广州市番禺区五种性传播疾病的流行病学分析
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摘要
目的了解本地区人群中5种常见性传播疾病病原体的感染情况及其特点,为地区防治工作提供可靠依据。方法采用实时荧光定量PCR法对本院10 858例疑似泌尿生殖道炎症患者进行解脲脲原体(Uu)、沙眼衣原体(CT)、淋病奈瑟菌(NG)、人乳头瘤病毒(HPV6,11)和单纯疱疹病毒(HSV-Ⅱ)等病原体的DNA定量检测,并进行统计分析。结果STD总阳性率为29.5%(3206/10858),病原体Uu、CT、NG、HPV6,11、HSV-Ⅱ阳性率分别为50.2%、12.1%、3.67%、5.68%、16.4%。男性、女性阳性率分别为22.9%、31.1%,差异有统计学意义(P<0.01)。20~40岁年龄段为主要感染人群,占86.68%。我区以Uu、CT流行为主,与其他地区存在差异。混合感染的总检出率为3.04%。结论本地区人群存在不同程度的5种性病病原体感染,加强泌尿生殖道炎症患者STD病原体的监测,对减少STD的流行与扩散具有重要意义。
Objective:To understand the infection situation and characteristics of 5 kinks of common pathogens of sexually transmitted diseases in this region and provide a reliable basis for the prevention and treatment. Methods:10 858 cases of patients with suspected urinary genital tract inflammation were taken DNA quantitative detection for Ureaplasma urealyticum(Uu),Chlamydia trachomatis(CT),Neisseria gonorrhoeae(NG),Human papilloma virus(HPV6,11)and herpes simplex virus(HSV-Ⅱ)by real-time fluorescence quantitative PCR. Results:The total positive rate of STD was 29.5%(3203/10858),and the positive rates of Uu,CT,NG,HPV6,11 and HSV-Ⅱwere 50.2%,12.1%,3.67%,5.68% and 16.4% respectively. The positive rate of man was 22.9%,while women was 31.1%,which were significantly different(P<0.01). The people at the age of 20 to 40 were more susceptible to infection(86.68%). The total mixed infection rate was 3.04%,and the most mixed infection in this area were Uu and CT,which was different from other area. Conclusion:The situation of the 5 kinds of STD infection was severe in this area. It is important to supervise these 5 kinds of STD,which can significantly reduce the prevalence of STD and diffusion.
Objective:To understand the infection situation and characteristics of 5 kinks of common pathogens of sexually transmitted diseases in this region and provide a reliable basis for the prevention and treatment. Methods:10 858 cases of patients with suspected urinary genital tract inflammation were taken DNA quantitative detection for Ureaplasma urealyticum(Uu),Chlamydia trachomatis(CT),Neisseria gonorrhoeae(NG),Human papilloma virus(HPV6,11)and herpes simplex virus(HSV-Ⅱ)by real-time fluorescence quantitative PCR. Results:The total positive rate of STD was 29.5%(3203/10858),and the positive rates of Uu,CT,NG,HPV6,11 and HSV-Ⅱwere 50.2%,12.1%,3.67%,5.68% and 16.4% respectively. The positive rate of man was 22.9%,while women was 31.1%,which were significantly different(P<0.01). The people at the age of 20 to 40 were more susceptible to infection(86.68%). The total mixed infection rate was 3.04%,and the most mixed infection in this area were Uu and CT,which was different from other area. Conclusion:The situation of the 5 kinds of STD infection was severe in this area. It is important to supervise these 5 kinds of STD,which can significantly reduce the prevalence of STD and diffusion.
引文
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[6]吴志华.现代性病学[M].广东:人民出版社,1996.133-138.
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[8]周文泉,桑红.生殖器疱疹的流行病学和诊治进展[J].中华男科学,2003,9(8):611-613.
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[10]李会平,霍新年.不孕不育夫妇生殖道解脲支原体、沙眼衣原体感染及抗精子抗体、抗子宫内膜抗体关系探讨[J].中国优生与遗传杂志,2014,22(1):108-109,53.
[11]叶玲玲,索永善,曹文丽.解脲支原体感染对男性精液常规主要参数及精子功能的影响[J].中国预防医学杂志,2008,9(3):186-188.
[12]Da Ros CT,da Silva Schmitt C.Global epidemiology of sexually transmitted diseases[J].Asian Journal of Andrology,2008,10(1):110-114.
[2]张银汉,喻晶,吴波,等.荧光定量PCR监测5种常见性传播疾病DNA结果分析[J].中国优生与遗传杂志,2011,19(9):26,37.
[3]林美珊,陈林兴,林广玲,等.粤东地区四种性传播疾病病原感染的流行状况[J].国际流行病学传染病学杂志,2009,36(3):162-164.
[4]赵志军,师志云,赵颖,等.泌尿生殖道感染者性传播疾病病原体荧光定量PCR检测分析[J].检验医学与临床,2011,8(14):1705-1706.
[5]曾广丽,周世林.重庆市綦江区人民医院2009~2012年7种性病检测率分析[J].检验医学与临床,2013,10(15),1944-1947.
[6]吴志华.现代性病学[M].广东:人民出版社,1996.133-138.
[7]黄云平,陈海州,陈华,等.解脲脲原体感染者与其正常携带者在量值间的区分研究[J].中国感染控制杂志,2004,3(2):111-113.
[8]周文泉,桑红.生殖器疱疹的流行病学和诊治进展[J].中华男科学,2003,9(8):611-613.
[9]高会广,王彩红,王景胜,等.泌尿生殖道性传播疾病病原体检测结果分析[J].中国预防医学杂志,2008,9(11):990-992.
[10]李会平,霍新年.不孕不育夫妇生殖道解脲支原体、沙眼衣原体感染及抗精子抗体、抗子宫内膜抗体关系探讨[J].中国优生与遗传杂志,2014,22(1):108-109,53.
[11]叶玲玲,索永善,曹文丽.解脲支原体感染对男性精液常规主要参数及精子功能的影响[J].中国预防医学杂志,2008,9(3):186-188.
[12]Da Ros CT,da Silva Schmitt C.Global epidemiology of sexually transmitted diseases[J].Asian Journal of Andrology,2008,10(1):110-114.