雪梨止咳糖浆联合孟鲁司特钠对小儿咳嗽变异性哮喘的疗效及安全性分析
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摘要
目的探讨雪梨止咳糖浆合孟鲁司特钠对小儿咳嗽变异性哮喘的疗效及安全性。方法选择安阳市妇幼保健院2015年1月—2018年1月收治的81例咳嗽变异性哮喘患儿,根据随机数字表法分为观察组(39例)及对照组(42例),对照组患儿给予孟鲁司特钠,观察组在对照组基础上给予雪梨止咳糖浆,两组治疗疗程均为1个月。对比两组患儿的临床疗效,治疗前后的咳嗽、喘息、咳痰、哮鸣音、胸膈满闷积分,治疗前后的用力呼气流量(FEF)取25%、50%肺活量呼气流速占预计值的百分比及血清IgE水平,治疗期间两组的不良反应。结果观察组总有效率为97.44%,明显高于对照组的80.95%,差异有统计学意义(P<0.05)。治疗后,两组的咳嗽、喘息、咳痰、哮鸣音、胸膈满闷评分均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组FEF25%、FEF50%均明显升高,IgE水平明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组FEF25%、FEF50%明显高于对照组,而IgE水平明显低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应组间对比无统计学意义。结论孟鲁司特钠联合雪梨止咳糖浆治疗小儿咳嗽变异性哮喘安全有效,值得临床推广应用。
Objective To investigate the efficacy and safety of Xueli Zhike Tangjiang combined with monteluk sodium in children with cough variant asthma.Methods 81 cases with cough variant asthma from Jan. 2015 to Jan. 2018 in our hospital were chosen and divided into the observation group (39 cases) and control group (42 cases), the control group were given monteluk sodium, the observation group were given Xueli Zhike Tangjiang on the base of control group, the clinical efficacy, the cough, wheezing,coughing, wheezing, and chest fullness before and after treatment, the FEF25%, FEF50% and IgE level in serum before and after treatment in two groups were compared, the adverse reaction of two groups were compared. Results The total effective rate was97.44% in the observation group, which was significantly higher than 80.95 in the control group (P < 0.05). After treatment, the scores of cough, wheezing, expectoration, wheezing and chest diaphragm fullness in the two groups were significantly lower than those in the control group (P < 0.05), and those in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of FEF 25% and FEF 50% in both groups were significantly increased, and IgE levels were significantly decreased. There was significant difference before and after treatment in the same group (P < 0.05). The levels of FEF25% and FEF50% in the observation group were significantly higher than those in the control group, while the levels of IgE were significantly lower than those in the control group (P < 0.05). There was no significant difference in adverse reactions between the two groups.Conclusion Xueli Zhike Tangjiang combined with montelukast sodium was safe and effective in treatment of cough variant asthma in children, which was worthy of clinical application.
Objective To investigate the efficacy and safety of Xueli Zhike Tangjiang combined with monteluk sodium in children with cough variant asthma.Methods 81 cases with cough variant asthma from Jan. 2015 to Jan. 2018 in our hospital were chosen and divided into the observation group (39 cases) and control group (42 cases), the control group were given monteluk sodium, the observation group were given Xueli Zhike Tangjiang on the base of control group, the clinical efficacy, the cough, wheezing,coughing, wheezing, and chest fullness before and after treatment, the FEF25%, FEF50% and IgE level in serum before and after treatment in two groups were compared, the adverse reaction of two groups were compared. Results The total effective rate was97.44% in the observation group, which was significantly higher than 80.95 in the control group (P < 0.05). After treatment, the scores of cough, wheezing, expectoration, wheezing and chest diaphragm fullness in the two groups were significantly lower than those in the control group (P < 0.05), and those in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of FEF 25% and FEF 50% in both groups were significantly increased, and IgE levels were significantly decreased. There was significant difference before and after treatment in the same group (P < 0.05). The levels of FEF25% and FEF50% in the observation group were significantly higher than those in the control group, while the levels of IgE were significantly lower than those in the control group (P < 0.05). There was no significant difference in adverse reactions between the two groups.Conclusion Xueli Zhike Tangjiang combined with montelukast sodium was safe and effective in treatment of cough variant asthma in children, which was worthy of clinical application.
引文
[1]邹艳萍,罗小兰,李敏.布地奈德联合孟鲁司特对小儿咳嗽变异性哮喘疗效和安全性的Meta分析[J].中国妇幼保健,2016,31(6):1335-1338.
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[3]练万里,唐向国,徐春辉,等.孟鲁司特联合糖皮质激素治疗小儿咳嗽变异性哮喘的疗效及安全性研究[J].吉林医学,2017,38(3):527-528.
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[5]蔡书芳.小儿咳嗽变异性哮喘采用孟鲁司特钠联合布地奈德治疗临床疗效分析[J].重庆医学,2017,46(A03):113-115.
[6]伏丽琼.肺功能检测在小儿哮喘和咳嗽变异性哮喘中的效果分析[J].三峡大学学报:自然科学版,2017,39(S1):129-131.
