《证治准绳·类方》治疗目病处方的用药规律
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摘要
目的总结《证治准绳·类方》治疗目病处方的用药规律。方法收集《证治准绳·类方》中治疗目病的方剂449首,包含338种药物。应用中医传承辅助平台软件进行频次统计、组方规律分析、药物间关联度分析及新方分析。结果使用频次前5位的药物依次为防风、甘草、当归、黄连、羌活。药性以寒性药物居首,温性药物次之。药味主要以甘、苦、辛为主。主入肝、肺、脾、心、胃、肾等经。临床配伍多由祛风类、补益类、清热类、清肝明目类、行气及活血类药物组成。配伍使用频率最高的核心药物是防风。熵聚类分析发现核心药物组合15组,发现新处方14个。结论《证治准绳·类方》中治疗目病的处方有规律可循,其用药规律对于药物的临床应用及新药的开发具有重要意义。
Objective To summarize the medication rules of prescriptions for treating ocular diseases in Zhengzhi Zhunsheng,Leifang. Methods A total of 449 prescriptions involving 338 kinds of herbs for treating ocular diseases were collected from Zhengzhi Zhunsheng,Leifang. Traditional Chinese Medicine Inheritance Auxiliary Platform was used for frequency statistics,analysis of formulation rules,correlation analysis between medicines and new prescription analysis. Results Five most frequently used herbs were radix sileris,liquorice root,Chinese angelica,golden thread and notopterygium root successively. Herbs with cold nature topped the medicine property list,followed by herbs with warm nature. The main flavors were sweetness,bitterness and pungency. The main meridians included liver meridian,lung meridian,spleen meridian,heart meridian,stomach meridian,and kidney meridian,etc. The clinical formulations were mainly composed of wind-expelling,invigorating,heat-clearing,liver-clearing and vision-improving,qi-promoting and blood-activating herbs. The most frequently used core herb in the formulation was radix sileris. Fifteen core herb groups and 14 new prescriptions were found by Entropy Cluster Analysis. Conclusion Rules exists in the prescriptions for treating ocular diseases in Zhengzhi Zhunsheng,Leifang,and it has an important significance to the clinical application of medicines and the development of new medicines.
Objective To summarize the medication rules of prescriptions for treating ocular diseases in Zhengzhi Zhunsheng,Leifang. Methods A total of 449 prescriptions involving 338 kinds of herbs for treating ocular diseases were collected from Zhengzhi Zhunsheng,Leifang. Traditional Chinese Medicine Inheritance Auxiliary Platform was used for frequency statistics,analysis of formulation rules,correlation analysis between medicines and new prescription analysis. Results Five most frequently used herbs were radix sileris,liquorice root,Chinese angelica,golden thread and notopterygium root successively. Herbs with cold nature topped the medicine property list,followed by herbs with warm nature. The main flavors were sweetness,bitterness and pungency. The main meridians included liver meridian,lung meridian,spleen meridian,heart meridian,stomach meridian,and kidney meridian,etc. The clinical formulations were mainly composed of wind-expelling,invigorating,heat-clearing,liver-clearing and vision-improving,qi-promoting and blood-activating herbs. The most frequently used core herb in the formulation was radix sileris. Fifteen core herb groups and 14 new prescriptions were found by Entropy Cluster Analysis. Conclusion Rules exists in the prescriptions for treating ocular diseases in Zhengzhi Zhunsheng,Leifang,and it has an important significance to the clinical application of medicines and the development of new medicines.
引文
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[11]李翔,周春阳,叶河江,等.廖品正教授治疗目痒经验[J].中国中医眼科杂志,2011,21(3):157-158.
[2] Zhao J,Ellwein LB,Cui H,et al. Prevalence of vision impairment in older adults in rural China:the China nine-province survey[J]. Ophthalmology,2010,117(3):409-416. e1.
[3]卢朋,李健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012,18(9):1-4.
[4]韩锋,刘国伟,刘超,等.基于中医传承辅助系统的痹证治疗方剂组方规律分析[J].中国实验方剂学杂志,2013,19(24):338-341.
[5]余瀛鳌.王肯堂主编两部医学丛书赞述[J].中医文献杂志,2008(6):1-4.
[6]王肯堂.证治准绳(二)类方证治准绳[M].北京:人民卫生出版社,2014:511-606.
[7]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术-中医药现代化,2009,11(2):225-228.
[8]庞万敏,张彬,张瑞华,等.庞赞襄老中医“目病多郁”论[J].山西中医,1986,2(5):15-16.
[9]强云升.白内障术后恢复应用中药联合西药抗炎药的作用分析[J].世界最新医学信息文摘(电子版),2016,16(16):141-142.
[10]侯乐,梁丽娜,唐由之.唐由之研究员运用辛散药治疗眼底病的体会[J].中国中医眼科杂志,2015,25(3):195-196.
[11]李翔,周春阳,叶河江,等.廖品正教授治疗目痒经验[J].中国中医眼科杂志,2011,21(3):157-158.