“乳头孔给药型”中药软膏剂的制备工艺研究
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摘要
为了研制防治奶牛乳房炎的新型中药制剂,本试验以中药提取物为主药,添加一定量的软膏基质制备成"乳头孔给药型"中药软膏剂.采用水提法与醇提法相结合提取中药中的有效成分,并制备成流浸膏;以流浸膏含量(%)、基质中油相比例、乳化剂的用量(%)、乳化剂的HLB值4个因素进行三水平的正交试验设计,以软膏外观性状和稳定性为主要评价指标筛选最佳的处方组分及用量.确定最佳工艺为流浸膏含量13%、油相比例4∶2.5∶1.5∶1、乳化剂用量5%、乳化剂HLB值13.通过初步稳定性试验考察和留样观察,该工艺条件下制备的中药软膏剂稳定且外观性状好.
In order to develop a new Chinese materia medica preparation for the prevention of cow mastitis,a"papillary foramina administration"compound ointment was made with Chinese herb extract medicine as the primary component,in combination with a certain amount of cream base,in an experiment reported herein.Water extraction and alcohol extraction were used in combination to extract the active ingredients in the traditional Chinese medicine to prepare fluid ointments.An orthogonal test was made with four factors(the content in proportion of the fluid ointments,the proportion of ointment in the cream base,the amount of emulsifier consumption and the HLB of emulsifier)at three levels.With the appearance characteristics and the stability of the ointment as main evaluation indicators,the best prescription components and their dosages were screened.The optimal prescription obtained was:fluid ointment content was 13%,emulsifier consumption was 5%,the proportion of ointment in the cream base was 4∶2,5∶1,5∶1and HLB of the emulsifier was 13.Based on the results of a preliminary stability experiment and sample observation,the compound ointment produced in this way had good stability and satisfactory appearance.
In order to develop a new Chinese materia medica preparation for the prevention of cow mastitis,a"papillary foramina administration"compound ointment was made with Chinese herb extract medicine as the primary component,in combination with a certain amount of cream base,in an experiment reported herein.Water extraction and alcohol extraction were used in combination to extract the active ingredients in the traditional Chinese medicine to prepare fluid ointments.An orthogonal test was made with four factors(the content in proportion of the fluid ointments,the proportion of ointment in the cream base,the amount of emulsifier consumption and the HLB of emulsifier)at three levels.With the appearance characteristics and the stability of the ointment as main evaluation indicators,the best prescription components and their dosages were screened.The optimal prescription obtained was:fluid ointment content was 13%,emulsifier consumption was 5%,the proportion of ointment in the cream base was 4∶2,5∶1,5∶1and HLB of the emulsifier was 13.Based on the results of a preliminary stability experiment and sample observation,the compound ointment produced in this way had good stability and satisfactory appearance.
引文
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[2]陈文珠,郭伟忠,林茵.栀子药材提取工艺的优化[J].井冈山学院学报(自然科学版),2008,29(3):75-77.
[3]刘春海,刘西京,杨永华.黄连及其复方提取工艺条件的优选[J].时珍国医国药,2006,17(11):2249-2250.
[4]王雷,富丽静,于翔,等.中草药五倍子、诃子有效成分提取工艺的研究[J].水生态学杂志,2009,2(1):135-137.
[5]刘可春,刘昌衡,王希敏,等.辣椒碱软膏基质及其配方的优选试验研究[J].山东科学,2004,17(2):33-36.
[6]武瑞,和翀翼,富艳玲,等.防治奶牛乳房炎中药乳膏剂的研制与质量鉴定[J].中国农学通报,2008,24(2):26-30.
[7]徐建峰.三黄解毒软膏的制备工艺研究[J].中国现代药物应用,2010,4(11):98-99.
[8]王建发,杨龙蛟,刘洋军.奶牛乳头消毒剂的现状及研发思路[J].兽药市场指南,2008(6):27.
[9]汪龙德.栀子对离体兔Oddi括约肌收缩活动的影响[J].兰州大学学报(医学版),2009,35(2):5-8.