首都医科大学附属北京妇产医院1998～2017年卵巢癌病例特点分析
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摘要
[目的]探讨首都医科大学附属北京妇产医院近20年间收治卵巢癌病例特点的变化。[方法]收集1998年1月至2017年12月首都医科大学附属北京妇产医院收治的北京籍卵巢癌患者1075例为研究对象。采用回顾性分析法,从发病年份、年龄、组织病理学类型、手术-病理分期等分析20年间卵巢癌病例特点的变化。[结果]<40岁组患者构成比从1988～2007年的28.03%下降到2008～2017年的14.17%(P<0.05),40～60岁组及>60岁组卵巢癌构成比分别由1998～2007年的57.50%及14.47%上升到2008～2017年的66.48%及19.34%(P<0.05)。不同年份组主要病理类型是上皮性卵巢癌,且构成比从1998～2007年的72.56%上升至2008～2017年的90.80%(P<0.05)。生殖细胞肿瘤及性索-间质肿瘤构成比均有下降,分别由1998～2007年的13.56%及12.66%下降到2008～2017年的3.83%及4.79%(P<0.05)。上皮性卵巢癌在40岁及以上年龄组是主要病理类型,特别是>60岁老年患者。年轻患者病理类型构成中,上皮性卵巢癌从1998～2007年的38.71%上升至2008～2017年的68.92%(P<0.05),生殖细胞肿瘤从1998～2007年的45.80%下降至2008～2017年的20.27%(P<0.05)。年轻患者多为Ⅰ期,Ⅲ期及以上卵巢癌患者所占比例从1998～2007年的46.11%上升到2008～2017年的60.34%(P<0.05)。[结论] 20年来卵巢癌主要发病人群年龄仍以40～60岁为主。上皮性卵巢癌是主要的病理类型,特别是>60岁老年患者人群,在年轻患者中其构成比呈上升趋势。
[Objective] To analyze the characteristics of ovarian cancer cases in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from 1998 to 2017. [Methods] The clinical and pathological data of1075 patients with ovarian cancer admitted in our hospital from January 1998 to December 2017 were retrospectively analyzed. [Results] Composition ratio of patients aged <40 years was decreased from 28.03% in1998～2007 to 14.17% in 2008～2017(P<0.05),while those of patients aged 40～60 years and >60 years were increased from 57.50% and 14.47% in 1998～2007 to 66.48% and 19.34% in 2008～2017(P<0.05),respectively.The rate of epithelial ovarian cancer rose from 72.56% in 1998～2007 to 90.80% in 2008～2017(P <0.05),while those of germ cell tumor and gonadal stromal cell tumor were decreased from 13.56% and 12.66% in 1998 ～2007 to 3.83% and 4.79% in 2008～2017(P<0.05). Epithelial ovarian cancer was the major pathological type in patients aged above 40 years,particularly in those aged >60 year-old. The rate of epithelial ovarian cancer in young patients rose from 38.71% in 1998 ～2007 to 68.92% in 2008 ～2017(P <0.05). The ovarian cancer was mostly in stage Ⅰ in younger patients. There was an increasing trend of stage Ⅲ ovarian cancer,which was increased from 46.11% in 1998～2007 to 60.34% in 2008～2017(P<0.05). [Conclusion] The age group 40 to 60 years is still the main risk population for ovarian cancer. Epithelial ovarian cancer is the main pathological type,especially in the patients aged over 60 years-old,and most patients are in the late stage at the diagnosis.
[Objective] To analyze the characteristics of ovarian cancer cases in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from 1998 to 2017. [Methods] The clinical and pathological data of1075 patients with ovarian cancer admitted in our hospital from January 1998 to December 2017 were retrospectively analyzed. [Results] Composition ratio of patients aged <40 years was decreased from 28.03% in1998～2007 to 14.17% in 2008～2017(P<0.05),while those of patients aged 40～60 years and >60 years were increased from 57.50% and 14.47% in 1998～2007 to 66.48% and 19.34% in 2008～2017(P<0.05),respectively.The rate of epithelial ovarian cancer rose from 72.56% in 1998～2007 to 90.80% in 2008～2017(P <0.05),while those of germ cell tumor and gonadal stromal cell tumor were decreased from 13.56% and 12.66% in 1998 ～2007 to 3.83% and 4.79% in 2008～2017(P<0.05). Epithelial ovarian cancer was the major pathological type in patients aged above 40 years,particularly in those aged >60 year-old. The rate of epithelial ovarian cancer in young patients rose from 38.71% in 1998 ～2007 to 68.92% in 2008 ～2017(P <0.05). The ovarian cancer was mostly in stage Ⅰ in younger patients. There was an increasing trend of stage Ⅲ ovarian cancer,which was increased from 46.11% in 1998～2007 to 60.34% in 2008～2017(P<0.05). [Conclusion] The age group 40 to 60 years is still the main risk population for ovarian cancer. Epithelial ovarian cancer is the main pathological type,especially in the patients aged over 60 years-old,and most patients are in the late stage at the diagnosis.
