摘要
目的采用分层应变技术评价非梗阻型肥厚型心肌病(NHCM)患者左心室收缩功能,为临床心功能的评价提供定量信息。方法选取西电集团医院收治的42例NHCM患者(NHCM组)与48例健康体检者(对照组),获取各心尖长轴水平超声二维动态图像进行存储,脱机采用EchoPAC 113软件测量各切面心内膜下、中层及心外膜下心肌整体纵向应变峰值(GLS-endo、GLS-mid、GLS-epi)。结果两组的GLS-endo、GLS-mid、GLS-epi均表现为梯度递减(P<0.001);NHCM组左心室GLS-endo、GLS-mid、GLS-epi均低于对照组(P<0.001)。NHCM组GLS-endo、GLS-mid、GLS-epi绝对值与最大室壁厚度呈线性负相关(P<0.001)。结论分层应变技术是评价NHCM患者左心室纵向收缩功能的一种新技术。
Objective The left ventricular systolic function in patients with non-obstructive hypertrophic cardiomyopathy(NHCM) was evaluated by stratified strain technique, which provided quantitative information for clinical evaluation of cardiac function. Methods A total of 42 NHCM patients(NHCM group) admitted in Xi'an XD group hospital and 48 healthy controls(control group) were selected. Two-dimensional dynamic echocardiographic images of each apex were acquired. The longitudinal strain peak values of the subendocardial and middle layer and epicardial inferior of each section(GLS-endo, GLS-mid, GLS-epi) were measured offline using EchoPAC 113 software. Results GLS-endo, GLS-mid and GLS-epi in both groups showed gradient decrease(P<0.001). The left ventricular GLS-endo, GLS-mid and GLS-epi in the NHCM group were lower than those in the control group(P<0.001). The absolute values of GLS-endo, GLS-mid and GLSepi in the NHCM group were negatively correlated with the maximum wall thickness(P <0.001). Conclusion Stratified strain technique is a new technique for evaluating left ventricular longitudinal systolic function in NHCM patients.
引文
[1]MARON BJ,MARON MS.Hypertrophic cardiomyopathy[J].Lancet.2013,381(9862):242-255.
[2]中华医学会心血管病学分会,中国成人肥厚型心肌病诊断与治疗指南编写组,中华心血管病杂志编辑委员会.中国成人肥厚型心肌病诊断与治疗指南[J].中华心血管病杂志,2017,45(12):1015-1031.
[3]MARON BJ,MARON MS.Nonobstructive hypertrophic cardiomyopathy[J].Mayo Clin Proc,2016,91(3):277-278.
[4]SHARIF H,TING S,FORSYTHE L,et al.Layer-specific systolic and diastolic strain in hypertensive patients with and without mild diastolic dysfunction[J].Echo Res Pract,2018,5(1):41-49.
[5]刘燕,孙丹丹,杨军,等.应用分层应变技术评价心尖肥厚型心肌病患者左心室心肌圆周应变[J].中国超声医学杂志,2018,34(6):508-511.
[6]姜校颖,王珂,丛涛,等.超声心动图分层应变技术评价左心室射血分数正常的肥厚型心肌病患者室壁收缩功能的改变[J].中华医学超声杂志:电子版,2017,14(7):512-518.