超短效肾上腺素β受体阻滞药:兰地洛尔
|
摘要
兰地洛尔是一个新型的超短效肾上腺素β受体阻滞药,具有选择性高、起效快、停药后失效快、对心脏血流动力学影响小等优点。兰地洛尔可减少围手术期窦性心动过速和室上性心动过速发生率,减少术后心房颤动发生率,有助于术后心房颤动患者复律,减轻经皮冠状动脉介入治疗时节律和血流动力学异常。
Landiolol is a newer ultra short-acting adrenergic β blocker, which has the advantages of highly selectivity, fast efficacy, fast offset after stopping drug and less cardiac haemodynamics effects. Landilol may decrease the occurrence of perioperative sinus tachycardia and super ventricular tachycardia, decrease the occurrence of postoperative atrial fibrillation, help to convert atrial fibrillation to sinus rhythm, attenuate the rhythm and haemodynamics abnormality during percutaneous coronary intervention.
Landiolol is a newer ultra short-acting adrenergic β blocker, which has the advantages of highly selectivity, fast efficacy, fast offset after stopping drug and less cardiac haemodynamics effects. Landilol may decrease the occurrence of perioperative sinus tachycardia and super ventricular tachycardia, decrease the occurrence of postoperative atrial fibrillation, help to convert atrial fibrillation to sinus rhythm, attenuate the rhythm and haemodynamics abnormality during percutaneous coronary intervention.
引文
[1]KIRCHHOF P,BENUSSI S,KOTECHA D,et al.2016 ESCguidelines for the management of atrial fibrillation developed in collaboration with EACTS[J].Eur Heart J,2016,37(38):2893-2962.
[2]KRUMPL G,ULC I,TREBS M,et al.Bolus application of landiolol and esmolol:comparison of the pharmacokinetic and pharmacodynamic profiles in a healthy Caucasian group[J].Eur JClin Pharmacol,2017,73(4):417-428.
[3]KRUMPL G,UIC I,TREBS M,et al.Pharmacokinetics andkinetic behavior of low-,intermediate-,and high-dose landiolol during long-term infusion in Whites[J].J Cardiovasc Pharmacol,2017,70(1):42-51.
[4]NASROLLAHI-SHIRAZI S,SUCIC S,YANG Q,et al.Acomparison of theβ-adrenergic receptor antagonists landiolol and esmolol:receptor selectivity,partial agonism and pharmacochaperoning actions[J].J Pharmacol Exp Ther,2016,359(1):73-81.
[5]PLOSKER GL.Landiolol:a review of its use in intraoperative and postoperative tachyarrhythmias[J].Drugs,2013,73(9):959-977.
[6]SYED YY.Landiolol:a review in tachyarrhythmias[J].Drugs,2018,78(3):377-388.
[7]TAENAKA N,KIKAWA S.The effectiveness and safety of landiolol hydrochloride,an ultra-short-actingβ1-blocker,in postoperative patients with supraventricular tachyarrhythmias:a multicenter,randomized,double-blind,placebo-controlled study[J].Am J Cardiovasc Drugs,2013,13(5):353-364.
[8]MORI K,YAMADA K,FUKUDA T,et al.Landiolol hydrochloride for early postoperative tachycardia after transthoracic esophagectomy[J].Surg Today,2014,44(5):848-854.
[9]NIWA Y,KOIKE M,IWATA N,et al.Effect of landiolol hydrochloride on tachyarrhythmia after esophagectomy[J].Hepatogastroenterology,2014,61(134):1546-1551.
[10]XIAO J,HE P,ZOU Q,et al.Landiolol in the treatment of the intraoperative supraventricular tachycardia:a multicenter,randomized,double-blind,placebo-controlled study[J].J Clin Anesth,2015,27(2):120-128.
[11]SAKAMOTO A,KITAKAZE M,TAKAMOTO S,et al.Landiolol,an ultra-short-actingβ1-blocker,more effectively terminates atrial fibrillation than diltiazem after open heart surgery:prospective,multicenter,randomized,open-label study(JL-KNIGHT study)[J].Circ J,2012,76(5):1097-1101.
[12]NISHI H,SAKAGUCHI T,MIYAGAWA S,et al.Efficacy of landiolol hydrochloride for atrial fibrillation after open heart surgery[J].Heart Vessels,2013,28(4):490-496.
[13]NAGAOKA E,ARAI H,TAMURA K,et al.Prevention of atrial fibrillation with ultra-low dose landiolol after off-pump coronary artery bypass grafting[J].Ann Throac Cardiovasc Surg,2014,20(2):129-134.
[14]OGAWA S,PKAWA Y,FOTO Y,et al.Perioperative use of a beta blocker in coronary artery bypass grafting[J].Asian Cardiovasc Thorac Ann,2013,21(3):265-269.
