花椰菜萝卜硫素对人体降糖作用的研究
|
摘要
为探究花椰菜萝卜硫素是否对人体具有降糖作用,对新鲜花椰菜中的萝卜硫素进行提取和分离,将受试者随机划分成对照组和观察组,只令观察组受试者服用花椰菜萝卜硫素,在实验开始前和结束后分别对血糖、尿糖进行检测,分析治疗效果,并对安全性指标进行测试。结果发现,实验前后对比之下,观察组比对照组血糖与尿糖显著降低(P <0. 05),观察组临床总有效例数均明显高于对照组(P <0. 05),观察组与对照组受试者血生化指标以及血常规实验前后无显著性差异(P>0. 05)。结果表明:花椰菜萝卜硫素具有辅助人体降糖的作用。
To investigate whether the sulforaphane from cauliflower have hypoglycemic effect on human body,the sulforaphane in fresh cauliflower was extracted and separated. The diabetic subjects who volunteered to participate in the experiment were randomly divided into control group and observation group. The observation group took sulforaphane in cauliflower,while the control group took the same dose of placebo. The therapeutic effect was analyzed and the safety indexes were tested. Complete indicators were tested. Before and after the experiment,the blood glucose and urine glucose in the observation group were significantly lower than those in the control group(P < 0. 05).The total effective cases in the observation group were significantly higher than those in the control group(P < 0. 05). There was no significant difference in blood biochemical indexes and blood routine test between the observation group and the control group(P > 0. 05). The results showed that the sulforaphane from cauliflower radish had the effect of assisting human body to reduce blood sugar,and was safe and harmless to human body.
To investigate whether the sulforaphane from cauliflower have hypoglycemic effect on human body,the sulforaphane in fresh cauliflower was extracted and separated. The diabetic subjects who volunteered to participate in the experiment were randomly divided into control group and observation group. The observation group took sulforaphane in cauliflower,while the control group took the same dose of placebo. The therapeutic effect was analyzed and the safety indexes were tested. Complete indicators were tested. Before and after the experiment,the blood glucose and urine glucose in the observation group were significantly lower than those in the control group(P < 0. 05).The total effective cases in the observation group were significantly higher than those in the control group(P < 0. 05). There was no significant difference in blood biochemical indexes and blood routine test between the observation group and the control group(P > 0. 05). The results showed that the sulforaphane from cauliflower radish had the effect of assisting human body to reduce blood sugar,and was safe and harmless to human body.
引文
[1]胡翠珍,李胜,马绍英,等.响应面优化西兰花中萝卜硫素复合提取工艺[J].食品工业科技,2016,37(4):271-277.
[2]方朝晖,仝小林,段俊国,等.糖尿病前期中医药循证临床实践指南[J].中医杂志,2017,58(3):266-270.
[3]应令雯,周健.2017年ADA糖尿病医学诊疗标准解读[J].中国医学前沿杂志(电子版),2017,9(1):48-55.
[4]Cheng H,Zhang J,Qi Z.Effects of interaction with sulphur compounds and free volume in imidazolium-based ionic liquid on desulphurisation:a molecular dynamics study[J].Molecular Simulation,2017,44(1):1-8.
[5]王文娟,郭思淼,安磊.萝卜硫素对体外成熟小鼠卵母细胞谷胱甘肽合成相关基因表达的影响[J].中国畜牧杂志,2018,54(6):65-68.
[6]宣伟,李帅,吴秀艳,等.萝卜硫素对小鼠放射性肺损伤的防护作用机制[J].中华放射医学与防护杂志,2017,37(4):251.
[7]Jerram S T,Leslie R D.The genetic architecture of type 1 diabetes[J].Genes,2017,8(8):209.
[8]高灿红,董丽丽,关晓弯,等.青花菜萝卜硫素合成相关基因Bo CYP83A1的克隆与表达分析[J].西北植物学报,2016,36(7):1302-1307.
[9]Marathe P H,Gao H X,Close K L.American diabetes association standards of medical care in diabetes 2017[J].Journal of Diabetes,2017,9(4):320.
