基于数据挖掘对中医药治疗结直肠息肉的用药规律研究
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摘要
目的:探讨中医药治疗结直肠息肉的组方用药规律,为中药治疗结直肠息肉的临床及科研提供新思路。方法:全面收集国内期刊公开发表的、具有一定临床疗效的、治疗结直肠息肉的中药处方,对最后筛选所得的39个医案中的方药进行信息提取并建立数据库,借助SPSS Modeler 14.1平台,对高频药物进行用药组方规律分析。结果:总计纳入39篇文献,63个中药处方,共使用药物132味,药物使用总频率为556,高频药物(频数大于10)为乌梅、甘草、僵蚕、白术、茯苓、党参、黄芪、赤芍等17味。经聚类分析、关联分析,得到强关联药对3组,推测具有潜在关联规则的药物为乌梅及僵蚕、乌梅、僵蚕及穿山甲等5条,且几乎所有相关配伍中均有乌梅。结论:中药汤剂治疗结直肠息肉的核心药物为乌梅,核心药对为乌梅配伍僵蚕。
Objective: To analyze the medication rules of traditional Chinese medicine treatment of colorectal polyps by data-mining and provide new ideas for treating colorectal polyps. Methods: Formulae for the treatment of colorectal polyps,with a certain clinical curative effect and published in domestic periodicals,were collected comprehensively. After screening,we have got 39 formulae and then extracted some information from formulae and established the database. Medication rules between high-frequency medicines was analyzed by SPSS Modeler 14. 1. Results: The study has enrolled 39 pieces of literature and 63 Chinese medicine prescriptions,132 drugs. The total drug use frequency was 556. High-frequency medicines(frequency greater than 10) included17 drugs(dark plum,liquorice,bpmbyx batryticatus,atractylodes,poria cocos,lanceolata,astragalus,red peony root,etc). By cluster analysis and correlation analysis,the three groups' strong correlation has been gotten. We hypothesized that there are five potential association rules of drugs,including plum,batryticated silkworm,ebony,batryticated silkworm,pangolin scales,etc. Conclusion: The core of traditional chinese medicine in treatment of colorectal polyps drugs is dark plum and core medicine pair is dark plu-bpmbyx batryticatus.
Objective: To analyze the medication rules of traditional Chinese medicine treatment of colorectal polyps by data-mining and provide new ideas for treating colorectal polyps. Methods: Formulae for the treatment of colorectal polyps,with a certain clinical curative effect and published in domestic periodicals,were collected comprehensively. After screening,we have got 39 formulae and then extracted some information from formulae and established the database. Medication rules between high-frequency medicines was analyzed by SPSS Modeler 14. 1. Results: The study has enrolled 39 pieces of literature and 63 Chinese medicine prescriptions,132 drugs. The total drug use frequency was 556. High-frequency medicines(frequency greater than 10) included17 drugs(dark plum,liquorice,bpmbyx batryticatus,atractylodes,poria cocos,lanceolata,astragalus,red peony root,etc). By cluster analysis and correlation analysis,the three groups' strong correlation has been gotten. We hypothesized that there are five potential association rules of drugs,including plum,batryticated silkworm,ebony,batryticated silkworm,pangolin scales,etc. Conclusion: The core of traditional chinese medicine in treatment of colorectal polyps drugs is dark plum and core medicine pair is dark plu-bpmbyx batryticatus.
引文
[1]赖晓嵘,沙卫红,林焕建,等.结直肠息肉癌变的内镜下表现治疗及癌变因素分析[J].现代消化及介入诊疗,2012,17(3):127-129.
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[7]宋雯,赵梁,朱萍,等.肠息肉发生发展与诊治研究新进展[J].胃肠病学和肝病学杂志,2012,21(9):876-879.
[8]黄兆胜.中药学[M].北京:人民卫生出版社,2011.
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[12]邹龙,刘红专,蔡华蓉,等.氩离子凝固术治疗肠息肉电凝切除术后18例出血患者临床观察[J].海南医学,2011,22(4):81.
[13]辛国秋,唐悦,唐先富.内镜下氩离子凝固术与高频电凝切除术治疗结肠息肉的疗效研究[J].局解手术学杂志,2010,19(5):392-393.