[15]SEZAI A,OSAKA S,YAOITA H,et al.Safety and efficacy of landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery in patients with left ventricular dysfunction:prevention of atrial fibrillation after cardiac surgery with landiolol hydrochloride for left ventricular dysfunction(PLATON)trial[J].JThorac Cardiovasc Surg,2015,150(4):957-964.
[16]TAMURA T,YATABE T,YOKOYAMA M.Prevention of atrial fibrillation after cardiac surgery using low-dose landiolol:a systematic review and meta-analysis[J].J Clin Anesth,2017,42:1-6.
[17]OJIMA T,NAKAMORI M,NAKAMURA M,et al.Randomized clinical trial of landiolol hydrochloride for the prevention of atrial fibrillation and postoperative complications after oesophagectomy for cancer[J].Br J Surg,2017,104(8):1003-1009.
[18]HORIKOSHI Y,GOYAGI T,KUDO R,et al.The suppressive effects of landiolol administration on the occurrence of postoperative atrial fibrillation and tachycardia,and plasma IL-6elevation in patients undergoing esophageal surgery:a randomized controlled clinical trial[J].J Clin Anesth,2017,38:111-116.
[19]NAGAI R,KINUGAWA K,INOUE H,et al.Urgent management of rapid heart rate in patients with atrial fibrillation/flutter and left ventricular dysfunction:comparison of the ultra-short-actingβ1-selective blocker landiolol with digoxin(J-Land Study)[J].Circ J,2013,77(4):908-916.
[20]KOBAYASHI S,MURAKAMI W,MYOREN T,et al.A lowdoseβ1-blocker effectively and safely slows the heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation[J].Cardiology,2014,127(2):105-113.
[21]ADACHI T,SATO A,BABA M,et al.Novel use of the ultrashort-acting intravenous beta1-selective blocker landiolol for supraventricular tachyarrhythmias in patients with congestive heart failure[J].Heart Vessels,2014,29(4):464-469.
[22]KIUCHI S,AIKAWA H,HISATAKE S,et al.Efficacy of intravenous administration of landiolol in patients with acute heart failure and supraventricular tachyarrhythmia[J].J Clin Med Res,2017,9(5):426-432.
[23]WADA Y,AIBA T,TSUJITA Y,et al.Practical applicability of landiolol,an ultra-short-actingβ1-selective blocker,for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction[J].J Arrhythm,2016,32(2):82-88.
[24]SHIBATA SC,UCHIYAMA A,OHTA N,et al.Efficacy and safety of landiolol compared to amiodarone for the management of post-operative atrial fibrillation in intensive care patients[J].JCardiothorac Vasc Anesth,2016,30(2):418-422.
[25]PARK H,OTANI H,NODA T,et al.Intracoronary followed by intravenous administration of the short-actingβ-blocker landiolol prevents myocardial injury in the face of elective percutaneous coronary intervention[J].Int J Cardiol,2013,167(4):1547-1551.
[26]KIYOKUNI M,KONISHI M,SAKAMAKI K,et al.Beneficial effect of early infusion of landiolol,a very short-acting beta-1adrenergic receptor blocker,on reperfusion status in acute myocardial infarction[J].Int J Cardiol,2016,221:321-326.
[27]TOCHIKUBO J,ADACHI YU,EJIMA T,et al.Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients[J].J Intensive Care,2014,2(1):6.
[2]KRUMPL G,ULC I,TREBS M,et al.Bolus application of landiolol and esmolol:comparison of the pharmacokinetic and pharmacodynamic profiles in a healthy Caucasian group[J].Eur JClin Pharmacol,2017,73(4):417-428.
[3]KRUMPL G,UIC I,TREBS M,et al.Pharmacokinetics andkinetic behavior of low-,intermediate-,and high-dose landiolol during long-term infusion in Whites[J].J Cardiovasc Pharmacol,2017,70(1):42-51.
[4]NASROLLAHI-SHIRAZI S,SUCIC S,YANG Q,et al.Acomparison of theβ-adrenergic receptor antagonists landiolol and esmolol:receptor selectivity,partial agonism and pharmacochaperoning actions[J].J Pharmacol Exp Ther,2016,359(1):73-81.
[5]PLOSKER GL.Landiolol:a review of its use in intraoperative and postoperative tachyarrhythmias[J].Drugs,2013,73(9):959-977.
[6]SYED YY.Landiolol:a review in tachyarrhythmias[J].Drugs,2018,78(3):377-388.
[7]TAENAKA N,KIKAWA S.The effectiveness and safety of landiolol hydrochloride,an ultra-short-actingβ1-blocker,in postoperative patients with supraventricular tachyarrhythmias:a multicenter,randomized,double-blind,placebo-controlled study[J].Am J Cardiovasc Drugs,2013,13(5):353-364.
[8]MORI K,YAMADA K,FUKUDA T,et al.Landiolol hydrochloride for early postoperative tachycardia after transthoracic esophagectomy[J].Surg Today,2014,44(5):848-854.
