肌源性干/祖细胞对造血干细胞分化、支持的研究进展
摘要
造血干细胞(HSCs)是能够自我更新并分化为多种谱系的造血细胞;骨髓中的基质细胞即间充质干细胞(MSCs)对HSCs生长发育和造血功能维持起到重要作用。但由于从骨髓获取基质细胞受到一些限制,研究者将目光转向了骨髓以外来源的基质细胞。肌源性干/祖细胞(MDSPCs)是一类在骨骼肌组织中发现的多功能干细胞群,研究发现MDSPCs在造血微环境诱导下可以分化为造血细胞。由于其具有来源丰富、取材方便和体外移植存活率高等特点,因此对HSCs分化、支持方面值得研究。本文就MDSPCs与HSCs之间的关系,以及MDSPCs作为基质细胞对HSCs可能的支持作用进行综述。
引文
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[2]FAJARDO-ORDUA G R,MAYANI H,MONTESINOS JJ.Hematopoietic support capacity of mesenchymal stem cells biology and clinical potential[J].Arch Med Res,2015,46(8):589-596.
[3]DE LUCA L,TRINO S,LAURENZANA I,et al.Mesenchymal stem cell derived extracellular vesicles:a role in hematopoietic transplantation?[J].Int J Mol Sci,2017,18(5):E1022.
[4]TIMARI H,SHAMSASENJAN K,MOVASSAGHPOUR A,et al.The effect of mesenchymal stem cell-derived extracellular vesicles on hematopoietic stem cells fate[J].Adv Pharm Bull,2017,7(4):531-546.
[5]XU X,WILSCHUT K J,KOUKLIS G,et al.Human satellite cell transplantation and regeneration from diverse skeletal muscles[J].Stem Cell Reports,2015,5(3):419-434.
[6]KAO G W,LAMB E K,KAO R L.Skeletal muscle stem cells[M]//KAO R L.Cellular Cardiomyoplasty:methods and protocols.New Jersey:Humana Press,2013:330-336.
[7]LABARGE M A,BLAU H M.Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury[J].Cell,2002,111(4):589-601.
[8]CAMARGO F D,GREEN R,CAPETANAKI Y,et al.Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates[J].Nat Med,2003,9(12):1520-1527.
[9]CORBEL S Y,LEE A,YI L,et al.Contribution of hematopoietic stem cells to skeletal muscle[J].Nat Med,2003,9(12):1528-1532.
[10]STRMBERG A,JANSSON M,FISCHER H,et al.Bone marrow derived cells in adult skeletal muscle tissue in humans[J].Skeletal Muscle,2013,3(1):12.
[11]QU-PETERSEN Z,DEASY B,JANKOWSKI R,et al.Identification of a novel population of muscle stem cells in mice:potential for muscle[J].J Cell Biol,2002,157(5):851-864.
[12]ZHENG B,CAO B,CRISAN M,et al.Prospective identification of myogenic endothelial cells in human skeletal muscle[J].Nat Biotechnol,2007,25(9):1025-1034.
[13]JACKSON K A,MI T,GOODELL M A.Hematopoietic potential of stem cells isolated from murine skeletal muscle[J].Proc Natl Acad Sci USA,1999,96(25):14482-14486.
[14]王娟娟,高晓宁,陈珊珊,等.体外培养肌源性干细胞向造血方向分化的实验研究进展[J].中国实验血液学杂志,2016,24(6):1897-1900.
[15]CAO B,ZHENG B,JANKOWSKI R J,et al.Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential[J].Nat Cell Biol,2003,5(7):640-646.
[16]陈玉芳,王媛媛,王娟娟,等.具有造血能力的肌源性干细胞的研究进展[J].中国实验血液学杂志,2015,23(5):1523-1526.
[17]ZHENG B,LI G,CHEN W C,et al.Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level[J].J Orthop Res,2013,31(7):1089-1095.
[18]VAIDYA A,KALE V.Hematopoietic stem cells,their niche,and the concept of co-culture systems:a critical review[J].J Stem Cells,2015,10(1):13-31.
[19]CHEN J,CHEN L,ZERN M A.The diversity and plasticity of adult hepatic progenitor cells and their niche[J].Liver Int,2017,37(9):1260-1271.
[20]LO IACONO M,RUSSO E,ANZALONE R,et al.Wharton′s jelly mesenchymal stromal cells support the expansion of cord blood-derived CD34+cells mimicking a hematopoietic niche in a direct cell-cell contact culture system[J].Cell Transplant,2018,27(1):117-129.
[21]MORRISON S J,SCADDEN D T.The bone marrow niche for haematopoietic stem cells[J].Nature,2014,505(7483):327-334.
[22]CRANE G M,JEFFERY E,MORRISON S J.Adult haematopoietic stem cell niches[J].Nat Rev Immunol,2017,17(9):573-590.
[23]BEMARDO M E,LOCATELLI F.Mesenchymal stromal cells in hematopoietic stem cell transplantation[M]//GNECCHI M.Mesenchymal stem cells.Methods in molecular biology.New York:Humana Press,2016:3-20.
[24]叶艳艳,江千里.造血干细胞定位及其与周围微环境相互作用的研究进展[J].白血病·淋巴瘤,2014,23(11):700-702.
[25]曹彦.骨髓造血干祖细胞微环境的形成[D].苏州大学,2016.
[26]费成明,常春康.成骨细胞在造血微环境中的作用及与部分血液系统疾病关系的研究进展[J].中国实验血液学杂志,2014,22(4):1133-1136.
[27]CASTIGLIONI A,HETTMER S,LYNES M D,et al.I-solation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle[J].Stem Cell Reports,2014,2(1):92-106.
[28]JAMES A W,ZARA J N,ZHANG X,et al.Perivascular stem cells:aprospectively purified mesenchymal stem cell population for bone tissue engineering[J].Stem Cells Transl Med,2012,1(6):510-519.
[29]WEST C C,HARDY W R,MURRAY I R,et al.Prospective purification of perivascular presumptive mesenchymal stem cells from human adipose tissue:process optimization and cell population metrics across a large cohort of diverse demographics[J].Stem Cell Res Ther,2016,7:47.
[30]CORSELLI M,CHIN C J,PAREKH C,et al.Perivascular support of human hematopoietic stem/progenitor cells[J].Blood,2013,121(15):2891-2901.