脂代谢紊乱患者牙种植体稳定性的评价
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摘要
目的研究脂代谢紊乱的牙列缺损患者种植义齿修复后唾液中炎性细胞因子表达和种植体稳定性,分析脂代谢紊乱患者的种植预后状况。方法将脂代谢紊乱的牙列缺损患者设为实验组,血脂健康的牙列缺损患者设为对照组,在种植前,种植后1个月、3个月收集患者唾液,ELISA方法检测唾液中的白细胞介素6(IL-6)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)表达,Osstell ISQTM共振频率无线分析仪检测种植体的稳定性,并用Florida探针检测牙周状况。结果 2组种植后探诊深度(PD)、出血指数(BI)、共振频率无线分析仪检测种植体稳定系数(ISQ)无统计学差异(均P>0.05)。2组种植前,种植后1个月、3个月ISQ值,IL-6、IL-1β、TNF-α表达比较差异有统计学意义(均P<0.05)。种植前实验组IL-6、IL-1β、TNF-α的表达高于对照组(均P<0.05);而实验组种植后3个月与对照组种植前IL-6、IL-1β、TNF-α的表达均无统计学差异(均P>0.05)。结论种植术后脂代谢紊乱患者同血脂健康者一样具有良好的种植体稳定性,即脂代谢紊乱患者同样可以取得良好的种植预后。
Objective To study the expression of inflammatory factors in the saliva and the stability of implants after implant denture repair in patients with dysplasia of the dentition defect,and to analyze the prognosis of patients with lipid metabolic disorder. Methods The dentition defect patients with lipid metabolism disorder were selected as the experimental group. Patients with lipid defect were selected as the control group. Saliva was collected before implantation,1 month and 3 months after implantation. ELISA method was used to detect IL-6,IL-1β and TNF-α. Osstell ISQTMradio frequency analyzer was used to detect the stability of the implants and the periodontal status was detected by Florida probe. Results There were no significant differences in the depth of implant probing(PD),bleeding index(BI)and ISQ between the two groups by radio frequency analyzer(all P > 0.05). The levels of IL-6,IL-1β and TNF-α in the pre-implantation,1 month and 3 months after implantation were significantly higher than those in the control group(all P < 0.05). The levels of IL-6,IL-1β and TNF-α in the experimental group were significantly higher than those in the control group before planting(all P < 0.05)3 months after planting,there were no significant differences of IL-6,IL-1β,and TNF-α between the experimental group and control group(all P > 0.05). Conclusion The patients with dyslipidemia after implantation have good implant stability as those with normal blood lipid,and the patients with dyslipidemia can also obtain good prognosis.
Objective To study the expression of inflammatory factors in the saliva and the stability of implants after implant denture repair in patients with dysplasia of the dentition defect,and to analyze the prognosis of patients with lipid metabolic disorder. Methods The dentition defect patients with lipid metabolism disorder were selected as the experimental group. Patients with lipid defect were selected as the control group. Saliva was collected before implantation,1 month and 3 months after implantation. ELISA method was used to detect IL-6,IL-1β and TNF-α. Osstell ISQTMradio frequency analyzer was used to detect the stability of the implants and the periodontal status was detected by Florida probe. Results There were no significant differences in the depth of implant probing(PD),bleeding index(BI)and ISQ between the two groups by radio frequency analyzer(all P > 0.05). The levels of IL-6,IL-1β and TNF-α in the pre-implantation,1 month and 3 months after implantation were significantly higher than those in the control group(all P < 0.05). The levels of IL-6,IL-1β and TNF-α in the experimental group were significantly higher than those in the control group before planting(all P < 0.05)3 months after planting,there were no significant differences of IL-6,IL-1β,and TNF-α between the experimental group and control group(all P > 0.05). Conclusion The patients with dyslipidemia after implantation have good implant stability as those with normal blood lipid,and the patients with dyslipidemia can also obtain good prognosis.
引文
[1]中华医学会心血管病学分会,中国老年学学会心脑血管病专业委员会.血脂相关性心血管剩留风险控制的中国专家共识[J].中华心血管病杂志,2012,40(7):547-553.DOI:10.3760/cma.j.issn.0253-3758.2012.07.002.
