黛力新联合加味逍遥丸对高血压合并抑郁症患者血清髓过氧化物酶活性、一氧化氮含量的影响及其疗效观察
|
摘要
目的观察黛力新(氟哌噻吨美利曲辛)联合逍遥散对高血压合并抑郁症患者抑郁状态、血清髓过氧化物酶(MPO)活性及一氧化氮(NO)含量的影响,并分析其降压疗效及其作用机制。方法将118例高血压合并抑郁症患者随机分为对照组和治疗组,两组均采用常规降压治疗,对照组加用黛力新口服,治疗组在对照组基础上予以加味逍遥丸,4周为1个疗程。两组患者治疗前后进行汉密尔顿抑郁量表(HAMD)评分,并检测血清MPO活性、NO含量的变化,及各组降压疗效。结果治疗组HAMD评分显著低于对照组(P<0.05);治疗组血清MPO水平显著低于对照组(P<0.05),NO含量显著高于对照组(P<0.05);治疗组降压效果及总疗效显著优于对照组(P<0.05)。结论黛力新联合逍遥散可以显著改善高血压合并抑郁症患者的抑郁状态,降低血清MPO活性,增加NO含量,血压控制良好,临床应用前景广阔。
Objective To observe the effect of Deanxit combined with Modified Xiaoyao pills on depressive state,serum Cys C and MPO of hypertension patients with depression. Methods 118 hypertension patients with depression were divided into observation group and control group randomly,both group were given routine therapy. Deanxit tablets were added to control group every morning. Observation group received modified Xiaoyao pills on the basis of control group. The total treatment course was 4 weeks. Hamilton depression rating scale( HAMD) was performed to both groups before and after the treatment in which the change of serum Cys C,MPO were detected. Results After 2 weeks of treatment,the HAMD score in observation group were significantly lower than that in control group( P < 0. 05),the level of serum activation of MPO in observation group was significantly lower than that of control group,the level of NO in observation group were higher than that of control group( P < 0. 05),the anti-hypertensive efficacy of observation group was superior to control group( P < 0. 05). Conclusion Deanxit combined with Modified Xiaoyao pills can significantly improve depressive state in hypertension patients with depression,and decrease serum activation of MPO,increase the level of NO,thus to controls blood pressure effectively,which has a wide prospect of clinical application.
Objective To observe the effect of Deanxit combined with Modified Xiaoyao pills on depressive state,serum Cys C and MPO of hypertension patients with depression. Methods 118 hypertension patients with depression were divided into observation group and control group randomly,both group were given routine therapy. Deanxit tablets were added to control group every morning. Observation group received modified Xiaoyao pills on the basis of control group. The total treatment course was 4 weeks. Hamilton depression rating scale( HAMD) was performed to both groups before and after the treatment in which the change of serum Cys C,MPO were detected. Results After 2 weeks of treatment,the HAMD score in observation group were significantly lower than that in control group( P < 0. 05),the level of serum activation of MPO in observation group was significantly lower than that of control group,the level of NO in observation group were higher than that of control group( P < 0. 05),the anti-hypertensive efficacy of observation group was superior to control group( P < 0. 05). Conclusion Deanxit combined with Modified Xiaoyao pills can significantly improve depressive state in hypertension patients with depression,and decrease serum activation of MPO,increase the level of NO,thus to controls blood pressure effectively,which has a wide prospect of clinical application.
引文
[1]陈伟伟,高润霖,刘力生,等.《中国心血管病报告2013》概要[J].中国循环杂志,2014,29(7):487-491.
[2]刑俊武,孔婷,周陵.高血压患者血清载脂蛋白与动脉粥样硬化的关系分析[J].现代中西医结合杂志,2015,24(5):516-518.
[3]闫微,王姝,李竹琴.冠状动脉疾病的生物学标志物[J].医学研究杂志,2015,44(7):13-16.
[4]张鹏飞,林晓婷,厉建,等.氧化氮合酶基因多态性与高血压病关系研究进展[J].中国疗养医学,2015,24(11):1142-1144.
[5]马文梅.心理护理干预联合黛力新对高血压患者临床疗效观察[J].中国实用医药,2015,10(30):244-245.
[6]中国高血压防治指南修订委员会.中国高血压防治指南[J].中华高血压杂志,2011,19(8):701-742.
[7]沈渔邨.精神病学[M].北京:人民卫生出版社,2009:548.
[8]戴英林.高血压合并抑郁患者的心理状态调查[J].深圳中西医结合杂志,2015,25(16):41-43.
