZHANG K,et al. ZiyuglycosideⅡinhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway[J]. Int J Mol Sci,2013,14(9):18041-18055.
[59] Kim J B,YU J E,Lee K W,et al. The alkaloid berberine inhibits the growth of anoikis-resistant MCF-7and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest[J]. Phytomed, 2010, 17(6):436-440.
[60] WANG L,WU J Z,LU J W,et al. Regulation of the cell cycle and PI3K/Akt/m TOR signaling pathway by tanshinone I in human breast cancer cell lines[J]. Mol Med Report,2015,11(2):931-939.
[61] WU G,QIAN Z,GUO J,et al. Ganoderma lucidum extract induces G1cell cycle arrest,and apoptosis in human breast cancer cells[J]. Am J Chinese Med,2012,40(3):631-642.
[62] Levine B, Sinha S C, Kroemer G. Bcl-2 family members:dual regulators of apoptosis and autophagy[J]. Autophagy,2008,4(5):600-606.
[63] Danial N N. Bcl-2 family proteins:critical checkpoints of apoptotic cell death[J]. Clin Cancer Res,2007,13(24):7254-7263.
[64] JUN S Y, Choi Y H, Shin H M. Siegesbeckia glabrescens induces apoptosis with different pathways in human MCF-7 and MDA-MB-231 breast carcinoma cells[J]. Oncol Rep,2006,15(6):1461-1467.
[65]俞鸣,黄国伟,史玉荣,等.三羟异黄酮诱导人乳腺癌MCF-7细胞凋亡作用机制的研究[J].中国肿瘤临床,2009,36(17):1006-1009.
[66] YUAN Z,JIANG H,ZHU X,et al. Ginsenoside Rg3promotes cytotoxicity of Paclitaxel through inhibiting NF-κB signaling and regulating Bax/Bcl-2 expression on triple-negative breast cancer[J]. Biomed Pharmacother,2017,89(5):227-232.
[67] ZHANG L. Quercetin inhibits human breast cancer cell proliferation and induces,apoptosis via Bcl-2 and Bax regulation[J]. Mol Med Report, 2012, 5(6):1453-1456.
[68] Ambudkar S V, Dey S, Hrycyna C A, et al.Biochemical,cellular,and pharmacological aspects of the multidrug transporter[J]. Annu Rev Pharmacol Toxicol,1999,39(1):361-398.
[69] Bani M,Decio A,Giavazzi R,et al. Contribution of tumor endothelial cells to drug resistance:antiangiogenic tyrosine kinase inhibitors act as Pglycoprotein antagonists[J]. Angiogenesis,2017,20(2):233-241.
[70] YE R P, CHEN Z D. Saikosaponin A, an active glycoside from Radix bupleuri,reverses P-glycoproteinmediated multidrug resistance in MCF-7/ADR cells and Hep G2/ADM cells[J]. Xenobiotica,2017,47(2):176-184.
[71] LI C, GUAN X, XUE H, et al. Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells[J]. Pathol Res Pract,2017,213(7):848-853.
[72] ZHANG P R,ZHANG J H,YU M,et al. Triptolide reverses MCF-7/ADR cell resistance by down-regulating P-glycoprotein expression[J]. Int J Clin Exp Med,2017,10(1):1513-1521.
[73] WANG S,WANG L,CHEN M,et al. Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression[J]. Chem-Biol Interact,2015,235(6):76-84.
[74] Acloque H,Adams M S,Fishwick K,et al. Epithelialmesenchymal transitions:the importance of changing cell state in development and disease[J]. J Clin Invest,2009,119(6):1438-1449.
[75]马一平.异长春花碱抑制人乳腺癌细胞转移侵袭的作用及其机制[J].中草药,2013,44(13):1786-1792.
[76] MA X,YAN W,DAI Z,et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway[J]. Drug Des Devel Ther,2016,10(1):1419-1441.