柴胡平亢汤用于Graves病甲状腺功能亢进症治疗的效果与作用机制分析
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摘要
目的:本文将对柴胡平亢汤用于Graves病甲状腺功能亢进症(简称:甲亢)治疗的效果与作用机制进行分析,从而有效改善Graves病甲亢患者病情。方法:选取我院2015年1月-2018年4月收治的36例Graves病甲亢患者作为此次实验研究对象,将患者随机分为对照组与观察组。其中的对照组使用常规治疗法,观察组融合了柴胡平亢汤治疗措施,分析治疗结果。结果:通过对两组患者治疗效果分析发现,观察组患者治疗效果总有效率(94.4%)明显高于对照组(83.3%);观察组患者不良反应总发生率(5.5%)明显少于对照组(22.22%);观察组症状改善时间以及症状恢复时间为(1.25±0.24)周,(2.01±0.24)月。对照组的改善时间以及症状恢复时间为(3.26±1.24)周,(4.25±1.25)月。经临床治疗之后,两组受试者的甲状腺功能均呈现出了改善迹象,就改善程度来讲,和对照组相比,观察组改善更为显著,P <0.05。结论:临床采用柴胡平亢汤治疗Graves病甲亢患者,治疗的效果十分明显,可以积极改善患者的病情,具有较为明显的安全性,降低不良反应发生率,较快降低促甲状腺素(Thyroid Stimulating Hormone,TSH)。值得临床进一步推广。
Objective: To analyze efficacy of the Chaihu Pingkang decoction( 柴 胡 平 亢 汤) on Graves hyperthyroidism and its action mechanism. Methods: 36 cases were divided into two groups. The control group was given conventional treatment; and the observation group was given the Chaihu Pingkang decoction more. Results: The total efficiency in the observation group was 94.4%, which was significantly higher than 83.3% in the control group. The total incidence of adverse reactions in the observation group was 5.5%, which was significantly less than 22.22% in the control group. The symptom improvement time and symptom recovery time in the observation group were(1.25±0.24) weeks and(2.01±0.24) months, respectively. The improvement time and symptom recovery time in the control group were(3.26±1.24) weeks and(4.25±1.25) months, respectively. After treatment, the thyroid function in both groups was improved significantly, and the improvement in the observation group was more significant, P<0.05. Conclusion: The Chaihu Pingkang decoction on Graves hyperthyroidism show a good effect, is safe and with less adverse reactions.
Objective: To analyze efficacy of the Chaihu Pingkang decoction( 柴 胡 平 亢 汤) on Graves hyperthyroidism and its action mechanism. Methods: 36 cases were divided into two groups. The control group was given conventional treatment; and the observation group was given the Chaihu Pingkang decoction more. Results: The total efficiency in the observation group was 94.4%, which was significantly higher than 83.3% in the control group. The total incidence of adverse reactions in the observation group was 5.5%, which was significantly less than 22.22% in the control group. The symptom improvement time and symptom recovery time in the observation group were(1.25±0.24) weeks and(2.01±0.24) months, respectively. The improvement time and symptom recovery time in the control group were(3.26±1.24) weeks and(4.25±1.25) months, respectively. After treatment, the thyroid function in both groups was improved significantly, and the improvement in the observation group was more significant, P<0.05. Conclusion: The Chaihu Pingkang decoction on Graves hyperthyroidism show a good effect, is safe and with less adverse reactions.
引文
[1]邓翠,李京,汤秀珍.柴胡疏肝散治疗甲状腺功能亢进症近期疗效及远期复发率观察[J].辽宁中医药大学学报,2017,19(06):107-110.
[2]倪青,李卉,林伟,等.病证结合诊疗方案治疗Graves病207例自身对照研究[J].中国临床医生杂志,2015,43(11):55-56.
[3]田津,胡玲.Graves病中医证型与血清25(OH)D3的相关性研究[J].中医临床研究,2015,7(19):1-3.
[4]陈原邻.Graves病中医证候与细胞免疫相关性及化痰散结中药对Graves小鼠T细胞亚群的影响[D].北京:中国中医科学院,2014.
[5]王麒又.柴胡疏肝散加减联合甲巯咪唑片治疗甲状腺功能亢进效果观察[J].实用中医药杂志,2017,33(07):786-787.
[6]邹丽妍,刘蔚,杨梅,等.当归六黄汤联合赛治治疗桥本甲亢的临床观察[J].中医临床研究,2016,8(12):84-85.
[7]马桂磊.于秀辰教授应用升陷汤治疗甲亢经验[J].中医临床研究,2017,9(21):8-9.
[2]倪青,李卉,林伟,等.病证结合诊疗方案治疗Graves病207例自身对照研究[J].中国临床医生杂志,2015,43(11):55-56.
[3]田津,胡玲.Graves病中医证型与血清25(OH)D3的相关性研究[J].中医临床研究,2015,7(19):1-3.
[4]陈原邻.Graves病中医证候与细胞免疫相关性及化痰散结中药对Graves小鼠T细胞亚群的影响[D].北京:中国中医科学院,2014.
[5]王麒又.柴胡疏肝散加减联合甲巯咪唑片治疗甲状腺功能亢进效果观察[J].实用中医药杂志,2017,33(07):786-787.
[6]邹丽妍,刘蔚,杨梅,等.当归六黄汤联合赛治治疗桥本甲亢的临床观察[J].中医临床研究,2016,8(12):84-85.
[7]马桂磊.于秀辰教授应用升陷汤治疗甲亢经验[J].中医临床研究,2017,9(21):8-9.