内镜揭盖术与唇齿沟径路切除术治疗鼻前庭囊肿患者的疗效及对炎性因子的影响
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摘要
目的:研究内镜揭盖术(ER)与唇齿沟径路切除术(LSPR)治疗鼻前庭囊肿(NVC)患者的临床疗效及对炎性因子的影响。方法:选择2015年7月至2017年6月来我院就诊的NVC患者106例,依据随机数字表法分别纳入ER组(53例)及LSPR组(53例)。ER组行ER治疗,LSPR组行唇齿沟径路切除术。观察两组术中出血量、手术时间、术后创口愈合时间、术后24 h疼痛评分及上皮化时间,两组术前、术后7 d白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平,两组术后并发症及复发情况。结果:ER组术中出血量、手术时间、术后创口愈合时间、术后24h疼痛评分及上皮化时间等手术指标均低于LSPR组,差异有统计学意义(P<0.05);术后7 d,两组IL-6、IL-8、TNF-α及CRP水平均低于治疗前,且ER组低于LSPR组,差异有统计学意义(P<0.05);ER组术后并发症发生率7.55%、术后复发率3.77%,均低于LSPR组的22.64%、20.75%,差异均有统计学意义(P<0.05)。结论:与LSPR相比较,ER治疗NVC创伤小,恢复快,可有效降低术后炎性因子水平,术后并发症及复发率低,值得临床应用。
Objective: To study the clinical efficacy of endoscopic resection(ER) and labiodental sulcus path resection(LSPR) in treatment of patients with nasal vestibular cyst(NVC) and influence on the Inflammatory factors of patients. Methods: A total of 106 NVC patients, who were admitted to Guangyuan Central Hospital of Sichuan Province from July 2015 to June 2017, were randomly divided into ER group(n=53) and LSPR group(n=53). The ER group was treated by ER, and the LSPR group was treated by labiodental sulcus path resection. The intraoperative bleeding volume, the operation time, the time of wound healing, pain scores 24 h after operation,the epithelial time, the levels of IL-6, IL-8, TNF-α and CRP before operation and 7 days after operation, the postoperative complications andrecurrence were observed in the two groups. Results: The intraoperative bleeding volume, the operation time, the time of wound healing, the pain scores 24 h after operation and the epithelial time in ER group were lower than those in LSPR group(P<0.05). 7 days after operation, the levels of IL-6, IL-8, TNF-α, CRP in the two groups were lower than those before operation, and the ER group was lower than the LSPR group, the difference was statistically significant(P<0.05). The incidence of postoperative complications(5.55%), and recurrence rate(3.77%) in ER group were lower than those(22.64%, 20.75%) in LSPR group, the difference was statistically significant(P<0.05). Conclusion: Compared with LSPR, in the treatment of NVC, ER can effectively reduce the levels of postoperative inflammatory factors, with less trauma, faster recovery, low incidence of postoperative complications and recurrence rate, which is worthy of clinical application.
Objective: To study the clinical efficacy of endoscopic resection(ER) and labiodental sulcus path resection(LSPR) in treatment of patients with nasal vestibular cyst(NVC) and influence on the Inflammatory factors of patients. Methods: A total of 106 NVC patients, who were admitted to Guangyuan Central Hospital of Sichuan Province from July 2015 to June 2017, were randomly divided into ER group(n=53) and LSPR group(n=53). The ER group was treated by ER, and the LSPR group was treated by labiodental sulcus path resection. The intraoperative bleeding volume, the operation time, the time of wound healing, pain scores 24 h after operation,the epithelial time, the levels of IL-6, IL-8, TNF-α and CRP before operation and 7 days after operation, the postoperative complications andrecurrence were observed in the two groups. Results: The intraoperative bleeding volume, the operation time, the time of wound healing, the pain scores 24 h after operation and the epithelial time in ER group were lower than those in LSPR group(P<0.05). 7 days after operation, the levels of IL-6, IL-8, TNF-α, CRP in the two groups were lower than those before operation, and the ER group was lower than the LSPR group, the difference was statistically significant(P<0.05). The incidence of postoperative complications(5.55%), and recurrence rate(3.77%) in ER group were lower than those(22.64%, 20.75%) in LSPR group, the difference was statistically significant(P<0.05). Conclusion: Compared with LSPR, in the treatment of NVC, ER can effectively reduce the levels of postoperative inflammatory factors, with less trauma, faster recovery, low incidence of postoperative complications and recurrence rate, which is worthy of clinical application.
