饲用碘酸钙/海藻酸钠微胶囊的制备及其稳定性
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摘要
为隔绝饲用碘酸钙[Ca(IO3)2]在贮存过程中与还原性物质,如维生素C(VC)的反应,以Ca(IO3)2为芯材,海藻酸钠(SA)为壁材,纳米碳酸钙(Nano-CaCO3)为交联钙源,采用改良的内源乳化法制备了碘酸钙/海藻酸钠微胶囊(CISAMC)。利用FTIR、SEM、TG、XRD对其进行了结构表征,同时测定了其在VC水溶液中的稳定性,探讨了CISAMC的形成机制。结果表明,CISAMC呈球形,粒径约为10～40μm,表面有大量Ca(IO3)2晶体。Ca(IO3)2和CISAMC在VC水溶液中VC分解50%用时(t50%)分别为54.8和78.3 min,CISAMC使Ca(IO3)2在饲料中的稳定性得到明显提升。
To avoid the reaction of calcium iodate [Ca(IO3)2] with reducing substances,such as vitamin C(VC) during storage in feeds,the microcapsules of calcium iodate(CISAMC) were prepared by improved emulsification/internal gelation with calcium iodate as core material,sodium alginate as wall material and nano-calcium carbonate as cross linker.The microcapsules were characterized by FTIR,SEM,TG and XRD.Its stability in Vc aqueous solution was also systematically measured.The embedding mechanism of CISAMC was proposed according to various analysis results.The results showed that the obtained CISAMC were spherical with a particle size of 10～40 μm and there were a large number of calcium iodate crystals on the surface of CISAMC.The half decomposition ratio time(t50%) of vitamin C by calcium iodate or CISAMC were 54.8 min and 78.3 min,respectively.It was found that CISAMC could significantly improve the stability of Ca(IO3)2 in feeds.
To avoid the reaction of calcium iodate [Ca(IO3)2] with reducing substances,such as vitamin C(VC) during storage in feeds,the microcapsules of calcium iodate(CISAMC) were prepared by improved emulsification/internal gelation with calcium iodate as core material,sodium alginate as wall material and nano-calcium carbonate as cross linker.The microcapsules were characterized by FTIR,SEM,TG and XRD.Its stability in Vc aqueous solution was also systematically measured.The embedding mechanism of CISAMC was proposed according to various analysis results.The results showed that the obtained CISAMC were spherical with a particle size of 10～40 μm and there were a large number of calcium iodate crystals on the surface of CISAMC.The half decomposition ratio time(t50%) of vitamin C by calcium iodate or CISAMC were 54.8 min and 78.3 min,respectively.It was found that CISAMC could significantly improve the stability of Ca(IO3)2 in feeds.
引文
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[2]Du Y,Gao Y,Meng F,et al.Iodine deficiency and excess coexist in China and induce thyroid dysfunction and disease:a cross-sectional study[J].Plos One,2014,9(11):e111937.
[3]Samios D N,Karayannis M I,Hadjiioannou T P.Investigation on the rate law of the reaction of ascorbic acid and iodate.calculation of kinetic parameters applying stopped-flow techniques[J].Zeitschriftfür Physikalische Chemie,1977,104(4/5/6):189-198.
[4]Winger R J,K?nig J,House D A.Technological issues associated with iodine fortification of foods[J].Trends in Food Science&Technology,2008,19(2):94-101.
[5]Mazumdar N,Ahmad S I,Ganie S A,et al.Iodine complexes of acid-functionalized poly(vinyl alcohol)hydrogels:synthesis,characterization and release studies[J].Journal of Polymer Materials,2016,33(1):41-52.
[6]Yin Z J,Xu S Q,Zhan T G,et al.Ultrahigh volatile iodine uptake by hollow microspheres formed from a heteropore covalent organic framework[J].Chemical Communications,2017,53(53):7266-7269.
[7]Zimmermann M B,Wegmueller R,Zeder C,et al.Triple fortification of salt with microcapsules of iodine,iron,and vitamin A[J].The American Journal of Clinical Nutrition,2004,80(5):1283-1290.
[8]?rning P,Hoem K S,Coron A E,et al.Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation[J].Journal of Controlled Release,2016,229:58-69.
