维生素D缺乏与心血管疾病关系的研究进展
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摘要
维生素D是一种脂溶性激素原,主要通过与维生素D受体结合在钙与骨代谢过程中起着至关重要的作用。最近研究发现维生素D缺乏除了与骨骼肌肉疾病、结缔组织疾病、等有关外,还与心血管疾病密切相关。但是,许多研究提出了与早期研究相矛盾的结果,也引起了广泛的关注。本文将总结近年来该领域的一些重要研究结果并对维生素D缺乏与心血管疾病危险因素发展的关系进行综述。
Vitamin D, a kind of fat-soluble prohormone, plays a pretty crucial role in the metabolic process of calcium and bone by combining with vitamin D receptor. Recent studies have found that lack of vitamin D is not only related to musculoskeletal diseases, connective tissue diseases, and immune system diseases, but also closely associated with angiocardiopathy. However, many studies have proposed the results that are contrary to earlier researches and have aroused wide attention. The review will summarize some important study results in this field in recent years and make a conclusion on the relationship between vitamin D deficiency and the development of angiocardiopathy hazards.
Vitamin D, a kind of fat-soluble prohormone, plays a pretty crucial role in the metabolic process of calcium and bone by combining with vitamin D receptor. Recent studies have found that lack of vitamin D is not only related to musculoskeletal diseases, connective tissue diseases, and immune system diseases, but also closely associated with angiocardiopathy. However, many studies have proposed the results that are contrary to earlier researches and have aroused wide attention. The review will summarize some important study results in this field in recent years and make a conclusion on the relationship between vitamin D deficiency and the development of angiocardiopathy hazards.
引文
[1]陈伟伟,高润霖,刘力生,等.《中国心血管病报告2017》概要[J].中国循环杂志, 2018,33(1):1-8.
[2] KIMLIN MG. Geographic location and vitamin D synthesis[J]. Mol Aspects Med, 2008, 29(6):453-461.
[3] KOLASZKO A, NOWALANY-KOZIELSKA E, CERANOWICZ P,et al. The role of parathyroid hormone and vitamin D serum concentrations in patients with cardiovascular diseases[J]. Dis Markers,2018, 2018(9):5287573.
[4]索涛,胡克.维生素D对常见呼吸系统疾病的影响[J].海南医学,2017, 28(15):2516-2519.
[5] MITHAL A, WAHL DA, BONJOUR JP, et al. Global vitamin D status and determinants of hypovitaminosis D[J]. Osteoporos Int, 2009,20(11):1807-1820.
[6] LEE JH, O'KEEFE JH, BELL D, et al. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?c[J].J Am Coll Cardiol, 2008,c52(24):1949-1956.
[7] HAQ A, SVOBODOVA J, IMRAN S, et al. Vitamin D deficiency:A single centre analysis of patients from 136 countries[J]. J Steroid Biochem Mol Biol, 2016, 164:209-213.
[8] YETLEY EA. Assessing the vitamin D status of the US population[J]. Am J Clin Nutr, 2008, 88(2):558S-564S.
[9] HYPPONEN E, POWER C. Hypovitaminosis D in British adults at age 45 y:nationwide cohort study of dietary and lifestyle predictors[J]. Am J Clin Nutr, 2007, 85(3):860-868.
[10] BREWER LC, MICHOS D, REIS JP. Vitamin D in atherosclerosis,vascular disease, and endothelial function[J]. Curr Drug Targets,2011, 12(1):54-60.
[11] MARTINI LA, WOOD RJ. Vitamin D status and the metabolic syndrome[J]. Nutr Rev, 2006, 64(11):479-486.
[12] ANDERSON JL, MAY HT, HORNE BD, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population[J]. Am J Cardiol,2010, 106(7):963-968.
[13] MILAZZO V, DE METRIO M, COSENTINO N, et al. Vitamin D and acute myocardial infarction[J]. World J Cardiol, 2017, 9(1):14-20.
[14] LUND B, BADSKJAER J, LUND B, et al. Vitamin D and ischaemic heart disease[J]. Horm Metab Res, 1978, 10(6):553-556.
[15] DZIEDZIC EA, G?SIOR JS, PAW?OWSKI M, et al. Association of vitamin D deficiency and degree of coronary artery disease in cardiac patients with type 2 diabetes[J]. J Diabetes Res, 2017, 2017:3929075.
[16] GIOVANNUCCI E, LIU Y, HOLLIS BW, et al. 25-hydroxyvitamin D and risk of myocardial infarction in men:a prospective study[J].Arch Intern Med, 2008,168(11):1174-1180.
[17] SIMPSON RU, HERSHEY SH, NIBBELINK KA. Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse[J]. J Steroid Biochem Mol Biol, 2007, 103(3-5):521-524.
[18] WENG S, SPRAGUE JE, OH J, et al. Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice[J].PLoS One, 2013, 8(1):e54625.
