宣肺通络止咳颗粒联合孟鲁司特钠治疗小儿变异性哮喘的疗效观察及其对hs-CRP IgE、TNF-α、IL-6的影响
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摘要
目的:观察中药宣肺通络止咳颗粒与孟鲁司特钠联合治疗儿童变异性哮喘(CVA)的临床疗效及其对hs-CRP(超敏C-反应蛋白)、TNF-α(肿瘤坏死因子α)、IL-6(白细胞介素-6)和Ig E水平的影响。方法:114例CVA患儿随机分为孟鲁司特钠治疗对照组和宣肺通络止咳颗粒与孟鲁司特钠联合治疗观察组,连续治疗4周,评定疗效,观察咳嗽、咳痰、咽痒症状改善;治疗前后检测患儿肺功能及hs-CRP、Ig E、TNF-α和IL-6水平。结果:观察组患儿疗效明显优于对照组(94. 7%VS 80. 7%,P <0. 05);治疗后两组咳嗽、咳痰、咽痒症状明显改善,肺功能(FEV1、FVC、FEV1/FVC)明显提高,血hs-CRP、Ig E、TNF-α、IL-6水平明显降低;上述指标观察组效果均明显于对照组(P <0. 05)。结论:中药宣肺通络止咳颗粒与孟鲁司特钠联合可明显提高CVA患儿的临床疗效,缓解临床症状,减轻气道炎症反应,降低气道高反应性。
Objective:To observe the curative effect of infant CVA treated with Xuanfei Tongluo Zhike Granule combining with Montelukast Sodium and its impacts on hs-CRP,Ig E,TNF-αand IL-6 levels.Methods:114 Cases with CVA were randomly divided into Western medicine control group and Xuanfei Tongluo Zhike Granule combining with Montelukast Sodium observation group,each with 57 cases.They were treated for4 weeks,then appraised the curative effect,meanwhile observing the improvement of symptoms,changes of pulmonary function,hs-CRP,Ig E,TNF-αand IL-6 levels before and after treatment.Results:The curative effect of observation group was better than that of control( 94.7% VS 80.7%,P < 0.05); after treatment,clinical symptoms,pulmonary function were improved and hs-CRP,Ig E,TNF-αand IL-6 levels were lowered significantly in the two groups,the effects of observation group were more significant than those in control group( P < 0.05).Conclusion:Xuanfei Tongluo Zhike Granule combining with Montelukast Sodium can enhance the curative effect of infant CVA,relieve symptoms,alleviate airway inflammation and hyper reactivity.
Objective:To observe the curative effect of infant CVA treated with Xuanfei Tongluo Zhike Granule combining with Montelukast Sodium and its impacts on hs-CRP,Ig E,TNF-αand IL-6 levels.Methods:114 Cases with CVA were randomly divided into Western medicine control group and Xuanfei Tongluo Zhike Granule combining with Montelukast Sodium observation group,each with 57 cases.They were treated for4 weeks,then appraised the curative effect,meanwhile observing the improvement of symptoms,changes of pulmonary function,hs-CRP,Ig E,TNF-αand IL-6 levels before and after treatment.Results:The curative effect of observation group was better than that of control( 94.7% VS 80.7%,P < 0.05); after treatment,clinical symptoms,pulmonary function were improved and hs-CRP,Ig E,TNF-αand IL-6 levels were lowered significantly in the two groups,the effects of observation group were more significant than those in control group( P < 0.05).Conclusion:Xuanfei Tongluo Zhike Granule combining with Montelukast Sodium can enhance the curative effect of infant CVA,relieve symptoms,alleviate airway inflammation and hyper reactivity.
引文
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[11]王曼芝,何庆南,袁红霞,等.IL-4 IL-5及Ig E在儿童咳嗽变异性哮喘中的价值[J].中国当代儿科杂志,2006,8(5):382-384.
[12]林俊荣,刘日阳.MMP9及炎性因子TNF-α、IL-4在小儿变异性哮喘中的诊断价值[J].辽宁医学院学报,2015,36(6):50-52.
[2]苏家辉.小儿咳嗽变异性哮喘治疗的研究进展[J].现代医学与健康研究,2019,2(19):172-173.
[3]吴东升,张彧,李玲,等.中西医结合治疗小儿咳嗽变异性哮喘的Meta分析[J].中医药学报,2016,44(2):19-23.
[4]中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-752.
[5]国家中医药管理理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:286.
[6]NIIMI A.Cough and asthma[J].Curr Respir Med Rev,2011,7(1):47-54.
[7]高明,任章平,谢彩,等.孟鲁司特钠治疗小儿咳嗽变异性哮喘的疗效分析[J].检验医学与临床,2014,11(21):3059-3060.
[8]郭玉兰,郦银芳,张莉.肺功能检查对小儿哮喘及咳嗽变异性哮喘的临床应用价值[J].中国医学前沿杂志(电子版),2015,7(12):81-83.
[9]张灵芳,凌杰.儿童咳嗽变异性哮喘治疗前后血清超敏C反应蛋白、白细胞介素-10和肿瘤坏死因子-α水平的变化[J].中国药物与临床,2014,14(5):642-643.
[10]徐巍,鲁继荣,高曼.Ig E、EOS及肺功能的检测在咳嗽变异性哮喘患儿中的临床意义[J].中国妇幼保健,2009,24(2):261-263.
[11]王曼芝,何庆南,袁红霞,等.IL-4 IL-5及Ig E在儿童咳嗽变异性哮喘中的价值[J].中国当代儿科杂志,2006,8(5):382-384.
[12]林俊荣,刘日阳.MMP9及炎性因子TNF-α、IL-4在小儿变异性哮喘中的诊断价值[J].辽宁医学院学报,2015,36(6):50-52.