摘要
目的了解本地区皮肤性病门诊患者单纯疱疹病毒(HSV)的感染情况。方法选取2013-2014年就诊于本院皮肤性病门诊的974例初诊疑似生殖器疱疹患者,采用酶联免疫法(ELISA)检测血清HSV1和HSV2的Ig G、Ig M抗体。结果 974例疑似生殖器疱疹患者HSV1-Ig G和Ig M的检出率分别为85.1%和2.0%,HSV2-Ig G和Ig M检出率分别为23.3%和5.4%。其中306例有典型生殖器疱疹症状者HSV1-Ig G和Ig M的感染率分别为84.0%和3.3%,HSV2-Ig G和Ig M感染率分别为44.8%和6.2%。疑似生殖器疱疹患者不同年龄组比较,除HSV1-Ig M差异无统计学意义外,其余抗体差异均有统计学意义(P<0.05);其中HSV2-Ig G以40~49岁检出率较高。结论本地区皮肤性病门诊患者HSV抗体检出率较高,生殖器疱疹主要由HSV2感染引起;女性HSV2感染率高于男性;且存在HSV的混合感染及与其他性传播疾病的复杂感染。
Objective To explore the infections of herpes simplex virus(HSV) in the outpatients of skin and sexually transmitted disease in Panyu District of Guangzhou. Methods Serologic detection of herpes simplex virus antibody(Ig G and Ig M of HSV1 and HSV2) was performed by ELISA in 974 suspected patients with genital herpes from2013 to 2014. Results In the 974 suspected patients, the positive rate of HSV1-Ig G and HSV1-Ig M were 85.1% and2.0%, respectively. The positive rate of HSV2-Ig G and HSV2-Ig M were 23.3% and 5.4%, respectively. Among 306 patients with typical genital herpes, the infection rates of HSV1-Ig G and HSV1-Ig M were 84.0% and 3.3%, and the infection rates of HSV2-Ig G and HSV2-Ig M were 44.8% and 6.2%, respectively. There were differences in HSV antibody positive rates between different age groups of suspected patients, except the HSV1-Ig M. Among different age groups,40~49 was higher than others in the positive rate of HSV2-Ig G. Conclusion There is a high positive detection rate of HSV antibody from the skin and sexually transmitted disease clinic in Panyu District of Guangzhou. Genital herpes is mainly caused by HSV2 infection. The infection rate of HSV2 in women is higher than that in men with suspected or typical genital herpes cases. Mixed infection with other sexually transmitted diseases and compound infections should be detected in some patients.
引文
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