基于“中医传承辅助系统”探索中医治疗寻常型银屑病血瘀证的用药规律
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摘要
目的:总结中药治疗寻常型银屑病血瘀证的用药规律,为临床用药和研究提供参考和指导。方法:检索Cochrane library、PubMed、Embase、CNKI、维普资讯、万方、CBM等数据库,检索策略围绕"银屑病""中医药"纳入中药治疗寻常型银屑病血瘀证的临床随机对照研究。借助"中医传承辅助系统"对纳入研究的治疗用药进行分析。结果:根据用药规律演化出治疗寻常型银屑病血瘀证的2个新处方,"丹参,穿山甲,鸡血藤,大黄""红花,赤芍,生地黄,土茯苓,桃仁"。结论:中药治疗寻常型银屑病血瘀证以活血化瘀药为主,辅以清热凉血药。
Objective:To summarize the medication rule of traditional Chinese medicine for the treatment of psoriasis vulgaris with blood stasis syndrome,providing reference and guidance for clinical use and research.Methods:"Psoriasis" and "Chinese medicine" were subjected to search clinical randomized controlled study in multiple database,including Cochrane library,PubMed,Embase,CNKI,VIP information,Wanfang,CBM and so on.The therapeutic drugs included in the study were analyzed with the help of the TCM inheritance aid system.Results:Two new prescriptions for treating blood stasis syndrome of psoriasis vulgaris were developed according to the law of medication.They are "Danshen(radix salviae miltiorrhizae),Chuanshanjia(manis pentadactyla),Jixueteng(caulis spatholobi),Dahuang(rheum officinale)" and "Honghua(safflower carthamus),Chishao(radix paeoniae rubra),Shengdihuang(radix rehmanniae recen),Tufuling(rhizoma smilacis glabrae),Taoren(peach kernel)".Conclusion:Chinese medicine for the treatment of psoriasis vulgaris is mainly based on blood stasis and phlegm,supplemented by heat-clearing and cooling blood.
Objective:To summarize the medication rule of traditional Chinese medicine for the treatment of psoriasis vulgaris with blood stasis syndrome,providing reference and guidance for clinical use and research.Methods:"Psoriasis" and "Chinese medicine" were subjected to search clinical randomized controlled study in multiple database,including Cochrane library,PubMed,Embase,CNKI,VIP information,Wanfang,CBM and so on.The therapeutic drugs included in the study were analyzed with the help of the TCM inheritance aid system.Results:Two new prescriptions for treating blood stasis syndrome of psoriasis vulgaris were developed according to the law of medication.They are "Danshen(radix salviae miltiorrhizae),Chuanshanjia(manis pentadactyla),Jixueteng(caulis spatholobi),Dahuang(rheum officinale)" and "Honghua(safflower carthamus),Chishao(radix paeoniae rubra),Shengdihuang(radix rehmanniae recen),Tufuling(rhizoma smilacis glabrae),Taoren(peach kernel)".Conclusion:Chinese medicine for the treatment of psoriasis vulgaris is mainly based on blood stasis and phlegm,supplemented by heat-clearing and cooling blood.
引文
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[21]李田田,王萍,周冬梅,等.活血解毒汤治疗银屑病血瘀证的临床疗效观察[J].实用皮肤病学杂志,2016,9(2):133-135,138.
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[23]杨道秋.1%地蒽酚软膏结合复元活血汤治疗慢性斑块状银屑病40例临床疗效观察[J].中国疗养医学,2016,25(3):304-306.
[24]周宇,谢知音,白方树.中药外洗联合窄谱中波紫外线治疗血瘀型银屑病[J].长春中医药大学学报,2016,32(1):134-135,190.
[25]刘效筠,石年,陈用军.冰黄软膏外用治疗寻常型稳定期银屑病临床疗效观察[J].湖北中医杂志,2012,34(6):46.
[26]向丽萍,席瑞阑,唐雪勇,等.克银膏治疗寻常型银屑病(血瘀证)的临床研究[J].中医药导报,2014,20(1):23-26.
[27]刘敏,徐俊涛,吴宏毅.香丹注射液联合阿维a治疗慢性斑块型银屑病疗效观察[J].中国实用乡村医生杂志,2015,22(6):56-57.
[28]周冬梅.赵炳南从血论治银屑病探源[N].中国中医药报,2015-09-15(4).
[2]Gupta R,M G Debbaneh,W Liao.Genetic Epidemiology of Psoriasis[J].Curr Dermatol Rep,2014,3(1):61-78.
