颈动脉斑块、狭窄与早期缺血性脑卒中的关系研究
摘要
目的探讨颈动脉斑块、狭窄与早期缺血性脑卒中(IS)的关系。方法回顾性选取2015年1月至2017年1月收治的早期IS患者128例作为早期IS组,同期选取无早期IS患者128例作为对照组,所有患者均给予超声检查颈动脉斑块与狭窄情况,分析颈动脉斑块、狭窄与早期IS的关系。结果单因素结果分析显示,早期IS组和对照组斑块发生率、性质和颈动脉内中膜厚度(IMT)、狭窄程度比较,差异有统计学意义(P<0.05);Logistic多因素分析结果显示,斑块不稳定和颈动脉IMT增厚、重度狭窄是早期IS发生的独立危险因素(P<0.05)。结论颈动脉斑块与狭窄与早期IS的发生有关,提示应加强对斑块不稳定和颈动脉IMT增厚、重度狭窄人群的干预,应能够有效预防早期IS。
引文
1王史健,冯玲.脑卒中偏瘫患者针灸联合推拿治疗的功能改善及疗效分析[J].中国医院统计,2017,24(3):218-220.
2 Saba L,Banchhor SK,Suri HS,et al.Accurate cloud-based smart IMT measurement,its validation and stroke risk stratification in carotid ultrasound:A webbased point-of-care tool for multicenter clinical trial[J].Comput Biol Med,2016,75(75):217-234.
3中华医学会神经病学分会中华医学会神经病学分会脑血管病学组,刘鸣,蒲传强.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
4徐鹏程,王天雄,吴小三,等.急性前循环缺血性脑卒中与颈动脉粥样硬化斑块的相关性研究[J].中国临床保健杂志,2016,19(3):240-243.
5 Ygarden H,Fromm A,Sand KM,et al.Afamily history of stroke is associated with increased Intima Media thickness in young ischemic stroke-the norwegian stroke in the young study(NOR-SYS)[J].PLoS One,2016,11(8):e0159811.
6侯跃辉,林莉,杨坚伟,等.急性缺血性脑卒中患者预后影响因素分析[J].中国医院统计,2016,23(6):421-423.
7沈黎,孙伟辉,王伟民.LDL/HDL比值与急性缺血性脑卒中危险因素的关系及预后价值[J].健康研究,2016,36(2):123-125.
8 Ibrahimi P,Jashari F,Bajraktari G,et al.Ultrasound assessment of carotid plaque echogenicity response to statin therapy:a systematic review and meta-analysis[J].Int J Mol Sci,2015,16(5):10734-10747.
9陈秀平;黄玲.脑卒中高危人群的颈动脉超声表现及相关因素分析[J].检验医学与临床,2017,14(A01):135-137.
10 Choi SH,Choi-Kwon S,Kim MS,et al.Poor nutrition and alcohol consumption are related to high serum homocysteine level at post-stroke[J].Nutr Res Pract,2015,9(5):503-510.
11秦玲,唐芳,张成琪.缺血性脑卒中高危人群颈动脉超声筛查及行为影响因素[J].中华行为医学与脑科学杂志,2014,23(5):433-435.
12黄飞,龚兰.颈动脉彩超在脑卒中高危人群检查中的应用价值[J].中国实用神经疾病杂志,2015,18(16):18-20.
13 Iezzi R,Petrone G,Ferrante A,et al.The role of contrast-enhanced ultrasound(CEUS)in visualizing atherosclerotic carotid plaquevulnerability:which injection protocol?Which scanning technique?[J].Eur J Radiol,2015,84(5):865-871.
14史小华.颈部血管超声对脑卒中功能早期改变的评估价值[J].神经损伤与功能重建,2015,10(4):375-376.
15 Devasia AJ,Joy B,Tarey SD.Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke:A cross sectional observational study[J].Ann Indian Acad Neurol,2016,19(1):48-51.
2 Saba L,Banchhor SK,Suri HS,et al.Accurate cloud-based smart IMT measurement,its validation and stroke risk stratification in carotid ultrasound:A webbased point-of-care tool for multicenter clinical trial[J].Comput Biol Med,2016,75(75):217-234.
3中华医学会神经病学分会中华医学会神经病学分会脑血管病学组,刘鸣,蒲传强.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
4徐鹏程,王天雄,吴小三,等.急性前循环缺血性脑卒中与颈动脉粥样硬化斑块的相关性研究[J].中国临床保健杂志,2016,19(3):240-243.
5 Ygarden H,Fromm A,Sand KM,et al.Afamily history of stroke is associated with increased Intima Media thickness in young ischemic stroke-the norwegian stroke in the young study(NOR-SYS)[J].PLoS One,2016,11(8):e0159811.
6侯跃辉,林莉,杨坚伟,等.急性缺血性脑卒中患者预后影响因素分析[J].中国医院统计,2016,23(6):421-423.
7沈黎,孙伟辉,王伟民.LDL/HDL比值与急性缺血性脑卒中危险因素的关系及预后价值[J].健康研究,2016,36(2):123-125.
8 Ibrahimi P,Jashari F,Bajraktari G,et al.Ultrasound assessment of carotid plaque echogenicity response to statin therapy:a systematic review and meta-analysis[J].Int J Mol Sci,2015,16(5):10734-10747.
9陈秀平;黄玲.脑卒中高危人群的颈动脉超声表现及相关因素分析[J].检验医学与临床,2017,14(A01):135-137.
10 Choi SH,Choi-Kwon S,Kim MS,et al.Poor nutrition and alcohol consumption are related to high serum homocysteine level at post-stroke[J].Nutr Res Pract,2015,9(5):503-510.
11秦玲,唐芳,张成琪.缺血性脑卒中高危人群颈动脉超声筛查及行为影响因素[J].中华行为医学与脑科学杂志,2014,23(5):433-435.
12黄飞,龚兰.颈动脉彩超在脑卒中高危人群检查中的应用价值[J].中国实用神经疾病杂志,2015,18(16):18-20.
13 Iezzi R,Petrone G,Ferrante A,et al.The role of contrast-enhanced ultrasound(CEUS)in visualizing atherosclerotic carotid plaquevulnerability:which injection protocol?Which scanning technique?[J].Eur J Radiol,2015,84(5):865-871.
14史小华.颈部血管超声对脑卒中功能早期改变的评估价值[J].神经损伤与功能重建,2015,10(4):375-376.
15 Devasia AJ,Joy B,Tarey SD.Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke:A cross sectional observational study[J].Ann Indian Acad Neurol,2016,19(1):48-51.