引文
[1] Huang Z, Li J, Yang Q, et al. A modified intranasal endoscopic excision for nasal vestibular cyst in China[J]. Eur Arch Otorhinolaryngol,2015, 272(3):591-595
[2] Bondi S, Limardo P, Toma S, et al. Non-vestibular head and neck schwannomas:a 10-year experience[J]. Eur Arch Otorhinolaryngol,2013, 270(8):2365-2369
[3]张晓,王全桂,万喆.鼻前庭囊肿伴真菌感染一例[J].中华耳鼻咽喉头颈外科杂志, 2016, 51(6):458-459Zhang Xiao, Wang Quan-gui, Wan Zhe. One case of nasal vestibular cyst with fungul infection[J]. ChineseJournal of Otorhinolaryngology Head and Neck Surgery, 2016, 51(6):458-459
[4]钱建娥.鼻内镜下低温等离子刀射频消融术与唇龈沟径路囊肿切除术治疗鼻前庭囊肿的疗效比较[J].中国临床医学, 2015, 22(4):547-549Qian Jian-e. Efficacy Comparison between Low Temperature-Controlled Plasma Radiofrequency Ablation by Nasal Endos-copy and Cystectomy via Labiogingival Groove Approach in the Treatment of Nasal Vestibular Cyst[J]. Chinese Journal of Clinical Medicine, 2015,22(4):547-549
[5]孙兵.视觉模拟评分法(VAS)[J].中华神经外科杂志, 2012, 28(6):645-645Sun Bing. Visual analogue scale(VAS)[J]. Chinese Journal of Neurosurgery, 2012, 28(6):645-645
[6] Choi JH, Cho JH, Kang HJ, et al. Nasolabial eyst, a retrospective analysis of 18[J]. Ear Nose Throat J, 2012, 81(2):94-96
[7] Boffano P, Callesio C, Campisi P, et al. Diagnosis and surgical treatment of a nasolabial cyst[J]. J Craniofae Surg, 2011, 22(5):1946-1948
[8]郝凯飞,闫朝晖,陶树东.内镜下经鼻行鼻前庭囊肿完整剥除术的疗效观察[J].中华耳鼻咽喉头颈外科杂志, 2017, 52(5):361-364Hao Kai-fei, Yan Zhao-hui, Tao Shu-dong. Effect of intranasal excision on nasal vestibular cyst under nasal endoscopy[J]. ChineseJournal of Otorhinolaryngology Head and Neck Surgery, 2017, 52(5):361-364
[9] Bendeck SE, Chow S, Bennett RG, et al. Staged trilobe pedicle flap to repair a large cutaneous lip and nasal vestibule defect[J]. Dermatologic Surgery, 2012, 38(3):498-501
[10]郭斌.鼻内镜下低温等离子射频消融与传统方式切除鼻前庭囊肿的临床疗效观察[J].中国内镜杂志, 2017, 23(5):53-56Guo Bin. Comparison between low temperature-controlled plasma radio frequency ablation by nasal endoscopy and traditional way in treatment of nasal vestibular cyst[J]. China Journal of Endoscopy,2017, 23(5):53-56
[11]马行凯,马永明,陆建斌,等.鼻内镜下离子刀切除鼻前庭囊肿18例分析[J].中国中西医结合耳鼻咽喉科杂志, 2014, 22(1):28-29Ma Xing-kai, Ma Yong-ming, Lu Jian-bin, et al. Analysis of 18 Cases with Nasal Vestibular Cyst Excision under Nasal Endoscope Plasma Cutter[J]. Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine, 2014, 22(1):28-29
[12]吴兴宇,佘文胜,周林.鼻前庭囊肿揭盖术与唇龈沟径路切除术的疗效比较[J].武汉大学学报(医学版), 2015, 36(5):754-756Wu Xing-yu, She Wen-sheng, Zhou Lin. Comparison Between Marsupialization and Labiogingival Groove Approach in the Treatment of Nasal Vestibular Cyst[J]. Medical Journal of Wuhan University,2015, 36(5):754-756
[13]岳显.不同手术方案在鼻前庭囊肿患者中的应用效果对比[J].安徽医药, 2015, 19(3):518-520Yue Xian. Application results comparing different surgical options in patients with nasal vestibule cyst[J]. Anhui Medical and Pharmaceutical Journal, 2015, 19(3):518-520