引文
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[9]Duan YF,Pan LL,Wang J,et al.Status of exclusive breastfeeding and influencing factors for 1882 pairs of mother and neonate:during 0-7 days postpartum in China[J].Chinese Journal of Preventive Medicine,2016,50(1):61-66.[段一凡,潘丽莉,王杰,等.中国1882对母婴0~7d纯母乳喂养状况及其影响因素[J].中华预防医学杂志,2016,50(1):61-66.]
[10]Zhang SS,Xia QM,Zheng RS,et al.Incidence and mortality of ovarian cancer in China,2010[J].China Cancer,2016,25(3):169-173.[张爽爽,夏庆民,郑荣寿,等.中国2010年卵巢癌发病与死亡分析[J].中国肿瘤,2016,25(3):169-173.]
[11]Ding XB,Lu XY,Mao DQ.Incidence and trend change of oophoroma in 11 tumor registration stations,Chongqing[J].Chinese Journal of Preventive Medicine,2016,50(3):274-276.[丁贤彬,吕晓燕,毛德强.2006-2014年重庆市肿瘤登记地区卵巢癌发病率及趋势变化[J].中华预防医学杂志,2016,50(3):274-276.]
[2]Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[3]Pan XD,Liu Y,Wang HW.Analysis on incidence trend of ovarian cancer in Shenyang city during 2005-2009[J].Modern Preventive Medicine,2014,41(15):2849-2851.[潘秀丹,刘艳,王慧文.沈阳市2005-2009年卵巢癌发病状况分析[J].现代预防医学,2014,41(15):2849-2851.]
[4]Yang NN,Yan YQ,Zheng RS,et al.An analysis of incidence and mortality for ovarian cancer in China,2009[J].China Cancer,2013,22(8):617-621.[杨念念,严亚琼,郑荣寿,等.中国2009年卵巢癌发病与死亡分析[J].中国肿瘤,2013,22(8):617-621.]
[5]Permuth-Wey J,Besharal A,Sellers TA.Epidemiology of ovarian cancer:an update[M].New York:Springer US,2014.1-21.
[6]LaVC.Ovarian cancer:epidemiology and risk factors[J].Eur J Cancer Prev,2017,26(1):55-62.
[7]Brookfield KF,Cheung MC,Koniaris LG,et al.A population-based analysis of 1037 malignant ovarian tumors in the pediatrie population[J].Surg Res,2009,156(1):45-49.
[8]Li DY,Wang ZY,Zhu XN,et al.Status and influencing factors of infants'parenting in Beijing urban area[J].Chinese Journal of Child Health Care,2015,23(6):619-623.[李东阳,王争艳,朱雪娜,等.北京市城区婴儿养育现状调查及影响因素分析[J].中国儿童保健杂志,2015,23(6):619-623.]
[9]Duan YF,Pan LL,Wang J,et al.Status of exclusive breastfeeding and influencing factors for 1882 pairs of mother and neonate:during 0-7 days postpartum in China[J].Chinese Journal of Preventive Medicine,2016,50(1):61-66.[段一凡,潘丽莉,王杰,等.中国1882对母婴0~7d纯母乳喂养状况及其影响因素[J].中华预防医学杂志,2016,50(1):61-66.]
[10]Zhang SS,Xia QM,Zheng RS,et al.Incidence and mortality of ovarian cancer in China,2010[J].China Cancer,2016,25(3):169-173.[张爽爽,夏庆民,郑荣寿,等.中国2010年卵巢癌发病与死亡分析[J].中国肿瘤,2016,25(3):169-173.]
[11]Ding XB,Lu XY,Mao DQ.Incidence and trend change of oophoroma in 11 tumor registration stations,Chongqing[J].Chinese Journal of Preventive Medicine,2016,50(3):274-276.[丁贤彬,吕晓燕,毛德强.2006-2014年重庆市肿瘤登记地区卵巢癌发病率及趋势变化[J].中华预防医学杂志,2016,50(3):274-276.]