[14]李爱凤.基于数据挖掘技术的购物篮模式研究[J].计算机应用与软件,2011,28(12):156-158.
[15]汪楠,王垂杰.李曰胜自拟息肉丸(散)治疗胃肠息肉[J].实用中医内科杂志,2013,27(4):22-23.
[16]王瑞平,舒鹏.刘沈林:乌梅丸消肠息肉[N].中国中医药报,2015-04-20(4).
[17]叶毅,范荣光.自拟乌梅汤治疗消化道息肉7例[J].江西中医药,1997,28(3):27-27.
[18]杨莹菲,胡汉昆,刘萍,等.乌梅的化学成分、临床应用及现代药理研究进展[J].中国药师,2012,15(3):415-418.
[19]阮毅铭.乌梅的化学成份及药理作用概述[J].中国医药导刊,2008,10(5):793-794.
[20]张飞,李劲松.乌梅的研究进展[J].海峡医学,2006,18(4):21
[21]张武强,张惠兰,刘荣娟,等.张文泰老中医妙用僵蚕验案举隅[J].光明中医,2015,1(30):138-139.
[2]麻树人,张宁.胃肠道息肉病及憩室病-结肠息肉病概述[J].中国实用内科杂志,2000,20(2):71-73.
[3]樊人瑜,许建明.家族性腺瘤性息肉病癌变危险因素分析[J].安徽医学,2016,37(3):276-279.
[4]Lieberman DA,Rex DK,Winawer SJ,et al.Guidelines for colonoscopy surveillance after screening and polypectomy:a consensus update by the US Multi-Society Task Force on Colorectal Cancer[J].Gastroenterology,2012,143(3):844-857.
[5]孔祥东,吴鸣.结直肠息肉的诊断和治疗现状[J].中国现代普通外科进展,2014,17(7):580-582.
[6]牛晓玲,孙志广,周芬敏,等.健脾消痰法防治多发性结直肠腺瘤内镜术后复发的临床观察[J].辽宁中医杂志,2015,42(4):738-740.
[7]宋雯,赵梁,朱萍,等.肠息肉发生发展与诊治研究新进展[J].胃肠病学和肝病学杂志,2012,21(9):876-879.
[8]黄兆胜.中药学[M].北京:人民卫生出版社,2011.
[9]郑嵘.结肠镜下治疗肠息肉的临床效果分析[J].中国当代医药,2013,20(24):38-40.
[10]张勇,王雁军,王青兵.肠息肉患者结肠镜下的治疗效果研究[J].中国卫生标准管理,2015,6(20):27-28.
[11]陈宏.电子内镜下治疗肠息肉266例临床效果分析[J].实用预防医学,2011,18(3):517-545.
[12]邹龙,刘红专,蔡华蓉,等.氩离子凝固术治疗肠息肉电凝切除术后18例出血患者临床观察[J].海南医学,2011,22(4):81.
[13]辛国秋,唐悦,唐先富.内镜下氩离子凝固术与高频电凝切除术治疗结肠息肉的疗效研究[J].局解手术学杂志,2010,19(5):392-393.
[14]李爱凤.基于数据挖掘技术的购物篮模式研究[J].计算机应用与软件,2011,28(12):156-158.
[15]汪楠,王垂杰.李曰胜自拟息肉丸(散)治疗胃肠息肉[J].实用中医内科杂志,2013,27(4):22-23.
[16]王瑞平,舒鹏.刘沈林:乌梅丸消肠息肉[N].中国中医药报,2015-04-20(4).
[17]叶毅,范荣光.自拟乌梅汤治疗消化道息肉7例[J].江西中医药,1997,28(3):27-27.
[18]杨莹菲,胡汉昆,刘萍,等.乌梅的化学成分、临床应用及现代药理研究进展[J].中国药师,2012,15(3):415-418.
[19]阮毅铭.乌梅的化学成份及药理作用概述[J].中国医药导刊,2008,10(5):793-794.
[20]张飞,李劲松.乌梅的研究进展[J].海峡医学,2006,18(4):21
[21]张武强,张惠兰,刘荣娟,等.张文泰老中医妙用僵蚕验案举隅[J].光明中医,2015,1(30):138-139.