[14]施芳.鼻前庭囊肿两种术式的临床分析[J].中国耳鼻咽喉颅底外科杂志, 2013, 19(3):273-274Shi Fang. Clinical analysis of two surgical methods for nasal vestibule cyst[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery,2013,19(3):273-274
[15]冀庆军,单亚萍,李大鹏,等.鼻内镜下两种手术方案在治疗鼻前庭囊肿中的临床疗效对比[J].中国耳鼻咽喉颅底外科杂志, 2016, 22(6):487-490Ji Qing-jun, Shan Ya-ping, Li Da-peng, et al. Comparison of clinical effect between two endoscopic surgical methods for nasal vestibule cyst[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery,2016, 22(6):487-490
[16]孙焕吉,卢永田,罗兴谷.两种鼻前庭囊肿手术疗效比较[J].山东医药, 2014, 54(32):74-75Sun Huan-ji, Lu Yong-tian, Luo Xing-gu. Comparing two surgical treatments for treatment of nasal vestibular cyst[J]. Shandong Medical Journal, 2014, 54(32):74-75
[17]陈永振,梁天喜,薛博广.鼻前庭囊肿揭盖术与经唇龈沟鼻前庭囊肿切除术治疗鼻前庭囊肿的疗效对比观察[J].中国临床新医学,2017, 10(6):521-523Chen Yong-zhen, Liang Tian-xi, Xue Bo-guang. Comparison of the surgical removal of nasal vestibular cyst and the excision of the nasal vestibular cyst via the sulcus of the lips in treatment of nasal vestibular cyst[J]. Chinese Journal of New Clinical Medicine, 2017, 10(6):521-523
[18]慕继霞,职良喜,赵勇.鼻内镜下揭盖法治疗鼻前庭囊肿临床分析[J].中国耳鼻咽喉颅底外科杂志, 2015, 21(3):254-255Mu Ji-xia, Zhi Liang-xi, Zhao Yong. Clinical analysis of nasal endoscopy in the treatment of nasal vestibule cyst[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery, 2015, 21(3):254-255
[19]覃焕桦,林琳.鼻内镜下低温等离子射频消融术与囊肿揭盖术治疗鼻前庭囊肿的临床分析[J].河北医药, 2017, 39(8):1231-1233Qin Huan-hua, Lin Lin. Clinical analysis of nasal endoscopy with low temperature plasma radiofrequency ablation and cyst uncovering for nasal vestibule cyst[J]. Hebei Medical Journal, 2017, 39(8):1231-1233
[20]赵艾君,谢鹏.鼻前庭嚢肿揭盖术与传统唇龈沟径路鼻前庭嚢肿切除术治疗鼻前庭嚢肿的疗效对比[J].广西医科大学学报, 2016, 33(5):880-882Zhao Ai-jun, Xie Peng. Comparison of the efficacy of nasal vestibule dissecting and traditional labiocutaneous sulcus approach in the treatment of nasal vestibular tumefaction[J]. Journal of Guangxi Medical University, 2016, 33(5):880-882
[21]佘国跃,唐兵华.鼻内镜下揭盖法治疗鼻前庭囊肿24例临床观察[J].西部医学, 2012, 24(7):1318-1319She Guo-yue, Tang Bing-hua. Effect of uncovering under nasal endoscopy on treatment of nasal vestibular cyst[J]. Medical Journal of West China, 2012, 24(7):1318-1319
[22]苟建军,张怡,王朝山,等.鼻内镜动力切削术对鼻前庭囊肿患者CRP、TNF-α、IL-6及IL-8的影响[J].现代生物医学进展, 2015, 15(25):4942-4945Gou Jian-jun, Zhang Yi, Wang Zhao-shan, et al. LEffect of CRP,TNF-α, IL-6 and IL-8 in Patients with Nasal Vestibular Cyst by Nasal Endoscopic Surgery[J]. Progress in Modern Biomedicine, 2015, 15(25):4942-4945
[23] Musilova I, Kacerovsky M, Stepan M, et al. Maternal serum C-reactive protein concentration and intra-amniotic inflammation in women with preterm prelabor rupture of membranes[J]. PLoS One, 2017, 12(8):e0182731
