3种方案治疗新生儿病理性黄疸的临床疗效对比
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摘要
目的:探讨蓝光照射分别联合白蛋白、妈咪爱、茵栀黄颗粒治疗新生儿病理性黄疸的临床疗效,并观察这3种方案对患儿体质量和细胞免疫功能的影响。方法:选取2017年1月～2018年2月我中心收治84例病理性黄疸新生儿作为研究对象,采用随机数字表法分为观察组、对照A组和对照B组,每组28例。观察组采用白蛋白、妈咪爱、茵栀黄颗粒联合蓝光照射治疗,对照A组采用白蛋白联合蓝光照射进行治疗,对照B组采用茵栀黄颗粒联合蓝光照射治疗,治疗后,统计比较三组的治疗总有效率、体质量和细胞免疫功能。结果:观察组的治疗总有效率、体质量和免疫功能指标均明显优于对照A组和对照B组,差异有统计学意义,P<0.05。结论:白蛋白、妈咪爱、茵栀黄颗粒联合蓝光照射治疗新生儿病理性黄疸疗效显著。
Objective: To investigate the clin ical efficacy of blue light irradiation combined with albumin, Medilac-Vita,Yinzhihuang granules respectively in the treatment of neonatal pathological jaundice and their influence on the body weight and cellular immune function. Methods: From January 2017 to February 2018, 84 neonates with pathological jaundice were selected as the research objects, they were randomly divided into observation group, control group A and control group B, with 28 cases each. The neonates in the observation group were treated with Albumin, Medilac-Vita, Yinzhihuang granules combined with blue light irradiation, the neonates in the control group A were treated with Albumin combined with blue light irradiation, and the neonates in the control group B were treated with Yinzhihuang granules combined with blue light irradiation. After the treatment, the total efficiency, body weight and cellular immune function of the three groups were compared. Results: The total efficiency, body weight, immune function indicators of the observation group were significantly better than those in the control group A and control group B, the differences were significant, P <0.05.Conclusion: Albumin, Medilac-Vita, Yinzhihuang granules combined with blue light irradiation can achieve significant effects in the treatment of neonatal pathological jaundice.
Objective: To investigate the clin ical efficacy of blue light irradiation combined with albumin, Medilac-Vita,Yinzhihuang granules respectively in the treatment of neonatal pathological jaundice and their influence on the body weight and cellular immune function. Methods: From January 2017 to February 2018, 84 neonates with pathological jaundice were selected as the research objects, they were randomly divided into observation group, control group A and control group B, with 28 cases each. The neonates in the observation group were treated with Albumin, Medilac-Vita, Yinzhihuang granules combined with blue light irradiation, the neonates in the control group A were treated with Albumin combined with blue light irradiation, and the neonates in the control group B were treated with Yinzhihuang granules combined with blue light irradiation. After the treatment, the total efficiency, body weight and cellular immune function of the three groups were compared. Results: The total efficiency, body weight, immune function indicators of the observation group were significantly better than those in the control group A and control group B, the differences were significant, P <0.05.Conclusion: Albumin, Medilac-Vita, Yinzhihuang granules combined with blue light irradiation can achieve significant effects in the treatment of neonatal pathological jaundice.
引文
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[12]冯兰芳,舒彩敏,季巧英.炎症因子、免疫细胞和纤维蛋白原检测在COPD诊断和预后判断中的价值[J].浙江医学,2017,39(11):882-886
[13]卢秀兰,左超,仇君,等.氨基末端脑钠肽前体对重症手足口病患儿病情及预后评估的意义[J].中华实用儿科临床杂志,2015,30(10):750-753
[14]胡明贤,惠正刚.蓝光对新生儿高未结合胆红素血症及对细胞免疫功能的影响[J].实用临床医药杂志,2016,20(23):113-115
[15]崔法新,王青霞,胥彬,等.病理性黄疸新生儿血清巨细胞病毒DNA检测结果及治疗策略[J].中华实用儿科临床杂志,2016,31(14):1105-1106
[2]孙昌友,苏畅,李清,等.维生素C联合果糖二磷酸钠治疗新生儿窒息后心肌损伤的疗效及对患儿CK-MB的影响[J].中国妇幼保健,2017,32(23):5930-5932
[3]敖小艳.前清蛋白、心肌酶、C反应蛋白检测在重症手足口病合并心肌损伤患儿诊治中的意义[J].中国基层医药,2016,23(22):3500-3503
[4]高宏,殷东风,邢向荣,等.奥施康定联合加巴喷丁治疗癌性神经病理性疼痛的临床疗效及对免疫功能的影响[J].现代生物医学进展,2017,17(23):4479-4482
[5]Gaunt E,Harvala H,Osterback R,et al.Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease:a potential role of recombination in emergence and pathogenicity[J].Journal of General Virology,2015,96(Pt5):1067-1079
[6]李国兴,朱丽虹.手足口病患儿早期检测血清炎症因子及免疫因子的临床意义[J].中国现代医生,2016,54(2):55-57
[7]梅江华,雷宏涛.不同蓝光照射联合苯巴比妥对新生儿病理性黄疸疗效对比[J].西南国防医药,2017,27(10):1076-1078
[8]王晓娇,王亚娟,邵芳,等.新生儿黄疸换血疗法对新生儿内环境的影响[J].首都医科大学学报,2016,37(2):136-140
[9]霍汝亚寒,陈晶,刘恒.多巴胺对新生儿肺动脉高压患儿血浆BNP的影响及临床疗效研究[J].临床肺科杂志,2016,21(7):1207-1209
[10]徐媛媛.手足口病患儿外周血炎性标志物及体液免疫联合检测的临床意义[J].医学理论与实践,2016,29(11):1420-1422
[11]张丽娇.静脉滴注丙种球蛋白辅助治疗新生儿败血症疗效及外周血清炎性因子影响[J].中国儿童保健杂志,2016,24(11):1222-1224
[12]冯兰芳,舒彩敏,季巧英.炎症因子、免疫细胞和纤维蛋白原检测在COPD诊断和预后判断中的价值[J].浙江医学,2017,39(11):882-886
[13]卢秀兰,左超,仇君,等.氨基末端脑钠肽前体对重症手足口病患儿病情及预后评估的意义[J].中华实用儿科临床杂志,2015,30(10):750-753
[14]胡明贤,惠正刚.蓝光对新生儿高未结合胆红素血症及对细胞免疫功能的影响[J].实用临床医药杂志,2016,20(23):113-115
[15]崔法新,王青霞,胥彬,等.病理性黄疸新生儿血清巨细胞病毒DNA检测结果及治疗策略[J].中华实用儿科临床杂志,2016,31(14):1105-1106