高原舱模拟大鼠急性高原肺水肿及脑水肿的研究概况
摘要
高原缺氧环境导致了急性高原病的发生,特别是高原肺水肿和脑水肿,其严重威胁人体健康。高原环境模拟舱可以模拟大鼠高原肺水肿和脑水肿模型,从而为高原肺水肿和脑水肿发病机制研究提供实验依据。本文从4个方面综述了国内外使用高原环境模拟舱模拟大鼠急性高原肺水肿及脑水肿动物模型研究概况,包括高原环境舱模拟急性高原肺水肿及脑水肿机制、应用方法、大鼠的选择、评价标准,并提出了该模型研究的发展趋势。
引文
[1]Naeije R,Swenson ER.Inhaled budesonide for acute mountain sickness[J].Eur Respir J,2017,50(3):1701355
[2]Brtsch P,Swenson ER.Clinical practice:Acute high-altitude illnesses[J].N Engl J Med,2013,368(24):2294-2302
[3]潘庆庆,吴玉.急性高原病的病理生理机制研究进展[J].西北国防医学杂志,2017,38(1):68-70
[4]Davis C,Hackett P.Advances in the prevention and treatment of high altitude illness[J].Emerg Med Clin North Am,2017,35(2):241-260
[5]Bhagi S,Srivastava S,Singh SB.High-altitude pulmonary edema:review[J].J Occup Health,2014,56(4):235-243
[6]Brtsch P.The brain in acute mountain sickness and cerebral edema[J].J Neurol Sci,2015,357(8):e504
[7]Jensen JD,Vincent AL.Altitude illness,cerebral syndromes,high altitude cerebral edema(HACE)[Updated 2017Oct 9].In:StatPearls[Internet].Treasure Island(FL):StatPearls Publishing;2017Jun-.Available from:https://www.ncbi.nlm.nih.gov/books/NBK430916/
[8]许永华,张琼,曹金军,等.创建大型复合低压舱扩大医学实验平台种类[J].中国比较医学杂志,2012,22(7):60-63
[9]罗晓红,郭文静,许瑞元,等.模拟不同海拔低氧对大鼠下丘脑-垂体-甲状腺轴及肺组织VEGF和HIF-1表达的影响[J].解放军医学院学报,2016,37(8):864-868
[10]张兆瑞,张波,何萍萍,等.高原肺水肿动物模型的初步建立[J].中国医药导报,2011,08(27):27-28;66
[11]郭文静.模拟不同海拔梯度低氧环境下大鼠HPA/HPT轴应激性功能变化的动态观察及对肺/脑组织的影响[D].甘肃中医药大学,2016
[12]Núez-Eespinosa C,Douziech A,Ríos-Kristjánsson J G,et al.Effect of intermittent hypoxia and exercise on blood rheology and oxygen transport in trained rats[J].Respir Physiol Neurobiol,2014,192(1):112-117
[13]谢印芝,杨曦明,张波,等.间断缺氧习服大鼠血浆、肺组织血管内皮生长因子变化及意义[J].中华航空航天医学杂志,2001,12(1):41-43;67
[14]陈有,高钰琪,李素芝,等.高原肺水肿动物模型的初步研究[J].第三军医大学学报,2006,28(11):1176-1177
[15]Bai C,She J,Goolaerts A,et al.Stress failure plays a major role in the development of high-altitude pulmonary oedema in rats[J].Eur Respir J,2010,35(3):584-591
[16]胡小艳,汤恩杰.地塞米松对高原肺水肿大鼠的影响研究[J].实用心脑肺血管病杂志,2017,25(4):56-62
[17]Zhou Q,Wang D,Liu Y,et al.Solnatide demonstrates profound therapeutic activity in a rat model of pulmonary edema induced by acute hypobaric hypoxia and exercise[J].Chest,2017,151(3):658-667
[18]Guo P,Luo H,Fan Y,et al.Establishment and evaluation of an experimental animal model of high altitude cerebral edema[J].Neurosci Lett,2013,547(10):82-86
[19]Wang CT,Lin HJ,Cheng BC,et al.Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats[J].J Formos Med Assoc,2015,114(4):328-338
[20]Shukla D,Saxena S,Purushothaman J,et al.Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat[J].Eur J Pharmacol,2011,656(1-3):101-109
[21]Yuhai GU,Zhao Z.Significance of the changes occurring in the levels of interleukins,SOD and MDA in rat pulmonary tissue following exposure to different altitudes and exposure times[J].Exp Ther Med,2015,10(3):915-920
[22]Singh DP,Nimker C,Paliwal P,et al.Ethyl 3,4-dihydroxybenzoate(EDHB):aprolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain[J].J Physiol Sci,2015,66(4):315-326
[23]Xu D,Niu W,Luo Y,et al.Endogenous estrogen attenuates hypoxia-induced pulmonary hypertension by inhibiting pulmonary arterial vasoconstriction and pulmonary arterial smooth muscle cells proliferation[J].IntJMedSci,2013,10(6):771-781
