化痰通腑汤联合常规西药治疗急性脑梗死的临床效果
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摘要
目的探讨化痰通腑汤联合常规西药治疗急性脑梗死的临床效果。方法选取我院收治的96例急性脑梗死的患者为研究对象,根据不同的治疗方法将其分为对照组(48例,常规西药治疗)与观察组(48例,常规西药+化痰通腑汤治疗),比较两组患者的治疗效果。结果观察组的治疗总有效率明显高于对照组(P<0.05);治疗后,两组患者的全血粘度高切、全血粘度低切、血浆粘度、红细胞聚集指数、纤维蛋白原、CRP、IL-6及TNF-α水平均显著降低,且观察组均显著低于对照组(P<0.05);治疗后,两组患者的NIHSS、BI评分及中医证候积分均改善,且观察组优于对照组(P<0.05)。结论化痰通腑汤联合常规西药治疗急性脑梗死的效果显著,可以改善患者的血液高凝状态,减轻患者的中医症状及炎症反应,提高患者的神经功能及日常生活能力,值得临床推广与应用。
Objective To investigate the clinical effect of Huatan Tongfu decoction combined with conventional western medicine in the treatment of acute cerebral infarction. Methods A total of 96 patients with acute cerebral infarction admitted in our hospital were selected as the study objects, and they were divided into control group(48 cases,conventional western medicine treatment) and observation group(48 cases, conventional western medicine+Huatan Tongfu decoction treatment) according to different treatment methods. The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P <0.05); after treatment, the high shear rate, low shear rate of whole blood viscosity, plasma viscosity, erythrocyte aggregation indexes, levels of fibrinogen, CRP, IL-6 and TNF-α in the two groups significantly decreased, and those in the observation group were significantly lower than the control group(P<0.05). After treatment, the scores of NIHSS, BI and TCM symptoms improved in both groups, and those in the observation group were better than the control group(P<0.05).Conclusion The Huatan Tongfu decoction combined with conventional western medicine in the treatment of acute cerebral infarction has a remarkable curative effect. It can improve the patients' blood hypercoagulability, reduce the patients' TCM symptoms and the inflammatory reaction, improve the patients' neurological function and daily life ability, which is worth clinical promotion and application.
Objective To investigate the clinical effect of Huatan Tongfu decoction combined with conventional western medicine in the treatment of acute cerebral infarction. Methods A total of 96 patients with acute cerebral infarction admitted in our hospital were selected as the study objects, and they were divided into control group(48 cases,conventional western medicine treatment) and observation group(48 cases, conventional western medicine+Huatan Tongfu decoction treatment) according to different treatment methods. The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P <0.05); after treatment, the high shear rate, low shear rate of whole blood viscosity, plasma viscosity, erythrocyte aggregation indexes, levels of fibrinogen, CRP, IL-6 and TNF-α in the two groups significantly decreased, and those in the observation group were significantly lower than the control group(P<0.05). After treatment, the scores of NIHSS, BI and TCM symptoms improved in both groups, and those in the observation group were better than the control group(P<0.05).Conclusion The Huatan Tongfu decoction combined with conventional western medicine in the treatment of acute cerebral infarction has a remarkable curative effect. It can improve the patients' blood hypercoagulability, reduce the patients' TCM symptoms and the inflammatory reaction, improve the patients' neurological function and daily life ability, which is worth clinical promotion and application.
引文
[1]张清科,饶梓辉.熄风化痰通络汤治疗急性脑梗死合并高同型半胱氨酸血症60例[J].河南中医,2015,35(2):282-284.
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[9]史文.益气活血化痰通络汤治疗急性脑梗死患者的临床效果[J].医疗装备,2016,29(24):143-144.
[10]曹新超.风痰阻络型急性脑梗死采取依达拉奉联合祛风化痰通络汤治疗的临床效果[J].临床医学研究与实践,2018,3(6):119-120.
[11]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[12]朱静德.急性脑梗死患者行益气活血化痰通络汤治疗的效果观察[J].中西医结合心血管病电子杂志,2016,4(31):154-155.
[13]雷蕊娥,康健.益气活血化痰通络汤治疗急性脑梗死64例疗效分析[J].航空航天医学杂志,2012,23(6):766-767.
[14]刘慧.益气活血化痰通络汤治疗急性脑梗死50例的病例报告[J]中国社区医师,2015,31(34):83,86.
[15]王世彬,程丽平,李冲,等.自拟化痰通络汤治疗急性脑梗死的临床疗效及对血清VEGF、Ang-2水平的影响[J].中医药导报,2015,21(6):100-103.
[2]唐世球,杨辉,周丽华,等.化痰通络汤治疗急性脑梗死的临床观察[J].中国中医急症,2016,25(10):1973-1975.
[3]何光洪.益气活血化痰通络汤治疗急性脑梗死临床疗效观察[J].亚太传统医药,2016,12(19):145-146.
[4]张元明.化痰通腑法治疗急性脑梗死痰热腑实证的疗效及对Hcy的影响[D].北京:北京中医药大学,2017.
[5]各类脑血管疾病诊断要点[J].中华神经外科杂志,1997,13(1):6-8.
[6]国家中医药管理局脑病急症科研协作组.中风病中医诊断与疗效评定标准[J].北京中医药大学学报,1996,19(1):55-56.
[7]中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[8]季平,郭翠敏.活血化痰通腑醒脑汤治疗脑梗死的效果观察[J].中西医结合心血管病电子杂志,2016,4(13):61,64.
[9]史文.益气活血化痰通络汤治疗急性脑梗死患者的临床效果[J].医疗装备,2016,29(24):143-144.
[10]曹新超.风痰阻络型急性脑梗死采取依达拉奉联合祛风化痰通络汤治疗的临床效果[J].临床医学研究与实践,2018,3(6):119-120.
[11]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[12]朱静德.急性脑梗死患者行益气活血化痰通络汤治疗的效果观察[J].中西医结合心血管病电子杂志,2016,4(31):154-155.
[13]雷蕊娥,康健.益气活血化痰通络汤治疗急性脑梗死64例疗效分析[J].航空航天医学杂志,2012,23(6):766-767.
[14]刘慧.益气活血化痰通络汤治疗急性脑梗死50例的病例报告[J]中国社区医师,2015,31(34):83,86.
[15]王世彬,程丽平,李冲,等.自拟化痰通络汤治疗急性脑梗死的临床疗效及对血清VEGF、Ang-2水平的影响[J].中医药导报,2015,21(6):100-103.