[10]Cho N H,Shaw J E,Karuranga S,et al.IDF diabetes atlas:global estimates of diabetes prevalence for 2017 and projections for 2045[J].Diabetes Research&Clinical Practice,2018,138:271.
[11]郭丽萍,王志英,杨润强,等.西兰花种子发芽过程中生理活性物质含量的变化[J].中国食品学报,2016,16(3):160-167.
[12]Soskolne W A,Klinger A.The relationship between periodontal diseases and diabetes:an overview[J].Ann Periodontol,2017,6(1):91.
[13]Neal B,Perkovic V,Mahaffey K W,et al.Canagliflozin and cardiovascular and renal events in Type 2 Diabetes|NEJM[J].N Engl J Med,2017,377(7):644-657.
[14]谷茂然,冯文,宋煌旺,等.萝卜硫素类化合物的合成及抑菌活性研究[J].化学研究与应用,2017,29(1):118-122.
[15]赵灵燕.2型糖尿病中医证候要素诊断量表的研制及初步应用研究[J].北京中医药大学学报,2018,41(10):848-853.
[16]Schauer P R,Bhatt D L,Kirwan J P,et al.Bariatric surgery versus intensive medical therapy for diabetes-3-year outcomes[J].New England Journal of Medicine,2017,376(7):641.
[2]方朝晖,仝小林,段俊国,等.糖尿病前期中医药循证临床实践指南[J].中医杂志,2017,58(3):266-270.
[3]应令雯,周健.2017年ADA糖尿病医学诊疗标准解读[J].中国医学前沿杂志(电子版),2017,9(1):48-55.
[4]Cheng H,Zhang J,Qi Z.Effects of interaction with sulphur compounds and free volume in imidazolium-based ionic liquid on desulphurisation:a molecular dynamics study[J].Molecular Simulation,2017,44(1):1-8.
[5]王文娟,郭思淼,安磊.萝卜硫素对体外成熟小鼠卵母细胞谷胱甘肽合成相关基因表达的影响[J].中国畜牧杂志,2018,54(6):65-68.
[6]宣伟,李帅,吴秀艳,等.萝卜硫素对小鼠放射性肺损伤的防护作用机制[J].中华放射医学与防护杂志,2017,37(4):251.
[7]Jerram S T,Leslie R D.The genetic architecture of type 1 diabetes[J].Genes,2017,8(8):209.
[8]高灿红,董丽丽,关晓弯,等.青花菜萝卜硫素合成相关基因Bo CYP83A1的克隆与表达分析[J].西北植物学报,2016,36(7):1302-1307.
[9]Marathe P H,Gao H X,Close K L.American diabetes association standards of medical care in diabetes 2017[J].Journal of Diabetes,2017,9(4):320.
[10]Cho N H,Shaw J E,Karuranga S,et al.IDF diabetes atlas:global estimates of diabetes prevalence for 2017 and projections for 2045[J].Diabetes Research&Clinical Practice,2018,138:271.
[11]郭丽萍,王志英,杨润强,等.西兰花种子发芽过程中生理活性物质含量的变化[J].中国食品学报,2016,16(3):160-167.
[12]Soskolne W A,Klinger A.The relationship between periodontal diseases and diabetes:an overview[J].Ann Periodontol,2017,6(1):91.
[13]Neal B,Perkovic V,Mahaffey K W,et al.Canagliflozin and cardiovascular and renal events in Type 2 Diabetes|NEJM[J].N Engl J Med,2017,377(7):644-657.
[14]谷茂然,冯文,宋煌旺,等.萝卜硫素类化合物的合成及抑菌活性研究[J].化学研究与应用,2017,29(1):118-122.
[15]赵灵燕.2型糖尿病中医证候要素诊断量表的研制及初步应用研究[J].北京中医药大学学报,2018,41(10):848-853.
[16]Schauer P R,Bhatt D L,Kirwan J P,et al.Bariatric surgery versus intensive medical therapy for diabetes-3-year outcomes[J].New England Journal of Medicine,2017,376(7):641.