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[11]MAGAN-FERNANDEZ A,PAPAY-RAMIREZ L,TOMAS J,et a1.Association of simvastatin and hyperlipidemia with periodontal status and bone metabolism markers[J].J Periodontol,2014,85(10):1405.DOI:10.1902/jop.2014.130652.
[12]JUEGINA S,DALIA G,RICARDAS K,et al.Cytokine production by leukocytes in patients with periodontitis[J].Central Eur,2014,9(6):821.DOI:10.2478/s11536-014-0699-2.
[13]CHEN S,LIN G,YOU X,et al.Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge:implications in acute and chronic infections[J].Arch Oral Biol,2014,59(10):1075.DOI:10.1016/j.archoralbio.2014.06.004.
[14]NITIKA M,SUSHMA C,OM P,et al.A study of interleukin 1βlevels in peri-miniscrew crevicular fluid(PMCF)[J].Progress Orthodont,2014,15(1):2-7.DOI:10.1186/s40510-014-0030-4.
[2]林秀红,陈超刚,林刁珠,等.新诊断2型糖尿病患者膳食血糖负荷与血糖、血脂的关系[J].中华内分泌代谢杂志,2014,30(7):562-564.DOI:10.3760/cma.j.issn.1000-6699.2014.07.005.
[3]周爽英,段晋瑜,欧阳翔英,等.牙周基础治疗降低高血脂伴牙周炎患者血清脂蛋白相关磷脂酶A2及血脂水平[J].中华口腔医学杂志,2012,47(1):6-10.DOI:10.3760/cma.j.issn.1002-0098.2012.s1.002.
[4]MILLER CS,FOLEY JD,BAILEY AL,et a1.Current developments in salivary diagnostics[J].Biomarkers Med,2010,4(1):171-189.DOI:10.1161/hs0102.101545.
[5]中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[M].北京:人民卫生出版社,2007.
[6]庄秀妹,朱呈小露,邓飞龙,等.Osstell ISQTM监测种植体稳定性的临床研究[J].中国口腔种植学杂志,2013,(3):133-137.DOI:10.3969/j.issn.1007-3957.2013.03.006.
[7]赵雪,潘亚萍,张冬梅,等.慢性牙周炎患者血清生化指标分析[J].华西口腔医学杂志,2010,28(6):584-586.DOI:10.3969/j.issn.1000-1182.2010.06.003.
[8]FITZSIMMONS TR,SANDERS AE,BARTOLD PM,et al.Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis[J].J Clin Periodontol,2010,37(1):30-36.DOI:10.1111/j.1600-051X.2009.01506.x.
[9]王洲,张明珠,喻卓,等.牙周炎对动脉粥样硬化影响的动物实验研究[J].华西口腔医学杂志,2012,30(3):308-313.DOI:10.3969/j.issn.1000-1182.2012.03.021.
[10]ENRICO M,ANNALISA M,LAURA P,et a1.Periodontal disease:the influence of metabolic syndrome[J].Nutrition Metabolism,2012,9(9):88.DOI:10.1186/1743-7075-9-88.
[11]MAGAN-FERNANDEZ A,PAPAY-RAMIREZ L,TOMAS J,et a1.Association of simvastatin and hyperlipidemia with periodontal status and bone metabolism markers[J].J Periodontol,2014,85(10):1405.DOI:10.1902/jop.2014.130652.
[12]JUEGINA S,DALIA G,RICARDAS K,et al.Cytokine production by leukocytes in patients with periodontitis[J].Central Eur,2014,9(6):821.DOI:10.2478/s11536-014-0699-2.
[13]CHEN S,LIN G,YOU X,et al.Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge:implications in acute and chronic infections[J].Arch Oral Biol,2014,59(10):1075.DOI:10.1016/j.archoralbio.2014.06.004.
[14]NITIKA M,SUSHMA C,OM P,et al.A study of interleukin 1βlevels in peri-miniscrew crevicular fluid(PMCF)[J].Progress Orthodont,2014,15(1):2-7.DOI:10.1186/s40510-014-0030-4.