脂质体阿霉素持续灌注对脾栓塞中远期疗效的影响
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摘要
目的探讨脂质体阿霉素持续灌注在部分脾栓塞术(PSE)中的临床应用价值,寻求一种能提高部分性脾栓塞中、远期疗效的方法。方法对20例脾功能亢进患者,均采用脂质体阿霉素持续灌注、明胶海绵颗粒(1~2 mm~3)栓塞,栓塞面积控制在60%~80%。采集每次脾栓塞术前、术后相关资料,并进行对比。结果术后第3天外周血白细胞、血小板计数均升至正常范围,术后12个月后20例患者血细胞仍稳定在正常范围;脾实质不同程度坏死机化,脾脏体积缩小,脾动脉血流量减少>50%;临床有效率达100%,且目前无1例复发。结论该方法治疗脾功能亢进,疗效稳定,值得推广应用。
Objective Aim To evaluate doxorubicin liposome infusion on spleen embolism.To explore an assay to enhance long term efficacy of spleen embolism.Methods In 20 cases of hypersplenism using liposomal doxorubicin infusion,gelatin sponge particles(1~2 mm~3) embolization,embolization area control in 60%~80%.acquisition time splenic embolization before data after operation,and compared.Results After third days of peripheral white blood cell,platelet counts were returned to normal within 12 months after operation,20 patients remained stable in the normal range of blood cells; spleen parenchyma in different degrees of necrosis,spleen size,>50% reduced splenic arterial blood flow; clinical effective rate was 100%,and there is no 1 cases of recurrence.Conclusion Spleen embolism with doxorubicin liposome infusion is effect in treating hypersplenism.
Objective Aim To evaluate doxorubicin liposome infusion on spleen embolism.To explore an assay to enhance long term efficacy of spleen embolism.Methods In 20 cases of hypersplenism using liposomal doxorubicin infusion,gelatin sponge particles(1~2 mm~3) embolization,embolization area control in 60%~80%.acquisition time splenic embolization before data after operation,and compared.Results After third days of peripheral white blood cell,platelet counts were returned to normal within 12 months after operation,20 patients remained stable in the normal range of blood cells; spleen parenchyma in different degrees of necrosis,spleen size,>50% reduced splenic arterial blood flow; clinical effective rate was 100%,and there is no 1 cases of recurrence.Conclusion Spleen embolism with doxorubicin liposome infusion is effect in treating hypersplenism.
引文
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[3]张之南.血液病诊断及疗效标准[M].天津:天津科学出版社,2012,247-248.
[4]陈灏珠,李宇明,段生福,等.内科学[M].北京:人民卫生出版社,2014,594-598.
[5]Porter BA,Frey CF,Link DP,et al.Splenic embolization monitored by the video dilution technique[J].AJR Am J Roentgen ol,2013,141(5):1063-1065.
[6]Murata K,Shiraki K,Takase K,et al.Long term follow﹣up for patients with liver cirrhosis after partial splenic embolization[J].Hepa togastroenterology 2014,43(11):1212-1217.
[7]Ando H,Ito T,Seo T,et al.Splenectomy in biliary atresia patients with recurrent jaundice following partial splenic embolization[J].Tohoku J Exp Med2012,181(1):167-174.
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