IRMOF3的合成后修饰(PSM)及其生物碱吸附研究
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摘要
采用热回流法制备IRMOF3微晶,经海藻酸钠(AA)修饰,得到产物IRMOF3-AA,采用X-射线光电子能谱(XPS)和红外光谱(IR)对IRMOF3微晶和修饰产物IRMOF3-AA表征进行结构确证.结果表明, AA修饰成功.将IRMOF3-AA用于生物碱巴马汀和小檗碱的吸附研究,采用紫外分光光度计检测,观察溶液在一定波长下的吸光度值,根据对比结果确定时间和pH对生物碱的吸附影响.其中, pH对生物碱的吸附效果影响较大,静电相互作用可能在吸附方面起主要作用,当p H=9时,IRMOF3-AA纳米粒子的羧基转化成羧负离子,而生物碱带有季铵正离子,因电荷相互作用,后者会明显吸附到羧基富集的IRMOF3-AA纳米粒子表面上;而吸附时间对于生物碱的吸附效果来说没有较显著影响.
IRMOF3 microcrystalline was prepared by thermal reflux method, and IRMOF3-AA was obtained by sodium alginate(AA). X-ray photoelectron spectroscopy(XPS) and infrared spectroscopy(IR)were used for characterization. The results showed that AA modification was successful. IRMOF3-AA was used to study the adsorption of alkaloids, such as palmatine and berberine. UV-vis spectra were used to observe the absorbance value of the supernatant at a certain wavelength. The effects of time and pH on the adsorption of alkaloids were determined according to the comparison results.
IRMOF3 microcrystalline was prepared by thermal reflux method, and IRMOF3-AA was obtained by sodium alginate(AA). X-ray photoelectron spectroscopy(XPS) and infrared spectroscopy(IR)were used for characterization. The results showed that AA modification was successful. IRMOF3-AA was used to study the adsorption of alkaloids, such as palmatine and berberine. UV-vis spectra were used to observe the absorbance value of the supernatant at a certain wavelength. The effects of time and pH on the adsorption of alkaloids were determined according to the comparison results.
引文
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19李益群,徐丽,朱华旭,等.蛋白质在膜表面的吸附特性及蛋白质存在的溶液环境对小檗碱膜透过行为的影响研究[J].中国中药杂志,2017,42(20):3 912-3 918.
2 Cohen S M.Postsynthetic methods for the functionalization of metal-organic frameworks[J].Chem Rev,2012,112:970-1 000.
3霍淑慧.金属-有机骨架应用于有机污染物的去除和固相(微)萃取[D].天津:南开大学化学学院,2012.
4 Ma S Q,Wang X S,Yuan D Q,et al.A coordinatively linked Yb metal-organic framework demonstrates high thermal stability and uncommon gas-adsorption selectivity[J].Angew Chem Inter Ed,2008,47(22):4 130-4 133.
5 Ma S Q,Zhou H C.A metal-organic framework with entatic metal centers exhibiting high gas adsorption affinity[J].J Am Chem Soc,2006,128(36):11 734-11 735.
6 Ma S Q,Sun D,Wang X S,et al.A mesh-adjustable molecular sieve for general use in gas separation[J].Angew Chem Inter Ed,2007,46(14):2 458-2 462.
7汪洪,孙敏,伍春莲,等.长春花生物碱生物合成途径中关键步骤与代谢调控研究进展[J].中国中药杂志,2001,26(10):656-659.
8马爱瑛.生物碱的提取与分离[J].固原师专学报,2006,27(3):25-30.
9李音.生物碱吸附分离规律研究[D].浙江:浙江大学化学工程与生物工程学院,2013.
10 Eddaoudi J M,Kim J,Rosi N L,et al.Systematic design of pore size and functionality in isoreticular MOFs and their application in methane storage[J].Science,2002,295(5 554):469-472.
11陈景丽.原子荧光测汞及MOFs材料吸附Hg2+研究[D].江西:东华理工大学化学生物与材料科学学院,2016.
12 Peyki A,Rahimpour A,Jahanshahi M.Preparation and characterization of thin film composite reverse osmosis membranes incorporated with hydrophilic SiO2nanoparticles[J].Desalination,2015,368:152-158.
13 Beamson G.Conformation and orientation effects in the X-ray photoelectron spectra of organic polymers[J].JElectron Spectrosc,2001,121:163-181.
14 El-Ashgar N M,El-Nahhal I M,Chehimi M M,et al.Synthesis and structural characterization of a new macrocyclic polysiloxane-immobilized ligand system[J].J Monatsh Chem,2006,137:263-275.
15 Siddiquey I A,Ukaji E,Furusawa T,et al.The effects of organic surface treatment by methacryloxypropyltrimethoxysilane on the photostability of TiO2[J].Mater Chem Phys,2007,105:162-168.
16彭婷婷.功能化磁性粒子的合成及在分离生物碱中的应用研究[D].湖南:湖南师范大学化学化工学院,2011.
17马永贵,袁龙,王文清,等.盐酸小檗碱磷脂固体分散体的体外透皮吸收研究[J].中国医院药学杂志,2017,37(9):822-825.
18袁梽漪,王玉刚,柴玉爽,等.小檗碱作用靶点及其吸收特点-老药如何新用[J].中国中药杂志,2016,41(12):2 362-2 370.
19李益群,徐丽,朱华旭,等.蛋白质在膜表面的吸附特性及蛋白质存在的溶液环境对小檗碱膜透过行为的影响研究[J].中国中药杂志,2017,42(20):3 912-3 918.