[9]NIWA Y,KOIKE M,IWATA N,et al.Effect of landiolol hydrochloride on tachyarrhythmia after esophagectomy[J].Hepatogastroenterology,2014,61(134):1546-1551.
[10]XIAO J,HE P,ZOU Q,et al.Landiolol in the treatment of the intraoperative supraventricular tachycardia:a multicenter,randomized,double-blind,placebo-controlled study[J].J Clin Anesth,2015,27(2):120-128.
[11]SAKAMOTO A,KITAKAZE M,TAKAMOTO S,et al.Landiolol,an ultra-short-actingβ1-blocker,more effectively terminates atrial fibrillation than diltiazem after open heart surgery:prospective,multicenter,randomized,open-label study(JL-KNIGHT study)[J].Circ J,2012,76(5):1097-1101.
[12]NISHI H,SAKAGUCHI T,MIYAGAWA S,et al.Efficacy of landiolol hydrochloride for atrial fibrillation after open heart surgery[J].Heart Vessels,2013,28(4):490-496.
[13]NAGAOKA E,ARAI H,TAMURA K,et al.Prevention of atrial fibrillation with ultra-low dose landiolol after off-pump coronary artery bypass grafting[J].Ann Throac Cardiovasc Surg,2014,20(2):129-134.
[14]OGAWA S,PKAWA Y,FOTO Y,et al.Perioperative use of a beta blocker in coronary artery bypass grafting[J].Asian Cardiovasc Thorac Ann,2013,21(3):265-269.
[15]SEZAI A,OSAKA S,YAOITA H,et al.Safety and efficacy of landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery in patients with left ventricular dysfunction:prevention of atrial fibrillation after cardiac surgery with landiolol hydrochloride for left ventricular dysfunction(PLATON)trial[J].JThorac Cardiovasc Surg,2015,150(4):957-964.
[16]TAMURA T,YATABE T,YOKOYAMA M.Prevention of atrial fibrillation after cardiac surgery using low-dose landiolol:a systematic review and meta-analysis[J].J Clin Anesth,2017,42:1-6.
[17]OJIMA T,NAKAMORI M,NAKAMURA M,et al.Randomized clinical trial of landiolol hydrochloride for the prevention of atrial fibrillation and postoperative complications after oesophagectomy for cancer[J].Br J Surg,2017,104(8):1003-1009.
[18]HORIKOSHI Y,GOYAGI T,KUDO R,et al.The suppressive effects of landiolol administration on the occurrence of postoperative atrial fibrillation and tachycardia,and plasma IL-6elevation in patients undergoing esophageal surgery:a randomized controlled clinical trial[J].J Clin Anesth,2017,38:111-116.
[19]NAGAI R,KINUGAWA K,INOUE H,et al.Urgent management of rapid heart rate in patients with atrial fibrillation/flutter and left ventricular dysfunction:comparison of the ultra-short-actingβ1-selective blocker landiolol with digoxin(J-Land Study)[J].Circ J,2013,77(4):908-916.
[20]KOBAYASHI S,MURAKAMI W,MYOREN T,et al.A lowdoseβ1-blocker effectively and safely slows the heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation[J].Cardiology,2014,127(2):105-113.
[21]ADACHI T,SATO A,BABA M,et al.Novel use of the ultrashort-acting intravenous beta1-selective blocker landiolol for supraventricular tachyarrhythmias in patients with congestive heart failure[J].Heart Vessels,2014,29(4):464-469.
[22]KIUCHI S,AIKAWA H,HISATAKE S,et al.Efficacy of intravenous administration of landiolol in patients with acute heart failure and supraventricular tachyarrhythmia[J].J Clin Med Res,2017,9(5):426-432.
[23]WADA Y,AIBA T,TSUJITA Y,et al.Practical applicability of landiolol,an ultra-short-actingβ1-selective blocker,for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction[J].J Arrhythm,2016,32(2):82-88.
[24]SHIBATA SC,UCHIYAMA A,OHTA N,et al.Efficacy and safety of landiolol compared to amiodarone for the management of post-operative atrial fibrillation in intensive care patients[J].JCardiothorac Vasc Anesth,2016,30(2):418-422.
[25]PARK H,OTANI H,NODA T,et al.Intracoronary followed by intravenous administration of the short-actingβ-blocker landiolol prevents myocardial injury in the face of elective percutaneous coronary intervention[J].Int J Cardiol,2013,167(4):1547-1551.
[26]KIYOKUNI M,KONISHI M,SAKAMAKI K,et al.Beneficial effect of early infusion of landiolol,a very short-acting beta-1adrenergic receptor blocker,on reperfusion status in acute myocardial infarction[J].Int J Cardiol,2016,221:321-326.
[27]TOCHIKUBO J,ADACHI YU,EJIMA T,et al.Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients[J].J Intensive Care,2014,2(1):6.