疏血通等10种中药注射剂与不同溶媒配伍的稳定性
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摘要
通过实验考察疏血通等10种中药注射剂与5种不同溶媒配伍后的稳定性,为临床安全合理使用中药注射剂提供依据。将10种中药注射剂分别与临床常用的静脉输液:质量分数0. 9%NaCl注射液、质量分数5%葡萄糖注射液、质量分数10%葡萄糖注射液、质量分数5%葡萄糖氯化钠注射液和果糖注射液配伍。在配制0、1、2、4和8h后,分别观察性状,测定pH和不溶性微粒数。研究发现:上述注射液与溶媒配伍后性状稳定,pH变化符合要求,不同溶媒中产生的不溶性微粒数各有差异,且会随放置时间发生变化。由此可知:上述中药注射剂与适宜的溶媒配伍,在一定时间内具有较好的稳定性,实验结果可供临床调配使用作为参考。
We study on stability of 10 traditional Chinese medicine( TCM) injections used in our hospital including shu-xue-tong injection with 5 different solvents,to provide reference for clinical safe and rational use of TCM injections. After the 10 TCM injections mixed with clinically used infusions,including 0. 9% sodium chloride injection,5% glucose injection,10% glucose injection,5% glucose and sodium chloride injection,and fructose injection,the characters were observed,the pH and insoluble particles were measured in 0,1,2,4 and 8 hours. The characters of above-mentioned mixed injections were stable; the pH changes were in compliance with regulations; the number of insoluble particles varied and changed with storage time. The above-mentioned TCM injections were compatible with suitable solvents and have good stability within a certain period. The experimental results can provide reference for clinical application.
We study on stability of 10 traditional Chinese medicine( TCM) injections used in our hospital including shu-xue-tong injection with 5 different solvents,to provide reference for clinical safe and rational use of TCM injections. After the 10 TCM injections mixed with clinically used infusions,including 0. 9% sodium chloride injection,5% glucose injection,10% glucose injection,5% glucose and sodium chloride injection,and fructose injection,the characters were observed,the pH and insoluble particles were measured in 0,1,2,4 and 8 hours. The characters of above-mentioned mixed injections were stable; the pH changes were in compliance with regulations; the number of insoluble particles varied and changed with storage time. The above-mentioned TCM injections were compatible with suitable solvents and have good stability within a certain period. The experimental results can provide reference for clinical application.
引文
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[2]曾聪彦,梅全喜.中药注射剂安全应用案例分析[M].北京:人民卫生出版社,2015.
[3]柳红霞,毛伟刚.引起中药注射剂不良反应的原因分析[J].中国药物经济学,2013(2):66-67.
[4]杨明.中药药剂学[M].北京:中国医药科技出版社,2012.
[5]国家药典委员会.中华人民共和国药典(四部)[M].2015年版.北京:中国医药科技出版社,2015.
[6]朱小丽,马红芳,孙红爽,等.8种常用中药注射剂输液配伍稳定性考察[J].解放军药学学报,2015,31(5):432-434.
[7]周天鸣,王锦玉,仝燕,等.复方苦参注射液在常用输液中的稳定性考察[J].中国实验方剂学杂志,2011,17(10):22-24.
[8]张建中,翁静燕.果糖注射液的临床应用及配伍特点[J].药学服务与研究,2015,15(1):42-45.
[9]汪怡.果糖注射液与5种中药注射剂配伍稳定性考察[J].北方药学,2014,11(11):106-107.
[10]刘建清,王佳坤,林冠,等.果糖注射液与临床常用药物配伍稳定性的研究进展[J].中南药学,2017,15(9):1252-1256.