[3]中华中医药学会皮肤科分会.寻常型银屑病(白疕)中医药循证临床实践指南(2013版)[J].中医杂志,2014,55(1):76-82.
[4]吴小红,王煜明.庄国康运用活血化瘀法治疗皮肤病经验[J].中医杂志,2013,54(6):466-469.
[5]秦万章.银屑病血证与调血研究[J].中国中西医结合皮肤性病学杂志,2008,7(1):1-4.
[6]丁履伸,赵绚德.银屑病的中医治疗[J].山东中医学院学报,1980,4(4):47-49.
[7]闫玉红,卢传坚,禤国维.寻常型银屑病核心病机探讨[J].辽宁中医杂志,2012,39(6):1013-1015.
[8]卢朋,李健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012,18(9):1-4.
[9]U Mrowietz,K Kragballe,K Reich,et al.Definition of treatment goals for moderate to severe psoriasis:a European consensus[J].Arch Dermatol Res,2011,303(1):1-10.
[10]苏晓媛,王金海,王峰,等.克银合剂治疗进展期血瘀型轻、中度寻常型银屑病疗效观察及对外周血tnf-α、Tgf-β水平的影响[J].福建中医药,2010,41(2):12-13.
[11]陈瑞玲.化瘀消银汤联合紫外线治疗血瘀型银屑病疗效观察及对血流变影响的研究[D].济南:山东中医药大学,2010.
[12]陈维文,周冬梅,王萍,等.“辨血为主,从血论治”规范化方药辨证治疗寻常型银屑病研究[J].中华中医药杂志,2015,30(10):3614-3618.
[13]陆星宇,任雁威,张莲,等.阿维a联合凉血活血汤治疗斑块状银屑病的临床效果及安全性[J].中国医药导报,2014,11(32):83-86.
[14]曹玉平,李波,王瑛.自拟痒疹汤联合阿维a胶囊治疗寻常型银屑病疗效分析[J].中国误诊学杂志,2010,10(7):1553-1554.
[15]黄咏菁,吴元胜,廖列辉,等.阿维A胶囊联合银屑灵片治疗寻常性银屑病的临床观察[J].中国皮肤性病学杂志,2007,21(10):加3-4.
[16]朱凤,朱黎明,李英,等.大黄蟅虫胶囊治疗血瘀型银屑病30例临床观察[J].中国皮肤性病学杂志,2014,28(2):195-196.
[17]董文启,陈德监.复元活血汤加味治疗慢性斑块型银屑病临床观察[J].四川中医,2015,33(9):130-131.
[18]柴勇,高宏艳.活血化瘀汤联合窄谱紫外线治疗寻常型斑块状银屑病疗效观察[J].齐齐哈尔医学院学报,2015,36(16):2373-2374.
[19]郭奕妤,全小荣.清疕饮联合窄谱中波紫外光治疗寻常型银屑病56例临床观察[J].新中医,2013,45(8):104-105.
[20]金力,马一兵,姜燕生,等.卡泊三醇软膏联合口服中药治疗寻常性斑块状银屑病的临床疗效观察[J].中国中西医结合皮肤性病学杂志,2009,8(4):216-218.
[21]李田田,王萍,周冬梅,等.活血解毒汤治疗银屑病血瘀证的临床疗效观察[J].实用皮肤病学杂志,2016,9(2):133-135,138.
[22]杨道秋.维a酸乳膏结合活血化瘀复元活血汤治疗银屑病的疗效观察[J].中国疗养医学,2016,25(4):412-413.
[23]杨道秋.1%地蒽酚软膏结合复元活血汤治疗慢性斑块状银屑病40例临床疗效观察[J].中国疗养医学,2016,25(3):304-306.
[24]周宇,谢知音,白方树.中药外洗联合窄谱中波紫外线治疗血瘀型银屑病[J].长春中医药大学学报,2016,32(1):134-135,190.
[25]刘效筠,石年,陈用军.冰黄软膏外用治疗寻常型稳定期银屑病临床疗效观察[J].湖北中医杂志,2012,34(6):46.
[26]向丽萍,席瑞阑,唐雪勇,等.克银膏治疗寻常型银屑病(血瘀证)的临床研究[J].中医药导报,2014,20(1):23-26.
[27]刘敏,徐俊涛,吴宏毅.香丹注射液联合阿维a治疗慢性斑块型银屑病疗效观察[J].中国实用乡村医生杂志,2015,22(6):56-57.
[28]周冬梅.赵炳南从血论治银屑病探源[N].中国中医药报,2015-09-15(4).