基于随机行走模型评价中医健脾单元疗法对骨关节炎患者炎症指标的影响
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摘要
运用随机行走模型评价中医健脾单元疗法对骨关节炎(osteoarthritis,OA)患者炎症指标的影响。利用安徽中医药大学第一附属医院住院病历数据处理系统采集患者信息。收集并整理该院风湿免疫科2012年6月—2016年12月OA住院患者。依据是否使用中药汤剂及院内制剂复方芪薏胶囊(新风胶囊)分为单元疗法组和单纯内治组,利用随机行走模型评价中医健脾单元疗法对OA患者血沉(ESR)、超敏C反应蛋白(hs-CRP)影响。共纳入3 517例OA患者符合研究要求,单纯内治组为1 771例(50. 36%),单元疗法组1 746例(49. 64%)。基线资料分析显示,患者的一般情况、内服中药频次及核心处方情况等方面,差异无统计学意义,具有可比性。单元疗法组ESR随机波动最大值924,行走步数1 771,行走正向增长率0. 264 5,比值3. 78,随机波动幂律值0. 306 5±0. 076 8,综合评价指标的正向递增率0. 264 5,综合评价指标记录次数1 771,而单纯内治组ESR随机波动最大值478,行走步数1 399,行走正向增长率0. 152 4,比值6. 56,随机波动幂律值0. 347 4±0. 101 7,综合评价指标的正向递增率0. 152 4,综合评价指标记录次数1 399,单元疗法组hs-CRP随机波动最大值391,行走步数1 081,行走正向增长率0. 178 1,比值5. 62,随机波动幂律值0. 343 6±0. 094 7,综合评价指标的正向递增率0. 178 1,综合评价指标记录次数1 081,单纯内治组hs-CRP随机波动最大值210,行走步数797,行走正向增长率0. 113 2,比值8. 83,随机波动幂律值0. 382 6±0. 109,综合评价指标的正向递增率0. 113 2,综合评价指标记录次数797。该院风湿科从脾论治OA,2组患者综合评价指标和接受的干预措施存在长程关联,中医健脾单元疗法对患者炎症指标的改善效果优于单纯中药内服。
To evaluate the effect of traditional Chinese medicine(TCM) invigorating spleen unit therapy on inflammatory markers of osteoarthritis(OA) patients by random walk model. The patient information was collected by the data processing system of medical records of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine. In-patient information of the department of rheumatology of the hospital between June 2012 and December 2016 was collected and summarized. Based on the use of traditional Chinese medicine decoction and hospital-prepared compound Qiyi Capsules(Xinfeng Capsules),the patients were divided into the unit therapy group and the simple endotherapy group. The random walk model was used to evaluate the effect of traditional Chinese medicine invigorating spleen unit therapy on TCM spleen therapy unit(ESR) and high sensitive C reactive protein(hs-CRP). A total of 3 517 cases of OA patients met the study requirements. The simple endotherapy group had 1 771 cases(50. 36%),while the unit therapy group had 1 746 cases(49. 64%). The baseline data analysis showed that the general information of the cases,the TCM oral intake frequency and the core prescription information had no statistically significant difference,with comparability. The unit therapy group showed the maximum ESR stochastic volatility at 924,walking step number of 1 771,forward walking growth rate at 0. 264 5,ratio at3. 78,random fluctuation power law at 0. 306 5± 0. 076 8,positive increase rate of comprehensive evaluation index at 0. 264 5,and comprehensive evaluation index record number of 1 771; whereas the simple endotherapy group showed the maximum ESR random fluctuation value at 478,walking step number of 1 399,forward walking growth rate at 0. 152 4,ratio at 6. 56,random fluctuation power law at 0. 347 4±0. 101 7,positive increase rate of comprehensive evaluation index at 0. 152 4,and comprehensive evaluation index record number of 1 399. The unit therapy group showed the maximum hs-CRP random fluctuation value at 391,walking step number of1 081,forward walking growth rate at 0. 178 1,ratio at 5. 62,random fluctuation power law at 0. 343 6±0. 094 7,positive increase rate of comprehensive evaluation index at 0. 178 1,and comprehensive evaluation index record number of 1 081; while the simple endotherapy groups showed the maximum hs-CRP random fluctuation value at 210,walking step number of 797,forward walking growth rate at0. 113 2,ratio at 8. 83,random fluctuation power law at 0. 382 6±0. 109,positive increase rate of comprehensive evaluation index at0. 113 2,and comprehensive evaluation index record number of 797. According to our department of rheumatism,there was a longrange correlation between the two groups in the comprehensive evaluation index and the intervention measures. TCM spleen strengthening unit therapy has a better effect in alleviating the inflammatory index of OA than traditional Chinese medicine.