[24] Buchheit J, Uhring J, Sergent P, et al. Can preoperative CRP levels predict infections of bipolar hemiarthroplasty performed for femoral neck fracture? A retrospective, multicenter study[J]. Eur J Orthop Surg Traumatol, 2015, 25(1):117-121
[25] Drutskaya MS, Nosenko MA, Atretkhany KS, et al. Interleukin-6From molecular mechanisms of signal transduction to physiological properties and therapeutic targeting[J]. Mol Biol(Mosk), 2015, 49(6):937-943
[26] Rao SA, Kunte AR. Interleukin-6:An Early Predictive Marker for Severity of Acute Pancreatitis[J]. Indian J Crit Care Med, 2017, 21(7):424-428
[27] Dong R, Chen G, Zheng S, et al. Hepatic expression of interleukin 8in diagnosing biliary atresia[J]. Hepatology, 2015, 61(2):731-732
[28] Milovanovic J, Todorovic-Rakovic N, Abu Rabi Z. The role of interleukin 8 and matrix metalloproteinases 2 and 9 in breast cancer treated with tamoxifen[J]. J Buon, 2017, 22(3):628-637
[29]王少勇,张忠民,黄进堂,等.腹腔镜与开腹手术对胃癌根治术患者TNF-α和IL-6水平的影响研究[J].现代生物医学进展, 2015, 15(3):481-483Wang Shao-yong, Zhang Zhong-min, Huang Jin-tang, et al. Effect of Laparoscopic Surgery and Open Surgical Resection on TNF-αand IL-6 Levels in Patients with Radical Gastrectomy[J]. Progress in Modern Biomedicine, 2015, 15(3):481-483
[30]孙桂好,孙宏亮,王海鹏.血清与脑脊液中炎性因子检测对颅内感染早期诊断的临床意义[J].中华医院感染学杂志, 2014, 24(18):4665-4667Sun Gui-hao, Sun Hong-liang, Wang Hai-peng. Study on clinical significance of inflammatory cytokines in serum and cerebrospinal fluid testing for early diagnosis of intracranial infection[J]. Chinese Journal of Nosocomiology, 2014, 24(18):4665-4667
[2] Bondi S, Limardo P, Toma S, et al. Non-vestibular head and neck schwannomas:a 10-year experience[J]. Eur Arch Otorhinolaryngol,2013, 270(8):2365-2369
[3]张晓,王全桂,万喆.鼻前庭囊肿伴真菌感染一例[J].中华耳鼻咽喉头颈外科杂志, 2016, 51(6):458-459Zhang Xiao, Wang Quan-gui, Wan Zhe. One case of nasal vestibular cyst with fungul infection[J]. ChineseJournal of Otorhinolaryngology Head and Neck Surgery, 2016, 51(6):458-459
[4]钱建娥.鼻内镜下低温等离子刀射频消融术与唇龈沟径路囊肿切除术治疗鼻前庭囊肿的疗效比较[J].中国临床医学, 2015, 22(4):547-549Qian Jian-e. Efficacy Comparison between Low Temperature-Controlled Plasma Radiofrequency Ablation by Nasal Endos-copy and Cystectomy via Labiogingival Groove Approach in the Treatment of Nasal Vestibular Cyst[J]. Chinese Journal of Clinical Medicine, 2015,22(4):547-549
[5]孙兵.视觉模拟评分法(VAS)[J].中华神经外科杂志, 2012, 28(6):645-645Sun Bing. Visual analogue scale(VAS)[J]. Chinese Journal of Neurosurgery, 2012, 28(6):645-645
[6] Choi JH, Cho JH, Kang HJ, et al. Nasolabial eyst, a retrospective analysis of 18[J]. Ear Nose Throat J, 2012, 81(2):94-96
[7] Boffano P, Callesio C, Campisi P, et al. Diagnosis and surgical treatment of a nasolabial cyst[J]. J Craniofae Surg, 2011, 22(5):1946-1948
