速度向量成像技术在评价甲状腺功能亢进性心脏病大鼠心功能中的应用
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摘要
目的应用速度向量成像(VVI)评价甲状腺功能亢进性心脏病(甲亢性心脏病)大鼠心功能。方法复制甲亢性心脏病大鼠模型,经超声VVI软件、检测大鼠血清TT3和TT4水平及电镜观察超微结构评价甲亢性心脏病大鼠心功能。结果模型组的收缩期和舒张期纵向峰值速度(Vs、Vd)、纵向峰值应变(Sr)及收缩期和舒张期纵向峰值应变率均低于对照组(P <0.05)。与对照组比较,模型组血清T3、T4浓度增高(P <0.05)。对照组大鼠心肌组织电镜下示心肌结构无变化,未见增生的心肌纤维结构。模型组可见心肌间质纤维化。结论VVI技术对评价甲亢性心脏病心功能有重要作用。
Objective To evaluate the cardiac function in rats with hyperthyroid heart disease by velocity vector imaging(VVI). Methods Rat models of hyperthyroid heart disease were established. The levels of serum TT3, TT4 and electron microscopy in the minor changes of rats of hyperthyroid heart disease were detected by ultrasound VVI. Results The systolic and diastolic radial velocity(Vs, Vd), radial strain(Sr), systolic and diastolic radial strain rate(SRr) of model group were lower than control group(P < 0.05). Serum TT3 and TT4 levels of model group were increased(P < 0.05) compared with the control group. There was no significant change for myocardial structure and no obvious hypertrophic myocardial fiber structure in the control group. The degree of myocardial interstitial fibrosis in the model group was significantly higher than that in the control group. Conclusion VVI plays an important role in evaluating the cardiac function of hyperthyroid heart disease.
Objective To evaluate the cardiac function in rats with hyperthyroid heart disease by velocity vector imaging(VVI). Methods Rat models of hyperthyroid heart disease were established. The levels of serum TT3, TT4 and electron microscopy in the minor changes of rats of hyperthyroid heart disease were detected by ultrasound VVI. Results The systolic and diastolic radial velocity(Vs, Vd), radial strain(Sr), systolic and diastolic radial strain rate(SRr) of model group were lower than control group(P < 0.05). Serum TT3 and TT4 levels of model group were increased(P < 0.05) compared with the control group. There was no significant change for myocardial structure and no obvious hypertrophic myocardial fiber structure in the control group. The degree of myocardial interstitial fibrosis in the model group was significantly higher than that in the control group. Conclusion VVI plays an important role in evaluating the cardiac function of hyperthyroid heart disease.
引文
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[17]KIM B H,CHO K I,KIM S M,et al.Heart rate reduction with ivabradine prevents thyroid hormone-induced cardiac remodeling in rat[J].Heart Vessels,2013,28(4):524-535.
[2]RUOTSALAINEN H,BELLSHAM-REVELL H,BELL A,et al.Right ventricular systolic function in hypoplastic left heart syndrome:a comparison of velocity vector imaging and magnetic resonance imaging[J].Eur Heart J Cardiovasc Imaging,2016,17(6):687-692.
[3]刘昕,王建华,丁桂春.超声斑点跟踪技术评价原发性高血压患者左心室整体收缩功能[J].中国医学影像技术,2010,26(7):1254-1257.
[4]马新欣,张跃力,王曼,等.自发性高血压大鼠左心室心肌应变与心肌纤维化程度的相关性[J].中国医学影像技术,2017,33(2):161-166.
[5]金松南,金景玉,苏延友,等.钙通道阻滞剂对甲亢性高血压大鼠胸主动脉舒张反应的影响[J].中国药理学通报,2009,25(12):1615-1618.
[6]SZKUDLAREK A C,ALDENUCCI B,MIYAGUI N I,et al.Shortterm thyroid hormone excess affects the heart but does not affect adrenal activity in rats[J].Arquivos Brasileiros de Cardiologia,2014,102(3):270-278.
[7]赵晓燕,苏金林,温旭凯,等.非诺贝特对慢性心力衰竭患者心肌纤维化和心功能的影响[J].中国现代医学杂志,2013,23(29):46-50.
[8]李萌,吕仕超,吴美芳,等.不同原因诱导的心肌纤维化动物模型的建立[J].医学研究生学报,2014,27(3):330-334.
[9]杨俊华,施亚明,周炳元,等.动态三维超声测量心肌梗死后左心室容积的实验研究[J].医学研究生学报,2005(S1):14-16.
[10]王书亚.经胸超声心动图在常用实验动物中切面及指标选择的实验研究[D].苏州:苏州大学,2012.
[11]WANG X,LIAN Y,WANG X,et al.Study of regional left ventricular longitudinal function in fetuses with gestational diabetes mellitus by velocity vector imaging[J].Echocardiography,2016,33(8):1228-1233.
[12]YANG Z R,ZHOU Q C,LEE L,et al.Quantitative assessment of left ventricular systolic function in patients with coronary heart disease by velocity vector imaging[J].Echocardiography,2012,29(3):340-345.
[13]YURDAKUL S,ERDEMIR V A,TAYYARECI Y,et al.Subclinical left and right ventricular systolic dysfunction in Behcet’s disease:a combined tissue doppler and velocity vector imaging study[J].J Clin Ultrasound,2013,41(6):347-353.
[14]AZAM S,DESJARDINS C L,SCHLUCHTER M,et al.Comparison of velocity vector imaging echocardiography with magnetic resonance imaging in mouse models of cardiomyopathy[J].Circ Cardiovasc Imaging,2012,5(6):776-781.
[15]ZENG S,JIANG T,ZHOU Q C,et al.Time-course changes in left ventricular myocardial deformation in STZ-induced rabbits on velocity vector imaging[J].Cardiovasc Ultrasound,2014(12):17.
[16]ZHANG H,WEI Z,ZHU X,et al.Assessment of left ventricular myocardial systolic acceleration in diabetic rats using velocity vector imaging[J].J Ultrasound Med,2014,33(5):875-883.
[17]KIM B H,CHO K I,KIM S M,et al.Heart rate reduction with ivabradine prevents thyroid hormone-induced cardiac remodeling in rat[J].Heart Vessels,2013,28(4):524-535.