To evaluate the effect of traditional Chinese medicine(TCM) invigorating spleen unit therapy on inflammatory markers of osteoarthritis(OA) patients by random walk model. The patient information was collected by the data processing system of medical records of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine. In-patient information of the department of rheumatology of the hospital between June 2012 and December 2016 was collected and summarized. Based on the use of traditional Chinese medicine decoction and hospital-prepared compound Qiyi Capsules(Xinfeng Capsules),the patients were divided into the unit therapy group and the simple endotherapy group. The random walk model was used to evaluate the effect of traditional Chinese medicine invigorating spleen unit therapy on TCM spleen therapy unit(ESR) and high sensitive C reactive protein(hs-CRP). A total of 3 517 cases of OA patients met the study requirements. The simple endotherapy group had 1 771 cases(50. 36%),while the unit therapy group had 1 746 cases(49. 64%). The baseline data analysis showed that the general information of the cases,the TCM oral intake frequency and the core prescription information had no statistically significant difference,with comparability. The unit therapy group showed the maximum ESR stochastic volatility at 924,walking step number of 1 771,forward walking growth rate at 0. 264 5,ratio at3. 78,random fluctuation power law at 0. 306 5± 0. 076 8,positive increase rate of comprehensive evaluation index at 0. 264 5,and comprehensive evaluation index record number of 1 771; whereas the simple endotherapy group showed the maximum ESR random fluctuation value at 478,walking step number of 1 399,forward walking growth rate at 0. 152 4,ratio at 6. 56,random fluctuation power law at 0. 347 4±0. 101 7,positive increase rate of comprehensive evaluation index at 0. 152 4,and comprehensive evaluation index record number of 1 399. The unit therapy group showed the maximum hs-CRP random fluctuation value at 391,walking step number of1 081,forward walking growth rate at 0. 178 1,ratio at 5. 62,random fluctuation power law at 0. 343 6±0. 094 7,positive increase rate of comprehensive evaluation index at 0. 178 1,and comprehensive evaluation index record number of 1 081; while the simple endotherapy groups showed the maximum hs-CRP random fluctuation value at 210,walking step number of 797,forward walking growth rate at0. 113 2,ratio at 8. 83,random fluctuation power law at 0. 382 6±0. 109,positive increase rate of comprehensive evaluation index at0. 113 2,and comprehensive evaluation index record number of 797. According to our department of rheumatism,there was a longrange correlation between the two groups in the comprehensive evaluation index and the intervention measures. TCM spleen strengthening unit therapy has a better effect in alleviating the inflammatory index of OA than traditional Chinese medicine.
引文
[1]刘健,徐桂琴.风湿病从脾论治研究[M].合肥:安徽科学技术出版社,2013.
[2]朱振安.重视膝关节骨关节炎的早期防治[J].中国骨伤,2010,23(12):887.
[3]谈冰,刘健,章平衡,等.基于NF-κB及细胞因子的变化探讨骨关节炎患者高凝状态的机制[J].免疫学杂志,2015,31(10):882.
[4]齐亚军,刘健,文建庭,等.基于关联规则挖掘健脾化湿、清热通络中药对骨关节炎患者血小板参数的影响[J].风湿病与关节炎,2017,6(11):11.
[5]孟楣,王芳,王晓玉,等.新风胶囊中水溶性蛋白的SDS-PAGE分析方法研究[J].中药材,2013,37(1):141.