[8]郝凯飞,闫朝晖,陶树东.内镜下经鼻行鼻前庭囊肿完整剥除术的疗效观察[J].中华耳鼻咽喉头颈外科杂志, 2017, 52(5):361-364Hao Kai-fei, Yan Zhao-hui, Tao Shu-dong. Effect of intranasal excision on nasal vestibular cyst under nasal endoscopy[J]. ChineseJournal of Otorhinolaryngology Head and Neck Surgery, 2017, 52(5):361-364
[9] Bendeck SE, Chow S, Bennett RG, et al. Staged trilobe pedicle flap to repair a large cutaneous lip and nasal vestibule defect[J]. Dermatologic Surgery, 2012, 38(3):498-501
[10]郭斌.鼻内镜下低温等离子射频消融与传统方式切除鼻前庭囊肿的临床疗效观察[J].中国内镜杂志, 2017, 23(5):53-56Guo Bin. Comparison between low temperature-controlled plasma radio frequency ablation by nasal endoscopy and traditional way in treatment of nasal vestibular cyst[J]. China Journal of Endoscopy,2017, 23(5):53-56
[11]马行凯,马永明,陆建斌,等.鼻内镜下离子刀切除鼻前庭囊肿18例分析[J].中国中西医结合耳鼻咽喉科杂志, 2014, 22(1):28-29Ma Xing-kai, Ma Yong-ming, Lu Jian-bin, et al. Analysis of 18 Cases with Nasal Vestibular Cyst Excision under Nasal Endoscope Plasma Cutter[J]. Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine, 2014, 22(1):28-29
[12]吴兴宇,佘文胜,周林.鼻前庭囊肿揭盖术与唇龈沟径路切除术的疗效比较[J].武汉大学学报(医学版), 2015, 36(5):754-756Wu Xing-yu, She Wen-sheng, Zhou Lin. Comparison Between Marsupialization and Labiogingival Groove Approach in the Treatment of Nasal Vestibular Cyst[J]. Medical Journal of Wuhan University,2015, 36(5):754-756
[13]岳显.不同手术方案在鼻前庭囊肿患者中的应用效果对比[J].安徽医药, 2015, 19(3):518-520Yue Xian. Application results comparing different surgical options in patients with nasal vestibule cyst[J]. Anhui Medical and Pharmaceutical Journal, 2015, 19(3):518-520
[14]施芳.鼻前庭囊肿两种术式的临床分析[J].中国耳鼻咽喉颅底外科杂志, 2013, 19(3):273-274Shi Fang. Clinical analysis of two surgical methods for nasal vestibule cyst[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery,2013,19(3):273-274
[15]冀庆军,单亚萍,李大鹏,等.鼻内镜下两种手术方案在治疗鼻前庭囊肿中的临床疗效对比[J].中国耳鼻咽喉颅底外科杂志, 2016, 22(6):487-490Ji Qing-jun, Shan Ya-ping, Li Da-peng, et al. Comparison of clinical effect between two endoscopic surgical methods for nasal vestibule cyst[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery,2016, 22(6):487-490
[16]孙焕吉,卢永田,罗兴谷.两种鼻前庭囊肿手术疗效比较[J].山东医药, 2014, 54(32):74-75Sun Huan-ji, Lu Yong-tian, Luo Xing-gu. Comparing two surgical treatments for treatment of nasal vestibular cyst[J]. Shandong Medical Journal, 2014, 54(32):74-75
[17]陈永振,梁天喜,薛博广.鼻前庭囊肿揭盖术与经唇龈沟鼻前庭囊肿切除术治疗鼻前庭囊肿的疗效对比观察[J].中国临床新医学,2017, 10(6):521-523Chen Yong-zhen, Liang Tian-xi, Xue Bo-guang. Comparison of the surgical removal of nasal vestibular cyst and the excision of the nasal vestibular cyst via the sulcus of the lips in treatment of nasal vestibular cyst[J]. Chinese Journal of New Clinical Medicine, 2017, 10(6):521-523
[18]慕继霞,职良喜,赵勇.鼻内镜下揭盖法治疗鼻前庭囊肿临床分析[J].中国耳鼻咽喉颅底外科杂志, 2015, 21(3):254-255Mu Ji-xia, Zhi Liang-xi, Zhao Yong. Clinical analysis of nasal endoscopy in the treatment of nasal vestibule cyst[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery, 2015, 21(3):254-255