[7]李艳,曾晓翠.加味射干麻黄汤对小儿咳嗽变异性哮喘的疗效观察[J].陕西中医,2016,37(10):1311-1312.
[8]朱晓婷,李艳,张磊,等.穴位埋线联合穴位贴敷治疗咳嗽变异性哮喘的随机对照研究[J].成都中医药大学学报,2017,40(2):56-59.
[9]李军文,陈凛凛,周芳.布地奈德气雾剂联合肺力咳糖浆治疗小儿咳嗽变异性哮喘的临床效果研究[J].陕西医学杂志,2016,45(8):1084-1085.
[10]魏延,李东升,刘建军,等.孟鲁司特钠联合布地奈德治疗儿童咳嗽变异性哮喘疗效和安全性的Meta分析[J].中国当代儿科杂志,2016,18(11):1100-1105.
[11]张佑,吴双.孟鲁司特钠联合苏黄止咳胶囊治疗咳嗽变异性哮喘的临床疗效及安全性研究[J].山西医药杂志,2017,46(16):1990-1992.
[12]冯文涛,易红,袁浩宇.沙美特罗替卡松联合孟鲁司特对比沙美特罗替卡松治疗咳嗽变异性哮喘疗效和安全性的Meta分析[J].中国药房,2018,29(5):699-703.
[13]陈建川,潘凤,余思捷,等.孟鲁司特钠联合丙酸氟替卡松治疗儿童咳嗽变异性哮喘的临床研究[J].中华全科医师杂志,2016,15(8):608-613.
[14]张雯霞,苗雨露,李媛,等.中医与现代医学治疗小儿咳嗽变异性哮喘的探讨[J].药物评价研究,2018,41(4):501-507.
[15]张丽霞,李雪青,石志敏.麻黄附子细辛汤联合孟鲁司特治疗咳嗽变异性哮喘的临床观察[J].中医药信息,2017,34(4):80-83.
[16]李忱.雪梨止咳糖浆联合匹多莫德治疗感染后咳嗽患儿疗效及对免疫功能的影响[J].现代中西医结合杂志,2016,25(26):2893-2895.
[2]胡波.中西医结合治疗小儿咳嗽变异性哮喘的效果及安全性探讨[J].基层医学论坛,2016,20(12):1671-1672.
[3]练万里,唐向国,徐春辉,等.孟鲁司特联合糖皮质激素治疗小儿咳嗽变异性哮喘的疗效及安全性研究[J].吉林医学,2017,38(3):527-528.
[4]陈晓磊.孟鲁司特钠治疗小儿咳嗽变异性哮喘的效果与安全性分析[J].河南医学研究,2016,25(5):930-931.
[5]蔡书芳.小儿咳嗽变异性哮喘采用孟鲁司特钠联合布地奈德治疗临床疗效分析[J].重庆医学,2017,46(A03):113-115.
[6]伏丽琼.肺功能检测在小儿哮喘和咳嗽变异性哮喘中的效果分析[J].三峡大学学报:自然科学版,2017,39(S1):129-131.
[7]李艳,曾晓翠.加味射干麻黄汤对小儿咳嗽变异性哮喘的疗效观察[J].陕西中医,2016,37(10):1311-1312.
[8]朱晓婷,李艳,张磊,等.穴位埋线联合穴位贴敷治疗咳嗽变异性哮喘的随机对照研究[J].成都中医药大学学报,2017,40(2):56-59.
[9]李军文,陈凛凛,周芳.布地奈德气雾剂联合肺力咳糖浆治疗小儿咳嗽变异性哮喘的临床效果研究[J].陕西医学杂志,2016,45(8):1084-1085.
[10]魏延,李东升,刘建军,等.孟鲁司特钠联合布地奈德治疗儿童咳嗽变异性哮喘疗效和安全性的Meta分析[J].中国当代儿科杂志,2016,18(11):1100-1105.
[11]张佑,吴双.孟鲁司特钠联合苏黄止咳胶囊治疗咳嗽变异性哮喘的临床疗效及安全性研究[J].山西医药杂志,2017,46(16):1990-1992.
[12]冯文涛,易红,袁浩宇.沙美特罗替卡松联合孟鲁司特对比沙美特罗替卡松治疗咳嗽变异性哮喘疗效和安全性的Meta分析[J].中国药房,2018,29(5):699-703.
[13]陈建川,潘凤,余思捷,等.孟鲁司特钠联合丙酸氟替卡松治疗儿童咳嗽变异性哮喘的临床研究[J].中华全科医师杂志,2016,15(8):608-613.
[14]张雯霞,苗雨露,李媛,等.中医与现代医学治疗小儿咳嗽变异性哮喘的探讨[J].药物评价研究,2018,41(4):501-507.
[15]张丽霞,李雪青,石志敏.麻黄附子细辛汤联合孟鲁司特治疗咳嗽变异性哮喘的临床观察[J].中医药信息,2017,34(4):80-83.
[16]李忱.雪梨止咳糖浆联合匹多莫德治疗感染后咳嗽患儿疗效及对免疫功能的影响[J].现代中西医结合杂志,2016,25(26):2893-2895.