[24]Ma YL,Qin P,Li Y,et al.The effects of different doses of estradiol(E2)on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion[J].BMC Neurosci,2013,14(1):1-15
[25]郑茂恩,李丽,吴书兰,等.6种SPF级大小鼠生长曲线的Bertanlanffy模型分析[J].实验动物科学,2015,32(4):10-13
[26]李静蔚,宋爱莉,刘晓菲.DMBA诱导大鼠乳腺癌癌前病变动物模型研究概况[J].中华肿瘤防治杂志,2009,16(3):234-237
[27]Chitra L,Boopathy R.Altered mitochondrial biogenesis and its fusion gene expression is involved in the high-altitude adaptation of rat lung[J].Respir Physiol Neurobiol,2014,192(2):74-84
[28]Wang C,Yan M,Jiang H,et al.Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin(AQP)via NF-κB signaling pathway[J].Int Immunopharmacol,2016(40):300-309
[29]李光宗,陈锋,刘英富,等.罗格列酮对高原肺水肿大鼠的保护作用[J].中华急诊医学杂志,2017,26(3):285-290
[30]栾飞,李茂星,周保柱,等.藏药螃蟹甲苯乙醇苷对急性高原肺水肿大鼠的保护作用[J].解放军医学杂志,2015,40(9):704-709
[31]Song TT,Bi YH,Gao YQ,et al.Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia[J].J Neuroinflammation,2016,13(1):1-14
[32]栾飞,李茂星,马蓉,等.藏药螃蟹甲中苯乙醇苷对模型大鼠急性高原脑水肿的改善作用[J].中国药房,2015(22):3075-3079
[33]是文辉,许永华,宋来阳,等.急性低氧暴露下大鼠脑组织的病理学改变及脑IL-6、TNF-α的表达变化[J].实验动物科学,2016,33(4):58-62
[34]Sarada S,Titto M,Himadri P,et al.Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain[J].J Neuroinflammation,2015,12(1):113
[35]Botao Y,Ma J,Xiao W,et al.Protective effect of ginkgolide B on high altitude cerebral edema of rats[J].High Alt Med Biol,2013,14(1):61-64
[36]蒙萍,王宁,漆欣柱,等.模拟海拔8000m高原缺氧环境对大鼠脑组织线粒体自噬的影响[J].解放军医药杂志,2016,28(6):9-13
[37]张文彬,苏畅,张永亮,等.急性低压缺氧脑损伤大鼠脑组织海马区HIF-1α时序性变化及意义[J].山东医药,2016,56(4):8-11
[38]Chen SJ,Yang JF,Kong FP,et al.Overactivation of corticotropin-releasing factor receptor type 1and aquaporin-4by hypoxia induces cerebral edema[J].Proc Natl Acad Sci USA,2014,111(36):13199-13204
[2]Brtsch P,Swenson ER.Clinical practice:Acute high-altitude illnesses[J].N Engl J Med,2013,368(24):2294-2302
[3]潘庆庆,吴玉.急性高原病的病理生理机制研究进展[J].西北国防医学杂志,2017,38(1):68-70
[4]Davis C,Hackett P.Advances in the prevention and treatment of high altitude illness[J].Emerg Med Clin North Am,2017,35(2):241-260
[5]Bhagi S,Srivastava S,Singh SB.High-altitude pulmonary edema:review[J].J Occup Health,2014,56(4):235-243
[6]Brtsch P.The brain in acute mountain sickness and cerebral edema[J].J Neurol Sci,2015,357(8):e504
[7]Jensen JD,Vincent AL.Altitude illness,cerebral syndromes,high altitude cerebral edema(HACE)[Updated 2017Oct 9].In:StatPearls[Internet].Treasure Island(FL):StatPearls Publishing;2017Jun-.Available from:https://www.ncbi.nlm.nih.gov/books/NBK430916/
[8]许永华,张琼,曹金军,等.创建大型复合低压舱扩大医学实验平台种类[J].中国比较医学杂志,2012,22(7):60-63
[9]罗晓红,郭文静,许瑞元,等.模拟不同海拔低氧对大鼠下丘脑-垂体-甲状腺轴及肺组织VEGF和HIF-1表达的影响[J].解放军医学院学报,2016,37(8):864-868
[10]张兆瑞,张波,何萍萍,等.高原肺水肿动物模型的初步建立[J].中国医药导报,2011,08(27):27-28;66
[11]郭文静.模拟不同海拔梯度低氧环境下大鼠HPA/HPT轴应激性功能变化的动态观察及对肺/脑组织的影响[D].甘肃中医药大学,2016
[12]Núez-Eespinosa C,Douziech A,Ríos-Kristjánsson J G,et al.Effect of intermittent hypoxia and exercise on blood rheology and oxygen transport in trained rats[J].Respir Physiol Neurobiol,2014,192(1):112-117
[13]谢印芝,杨曦明,张波,等.间断缺氧习服大鼠血浆、肺组织血管内皮生长因子变化及意义[J].中华航空航天医学杂志,2001,12(1):41-43;67
[14]陈有,高钰琪,李素芝,等.高原肺水肿动物模型的初步研究[J].第三军医大学学报,2006,28(11):1176-1177