[9]Martín M J,Calpena A C,Fernández F,et al.Development of alginate microspheres as nystatin carriers for oral mucosa drug delivery[J].Carbohydrate Polymers,2015,117:140-149.
[10]Hossain K M Z,Patel U,Ahmed I.Development of microspheres for biomedical applications:a review[J].Progress in Biomaterials,2015,4(1):1-19.
[11]Martín M J,Lara-Villoslada F,Ruiz M A,et al.Microencapsulation of bacteria:a review of different technologies and their impact on the probiotic effects[J].Innovative Food Science&Emerging Technologies,2015,27:15-25.
[12]Zhou Mingson(周明松),Liu Qingfang(刘庆芳),Wang Suya(王素雅),et al.Preparation of avermectin microcapsules by electrostatic selfassembly method[J].Fine Chemicals(精细化工),2017,34(5):519-524.
[13]Zou Q,Zhao J,Liu X,et al.Microencapsulation of bifidobacteriumbifidum F-35 in reinforced alginate microspheres prepared by emulsification/internal gelation[J].International Journal of Food Science&Technology,2011,46(8):1672-1678.
[14]Lupo B,Maestro A,Porras M,et al.Preparation of alginate microspheres by emulsification/internal gelation to encapsulate cocoa polyphenols[J].Food Hydrocolloids,2014,38:56-65.
[15]Cai S,Zhao M,Fang Y,et al.Microencapsulation of lactobacillus acidophilus CGMCC1.2686 via emulsification/internal gelation of alginate using Ca-EDTA and Ca CO3 as calcium sources[J].Food Hydrocolloids,2014,39:295-300.
[16]Pérez-Madrigal M M,Torras J,Casanovas J,et al.Paradigm shift for preparing versatile M2+-free gels from unmodified sodium alginate[J].Biomacromolecules,2017,18(9):2967-2979.
[17]Ching S H,Bansal N,Bhandari B.Alginate gel particles-a review of production techniques and physical properties[J].Critical Reviews in Food Science and Nutrition,2017,57(6):1133-1152.
[18]Paques J P,Sagis L M C,van Rijn C J M,et al.Nanospheres of alginate prepared through W/O emulsification and internal gelation with nanoparticles of Ca CO3[J].Food Hydrocolloids,2014,40:182-188.
[19]National Center for Health Inspection and Supervision(卫生部食品卫生监督检验所).Methods of food hygienic analysis-physical and chemical section-general principles(食品卫生检验方法理化部分总则):GB/T 5009.1-2003[S].Beijing:Standards Press of China(北京:中国标准出版社),2003,14-15.
[20]Wang Haijia(王海佳).Study the stability vitamin C by ultraviolet spectrophotometry and determination of the contents in several kinds of fruits,vegetables and juices[D].Taiyuan:Shanxi Medical University(山西医科大学),2015.
[21]Deepa B,Abraham E,Pothan L A,et al.Biodegradable nanocomposite films based on sodium alginate and cellulose nanofibrils[J].Materials,2016,9(1):50.
[22]Na Shasha(那沙沙),Li Weixing(李卫星),Xing Weihong(邢卫红).Development of inorganic nano particles modified sodium alginate hybrid membranes for pervaporation[J].CIESC Journal(化工学报),2016,67(9):3730-3737.
[23]Lin Yueshun(林粤顺),Zhou Xinhua(周新华),Zhou Hongjun(周红军),et al.Preparation and slow-release performance of chlorpyrifos/feather keratin/sodium alginate microspheres[J].Agrochemicals(农药),2014,53(12):892-896
[24]Gasmi H,Danede F,Siepmann J,et al.Does PLGA microparticle swelling control drug release?New insight based on single particle swelling studies[J].Journal of Controlled Release,2015,213:120-127.
[25]Shitole S J.Synthesis and characterization of calcium iodate,monohydrate crystals grown in silica gel[M]//Recent Trends in Physics of Material Science and Technology.Singapore:Springer Science Business Media,2015:245-257.
[26]Kong Q,Wang B,Ji Q,et al.Thermal degradation and flame retardancy of calcium alginate fibers[J].Chinese Journal of Polymer Science,2009,27(6):807-812.
[27]Seebauer V,Petek J,Staudinger G.Effects of particle size,heating rate and pressure on measurement of pyrolysis kinetics by thermogravimetricanalysis[J].Fuel,1997,76(13):1277-1282.