[19] DORJGOCHOO T, OU SHU X, XIANG YB, et al. Circulating 25-hydroxyvitamin D levels in relation to blood pressure parameters and hypertension in the Shanghai Women's and Men's Health Studies[J].Br J Nutr, 2012, 108(3):449-458.
[20] BELEN E,?AHIN?, GüNG?R B, et al. Assessment of 25-hydroxyvitamin D levels in patients with resistant hypertension[J].Med Princ Pract, 2016, 25(1):25-30.
[21] VAIDYA A, SUN B, FORMAN JP, et al. The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians[J]. Clinical Endocrinology, 2011,74(6):783-790.
[22] LM M, FP B, MM J, et al. Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a populationbased cohort study[J]. ESC Heart Failure, 2016, 3(3):189-197.
[23] GULLESTAD L, UELAND T, VINGE LE, et al. Inflammatory cytokines in heart failure:mediators and markers[J]. Cardiology, 2012,122(1):23-35.
[24] BAE S, SINGH SS, YU H, et al. Vitamin D signaling pathway plays an important role in the development of heart failure after myocardial infarction[J]. J Appl Physiol(1985), 2013, 114(8):979-987.
[25] YAO HC, LI XY2, HAN QF, et al. Elevated serum soluble ST2 levels may predict the fatal outcomes in patients with chronic heart failure[J]. Int J Cardiol, 2015, 186:303-304.
[26] MASSON S, BARLERA S2, COLOTTA F, et al. A low plasma 1,25(OH)2vitamin D/PTH(1-84)ratio predicts worsening of renal function in patients with chronic heart failure[J]. Int J Cardiol, 2016,224:220-225.
[27] CERIT L. Genetic variation in vitamin D receptor gene(Fok1:rs2228570)is associated with risk of coronary artery disease[J]. Biomarkers, 2017, 22(3-4):387.
[28] SCRAGG R, STEWART AW, WAAYER D, et al. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study:a randomized clinical trial[J]. JAMA Cardiol, 2017, 2(6):608-616.
[29] ZITTERMANN A, ERNST JB, PROKOP S, et al. Effect of vitamin D on all-cause mortality in heart failure(EVITA):a 3-year randomized clinical trial with 4000 IU vitamin D daily[J]. Eur Heart J,2017, 38(29):2279-2286.
[30] PFEIFER M, BEGEROW B, MINNE HW, et al. Effects of a shortterm vitamin D(3)and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women[J]. J Clin Endocrinol Metab, 2001, 86(4):1633-1637.
[31] SCRAGG R, SLOW S2, STEWART AW, et al. Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults:a randomized controlled trial[J]. Hypertension, 2014, 64(4):725-730.
[32] ARORA P, SONG Y, DUSEK J, et al. Vitamin D therapy in individuals with prehypertension or hypertension:the DAYLIGHT trial[J].Circulation, 2015, 131(3):254-262.
[33] WU L, SUN D. Effects of calcium plus vitamin D supplementation on blood pressure:a systematic review and meta-analysis of randomized controlled trials[J]. J Hum Hypertens, 2017, 31(9):547-554.
[34] RODRIGUEZ AJ, SCOTT D, SRIKANTH V, et al. Effect of vitamin D supplementation on measures of arterial stiffness:a systematic review and meta-analysis of randomised controlled trials[J]. Clinical Endocrinology, 2016, 84(5):645-657.
[2] KIMLIN MG. Geographic location and vitamin D synthesis[J]. Mol Aspects Med, 2008, 29(6):453-461.
[3] KOLASZKO A, NOWALANY-KOZIELSKA E, CERANOWICZ P,et al. The role of parathyroid hormone and vitamin D serum concentrations in patients with cardiovascular diseases[J]. Dis Markers,2018, 2018(9):5287573.
[4]索涛,胡克.维生素D对常见呼吸系统疾病的影响[J].海南医学,2017, 28(15):2516-2519.
[5] MITHAL A, WAHL DA, BONJOUR JP, et al. Global vitamin D status and determinants of hypovitaminosis D[J]. Osteoporos Int, 2009,20(11):1807-1820.
[6] LEE JH, O'KEEFE JH, BELL D, et al. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?c[J].J Am Coll Cardiol, 2008,c52(24):1949-1956.
[7] HAQ A, SVOBODOVA J, IMRAN S, et al. Vitamin D deficiency:A single centre analysis of patients from 136 countries[J]. J Steroid Biochem Mol Biol, 2016, 164:209-213.
[8] YETLEY EA. Assessing the vitamin D status of the US population[J]. Am J Clin Nutr, 2008, 88(2):558S-564S.
[9] HYPPONEN E, POWER C. Hypovitaminosis D in British adults at age 45 y:nationwide cohort study of dietary and lifestyle predictors[J]. Am J Clin Nutr, 2007, 85(3):860-868.
