重症急性胰腺炎两次病死高峰的综合救治
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摘要
<正>重症急性胰腺炎(severe acute pancreatitis,SAP)依然是危重病的代表,其病死率高达15%,且以青壮年高发,高峰发病年龄为50岁左右。若获治愈(包括去除病因等),绝大多数患者可长期存活。因此,提高SAP的治愈率具有极其重要的临床意义和社会意义。在SAP的病变过程中存在两次病死高峰,第一次病死高峰发生在急性反应期,占SAP总病死人数的64.9%;第二次病死高峰发生在感染期,占SAP
引文
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[10]Gou S,Yang C,Yin T,et al.Percutaneous catheter drainage of pancreatitis-associated ascitic fluid in early-stage severe acute pancreatitis[J].Pancreas,2015,44(7):1161-1162.
[11]Gou S,Xiong J,Wu H,et al.Five-year cohort study of open pancreatic necrosectomy for necotizing pancreatitis suggests it is a safe and effective operation[J].J Gastrointest Surg,2013,17(9):1634-1642.
[2]Xie Y,Zhou Z,Duan W,et al.Pharmacokinetic comparison between regional arterial infusion and intravenous injection with 5-fluorouracil in experimental severe acute pancreatitis[J].Lat Am J Pharm,2013,32(4):477-483.
[3]Zhou M,Chen B,Sun H,et al.The protective effects of Lipoxin A4 during the early phase of severe acute pancreatitis in rats[J].Scand J Gastroenterol,2011,46(2):211-219.
[4]Lv W,Lv C,Yu S,et al.Lipoxin A4 attenuation of endothelial inflammation response mimicking pancreatitis-induced lung injury[J].Exp Biol Med(Maywood),2013,238(12):1388-1395.
[5]Zhang ZW,Zhang QY,Zhou MT,et al.Antioxidant inhibits HMGB1 expression and reduces pancreas injury in rats with severe acute pancreatitis[J].Dig Dis Sci,2010,55(9):2529-2536.
[6]Wang W,Zhou X,Yang F,et al.The effects of 5-Fluorouracil on severe acute pancreatitis-inducing apoptosis of macrophages[J].Pancreas,2014,43(4):660-663.
[7]Hong W,Dong L,Huang Q,et al.Prediction of severe acute pancreatitis using classification and regression tree analysis[J].Dig Dis Sci,2011,56(12):3664-3671.
[8]Hong WD,Chen XR,Jin SQ,et al.Use of an artificial neural network to predict persistent organ failure in patients with acute pancreatitis[J].Clinics(Sao Paulo),2013,68(1):27-31.
[9]Zhao G,Wang CY,Wang F,et al.Clinical study on nutrition support in patients with severe acute pancreatitis[J].World JGastroenterol,2003,9(9):2105-2108.
[10]Gou S,Yang C,Yin T,et al.Percutaneous catheter drainage of pancreatitis-associated ascitic fluid in early-stage severe acute pancreatitis[J].Pancreas,2015,44(7):1161-1162.
[11]Gou S,Xiong J,Wu H,et al.Five-year cohort study of open pancreatic necrosectomy for necotizing pancreatitis suggests it is a safe and effective operation[J].J Gastrointest Surg,2013,17(9):1634-1642.