妊娠期高血压疾病合并高尿酸血症孕妇血清尿酸监测的临床意义
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摘要
目的:探讨妊娠期高血压疾病孕妇血清尿酸监测的临床意义及对妊娠结局影响。方法:2015年4月—2016年4月本院收治的妊娠期高血压孕妇150例,按照血清尿酸水平分为高尿酸血组72例、尿酸正常组78例。选择同期本院产前检查的健康孕妇74例为正常对照组。对比3组血清尿酸水平变化及妊娠结局。结果:妊娠高血压孕妇血清尿酸水平高于正常对照组,且血压分期越高血清尿酸水平越高(P<0.05);高尿酸组剖宫产率以及早产、胎膜早破、胎盘早剥、胎儿宫内窘迫发生率均最高(P<0.05)。结论:妊娠期高血压疾病孕妇尿酸水平随高血压严重程度增加而提升,增加不良妊娠结局发生风险,动态监测血尿酸水平对妊娠期高血压病情评估具有重要作用,需引起临床高度关注。
Objective:To explore the clinical significance of serum uric acid monitoring in pregnant women with gestational hypertension and its effect on pregnancy outcome.Methods:From April 2015 to April 2016,150 women with pregnancy-induced hypertension in Xinchang people's hospital were divided into 72 women in high uric acid blood group and 78 women in normal uric acid group according to their serum uric acid level.74 healthy pregnant women who selected for prenatal examination in the same period were in normal control group.Change of serum uric acid levels and pregnancy outcomes were compared among the three 3 groups.Results:Serum uric acid level of pregnant women with gestational hypertension was higher than that of women in normal control group,and the serum uric acid level became higher and higher followed the blood pressure increased(P<0.05).The rate of cesarean section,premature delivery,premature rupture of the membranes,early abruption of the placenta and fetal distress of women in high uric acid group were all significant higher than those of women in normal uric acid group and in normal control group(P <0.05).Conclusion:The uric acid level of pregnant woman with gestational hypertension disease increases following the severity of hypertension and ascension,which also increases the risk of adverse pregnancy outcomes.The dynamic monitoring of blood uric acid level plays an important role in gestational hypertension disease assessment,and it should be paid close attention to in clinical.
Objective:To explore the clinical significance of serum uric acid monitoring in pregnant women with gestational hypertension and its effect on pregnancy outcome.Methods:From April 2015 to April 2016,150 women with pregnancy-induced hypertension in Xinchang people's hospital were divided into 72 women in high uric acid blood group and 78 women in normal uric acid group according to their serum uric acid level.74 healthy pregnant women who selected for prenatal examination in the same period were in normal control group.Change of serum uric acid levels and pregnancy outcomes were compared among the three 3 groups.Results:Serum uric acid level of pregnant women with gestational hypertension was higher than that of women in normal control group,and the serum uric acid level became higher and higher followed the blood pressure increased(P<0.05).The rate of cesarean section,premature delivery,premature rupture of the membranes,early abruption of the placenta and fetal distress of women in high uric acid group were all significant higher than those of women in normal uric acid group and in normal control group(P <0.05).Conclusion:The uric acid level of pregnant woman with gestational hypertension disease increases following the severity of hypertension and ascension,which also increases the risk of adverse pregnancy outcomes.The dynamic monitoring of blood uric acid level plays an important role in gestational hypertension disease assessment,and it should be paid close attention to in clinical.
引文
[1]李明,李玉秀.肾病综合征妊娠期高血压患者临床特点及其对母婴的影响研究[J].中国全科医学,2013,16(11):1228-1229.
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[3]覃春莲,谢娟,周靓,等.科素亚治疗高尿酸血症合并高血压患者的临床分析[J].中南医学科学杂志,2013,41(5):490-491.
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[7]纪国欣,赵慧栋,吴纪芬,等.妊娠期高尿酸血症研究新进展[J].中国计划生育和妇产科,2016,8(3):9-12.
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[10]孙毅.CD105在妊娠期高血压发病机制的研究进展[J].中国计划生育学杂志,2016,24(3):199-200.