[10] BREWER LC, MICHOS D, REIS JP. Vitamin D in atherosclerosis,vascular disease, and endothelial function[J]. Curr Drug Targets,2011, 12(1):54-60.
[11] MARTINI LA, WOOD RJ. Vitamin D status and the metabolic syndrome[J]. Nutr Rev, 2006, 64(11):479-486.
[12] ANDERSON JL, MAY HT, HORNE BD, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population[J]. Am J Cardiol,2010, 106(7):963-968.
[13] MILAZZO V, DE METRIO M, COSENTINO N, et al. Vitamin D and acute myocardial infarction[J]. World J Cardiol, 2017, 9(1):14-20.
[14] LUND B, BADSKJAER J, LUND B, et al. Vitamin D and ischaemic heart disease[J]. Horm Metab Res, 1978, 10(6):553-556.
[15] DZIEDZIC EA, G?SIOR JS, PAW?OWSKI M, et al. Association of vitamin D deficiency and degree of coronary artery disease in cardiac patients with type 2 diabetes[J]. J Diabetes Res, 2017, 2017:3929075.
[16] GIOVANNUCCI E, LIU Y, HOLLIS BW, et al. 25-hydroxyvitamin D and risk of myocardial infarction in men:a prospective study[J].Arch Intern Med, 2008,168(11):1174-1180.
[17] SIMPSON RU, HERSHEY SH, NIBBELINK KA. Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse[J]. J Steroid Biochem Mol Biol, 2007, 103(3-5):521-524.
[18] WENG S, SPRAGUE JE, OH J, et al. Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice[J].PLoS One, 2013, 8(1):e54625.
[19] DORJGOCHOO T, OU SHU X, XIANG YB, et al. Circulating 25-hydroxyvitamin D levels in relation to blood pressure parameters and hypertension in the Shanghai Women's and Men's Health Studies[J].Br J Nutr, 2012, 108(3):449-458.
[20] BELEN E,?AHIN?, GüNG?R B, et al. Assessment of 25-hydroxyvitamin D levels in patients with resistant hypertension[J].Med Princ Pract, 2016, 25(1):25-30.
[21] VAIDYA A, SUN B, FORMAN JP, et al. The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians[J]. Clinical Endocrinology, 2011,74(6):783-790.
[22] LM M, FP B, MM J, et al. Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a populationbased cohort study[J]. ESC Heart Failure, 2016, 3(3):189-197.
[23] GULLESTAD L, UELAND T, VINGE LE, et al. Inflammatory cytokines in heart failure:mediators and markers[J]. Cardiology, 2012,122(1):23-35.
[24] BAE S, SINGH SS, YU H, et al. Vitamin D signaling pathway plays an important role in the development of heart failure after myocardial infarction[J]. J Appl Physiol(1985), 2013, 114(8):979-987.
[25] YAO HC, LI XY2, HAN QF, et al. Elevated serum soluble ST2 levels may predict the fatal outcomes in patients with chronic heart failure[J]. Int J Cardiol, 2015, 186:303-304.
[26] MASSON S, BARLERA S2, COLOTTA F, et al. A low plasma 1,25(OH)2vitamin D/PTH(1-84)ratio predicts worsening of renal function in patients with chronic heart failure[J]. Int J Cardiol, 2016,224:220-225.
[27] CERIT L. Genetic variation in vitamin D receptor gene(Fok1:rs2228570)is associated with risk of coronary artery disease[J]. Biomarkers, 2017, 22(3-4):387.
[28] SCRAGG R, STEWART AW, WAAYER D, et al. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study:a randomized clinical trial[J]. JAMA Cardiol, 2017, 2(6):608-616.
[29] ZITTERMANN A, ERNST JB, PROKOP S, et al. Effect of vitamin D on all-cause mortality in heart failure(EVITA):a 3-year randomized clinical trial with 4000 IU vitamin D daily[J]. Eur Heart J,2017, 38(29):2279-2286.
[30] PFEIFER M, BEGEROW B, MINNE HW, et al. Effects of a shortterm vitamin D(3)and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women[J]. J Clin Endocrinol Metab, 2001, 86(4):1633-1637.
[31] SCRAGG R, SLOW S2, STEWART AW, et al. Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults:a randomized controlled trial[J]. Hypertension, 2014, 64(4):725-730.
[32] ARORA P, SONG Y, DUSEK J, et al. Vitamin D therapy in individuals with prehypertension or hypertension:the DAYLIGHT trial[J].Circulation, 2015, 131(3):254-262.
[33] WU L, SUN D. Effects of calcium plus vitamin D supplementation on blood pressure:a systematic review and meta-analysis of randomized controlled trials[J]. J Hum Hypertens, 2017, 31(9):547-554.
[34] RODRIGUEZ AJ, SCOTT D, SRIKANTH V, et al. Effect of vitamin D supplementation on measures of arterial stiffness:a systematic review and meta-analysis of randomised controlled trials[J]. Clinical Endocrinology, 2016, 84(5):645-657.