[6]程园园,刘健,冯云霞,等.新风胶囊通过BTLA-HVEM诱导Treg免疫耐受改善膝骨关节炎大鼠心肺功能[J].细胞与分子免疫学杂志,2012,28(11):1133.
[7]阮丽萍,刘健,葛瑶,等.骨关节炎大鼠软骨PI3K/Akt-mTOR及Beclin-1自噬通路的表达及相关性分析[J].华中科技大学学报:医学版,2015,44(4):429.
[8]方妍妍,刘健,万磊,等.1 658例骨关节炎患者健脾化湿、补肾通络方药运用的队列研究[J].风湿病与关节炎,2017,6(8):15.
[9]中华医学会风湿病学分会.骨关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(6):416.
[10]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994.
[11]康乐,蔡懿慈,洪先龙.随机行走算法研究及其在电源地线网络瞬态优化中的应用[J].计算机辅助设计与图形学学报,2007,19(9):1178.
[12]高铸烨,徐浩,陈可冀,等.用随机行走模型评价生脉注射液治疗冠心病的临床疗效[J].中西医结合学报,2008,6(9):902.
[13]谌曦,刘健,黄传兵,等.健脾补肾通络止痛法联合中药离子导入治疗膝骨关节炎的临床研究[J].中华中医药杂志,2015,30(3):943.
[14]周巧,刘健,忻凌,等.673例骨关节炎患者超氧化物歧化酶的变化及关联规则挖掘研究[J].世界中西医结合杂志,2017,12(7):961.
[15]周巧,刘健,忻凌,等.基于关联规则挖掘健脾类中药对骨关节炎患者免疫炎症指标的影响[J].时珍国医国药,2017,28(4):1005.
[2]朱振安.重视膝关节骨关节炎的早期防治[J].中国骨伤,2010,23(12):887.
[3]谈冰,刘健,章平衡,等.基于NF-κB及细胞因子的变化探讨骨关节炎患者高凝状态的机制[J].免疫学杂志,2015,31(10):882.
[4]齐亚军,刘健,文建庭,等.基于关联规则挖掘健脾化湿、清热通络中药对骨关节炎患者血小板参数的影响[J].风湿病与关节炎,2017,6(11):11.
[5]孟楣,王芳,王晓玉,等.新风胶囊中水溶性蛋白的SDS-PAGE分析方法研究[J].中药材,2013,37(1):141.
[6]程园园,刘健,冯云霞,等.新风胶囊通过BTLA-HVEM诱导Treg免疫耐受改善膝骨关节炎大鼠心肺功能[J].细胞与分子免疫学杂志,2012,28(11):1133.
[7]阮丽萍,刘健,葛瑶,等.骨关节炎大鼠软骨PI3K/Akt-mTOR及Beclin-1自噬通路的表达及相关性分析[J].华中科技大学学报:医学版,2015,44(4):429.
[8]方妍妍,刘健,万磊,等.1 658例骨关节炎患者健脾化湿、补肾通络方药运用的队列研究[J].风湿病与关节炎,2017,6(8):15.
[9]中华医学会风湿病学分会.骨关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(6):416.
[10]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994.
[11]康乐,蔡懿慈,洪先龙.随机行走算法研究及其在电源地线网络瞬态优化中的应用[J].计算机辅助设计与图形学学报,2007,19(9):1178.
[12]高铸烨,徐浩,陈可冀,等.用随机行走模型评价生脉注射液治疗冠心病的临床疗效[J].中西医结合学报,2008,6(9):902.
[13]谌曦,刘健,黄传兵,等.健脾补肾通络止痛法联合中药离子导入治疗膝骨关节炎的临床研究[J].中华中医药杂志,2015,30(3):943.
[14]周巧,刘健,忻凌,等.673例骨关节炎患者超氧化物歧化酶的变化及关联规则挖掘研究[J].世界中西医结合杂志,2017,12(7):961.
[15]周巧,刘健,忻凌,等.基于关联规则挖掘健脾类中药对骨关节炎患者免疫炎症指标的影响[J].时珍国医国药,2017,28(4):1005.