[9]戴伦.抑郁症与高血压有什么关系?[J].中华高血压杂志,2016,24(2):110-114.
[10]姜甜,贾友宏,李一石.高血压伴发焦虑和抑郁的研究进展[J].中国分子心脏病学杂志,2015,15(4):1424-1427.
[11]李海聪,李求兵,杨毅玲,等.抗抑郁治疗对老年高血压合并抑郁障碍患者血压的影响[J].中华老年心脑血管杂志,2016,18(2):143-148.
[12]张春玲,魏立和.喹硫平联合曲唑酮治疗重度抑郁症的疗效观察[J].现代药物与临床,20l5,30(5):579-582.
[13]曾国庆,刘忠镗,高晶,等.综合干预对高血压合并焦虑抑郁患者血压的影响[J].中国心血管病研究,2015,23(9):880-882.
[14]Ismael FO,Proudfoot JM,Brown BE,et al.Comparative react-ivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein(LDL):Implications for foam cell format-ion in atherosclerosis[J].Arch Biochem Biophys,2015,1(573):40-51.
[15]翟震宇,刘喜.髓过氧化物酶对行经皮冠状动脉介入治疗患者预后的临床价值[J].内蒙古医学杂志,2016,48(1):56-59.
[16]王卫明,于佳慧,樊官伟.一氧化氮和内皮素的生理病理辨证关系[J].医学综述,2015,21(22):4048-4051.
[17]郭璠.丹红注射剂对急性冠脉综合征患者的血浆NO、MPO及MDA浓度的影响[J].心血管康复医学杂志,2014,23(1):89-91.
[18]周白丽,苏晓灵,刘彦民.不同海拔地区高血压病患者血清髓过氧化物酶、脑利钠肽含量变化.高原医学杂志,2011,21(1):11-12.
[2]刑俊武,孔婷,周陵.高血压患者血清载脂蛋白与动脉粥样硬化的关系分析[J].现代中西医结合杂志,2015,24(5):516-518.
[3]闫微,王姝,李竹琴.冠状动脉疾病的生物学标志物[J].医学研究杂志,2015,44(7):13-16.
[4]张鹏飞,林晓婷,厉建,等.氧化氮合酶基因多态性与高血压病关系研究进展[J].中国疗养医学,2015,24(11):1142-1144.
[5]马文梅.心理护理干预联合黛力新对高血压患者临床疗效观察[J].中国实用医药,2015,10(30):244-245.
[6]中国高血压防治指南修订委员会.中国高血压防治指南[J].中华高血压杂志,2011,19(8):701-742.
[7]沈渔邨.精神病学[M].北京:人民卫生出版社,2009:548.
[8]戴英林.高血压合并抑郁患者的心理状态调查[J].深圳中西医结合杂志,2015,25(16):41-43.
[9]戴伦.抑郁症与高血压有什么关系?[J].中华高血压杂志,2016,24(2):110-114.
[10]姜甜,贾友宏,李一石.高血压伴发焦虑和抑郁的研究进展[J].中国分子心脏病学杂志,2015,15(4):1424-1427.
[11]李海聪,李求兵,杨毅玲,等.抗抑郁治疗对老年高血压合并抑郁障碍患者血压的影响[J].中华老年心脑血管杂志,2016,18(2):143-148.
[12]张春玲,魏立和.喹硫平联合曲唑酮治疗重度抑郁症的疗效观察[J].现代药物与临床,20l5,30(5):579-582.
[13]曾国庆,刘忠镗,高晶,等.综合干预对高血压合并焦虑抑郁患者血压的影响[J].中国心血管病研究,2015,23(9):880-882.
[14]Ismael FO,Proudfoot JM,Brown BE,et al.Comparative react-ivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein(LDL):Implications for foam cell format-ion in atherosclerosis[J].Arch Biochem Biophys,2015,1(573):40-51.
[15]翟震宇,刘喜.髓过氧化物酶对行经皮冠状动脉介入治疗患者预后的临床价值[J].内蒙古医学杂志,2016,48(1):56-59.
[16]王卫明,于佳慧,樊官伟.一氧化氮和内皮素的生理病理辨证关系[J].医学综述,2015,21(22):4048-4051.
[17]郭璠.丹红注射剂对急性冠脉综合征患者的血浆NO、MPO及MDA浓度的影响[J].心血管康复医学杂志,2014,23(1):89-91.
[18]周白丽,苏晓灵,刘彦民.不同海拔地区高血压病患者血清髓过氧化物酶、脑利钠肽含量变化.高原医学杂志,2011,21(1):11-12.