[11]狄英波,白洋.妊娠期高血压疾病与尿微量白蛋白和血清胱抑素的相关性研究[J].中国妇幼保健,2013,28(33):5457-5458.
[12]陈园园,李红梅.VEGF和vWF与妊娠期高血压疾病发病机制的相关性探讨[J].西南国防医药,2014,24(8):917-919.
[13]秦秀妹,彭凌湘.妊娠期高血压疾病血尿酸检测临床分析[J].中国妇幼健康研究,2014,25(3):448-449.
[14]Wang S F,Shu L,Wang S,et al.Gender difference in the association of hyperuricemia with hypertension in a middleaged Chinese population.[J].Blood Pressure,2014,23(6):339.
[15]Yokokawa H,Fukuda H,Suzuki A,et al.Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286Japanese Workers[J].Journal of Clinical Hypertension,2016,18(1):53-59.
[16]马丽华,戴雁彦.高血压合并高尿酸血症的相关研究进展[J].中国循证心血管医学杂志,2014,6(5):643-644.
[17]宋健,黄亚绢,陆继红.子痫前期孕妇的血清尿酸水平对母胎妊娠结局的预测作用[J].国际妇产科学杂志,2017,44(2):219-221.
[18]周晓珍,娄甜平,周桂月.妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义[J].生殖医学杂志,2013,22(11):855-859.
[2]周艳琼.妊娠期高血压疾病肾脏损伤与母婴结局的相关性研究[J].中国妇幼保健,2016,31(8):1613-1615.
[3]覃春莲,谢娟,周靓,等.科素亚治疗高尿酸血症合并高血压患者的临床分析[J].中南医学科学杂志,2013,41(5):490-491.
[4]林静,李红.妊娠期高血压疾病孕妇血清尿酸监测的临床意义[J].中国妇产科临床杂志,2016,17(6):546-548.
[5]沈菊芳,钱隽,金秋明,等.妊娠期高血压疾病患者乳酸脱氢酶水平的变化及其对妊娠结局的影响?[J].成都医学院学报,2015,10(5):541-543.
[6]马莉.高尿酸血症与妊娠高血压的关系研究[J].中国医药导刊,2013,15(3):421-422.
[7]纪国欣,赵慧栋,吴纪芬,等.妊娠期高尿酸血症研究新进展[J].中国计划生育和妇产科,2016,8(3):9-12.
[8]谢幸,苟文丽.妇产科学.第8版[M].人民卫生出版社,2013:97.
[9]Roberts J M,Mascalzoni D,Ness R B,et al.Collaboration to Understand Complex Diseases:Preeclampsia and Adverse Pregnancy Outcomes[J].Hypertension,2016,67(4):681-687.
[10]孙毅.CD105在妊娠期高血压发病机制的研究进展[J].中国计划生育学杂志,2016,24(3):199-200.
[11]狄英波,白洋.妊娠期高血压疾病与尿微量白蛋白和血清胱抑素的相关性研究[J].中国妇幼保健,2013,28(33):5457-5458.
[12]陈园园,李红梅.VEGF和vWF与妊娠期高血压疾病发病机制的相关性探讨[J].西南国防医药,2014,24(8):917-919.
[13]秦秀妹,彭凌湘.妊娠期高血压疾病血尿酸检测临床分析[J].中国妇幼健康研究,2014,25(3):448-449.
[14]Wang S F,Shu L,Wang S,et al.Gender difference in the association of hyperuricemia with hypertension in a middleaged Chinese population.[J].Blood Pressure,2014,23(6):339.
[15]Yokokawa H,Fukuda H,Suzuki A,et al.Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286Japanese Workers[J].Journal of Clinical Hypertension,2016,18(1):53-59.
[16]马丽华,戴雁彦.高血压合并高尿酸血症的相关研究进展[J].中国循证心血管医学杂志,2014,6(5):643-644.
[17]宋健,黄亚绢,陆继红.子痫前期孕妇的血清尿酸水平对母胎妊娠结局的预测作用[J].国际妇产科学杂志,2017,44(2):219-221.
[18]周晓珍,娄甜平,周桂月.妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义[J].生殖医学杂志,2013,22(11):855-859.