[15]Bai C,She J,Goolaerts A,et al.Stress failure plays a major role in the development of high-altitude pulmonary oedema in rats[J].Eur Respir J,2010,35(3):584-591
[16]胡小艳,汤恩杰.地塞米松对高原肺水肿大鼠的影响研究[J].实用心脑肺血管病杂志,2017,25(4):56-62
[17]Zhou Q,Wang D,Liu Y,et al.Solnatide demonstrates profound therapeutic activity in a rat model of pulmonary edema induced by acute hypobaric hypoxia and exercise[J].Chest,2017,151(3):658-667
[18]Guo P,Luo H,Fan Y,et al.Establishment and evaluation of an experimental animal model of high altitude cerebral edema[J].Neurosci Lett,2013,547(10):82-86
[19]Wang CT,Lin HJ,Cheng BC,et al.Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats[J].J Formos Med Assoc,2015,114(4):328-338
[20]Shukla D,Saxena S,Purushothaman J,et al.Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat[J].Eur J Pharmacol,2011,656(1-3):101-109
[21]Yuhai GU,Zhao Z.Significance of the changes occurring in the levels of interleukins,SOD and MDA in rat pulmonary tissue following exposure to different altitudes and exposure times[J].Exp Ther Med,2015,10(3):915-920
[22]Singh DP,Nimker C,Paliwal P,et al.Ethyl 3,4-dihydroxybenzoate(EDHB):aprolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain[J].J Physiol Sci,2015,66(4):315-326
[23]Xu D,Niu W,Luo Y,et al.Endogenous estrogen attenuates hypoxia-induced pulmonary hypertension by inhibiting pulmonary arterial vasoconstriction and pulmonary arterial smooth muscle cells proliferation[J].IntJMedSci,2013,10(6):771-781
[24]Ma YL,Qin P,Li Y,et al.The effects of different doses of estradiol(E2)on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion[J].BMC Neurosci,2013,14(1):1-15
[25]郑茂恩,李丽,吴书兰,等.6种SPF级大小鼠生长曲线的Bertanlanffy模型分析[J].实验动物科学,2015,32(4):10-13
[26]李静蔚,宋爱莉,刘晓菲.DMBA诱导大鼠乳腺癌癌前病变动物模型研究概况[J].中华肿瘤防治杂志,2009,16(3):234-237
[27]Chitra L,Boopathy R.Altered mitochondrial biogenesis and its fusion gene expression is involved in the high-altitude adaptation of rat lung[J].Respir Physiol Neurobiol,2014,192(2):74-84
[28]Wang C,Yan M,Jiang H,et al.Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin(AQP)via NF-κB signaling pathway[J].Int Immunopharmacol,2016(40):300-309
[29]李光宗,陈锋,刘英富,等.罗格列酮对高原肺水肿大鼠的保护作用[J].中华急诊医学杂志,2017,26(3):285-290
[30]栾飞,李茂星,周保柱,等.藏药螃蟹甲苯乙醇苷对急性高原肺水肿大鼠的保护作用[J].解放军医学杂志,2015,40(9):704-709
[31]Song TT,Bi YH,Gao YQ,et al.Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia[J].J Neuroinflammation,2016,13(1):1-14
[32]栾飞,李茂星,马蓉,等.藏药螃蟹甲中苯乙醇苷对模型大鼠急性高原脑水肿的改善作用[J].中国药房,2015(22):3075-3079
[33]是文辉,许永华,宋来阳,等.急性低氧暴露下大鼠脑组织的病理学改变及脑IL-6、TNF-α的表达变化[J].实验动物科学,2016,33(4):58-62
[34]Sarada S,Titto M,Himadri P,et al.Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain[J].J Neuroinflammation,2015,12(1):113
[35]Botao Y,Ma J,Xiao W,et al.Protective effect of ginkgolide B on high altitude cerebral edema of rats[J].High Alt Med Biol,2013,14(1):61-64
[36]蒙萍,王宁,漆欣柱,等.模拟海拔8000m高原缺氧环境对大鼠脑组织线粒体自噬的影响[J].解放军医药杂志,2016,28(6):9-13
[37]张文彬,苏畅,张永亮,等.急性低压缺氧脑损伤大鼠脑组织海马区HIF-1α时序性变化及意义[J].山东医药,2016,56(4):8-11
[38]Chen SJ,Yang JF,Kong FP,et al.Overactivation of corticotropin-releasing factor receptor type 1and aquaporin-4by hypoxia induces cerebral edema[J].Proc Natl Acad Sci USA,2014,111(36):13199-13204