[19]覃焕桦,林琳.鼻内镜下低温等离子射频消融术与囊肿揭盖术治疗鼻前庭囊肿的临床分析[J].河北医药, 2017, 39(8):1231-1233Qin Huan-hua, Lin Lin. Clinical analysis of nasal endoscopy with low temperature plasma radiofrequency ablation and cyst uncovering for nasal vestibule cyst[J]. Hebei Medical Journal, 2017, 39(8):1231-1233
[20]赵艾君,谢鹏.鼻前庭嚢肿揭盖术与传统唇龈沟径路鼻前庭嚢肿切除术治疗鼻前庭嚢肿的疗效对比[J].广西医科大学学报, 2016, 33(5):880-882Zhao Ai-jun, Xie Peng. Comparison of the efficacy of nasal vestibule dissecting and traditional labiocutaneous sulcus approach in the treatment of nasal vestibular tumefaction[J]. Journal of Guangxi Medical University, 2016, 33(5):880-882
[21]佘国跃,唐兵华.鼻内镜下揭盖法治疗鼻前庭囊肿24例临床观察[J].西部医学, 2012, 24(7):1318-1319She Guo-yue, Tang Bing-hua. Effect of uncovering under nasal endoscopy on treatment of nasal vestibular cyst[J]. Medical Journal of West China, 2012, 24(7):1318-1319
[22]苟建军,张怡,王朝山,等.鼻内镜动力切削术对鼻前庭囊肿患者CRP、TNF-α、IL-6及IL-8的影响[J].现代生物医学进展, 2015, 15(25):4942-4945Gou Jian-jun, Zhang Yi, Wang Zhao-shan, et al. LEffect of CRP,TNF-α, IL-6 and IL-8 in Patients with Nasal Vestibular Cyst by Nasal Endoscopic Surgery[J]. Progress in Modern Biomedicine, 2015, 15(25):4942-4945
[23] Musilova I, Kacerovsky M, Stepan M, et al. Maternal serum C-reactive protein concentration and intra-amniotic inflammation in women with preterm prelabor rupture of membranes[J]. PLoS One, 2017, 12(8):e0182731
[24] Buchheit J, Uhring J, Sergent P, et al. Can preoperative CRP levels predict infections of bipolar hemiarthroplasty performed for femoral neck fracture? A retrospective, multicenter study[J]. Eur J Orthop Surg Traumatol, 2015, 25(1):117-121
[25] Drutskaya MS, Nosenko MA, Atretkhany KS, et al. Interleukin-6From molecular mechanisms of signal transduction to physiological properties and therapeutic targeting[J]. Mol Biol(Mosk), 2015, 49(6):937-943
[26] Rao SA, Kunte AR. Interleukin-6:An Early Predictive Marker for Severity of Acute Pancreatitis[J]. Indian J Crit Care Med, 2017, 21(7):424-428
[27] Dong R, Chen G, Zheng S, et al. Hepatic expression of interleukin 8in diagnosing biliary atresia[J]. Hepatology, 2015, 61(2):731-732
[28] Milovanovic J, Todorovic-Rakovic N, Abu Rabi Z. The role of interleukin 8 and matrix metalloproteinases 2 and 9 in breast cancer treated with tamoxifen[J]. J Buon, 2017, 22(3):628-637
[29]王少勇,张忠民,黄进堂,等.腹腔镜与开腹手术对胃癌根治术患者TNF-α和IL-6水平的影响研究[J].现代生物医学进展, 2015, 15(3):481-483Wang Shao-yong, Zhang Zhong-min, Huang Jin-tang, et al. Effect of Laparoscopic Surgery and Open Surgical Resection on TNF-αand IL-6 Levels in Patients with Radical Gastrectomy[J]. Progress in Modern Biomedicine, 2015, 15(3):481-483
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